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1 April 2018
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Cover Image
Cover Image
On the cover: Immunofluorescence staining of transporter associated with antigen processing 1 (TAP1) (green), HLA-ABC (red), and insulin (cyan) on a human pancreas sample from a patient with type 1 diabetes shows high expression of TAP1 and HLA-ABC in an insulin-containing islet, indicative of a predisposition for immune recognition. Image courtesy of Mark A. Russell, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, U.K. His article, “Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes,” appears in this issue of Diabetes (p. 687)
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes March 2018, Vol.67, 535-536. doi:https://doi.org/10.2337/db18-ti04
Perspectives in Diabetes
New Understanding of β-Cell Heterogeneity and In Situ Islet Function
Diabetes March 2018, Vol.67, 537-547. doi:https://doi.org/10.2337/dbi17-0040
Commentaries
SRGAP2a: A New Player That Modulates Podocyte Cytoskeleton and Injury in Diabetes
Diabetes March 2018, Vol.67, 550-551. doi:https://doi.org/10.2337/dbi17-0050
Values and Limitations of Targeting lncRNAs in Diabetic Nephropathy
Diabetes March 2018, Vol.67, 552-553. doi:https://doi.org/10.2337/dbi17-0052
Metabolism
The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function
Xi Chen; Iriscilla Ayala; Chris Shannon; Marcel Fourcaudot; Nikhil K. Acharya; Christopher P. Jenkinson; Sami Heikkinen; Luke Norton
Diabetes January 2018, Vol.67, 554-568. doi:https://doi.org/10.2337/db17-0318
SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity
Yalan Deng; Yuzhong Xiao; Feixiang Yuan; Yaping Liu; Xiaoxue Jiang; Jiali Deng; Geza Fejes-Toth; Aniko Naray-Fejes-Toth; Shanghai Chen; Yan Chen; Hao Ying; Qiwei Zhai; Yousheng Shu; Feifan Guo
Diabetes January 2018, Vol.67, 569-580. doi:https://doi.org/10.2337/db17-1069
Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis
Junpei Wang; Weili Yang; Zhenzhen Chen; Ji Chen; Yuhong Meng; Biaoqi Feng; Libo Sun; Lin Dou; Jian Li; Qinghua Cui; Jichun Yang
Diabetes January 2018, Vol.67, 581-593. doi:https://doi.org/10.2337/db17-0799
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle
Magdalene K. Montgomery; Ruzaidi Mokhtar; Jacqueline Bayliss; Helena C. Parkington; Victor M. Suturin; Clinton R. Bruce; Matthew J. Watt
Diabetes January 2018, Vol.67, 594-606. doi:https://doi.org/10.2337/db17-0923
Signal Transduction
Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes
Hema Kalyanaraman; Gerburg Schwaerzer; Ghania Ramdani; Francine Castillo; Brian T. Scott; Wolfgang Dillmann; Robert L. Sah; Darren E. Casteel; Renate B. Pilz
Diabetes January 2018, Vol.67, 607-623. doi:https://doi.org/10.2337/db17-0965
Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance
Ahmed Lawan; Kisuk Min; Lei Zhang; Alberto Canfran-Duque; Michael J. Jurczak; Joao Paulo G. Camporez; Yaohui Nie; Timothy P. Gavin; Gerald I. Shulman; Carlos Fernandez-Hernando; Anton M. Bennett
Diabetes January 2018, Vol.67, 624-635. doi:https://doi.org/10.2337/db17-0826
Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans
Emily Tubbs; Stéphanie Chanon; Maud Robert; Nadia Bendridi; Gabriel Bidaux; Marie-Agnès Chauvin; Jingwei Ji-Cao; Christine Durand; Daphné Gauvrit-Ramette; Hubert Vidal; Etienne Lefai; Jennifer Rieusset
Diabetes January 2018, Vol.67, 636-650. doi:https://doi.org/10.2337/db17-0316
Obesity Studies
Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance
Michael C. Rudolph; Matthew R. Jackman; David M. Presby; Julie A. Houck; Patricia G. Webb; Ginger C. Johnson; Taylor K. Soderborg; Becky A. de la Houssaye; Ivana V. Yang; Jacob E. Friedman; Paul S. MacLean
Diabetes November 2017, Vol.67, 651-661. doi:https://doi.org/10.2337/db17-0890
Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism
Di Yang; Marta G. Vuckovic; Carolyn P. Smullin; Myeongcheol Kim; Christabel Pui-See Lo; Emily Devericks; Hong Sik Yoo; Milena Tintcheva; Yinghua Deng; Joseph L. Napoli
Diabetes January 2018, Vol.67, 662-673. doi:https://doi.org/10.2337/db17-0946
Islet Studies
Highly Proliferative α-Cell–Related Islet Endocrine Cells in Human Pancreata
Diabetes January 2018, Vol.67, 674-686. doi:https://doi.org/10.2337/db17-1114
Immunology and Transplantation
Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes
Deborah Kronenberg-Versteeg; Martin Eichmann; Mark A. Russell; Arnoud de Ru; Beate Hehn; Norkhairin Yusuf; Peter A. van Veelen; Sarah J. Richardson; Noel G. Morgan; Marius K. Lemberg; Mark Peakman
Diabetes January 2018, Vol.67, 687-696. doi:https://doi.org/10.2337/db17-0021
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles
Mia J. Smith; Marynette Rihanek; Clive Wasserfall; Clayton E. Mathews; Mark A. Atkinson; Peter A. Gottlieb; John C. Cambier
Diabetes January 2018, Vol.67, 697-703. doi:https://doi.org/10.2337/db17-0937
Pathophysiology
PDGF-BB Carried by Endothelial Cell–Derived Extracellular Vesicles Reduces Vascular Smooth Muscle Cell Apoptosis in Diabetes
Gabriele Togliatto; Patrizia Dentelli; Arturo Rosso; Giusy Lombardo; Maddalena Gili; Sara Gallo; Chiara Gai; Anna Solini; Giovanni Camussi; Maria Felice Brizzi
Diabetes January 2018, Vol.67, 704-716. doi:https://doi.org/10.2337/db17-0371
Complications
Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function
Yu Pan; Song Jiang; Qing Hou; Dandan Qiu; Jingsong Shi; Ling Wang; Zhaohong Chen; Mingchao Zhang; Aiping Duan; Weisong Qin; Ke Zen; Zhihong Liu
Diabetes December 2017, Vol.67, 717-730. doi:https://doi.org/10.2337/db17-0755
Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b
Si F. Sun; Patrick M.K. Tang; Min Feng; Jun Xiao; Xiao R. Huang; Ping Li; Ronald C.W. Ma; Hui Y. Lan
Diabetes December 2017, Vol.67, 731-744. doi:https://doi.org/10.2337/db17-0816
Sirt1: A Guardian of the Development of Diabetic Retinopathy
Diabetes January 2018, Vol.67, 745-754. doi:https://doi.org/10.2337/db17-0996
Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1)
Jiaze Li; Pacific Huynh; Aozhi Dai; Tieqiao Wu; Yugang Tu; Bryna Chow; Helen Kiriazis; Xiao-Jun Du; Leon A. Bach; Jennifer L. Wilkinson-Berka; Erik Biros; Philip Walker; Maria Nataatmadja; Malcolm West; Jonathan Golledge; Terri J. Allen; Mark E. Cooper; Zhonglin Chai
Diabetes January 2018, Vol.67, 755-768. doi:https://doi.org/10.2337/db17-0134
ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability
Nermin M. Kady; Xuwen Liu; Todd A. Lydic; Meesum H. Syed; Svetlana Navitskaya; Qi Wang; Sandra S. Hammer; Sandra O’Reilly; Chao Huang; Sergey S. Seregin; Andrea Amalfitano; Vince A. Chiodo; Sanford L. Boye; William W. Hauswirth; David A. Antonetti; Julia V. Busik
Diabetes January 2018, Vol.67, 769-781. doi:https://doi.org/10.2337/db17-1034
