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1 August 2017
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Cover Image
Cover Image
On the cover: Color-enhanced transmission electron micrograph of a hepatic cell from a fasted hamster after an injection of cortisone. In mammalian liver, glycogen appears in the form of coarse rosettes (blue) or alpha particles. Credit: Don W. Fawcett/Science Source. For further information, please visit www.sciencesource.com. This issue of Diabetes includes the article “Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting” by Franklin et al. (p. 2112).
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes July 2017, Vol.66, 2061-2062. doi:https://doi.org/10.2337/db17-ti08
Commentaries
Species-Dependent Mechanisms Regulating Glucose-Dependent GLP-1 Secretion?
Diabetes July 2017, Vol.66, 2063-2065. doi:https://doi.org/10.2337/dbi17-0020
Bait and Trap: Enriching Autoreactive T Cells With β-Cell Antigen-Loading Biomaterial Scaffolds for Early Detection of Type 1 Diabetes
Diabetes July 2017, Vol.66, 2066-2068. doi:https://doi.org/10.2337/dbi17-0019
Some Doubts About the Mantra on the Deleterious Cardiovascular Effects of Sulfonylureas
Diabetes July 2017, Vol.66, 2069-2071. doi:https://doi.org/10.2337/dbi17-0023
Metabolism
Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation
Hui-Young Lee; Jae Sung Lee; Tiago Alves; Warren Ladiges; Peter S. Rabinovitch; Michael J. Jurczak; Cheol Soo Choi; Gerald I. Shulman; Varman T. Samuel
Diabetes May 2017, Vol.66, 2072-2081. doi:https://doi.org/10.2337/db16-1334
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice
Diabetes May 2017, Vol.66, 2092-2101. doi:https://doi.org/10.2337/db16-1213
Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity
Diabetes May 2017, Vol.66, 2102-2111. doi:https://doi.org/10.2337/db16-1558
Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting
Diabetes June 2017, Vol.66, 2112-2123. doi:https://doi.org/10.2337/db16-1519
Maternal Exercise Improves Glucose Tolerance in Female Offspring
Kristin I. Stanford; Hirokazu Takahashi; Kawai So; Ana Barbara Alves-Wagner; Noah B. Prince; Adam C. Lehnig; Kristen M. Getchell; Min-Young Lee; Michael F. Hirshman; Laurie J. Goodyear
Diabetes June 2017, Vol.66, 2124-2136. doi:https://doi.org/10.2337/db17-0098
Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia
Airu Zhu; Jingjing Chen; Pengfei Wu; Mei Luo; Yilan Zeng; Yong Liu; Han Zheng; Li Zhang; Zishou Chen; Qun Sun; Wenwen Li; Yixiang Duan; Danmei Su; Zhixiong Xiao; Zhongping Duan; Sujun Zheng; Li Bai; Xiaohui Zhang; Zhongyuan Ju; Yan Li; Richard Hu; Stephen J. Pandol; Yuan-Ping Han
Diabetes April 2017, Vol.66, 2137-2143. doi:https://doi.org/10.2337/db17-0070
Signal Transduction
Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine
Emily W. Sun; Dayan de Fontgalland; Philippa Rabbitt; Paul Hollington; Luigi Sposato; Steven L. Due; David A. Wattchow; Christopher K. Rayner; Adam M. Deane; Richard L. Young; Damien J. Keating
Diabetes April 2017, Vol.66, 2144-2149. doi:https://doi.org/10.2337/db17-0058
Islet Studies
Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass
Emilyn U. Alejandro; Nadejda Bozadjieva; Manuel Blandino-Rosano; Michelle Ann Wasan; Lynda Elghazi; Suryakiran Vadrevu; Leslie Satin; Ernesto Bernal-Mizrachi
Diabetes May 2017, Vol.66, 2150-2162. doi:https://doi.org/10.2337/db16-1349
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes
Reinier Hernandez; Stephen A. Graves; Trillian Gregg; Halena R. VanDeusen; Rachel J. Fenske; Haley N. Wienkes; Christopher G. England; Hector F. Valdovinos; Justin J. Jeffery; Todd E. Barnhart; Gregory W. Severin; Robert J. Nickles; Michelle E. Kimple; Matthew J. Merrins; Weibo Cai
Diabetes May 2017, Vol.66, 2163-2174. doi:https://doi.org/10.2337/db16-1285
Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes
Jennifer S. Stancill; Jean-Philippe Cartailler; Hannah W. Clayton; James T. O’Connor; Matthew T. Dickerson; Prasanna K. Dadi; Anna B. Osipovich; David A. Jacobson; Mark A. Magnuson
Diabetes May 2017, Vol.66, 2175-2187. doi:https://doi.org/10.2337/db16-1355
Temporal Transcriptomic and Proteomic Landscapes of Deteriorating Pancreatic Islets in Type 2 Diabetic Rats
Junjie Hou; Zonghong Li; Wen Zhong; Qiang Hao; Lei Lei; Linlin Wang; Dongyu Zhao; Pingyong Xu; Yifa Zhou; You Wang; Tao Xu
Diabetes May 2017, Vol.66, 2188-2200. doi:https://doi.org/10.2337/db16-1305
Neprilysin Is Required for Angiotensin-(1–7)’s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1–2)
Gurkirat S. Brar; Breanne M. Barrow; Matthew Watson; Ryan Griesbach; Edwina Choung; Andrew Welch; Bela Ruzsicska; Daniel P. Raleigh; Sakeneh Zraika
Diabetes May 2017, Vol.66, 2201-2212. doi:https://doi.org/10.2337/db16-1318
SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a
Diabetes May 2017, Vol.66, 2213-2219. doi:https://doi.org/10.2337/db16-1074
Immunology and Transplantation
In Vivo Enrichment of Diabetogenic T Cells
Martin A. Thelin; Stephan Kissler; Frederic Vigneault; Alexander L. Watters; Des White; Sandeep T. Koshy; Sarah A. Vermillion; David J. Mooney; Thomas Serwold; Omar A. Ali
Diabetes April 2017, Vol.66, 2220-2229. doi:https://doi.org/10.2337/db16-0946
Pathophysiology
Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction
Daniel J. Sassoon; Johnathan D. Tune; Kieren J. Mather; Jillian N. Noblet; Mackenzie A. Eagleson; Abass M. Conteh; Joshua T. Sturek; Adam G. Goodwill
Diabetes May 2017, Vol.66, 2230-2240. doi:https://doi.org/10.2337/db16-1206
Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver
Tomas Jelenik; Kirti Kaul; Gilles Séquaris; Ulrich Flögel; Esther Phielix; Jörg Kotzka; Birgit Knebel; Pia Fahlbusch; Tina Hörbelt; Stefan Lehr; Anna Lena Reinbeck; Dirk Müller-Wieland; Irene Esposito; Gerald I. Shulman; Julia Szendroedi; Michael Roden
Diabetes May 2017, Vol.66, 2241-2253. doi:https://doi.org/10.2337/db16-1147
Complications
Topical Erythropoietin Treatment Accelerates the Healing of Cutaneous Burn Wounds in Diabetic Pigs Through an Aquaporin-3–Dependent Mechanism
Saher Hamed; Yehuda Ullmann; Dana Egozi; Aviad Keren; Essam Daod; Omer Anis; Hoda Kabha; Mark Belokopytov; Manal Ashkar; Rona Shofti; Asaph Zaretsky; Michal Schlesinger; Luc Teot; Paul Y. Liu
Diabetes May 2017, Vol.66, 2254-2265. doi:https://doi.org/10.2337/db16-1205
Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis
Eoin Brennan; Bo Wang; Aaron McClelland; Muthukumar Mohan; Mariam Marai; Ophelie Beuscart; Sinda Derouiche; Stephen Gray; Raelene Pickering; Chris Tikellis; Monica de Gaetano; Mary Barry; Orina Belton; Syed Tasadaque Ali-Shah; Patrick Guiry; Karin A.M. Jandeleit-Dahm; Mark E. Cooper; Catherine Godson; Phillip Kantharidis
Diabetes May 2017, Vol.66, 2266-2277. doi:https://doi.org/10.2337/db16-1405
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study
Nordin M.J. Hanssen; Jean L.J.M. Scheijen; Anders Jorsal; Hans-Henrik Parving; Lise Tarnow; Peter Rossing; Coen D.A. Stehouwer; Casper G. Schalkwijk
Diabetes June 2017, Vol.66, 2278-2283. doi:https://doi.org/10.2337/db16-1578
Genetics / Genomes / Proteomics / Metabolomics
A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians
Paolo Piaggi; Ivica Masindova; Yunhua L. Muller; Josep Mercader; Gregory B. Wiessner; Peng Chen; SIGMA Type 2 Diabetes Consortium; Sayuko Kobes; Wen-Chi Hsueh; Milliejoan Mongalo; William C. Knowler; Jonathan Krakoff; Robert L. Hanson; Clifton Bogardus; Leslie J. Baier
Diabetes May 2017, Vol.66, 2284-2295. doi:https://doi.org/10.2337/db16-1565
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
Andrew R. Wood; Anna Jonsson; Anne U. Jackson; Nan Wang; Nienke van Leewen; Nicholette D. Palmer; Sayuko Kobes; Joris Deelen; Lorena Boquete-Vilarino; Jussi Paananen; Alena Stančáková; Dorret I. Boomsma; Eco J.C. de Geus; Elisabeth M.W. Eekhoff; Andreas Fritsche; Mark Kramer; Giel Nijpels; Annemarie Simonis-Bik; Timon W. van Haeften; Anubha Mahajan; Michael Boehnke; Richard N. Bergman; Jaakko Tuomilehto; Francis S. Collins; Karen L. Mohlke; Karina Banasik; Christopher J. Groves; Mark I. McCarthy; Diabetes Research on Patient Stratification (DIRECT); Ewan R. Pearson; Andrea Natali; Andrea Mari; Thomas A. Buchanan; Kent D. Taylor; Anny H. Xiang; Anette P. Gjesing; Niels Grarup; Hans Eiberg; Oluf Pedersen; Yii-Derr Chen; Markku Laakso; Jill M. Norris; Ulf Smith; Lynne E. Wagenknecht; Leslie Baier; Donald W. Bowden; Torben Hansen; Mark Walker; Richard M. Watanabe; Leen M. ‘t Hart; Robert L. Hanson; Timothy M. Frayling
Diabetes May 2017, Vol.66, 2296-2309. doi:https://doi.org/10.2337/db16-1452
Recessively Inherited LRBA Mutations Cause Autoimmunity Presenting as Neonatal Diabetes
Matthew B. Johnson; Elisa De Franco; Hana Lango Allen; Aisha Al Senani; Nancy Elbarbary; Zeynep Siklar; Merih Berberoglu; Zineb Imane; Alireza Haghighi; Zahra Razavi; Irfan Ullah; Saif Alyaarubi; Daphne Gardner; Ayla Güven; Sian Ellard; Andrew T. Hattersley; Sarah E. Flanagan
Diabetes May 2017, Vol.66, 2316-2322. doi:https://doi.org/10.2337/db17-0040
