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November 2018
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Cover Image
Cover Image
On the cover: Colored scanning electron micrograph of a rat insulinoma-derived pancreatic β-cell treated with 10 μmol/L of tunicamycin for 24 h. Photograph courtesy of Tatsuyoshi Kono and Carmella Evans-Molina, Indiana University School of Medicine, Indianapolis, IN. Their article, “Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell,” appears in this issue of Diabetes (p. 2293).
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes October 2018, Vol.67, 2127-2128. doi:https://doi.org/10.2337/db18-ti11
Perspectives in Diabetes
Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability
Diabetes October 2018, Vol.67, 2129-2136. doi:https://doi.org/10.2337/db18-0539
Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?
Diabetes October 2018, Vol.67, 2137-2151. doi:https://doi.org/10.2337/dbi17-0011
Commentaries
Mitochondrial ADP Sensitivity and Transport: New Insights Into Diet-Induced Mitochondrial Impairments
Diabetes October 2018, Vol.67, 2152-2153. doi:https://doi.org/10.2337/dbi18-0030
Exosomes or Microvesicles, a Secreted Subcellular Organelle Contributing to Inflammation and Diabetes
Diabetes October 2018, Vol.67, 2154-2156. doi:https://doi.org/10.2337/dbi18-0021
Metabolism
Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents
Teayoun Kim; Cassie L. Holleman; Shelly Nason; Deanna M. Arble; Nickki Ottaway; Joseph Chabenne; Christine Loyd; Jeong-a Kim; Darleen Sandoval; Daniel J. Drucker; Richard DiMarchi; Diego Perez-Tilve; Kirk M. Habegger
Diabetes August 2018, Vol.67, 2157-2166. doi:https://doi.org/10.2337/db18-0068
Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis
Yuxin Wu; Quan Pan; Hui Yan; Kebin Zhang; Xiaoqin Guo; Zihui Xu; Wanbao Yang; Yajuan Qi; Cathy A. Guo; Caitlyn Hornsby; Lin Zhang; Aimin Zhou; Ling Li; Yunmei Chen; Weiping Zhang; Yuxiang Sun; Hongting Zheng; Fred Wondisford; Ling He; Shaodong Guo
Diabetes September 2018, Vol.67, 2167-2182. doi:https://doi.org/10.2337/db18-0674
H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK
Tingting Geng; Ya Liu; Yetao Xu; Ying Jiang; Na Zhang; Zhangsheng Wang; Gordon G. Carmichael; Hugh S. Taylor; Da Li; Yingqun Huang
Diabetes September 2018, Vol.67, 2183-2198. doi:https://doi.org/10.2337/db18-0370
High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity
Diabetes July 2018, Vol.67, 2199-2205. doi:https://doi.org/10.2337/db18-0417
Signal Transduction
Inactivation of p66Shc Decreases Afferent Arteriolar KATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats
Bradley S. Miller; Shoshana R. Blumenthal; Alexey Shalygin; Kevin D. Wright; Alexander Staruschenko; John D. Imig; Andrey Sorokin
Diabetes August 2018, Vol.67, 2206-2212. doi:https://doi.org/10.2337/db18-0308
Obesity Studies
SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity
Patricia Seoane-Collazo; Juan Roa; Eva Rial-Pensado; Laura Liñares-Pose; Daniel Beiroa; Francisco Ruíz-Pino; Tania López-González; Donald A. Morgan; José Ángel Pardavila; María Jesús Sánchez-Tapia; Noelia Martínez-Sánchez; Cristina Contreras; Miguel Fidalgo; Carlos Diéguez; Roberto Coppari; Kamal Rahmouni; Rubén Nogueiras; Manuel Tena-Sempere; Miguel López
Diabetes August 2018, Vol.67, 2213-2226. doi:https://doi.org/10.2337/db17-1538
SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c
Yang Jiao; Jiejie Zhao; Zhijian Zhang; Min Li; Xi Yu; Yanying Yang; Jie Liu; Shengjie Liao; Duanzhuo Li; Yuxing Wang; Die Zhang; Yulu Chen; Guojun Shi; Bin Liu; Yan Lu; Xiaoying Li
Diabetes September 2018, Vol.67, 2227-2238. doi:https://doi.org/10.2337/db18-0184
Islet Studies
Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers
Bao-Khanh Lai; Heeyoung Chae; Ana Gómez-Ruiz; Panpan Cheng; Paola Gallo; Nancy Antoine; Christophe Beauloye; Jean-Christophe Jonas; Victor Seghers; Susumu Seino; Patrick Gilon
Diabetes August 2018, Vol.67, 2239-2253. doi:https://doi.org/10.2337/db17-0880
Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents
Clara Sanchez-Parra; Cécile Jacovetti; Olivier Dumortier; Kailun Lee; Marie-Line Peyot; Claudiane Guay; Marc Prentki; D. Ross Laybutt; Emmanuel Van Obberghen; Romano Regazzi
Diabetes August 2018, Vol.67, 2254-2267. doi:https://doi.org/10.2337/db18-0201
Whole-Organism Chemical Screening Identifies Modulators of Pancreatic β-Cell Function
Hiroki Matsuda; Sri Teja Mullapudi; Yu Hsuan Carol Yang; Hideki Masaki; Daniel Hesselson; Didier Y.R. Stainier
Diabetes August 2018, Vol.67, 2268-2279. doi:https://doi.org/10.2337/db17-1223
Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival
Qiqing Huang; Weiyan You; Yating Li; Yi Sun; Yuncai Zhou; Yan Zhang; Dechen Liu; Shanshan Zhan; Yunxia Zhu; Xiao Han
Diabetes August 2018, Vol.67, 2280-2292. doi:https://doi.org/10.2337/db18-0223
Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell
Tatsuyoshi Kono; Xin Tong; Solaema Taleb; Robert N. Bone; Hitoshi Iida; Chih-Chun Lee; Paul Sohn; Patrick Gilon; Michael W. Roe; Carmella Evans-Molina
Diabetes August 2018, Vol.67, 2293-2304. doi:https://doi.org/10.2337/db17-1351
β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes
Elad Horwitz; Lars Krogvold; Sophia Zhitomirsky; Avital Swisa; Maya Fischman; Tsuria Lax; Tehila Dahan; Noa Hurvitz; Noa Weinberg-Corem; Agnes Klochendler; Alvin C. Powers; Marcela Brissova; Anne Jörns; Sigurd Lenzen; Benjamin Glaser; Knut Dahl-Jørgensen; Yuval Dor
Diabetes August 2018, Vol.67, 2305-2318. doi:https://doi.org/10.2337/db17-1006
Immunology and Transplantation
Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells
Kaitlin R. Carroll; Eileen E. Elfers; Joseph J. Stevens; Jonathan P. McNally; David A. Hildeman; Michael B. Jordan; Jonathan D. Katz
Diabetes August 2018, Vol.67, 2319-2328. doi:https://doi.org/10.2337/db18-0204
Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes
Falastin Salami; Hye-Seung Lee; Eva Freyhult; Helena Elding Larsson; Åke Lernmark; Carina Törn; The TEDDY Study Group
Diabetes August 2018, Vol.67, 2329-2336. doi:https://doi.org/10.2337/db18-0355
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
Mijke Buitinga; Aïsha Callebaut; Fernanda Marques Câmara Sodré; Inne Crèvecoeur; Gabriele Blahnik-Fagan; Mei-Ling Yang; Marco Bugliani; David Arribas-Layton; Meghan Marré; Dana P. Cook; Etienne Waelkens; Roberto Mallone; Jon D. Piganelli; Piero Marchetti; Mark J. Mamula; Rita Derua; Eddie A. James; Chantal Mathieu; Lut Overbergh
Diabetes October 2018, Vol.67, 2337-2348. doi:https://doi.org/10.2337/db18-0295
Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice
Christopher S. Wilson; Preeti Chhabra; Andrew F. Marshall; Caleigh V. Morr; Blair T. Stocks; Emilee M. Hoopes; Rachel H. Bonami; Greg Poffenberger; Kenneth L. Brayman; Daniel J. Moore
Diabetes August 2018, Vol.67, 2349-2360. doi:https://doi.org/10.2337/db18-0456
High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity
Wyatt J. McDonnell; John R. Koethe; Simon A. Mallal; Mark A. Pilkinton; Annet Kirabo; Magdalene K. Ameka; Matthew A. Cottam; Alyssa H. Hasty; Arion J. Kennedy
Diabetes September 2018, Vol.67, 2361-2376. doi:https://doi.org/10.2337/db18-0040
Pathophysiology
Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes
David W. Freeman; Nicole Noren Hooten; Erez Eitan; Jamal Green; Nicolle A. Mode; Monica Bodogai; Yongqing Zhang; Elin Lehrmann; Alan B. Zonderman; Arya Biragyn; Josephine Egan; Kevin G. Becker; Mark P. Mattson; Ngozi Ejiogu; Michele K. Evans
Diabetes May 2018, Vol.67, 2377-2388. doi:https://doi.org/10.2337/db17-1308
Increased β-Cell Workload Modulates Proinsulin-to-Insulin Ratio in Humans
Teresa Mezza; Pietro M. Ferraro; Vinsin A. Sun; Simona Moffa; Chiara M.A. Cefalo; Giuseppe Quero; Francesca Cinti; Gian Pio Sorice; Alfredo Pontecorvi; Franco Folli; Andrea Mari; Sergio Alfieri; Andrea Giaccari
Diabetes August 2018, Vol.67, 2389-2396. doi:https://doi.org/10.2337/db18-0279
The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy
Zhuohao Liu; Leigang Jin; Jin-Kui Yang; Baile Wang; Kelvin K.L. Wu; Philip Hallenborg; Aimin Xu; Kenneth K.Y. Cheng
Diabetes August 2018, Vol.67, 2397-2409. doi:https://doi.org/10.2337/db18-0684
Complications
Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy
Julia Moellmann; Barbara Mara Klinkhammer; Julia Onstein; Robert Stöhr; Vera Jankowski; Joachim Jankowski; Corinna Lebherz; Frank Tacke; Nikolaus Marx; Peter Boor; Michael Lehrke
Diabetes August 2018, Vol.67, 2410-2419. doi:https://doi.org/10.2337/db17-1212
Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease
Sylvia J. Horne; Jessica M. Vasquez; Yiqing Guo; Victoria Ly; Sian E. Piret; Alexandra R. Leonardo; Jason Ling; Monica P. Revelo; Daniel Bogenhagen; Vincent W. Yang; John C. He; Sandeep K. Mallipattu
Diabetes August 2018, Vol.67, 2420-2433. doi:https://doi.org/10.2337/db17-0958
A Systemic Inflammatory Signature Reflecting Cross Talk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study
Christian Herder; Julia M. Kannenberg; Maren Carstensen-Kirberg; Alexander Strom; Gidon J. Bönhof; Wolfgang Rathmann; Cornelia Huth; Wolfgang Koenig; Margit Heier; Jan Krumsiek; Annette Peters; Christa Meisinger; Michael Roden; Barbara Thorand; Dan Ziegler
Diabetes August 2018, Vol.67, 2434-2442. doi:https://doi.org/10.2337/db18-0060
The Dipeptidyl Peptidase 4 Substrate CXCL12 Has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated by Ca2+ Flux and Phosphoinositide 3-Kinase γ
Sri N. Batchu; Karina Thieme; Farigol H. Zadeh; Tamadher A. Alghamdi; Veera Ganesh Yerra; Mitchell J. Hadden; Syamantak Majumder; M. Golam Kabir; Bridgit B. Bowskill; Danyal Ladha; Anthony O. Gramolini; Kim A. Connelly; Andrew Advani
Diabetes August 2018, Vol.67, 2443-2455. doi:https://doi.org/10.2337/db18-0410
Pharmacology and Therapeutics
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
Katrin Pfuhlmann; Sonja C. Schriever; Peter Baumann; Dhiraj G. Kabra; Luke Harrison; Sithandiwe E. Mazibuko-Mbeje; Raian E. Contreras; Eleni Kyriakou; Stephanie E. Simonds; Tony Tiganis; Michael A. Cowley; Stephen C. Woods; Martin Jastroch; Christoffer Clemmensen; Meri De Angelis; Karl-Werner Schramm; Michael Sattler; Ana C. Messias; Matthias H. Tschöp; Paul T. Pfluger
Diabetes August 2018, Vol.67, 2456-2465. doi:https://doi.org/10.2337/db18-0146
Genetics / Genomes / Proteomics / Metabolomics
Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets
Shubham Khetan; Romy Kursawe; Ahrim Youn; Nathan Lawlor; Alexandria Jillette; Eladio J. Marquez; Duygu Ucar; Michael L. Stitzel
Diabetes September 2018, Vol.67, 2466-2477. doi:https://doi.org/10.2337/db18-0393
Expressions of Concern
Expression of Concern. Kathrin Maedler, Desiree M. Schumann, Fabienne Schulthess, José Oberholzer, Domenico Bosco, Thierry Berney, and Marc Y. Donath. Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1. Diabetes 2006;55:2455–2462. DOI: 10.2337/db05-1586. PMID: 16936193
Diabetes October 2018, Vol.67, 2478-2479. doi:https://doi.org/10.2337/db18-ec2018a
Update to Expression of Concern. Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, and Marc Y. Donath. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722. DOI:10.2337/db05-1430. PMID: 17003335
Diabetes October 2018, Vol.67, 2479-2480. doi:https://doi.org/10.2337/db18-ec2018b
