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1 September 2017
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes August 2017, Vol.66, 2325-2326. doi:https://doi.org/10.2337/db17-ti09
Metabolism
The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1
Sarah E. Wheeler; Holly M. Stacey; Yasaman Nahaei; Stephen J. Hale; Alexandre B. Hardy; Frank Reimann; Fiona M. Gribble; Pierre Larraufie; Herbert Y. Gaisano; Patricia L. Brubaker
Diabetes June 2017, Vol.66, 2327-2338. doi:https://doi.org/10.2337/db16-1403
Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney
Motohiro Sasaki; Takayoshi Sasako; Naoto Kubota; Yoshitaka Sakurai; Iseki Takamoto; Tetsuya Kubota; Reiko Inagi; George Seki; Moritaka Goto; Kohjiro Ueki; Masaomi Nangaku; Takahito Jomori; Takashi Kadowaki
Diabetes June 2017, Vol.66, 2339-2350. doi:https://doi.org/10.2337/db16-1602
Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis
Natsuko Ohashi; Katsutaro Morino; Shogo Ida; Osamu Sekine; Mengistu Lemecha; Shinji Kume; Shi-Young Park; Cheol Soo Choi; Satoshi Ugi; Hiroshi Maegawa
Diabetes June 2017, Vol.66, 2351-2362. doi:https://doi.org/10.2337/db16-1427
The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor
Meena Asmar; Ali Asmar; Lene Simonsen; Lærke Smidt Gasbjerg; Alexander Hovard Sparre-Ulrich; Mette Marie Rosenkilde; Bolette Hartmann; Flemming Dela; Jens Juul Holst; Jens Bülow
Diabetes June 2017, Vol.66, 2363-2371. doi:https://doi.org/10.2337/db17-0480
Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues
Eulalia A. Coutinho; Shiki Okamoto; Ayako Wendy Ishikawa; Shigefumi Yokota; Nobuhiro Wada; Takahiro Hirabayashi; Kumiko Saito; Tatsuya Sato; Kazuyo Takagi; Chen-Chi Wang; Kenta Kobayashi; Yoshihiro Ogawa; Seiji Shioda; Yumiko Yoshimura; Yasuhiko Minokoshi
Diabetes July 2017, Vol.66, 2372-2386. doi:https://doi.org/10.2337/db16-1344
Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage
Qiaoli Chen; Ping Rong; Dijin Xu; Sangsang Zhu; Liang Chen; Bingxian Xie; Qian Du; Chao Quan; Yang Sheng; Tong-Jin Zhao; Peng Li; Hong Yu Wang; Shuai Chen
Diabetes July 2017, Vol.66, 2387-2399. doi:https://doi.org/10.2337/db17-0077
The Effect of Ingested Glucose Dose on the Suppression of Endogenous Glucose Production in Humans
Diabetes July 2017, Vol.66, 2400-2406. doi:https://doi.org/10.2337/db17-0433
Obesity Studies
Hypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors
Carina Kreutzer; Sönke Peters; Dominik M. Schulte; Daniela Fangmann; Kathrin Türk; Stephan Wolff; Thilo van Eimeren; Markus Ahrens; Jan Beckmann; Clemens Schafmayer; Thomas Becker; Tina Kerby; Axel Rohr; Christian Riedel; Femke-Anouska Heinsen; Frauke Degenhardt; Andre Franke; Philip Rosenstiel; Nana Zubek; Christian Henning; Sandra Freitag-Wolf; Astrid Dempfle; Aristea Psilopanagioti; Helen Petrou-Papadaki; Lennart Lenk; Olav Jansen; Stefan Schreiber; Matthias Laudes
Diabetes June 2017, Vol.66, 2407-2415. doi:https://doi.org/10.2337/db17-0067
Starch Digestion–Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial
Diabetes June 2017, Vol.66, 2416-2423. doi:https://doi.org/10.2337/db16-1482
Ablation of Neuropilin 1 in Myeloid Cells Exacerbates High-Fat Diet–Induced Insulin Resistance Through Nlrp3 Inflammasome In Vivo
Xiaoyan Dai; Imoh Okon; Zhaoyu Liu; Tatiana Bedarida; Qilong Wang; Tharmarajan Ramprasath; Miao Zhang; Ping Song; Ming-Hui Zou
Diabetes June 2017, Vol.66, 2424-2435. doi:https://doi.org/10.2337/db17-0132
Islet Studies
Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets
Matthew J. Westacott; Nikki L. Farnsworth; Joshua R. St. Clair; Greg Poffenberger; Audrey Heintz; Nurin W. Ludin; Nathaniel J. Hart; Alvin C. Powers; Richard K.P. Benninger
Diabetes June 2017, Vol.66, 2436-2445. doi:https://doi.org/10.2337/db17-0137
MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells
Kira Meyerovich; Natalia M. Violato; Makiko Fukaya; Violette Dirix; Nathalie Pachera; Lorella Marselli; Piero Marchetti; Andreas Strasser; Decio L. Eizirik; Alessandra K. Cardozo
Diabetes June 2017, Vol.66, 2446-2458. doi:https://doi.org/10.2337/db16-1252
Immunology and Transplantation
The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes
Andrew S. Kimball; Amrita Joshi; William F. Carson, IV; Anna E. Boniakowski; Matthew Schaller; Ronald Allen; Jennifer Bermick; Frank M. Davis; Peter K. Henke; Charles F. Burant; Steve L. Kunkel; Katherine A. Gallagher
Diabetes June 2017, Vol.66, 2459-2471. doi:https://doi.org/10.2337/db17-0194
Pathophysiology
Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels
Sarah Costantino; Francesco Paneni; Rodolfo Battista; Lorenzo Castello; Giuliana Capretti; Sergio Chiandotto; Luigi Tanese; Giulio Russo; Dario Pitocco; Gaetano A. Lanza; Massimo Volpe; Thomas F. Lüscher; Francesco Cosentino
Diabetes June 2017, Vol.66, 2472-2482. doi:https://doi.org/10.2337/db17-0294
Complications
Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study
Thomas S. Voss; Mikkel H. Vendelbo; Ulla Kampmann; Janne R. Hingst; Jørgen F.P. Wojtaszewski; Mads V. Svart; Niels Møller; Niels Jessen
Diabetes June 2017, Vol.66, 2483-2494. doi:https://doi.org/10.2337/db16-1559
Inhibition of Renal Sodium–Glucose Cotransport With Empagliflozin Lowers Fasting Plasma Glucose and Improves β-Cell Function in Subjects With Impaired Fasting Glucose
Muhammad Abdul-Ghani; Hussein Al Jobori; Giuseppe Daniele; John Adams; Eugenio Cersosimo; Curtis Triplitt; Ralph A. DeFronzo
Diabetes June 2017, Vol.66, 2495-2502. doi:https://doi.org/10.2337/db17-0055
Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy: Cross-sectional Analyses of Baseline Data of the EUROCONDOR Project
Ana Rita Santos; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Luísa Ribeiro; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Francesco Bandello; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Rosangela Lattanzio; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Catherine Egan; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Ulrik Frydkjaer-Olsen; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); José García-Arumí; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Jonathan Gibson; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Jakob Grauslund; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Simon P. Harding; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Gabriele E. Lang; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Pascale Massin; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Edoardo Midena; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Peter Scanlon; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Stephen J. Aldington; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Sílvia Simão; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Christian Schwartz; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Berta Ponsati; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Massimo Porta; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Miguel Ângelo Costa; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Cristina Hernández; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); José Cunha-Vaz; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR); Rafael Simó; for the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)
Diabetes June 2017, Vol.66, 2503-2510. doi:https://doi.org/10.2337/db16-1453
Pharmacology and Therapeutics
Recovery of Corneal Sensitivity and Increase in Nerve Density and Wound Healing in Diabetic Mice After PEDF Plus DHA Treatment
Diabetes June 2017, Vol.66, 2511-2520. doi:https://doi.org/10.2337/db17-0249
Genetics / Genomes / Proteomics / Metabolomics
A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus
Tamara S. Roman; Maren E. Cannon; Swarooparani Vadlamudi; Martin L. Buchkovich; Brooke N. Wolford; Ryan P. Welch; Mario A. Morken; Grace J. Kwon; Arushi Varshney; Romy Kursawe; Ying Wu; Anne U. Jackson; National Institutes of Health Intramural Sequencing Center (NISC) Comparative Sequencing Program; Michael R. Erdos; Johanna Kuusisto; Markku Laakso; Laura J. Scott; Michael Boehnke; Francis S. Collins; Stephen C.J. Parker; Michael L. Stitzel; Karen L. Mohlke
Diabetes July 2017, Vol.66, 2521-2530. doi:https://doi.org/10.2337/db17-0464
Errata
Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418–3428
Camillo Ricordi; Julia S. Goldstein; A.N. Balamurugan; Gregory L. Szot; Tatsuya Kin; Chengyang Liu; Christine W. Czarniecki; Barbara Barbaro; Nancy D. Bridges; Jose Cano; William R. Clarke; Thomas L. Eggerman; Lawrence G. Hunsicker; Dixon B. Kaufman; Aisha Khan; David-Erick Lafontant; Elina Linetsky; Xunrong Luo; James F. Markmann; Ali Naji; Olle Korsgren; Jose Oberholzer; Nicole A. Turgeon; Daniel Brandhorst; Andrew S. Friberg; Ji Lei; Ling-jia Wang; Joshua J. Wilhelm; Jamie Willits; Xiaomin Zhang; Bernhard J. Hering; Andrew M. Posselt; Peter G. Stock; A.M. James Shapiro
Diabetes June 2017, Vol.66, 2531. doi:https://doi.org/10.2337/db17-er09a
Erratum. Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65:3384–3395
Jia Cheng; Jia Song; Xiaoyu He; Meng Zhang; Shuang Hu; Shu Zhang; Qilin Yu; Ping Yang; Fei Xiong; Dao Wen Wang; Jianfeng Zhou; Qin Ning; Zhishui Chen; Decio L. Eizirik; Zhiguang Zhou; Chunxia Zhao; Cong-Yi Wang
Diabetes July 2017, Vol.66, 2531. doi:https://doi.org/10.2337/db17-er09b
