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1 April 2017
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Cover Image
Cover Image
On the cover: A microscopic image of an islet graft in the C57BL/6 mouse liver 6 h after syngeneic intraportal islet transplantation. Brown indicates islet β-cells stained with anti-insulin antibody. Blue indicates nuclei stained with hematoxylin. Image courtesy of Jingjing Wang, Department of Surgery, Medical University of South Carolina, Charleston, SC. Her article, “α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction,” appears in this issue of Diabetes (p. 970).
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes March 2017, Vol.66, 789-790. doi:https://doi.org/10.2337/db17-ti04
Perspectives in Diabetes
Proximal Tubulopathy: Prime Mover and Key Therapeutic Target in Diabetic Kidney Disease
Diabetes March 2017, Vol.66, 791-800. doi:https://doi.org/10.2337/db16-0796
Commentaries
Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?
Diabetes March 2017, Vol.66, 804-805. doi:https://doi.org/10.2337/dbi16-0073
Metabolism
Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype
Diabetes December 2016, Vol.66, 806-814. doi:https://doi.org/10.2337/db16-0779
Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study
Diabetes January 2017, Vol.66, 815-822. doi:https://doi.org/10.2337/db16-1167
Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure
Gregory J. Morton; Kenjiro Muta; Karl J. Kaiyala; Jennifer M. Rojas; Jarrad M. Scarlett; Miles E. Matsen; Jarrell T. Nelson; Nikhil K. Acharya; Francesca Piccinini; Darko Stefanovski; Richard N. Bergman; Gerald J. Taborsky, Jr.; Steven E. Kahn; Michael W. Schwartz
Diabetes January 2017, Vol.66, 823-834. doi:https://doi.org/10.2337/db16-1351
Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity
Diabetes January 2017, Vol.66, 835-847. doi:https://doi.org/10.2337/db16-1122
Obesity-Associated Alterations in Glucose Metabolism Are Reversed by Chronic Bilateral Stimulation of the Abdominal Vagus Nerve
Diabetes January 2017, Vol.66, 848-857. doi:https://doi.org/10.2337/db16-0847
FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism
Diabetes January 2017, Vol.66, 858-867. doi:https://doi.org/10.2337/db16-1212
Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet–Fed Mice
Erina Joo; Norio Harada; Shunsuke Yamane; Toru Fukushima; Daisuke Taura; Kanako Iwasaki; Akiko Sankoda; Kimitaka Shibue; Takanari Harada; Kazuyo Suzuki; Akihiro Hamasaki; Nobuya Inagaki
Diabetes January 2017, Vol.66, 868-879. doi:https://doi.org/10.2337/db16-0758
Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes
Henri Honka; Jukka Koffert; Saila Kauhanen; Jarmo Teuho; Saija Hurme; Andrea Mari; Andreas Lindqvist; Nils Wierup; Leif Groop; Pirjo Nuutila
Diabetes January 2017, Vol.66, 880-885. doi:https://doi.org/10.2337/db16-0762
Signal Transduction
Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor
Siegfried Ussar; Max-Felix Haering; Shiho Fujisaka; Dominik Lutter; Kevin Y. Lee; Ning Li; Georg K. Gerber; Lynn Bry; C. Ronald Kahn
Diabetes January 2017, Vol.66, 886-896. doi:https://doi.org/10.2337/db15-1349
Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes
Vincenzo Mastrolia; Sylvia M. Flucher; Gerald J. Obermair; Mathias Drach; Helene Hofer; Erik Renström; Arnold Schwartz; Jörg Striessnig; Bernhard E. Flucher; Petronel Tuluc
Diabetes January 2017, Vol.66, 897-907. doi:https://doi.org/10.2337/db16-0336
Obesity Studies
Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation
Caroline André; Omar Guzman-Quevedo; Charlotte Rey; Julie Rémus-Borel; Samantha Clark; Ashley Castellanos-Jankiewicz; Elodie Ladeveze; Thierry Leste-Lasserre; Agnes Nadjar; Djoher Nora Abrous; Sophie Laye; Daniela Cota
Diabetes November 2016, Vol.66, 908-919. doi:https://doi.org/10.2337/db16-0586
Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity
Mauricio D. Dorfman; Jordan E. Krull; Jarrad M. Scarlett; Stephan J. Guyenet; Mini P. Sajan; Vincent Damian; Hong T. Nguyen; Michael Leitges; Gregory J. Morton; Robert V. Farese; Michael W. Schwartz; Joshua P. Thaler
Diabetes January 2017, Vol.66, 920-934. doi:https://doi.org/10.2337/db16-0482
Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity
Ruixin Liu; Yaoyu Zou; Jie Hong; Min Cao; Bin Cui; Huiwen Zhang; Maopei Chen; Juan Shi; Tinglu Ning; Shaoqian Zhao; Wen Liu; Hui Xiong; Cuijie Wei; Zhengqing Qiu; Weiqiong Gu; Yifei Zhang; Wanyu Li; Lin Miao; Yingkai Sun; Minglan Yang; Rui Wang; Qinyun Ma; Min Xu; Yu Xu; Tiange Wang; Kei-hang Katie Chan; Xianbo Zuo; Haoyan Chen; Lu Qi; Shenghan Lai; Shumin Duan; Baoliang Song; Yufang Bi; Simin Liu; Weiqing Wang; Guang Ning; Jiqiu Wang
Diabetes January 2017, Vol.66, 935-947. doi:https://doi.org/10.2337/db16-0877
Islet Studies
Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis
Dan Zhu; Li Xie; Youhou Kang; Subhankar Dolai; Jakob Bondo Hansen; Tairan Qin; Huanli Xie; Tao Liang; Deborah C. Rubin; Lucy Osborne; Herbert Y. Gaisano
Diabetes January 2017, Vol.66, 948-959. doi:https://doi.org/10.2337/db16-0636
Reestablishment of Glucose Inhibition of Glucagon Secretion in Small Pseudoislets
Diabetes January 2017, Vol.66, 960-969. doi:https://doi.org/10.2337/db16-1291
Immunology and Transplantation
α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction
Jingjing Wang; Zhen Sun; Wenyu Gou; David B. Adams; Wanxing Cui; Katherine A. Morgan; Charlie Strange; Hongjun Wang
Diabetes January 2017, Vol.66, 970-980. doi:https://doi.org/10.2337/db16-1036
Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity
Diabetes January 2017, Vol.66, 981-986. doi:https://doi.org/10.2337/db16-0218
Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs
Apolline Salama; Mathilde Mosser; Xavier Lévêque; Andrea Perota; Jean-Paul Judor; Corentin Danna; Sylvie Pogu; Anne Mouré; Dominique Jégou; Nicolas Gaide; Jérôme Abadie; Olivier Gauthier; Jean-Paul Concordet; Stéphanie Le Bas-Bernardet; David Riochet; Ludmilla Le Berre; Jérémy Hervouet; David Minault; Pierre Weiss; Jérôme Guicheux; Sophie Brouard; Steffi Bosch; Irina Lagutina; Roberto Duchi; Giovanna Lazzari; Emanuele Cozzi; Gilles Blancho; Sophie Conchon; Cesare Galli; Jean-Paul Soulillou; Jean-Marie Bach
Diabetes January 2017, Vol.66, 987-993. doi:https://doi.org/10.2337/db16-1060
Pathophysiology
Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes
Tony Jourdan; Gergő Szanda; Resat Cinar; Grzegorz Godlewski; David J. Holovac; Joshua K. Park; Sarah Nicoloro; Yuefei Shen; Jie Liu; Avi Z. Rosenberg; Ziyi Liu; Michael P. Czech; George Kunos
Diabetes January 2017, Vol.66, 994-1007. doi:https://doi.org/10.2337/db16-1199
PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity
Yasuhiro Onogi; Tsutomu Wada; Chie Kamiya; Kento Inata; Takatoshi Matsuzawa; Yuka Inaba; Kumi Kimura; Hiroshi Inoue; Seiji Yamamoto; Yoko Ishii; Daisuke Koya; Hiroshi Tsuneki; Masakiyo Sasahara; Toshiyasu Sasaoka
Diabetes January 2017, Vol.66, 1008-1021. doi:https://doi.org/10.2337/db16-0881
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis
Teresa Velayos; Rosa Martínez; Milagros Alonso; Koldo Garcia-Etxebarria; Anibal Aguayo; Cristina Camarero; Inés Urrutia; Idoia Martínez de LaPiscina; Raquel Barrio; Izortze Santin; Luis Castaño
Diabetes January 2017, Vol.66, 1022-1029. doi:https://doi.org/10.2337/db16-0867
Complications
The Sodium–Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model
Michael Joubert; Benoît Jagu; David Montaigne; Xavier Marechal; Angela Tesse; Audrey Ayer; Lucile Dollet; Cédric Le May; Gilles Toumaniantz; Alain Manrique; Flavien Charpentier; Bart Staels; Jocelyne Magré; Bertrand Cariou; Xavier Prieur
Diabetes January 2017, Vol.66, 1030-1040. doi:https://doi.org/10.2337/db16-0733
Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes
Leo M.Y. Lee; Maran B.W. Leung; Rachel C.Y. Kwok; Yun Chung Leung; Chi Chiu Wang; Peter J. McCaffery; Andrew J. Copp; Alisa S.W. Shum
Diabetes January 2017, Vol.66, 1041-1051. doi:https://doi.org/10.2337/db15-1570
Proinflammatory Effects of Hypoglycemia in Humans With or Without Diabetes
Jacqueline M. Ratter; Hanne M.M. Rooijackers; Cees J. Tack; Anneke G.M. Hijmans; Mihai G. Netea; Bastiaan E. de Galan; Rinke Stienstra
Diabetes January 2017, Vol.66, 1052-1061. doi:https://doi.org/10.2337/db16-1091
Pharmacology and Therapeutics
Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight
Rozita H. Anderberg; Jennifer E. Richard; Kim Eerola; Lorena López-Ferreras; Elin Banke; Caroline Hansson; Hans Nissbrandt; Filip Berqquist; Fiona M. Gribble; Frank Reimann; Ingrid Wernstedt Asterholm; Christophe M. Lamy; Karolina P. Skibicka
Diabetes January 2017, Vol.66, 1062-1073. doi:https://doi.org/10.2337/db16-0755
Genetics / Genomes / Proteomics / Metabolomics
Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
Petr Volkov; Karl Bacos; Jones K. Ofori; Jonathan Lou S. Esguerra; Lena Eliasson; Tina Rönn; Charlotte Ling
Diabetes January 2017, Vol.66, 1074-1085. doi:https://doi.org/10.2337/db16-0996
dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure
Reinaldo Sousa Dos Santos; Mathilde Daures; Anne Philippi; Sophie Romero; Lorella Marselli; Piero Marchetti; Valérie Senée; Delphine Bacq; Céline Besse; Baz Baz; Laura Marroquí; Sarah Ivanoff; Julien Masliah-Planchon; Marc Nicolino; Jean Soulier; Gérard Socié; Decio L. Eizirik; Jean-François Gautier; Cécile Julier
Diabetes January 2017, Vol.66, 1086-1096. doi:https://doi.org/10.2337/db16-0839
Errata
Erratum. Metabolomic Profile of Low–Copy Number Carriers at the Salivary α-Amylase Gene Suggests a Metabolic Shift Toward Lipid-Based Energy Production. Diabetes 2016;65:3362–3368
Abdelilah Arredouani; Matteo Stocchero; Nicola Culeddu; Julia El-Sayed Moustafa; D.E.S.I.R. Study Group; Jean Tichet; Beverley Balkau; Thierry Brousseau; Marco Manca; Mario Falchi
Diabetes February 2017, Vol.66, 1097. doi:https://doi.org/10.2337/db17-er04a
Erratum. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes 2016;65:3091–3103
Joanne T.M. Tan; Hamish C.G. Prosser; Louise L. Dunn; Laura Z. Vanags; Anisyah Ridiandries; Tania Tsatralis; Laura Leece; Zoë E. Clayton; Sui Ching G. Yuen; Stacy Robertson; Yuen Ting Lam; David S. Celermajer; Martin K.C. Ng; Christina A. Bursill
Diabetes February 2017, Vol.66, 1097. doi:https://doi.org/10.2337/db17-er04b
Expression of Concern
Expression of Concern. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice. Diabetes 2009;58:2910–2919. DOI: 10.2337/db08-0506. PMID: 19696185
Patricia O. Prada; Eduardo R. Ropelle; Rosa H. Mourão; Claudio T. de Souza; Jose R. Pauli; Dennys E. Cintra; André Schenka; Silvana A. Rocco; Roberto Rittner; Kleber G. Franchini; José Vassallo; Lício A. Velloso; José B. Carvalheira; Mario J.A. Saad
Diabetes February 2017, Vol.66, 1098. doi:https://doi.org/10.2337/db17-ec04a
