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1 May 2017
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Cover Image
Cover Image
On the cover: An image of broccoli sprouts, the dietary source of the antiobesity functional ingredient glucoraphanin. Image courtesy of Murakami Farm Co., Ltd. The article by Naoto Nagata et al., “Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice,” appears in this issue of Diabetes (p. 1222).
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process. Click here for more information. - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes April 2017, Vol.66, 1101-1102. doi:https://doi.org/10.2337/db17-ti05
Perspectives in Diabetes
Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer
Dana K. Andersen; Murray Korc; Gloria M. Petersen; Guido Eibl; Donghui Li; Michael R. Rickels; Suresh T. Chari; James L. Abbruzzese
Diabetes April 2017, Vol.66, 1103-1110. doi:https://doi.org/10.2337/db16-1477
Autologous Pluripotent Stem Cell–Derived β-Like Cells for Diabetes Cellular Therapy
Diabetes April 2017, Vol.66, 1111-1120. doi:https://doi.org/10.2337/db16-1406
Commentaries
Metabolism
Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice
Liping Qiao; Jean-Sebastien Wattez; Samuel Lee; Amanda Nguyen; Jerome Schaack; William W. Hay, Jr.; Jianhua Shao
Diabetes January 2017, Vol.66, 1126-1135. doi:https://doi.org/10.2337/db16-1096
Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day
Mary Courtney Moore; Marta S. Smith; Ben Farmer; Guillaume Kraft; Masakazu Shiota; Phillip E. Williams; Alan D. Cherrington
Diabetes February 2017, Vol.66, 1136-1145. doi:https://doi.org/10.2337/db16-1308
ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure
Yuzhong Xiao; Yalan Deng; Feixiang Yuan; Tingting Xia; Hao Liu; Zhigang Li; Zhixue Liu; Hao Ying; Yi Liu; Qiwei Zhai; Shanghai Chen; Feifan Guo
Diabetes February 2017, Vol.66, 1146-1158. doi:https://doi.org/10.2337/db16-1546
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis
Jiangying Kuang; Yuwei Zhang; Qinhui Liu; Jing Shen; Shiyun Pu; Shihai Cheng; Lei Chen; Hong Li; Tong Wu; Rui Li; Yanping Li; Min Zou; Zhiyong Zhang; Wei Jiang; Guoheng Xu; Aijuan Qu; Wen Xie; Jinhan He
Diabetes March 2017, Vol.66, 1159-1171. doi:https://doi.org/10.2337/db16-1225
Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle
Tracy P. O’Brien; Erin C. Jenkins; Shanea K. Estes; Antonio V. Castaneda; Kiichiro Ueta; Tiffany D. Farmer; Allison E. Puglisi; Larry L. Swift; Richard L. Printz; Masakazu Shiota
Diabetes February 2017, Vol.66, 1172-1184. doi:https://doi.org/10.2337/db16-1410
Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice
Zhenzhen Chen; Liwei Ding; Weili Yang; Junpei Wang; Liming Chen; Yongsheng Chang; Bin Geng; Qinghua Cui; Youfei Guan; Jichun Yang
Diabetes February 2017, Vol.66, 1185-1197. doi:https://doi.org/10.2337/db16-0993
Obesity Studies
Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway
Wen Meng; Xiuci Liang; Hongzhi Chen; Hairong Luo; Juli Bai; Guangdi Li; Qinghai Zhang; Ting Xiao; Sijia He; Yacheng Zhang; Zhipeng Xu; Bo Xiao; Meilian Liu; Fang Hu; Feng Liu
Diabetes February 2017, Vol.66, 1198-1213. doi:https://doi.org/10.2337/db16-0886
Vascular Effects of Obestatin in Lean and Obese Subjects
Francesca Schinzari; Augusto Veneziani; Nadia Mores; Angela Barini; Nicola Di Daniele; Carmine Cardillo; Manfredi Tesauro
Diabetes February 2017, Vol.66, 1214-1221. doi:https://doi.org/10.2337/db16-1067
Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice
Naoto Nagata; Liang Xu; Susumu Kohno; Yusuke Ushida; Yudai Aoki; Ryohei Umeda; Nobuo Fuke; Fen Zhuge; Yinhua Ni; Mayumi Nagashimada; Chiaki Takahashi; Hiroyuki Suganuma; Shuichi Kaneko; Tsuguhito Ota
Diabetes February 2017, Vol.66, 1222-1236. doi:https://doi.org/10.2337/db16-0662
Mast Cells Promote Seasonal White Adipose Beiging in Humans
Brian S. Finlin; Beibei Zhu; Amy L. Confides; Philip M. Westgate; Brianna D. Harfmann; Esther E. Dupont-Versteegden; Philip A. Kern
Diabetes March 2017, Vol.66, 1237-1246. doi:https://doi.org/10.2337/db16-1057
Islet Studies
Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion
Uma D. Kabra; Katrin Pfuhlmann; Adriana Migliorini; Susanne Keipert; Daniel Lamp; Olle Korsgren; Moritz Gegg; Stephen C. Woods; Paul T. Pfluger; Heiko Lickert; Charles Affourtit; Matthias H. Tschöp; Martin Jastroch
Diabetes February 2017, Vol.66, 1247-1257. doi:https://doi.org/10.2337/db16-1088
Identification and Functional Implications of Sodium/Myo-Inositol Cotransporter 1 in Pancreatic β-Cells and Type 2 Diabetes
Diabetes February 2017, Vol.66, 1258-1271. doi:https://doi.org/10.2337/db16-0880
Glucagon-Like Peptide 1 Protects Pancreatic β-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function
Francesco P. Zummo; Kirsty S. Cullen; Minna Honkanen-Scott; James A.M. Shaw; Penny E. Lovat; Catherine Arden
Diabetes February 2017, Vol.66, 1272-1285. doi:https://doi.org/10.2337/db16-1009
[11C]5-hydroxy-tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes
Lina Carlbom; Daniel Espes; Mark Lubberink; Mats Martinell; Lars Johansson; Håkan Ahlström; Per-Ola Carlsson; Olle Korsgren; Olof Eriksson
Diabetes February 2017, Vol.66, 1286-1292. doi:https://doi.org/10.2337/db16-1449
Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
Taka-aki Matsuoka; Satoshi Kawashima; Takeshi Miyatsuka; Shugo Sasaki; Naoki Shimo; Naoto Katakami; Dan Kawamori; Satomi Takebe; Pedro L. Herrera; Hideaki Kaneto; Roland Stein; Iichiro Shimomura
Diabetes February 2017, Vol.66, 1293-1300. doi:https://doi.org/10.2337/db16-0887
Immunology and Transplantation
Local Sphingosine Kinase 1 Activity Improves Islet Transplantation
Darling Rojas-Canales; Daniella Penko; Kay K. Myo Min; Kate A. Parham; Heshan Peiris; Rainer V. Haberberger; Stuart M. Pitson; Chris Drogemuller; Damien J. Keating; Shane T. Grey; Patrick T. Coates; Claudine S. Bonder; Claire F. Jessup
Diabetes February 2017, Vol.66, 1301-1311. doi:https://doi.org/10.2337/db16-0837
Cotransplantation of Mesenchymal Stem Cells With Neonatal Porcine Islets Improve Graft Function in Diabetic Mice
Julie A. Hayward; Cara E. Ellis; Karen Seeberger; Timothy Lee; Bassem Salama; Aillette Mulet-Sierra; Purushothaman Kuppan; Adetola Adesida; Gregory S. Korbutt
Diabetes February 2017, Vol.66, 1312-1321. doi:https://doi.org/10.2337/db16-1068
Pathophysiology
Cardiac Autonomic Regulation and Repolarization During Acute Experimental Hypoglycemia in Type 2 Diabetes
Elaine Chow; Alan Bernjak; Emma Walkinshaw; Alexandra Lubina-Solomon; Jenny Freeman; Ian A. Macdonald; Paul J. Sheridan; Simon R. Heller
Diabetes January 2017, Vol.66, 1322-1333. doi:https://doi.org/10.2337/db16-1310
Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset
Teresa Rodriguez-Calvo; Jose Zapardiel-Gonzalo; Natalie Amirian; Ericka Castillo; Yasaman Lajevardi; Lars Krogvold; Knut Dahl-Jørgensen; Matthias G. von Herrath
Diabetes January 2017, Vol.66, 1334-1345. doi:https://doi.org/10.2337/db16-1343
Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart
Erkan Tuncay; Verda C. Bitirim; Aysegul Durak; Gaelle R.J. Carrat; Kathryn M. Taylor; Guy A. Rutter; Belma Turan
Diabetes February 2017, Vol.66, 1346-1358. doi:https://doi.org/10.2337/db16-1099
Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules
Atsushi Takahashi; Yoshitsugu Takabatake; Tomonori Kimura; Ikuko Maejima; Tomoko Namba; Takeshi Yamamoto; Jun Matsuda; Satoshi Minami; Jun-ya Kaimori; Isao Matsui; Taiji Matsusaka; Fumio Niimura; Tamotsu Yoshimori; Yoshitaka Isaka
Diabetes February 2017, Vol.66, 1359-1372. doi:https://doi.org/10.2337/db16-0397
Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance
Róbert Wagner; Liisa H. Hakaste; Emma Ahlqvist; Martin Heni; Jürgen Machann; Fritz Schick; Emmanuel Van Obberghen; Norbert Stefan; Baptist Gallwitz; Tiinamaija Tuomi; Hans-Ulrich Häring; Leif Groop; Andreas Fritsche
Diabetes December 2016, Vol.66, 1373-1379. doi:https://doi.org/10.2337/db16-0354
Complications
Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy
Andrew G. Marshall; Corinne Lee-Kubli; Shazli Azmi; Michael Zhang; Maryam Ferdousi; Teresa Mixcoatl-Zecuatl; Ioannis N. Petropoulos; Georgios Ponirakis; Mark S. Fineman; Hassan Fadavi; Katie Frizzi; Mitra Tavakoli; Maria Jeziorska; Corinne G. Jolivalt; Andrew J.M. Boulton; Nathan Efron; Nigel A. Calcutt; Rayaz A. Malik
Diabetes February 2017, Vol.66, 1380-1390. doi:https://doi.org/10.2337/db16-1181
Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy
Shankhajit De; Shoji Kuwahara; Michihiro Hosojima; Tomomi Ishikawa; Ryohei Kaseda; Piyali Sarkar; Yusuke Yoshioka; Hideyuki Kabasawa; Tomomichi Iida; Sawako Goto; Koji Toba; Yuki Higuchi; Yoshiki Suzuki; Masanori Hara; Hiroyuki Kurosawa; Ichiei Narita; Yoshiaki Hirayama; Takahiro Ochiya; Akihiko Saito
Diabetes March 2017, Vol.66, 1391-1404. doi:https://doi.org/10.2337/db16-1031
Pharmacology and Therapeutics
Butyrate Regulates Liver Mitochondrial Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice
Maria Pina Mollica; Giuseppina Mattace Raso; Gina Cavaliere; Giovanna Trinchese; Chiara De Filippo; Serena Aceto; Marina Prisco; Claudio Pirozzi; Francesca Di Guida; Adriano Lama; Marianna Crispino; Diana Tronino; Paola Di Vaio; Roberto Berni Canani; Antonio Calignano; Rosaria Meli
Diabetes February 2017, Vol.66, 1405-1418. doi:https://doi.org/10.2337/db16-0924
Genetics / Genomes / Proteomics / Metabolomics
Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Qibin Qi; Adrienne M. Stilp; Tamar Sofer; Jee-Young Moon; Bertha Hidalgo; Adam A. Szpiro; Tao Wang; Maggie C.Y. Ng; Xiuqing Guo; MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium; Yii-Der Ida Chen; Kent D. Taylor; M. Larissa Aviles-Santa; George Papanicolaou; James S. Pankow; Neil Schneiderman; Cathy C. Laurie; Jerome I. Rotter; Robert C. Kaplan
Diabetes March 2017, Vol.66, 1419-1425. doi:https://doi.org/10.2337/db16-1150
Statement of Retraction
Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59:1870–1878. DOI: 10.2337/db09-1503. PMID: 20460426
Pontus Boström; Linda Andersson; Birgitte Vind; Liliana Håversen; Mikael Rutberg; Ylva Wickström; Erik Larsson; Per-Anders Jansson; Maria K. Svensson; Richard Brånemark; Charlotte Ling; Henning Beck-Nielsen; Jan Borén; Kurt Højlund; Sven-Olof Olofsson
Diabetes February 2017, Vol.66, 1426. doi:https://doi.org/10.2337/db17-rt05a
Issues and Events
e-Letters: Comments and Responses
Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776–3785
Jonathan Adam; Stefan Brandmaier; Martina Troll; Markus Rotter; Robert P. Mohney; Margit Heier; Jerzy Adamski; Yixue Li; Susanne Neschen; Gabi Kastenmüller; Karsten Suhre; Donna Ankerst; Thomas Meitinger; Rui Wang-Sattler
Diabetes April 2017, Vol.66, e3-e4. doi:https://doi.org/10.2337/dbi17-0010
