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1 June 2018
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On the cover: Polarized light microscopy of glucose (magnification ×64). Credit: Eye of Science/Science Source. For further information, please visit www.sciencesource.com
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes May 2018, Vol.67, 1033-1034. doi:https://doi.org/10.2337/db18-ti06
Perspectives in Diabetes
Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance
Diabetes May 2018, Vol.67, 1035-1042. doi:https://doi.org/10.2337/dbi17-0030
Commentary
Mechanisms Responsible for Metabolic Improvements of Bariatric Surgeries
Diabetes May 2018, Vol.67, 1043-1044. doi:https://doi.org/10.2337/dbi18-0011
Metabolism
Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-Leptin, Which Regulates Leptin
Kinyui Alice Lo; Shiqi Huang; Arcinas Camille Esther Walet; Zhi-chun Zhang; Melvin Khee-Shing Leow; Meihui Liu; Lei Sun
Diabetes March 2018, Vol.67, 1045-1056. doi:https://doi.org/10.2337/db17-0526
Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia
Maria Rohm; Dragana Savic; Vicky Ball; M. Kate Curtis; Sarah Bonham; Roman Fischer; Nathalie Legrave; James I. MacRae; Damian J. Tyler; Frances M. Ashcroft
Diabetes April 2018, Vol.67, 1057-1067. doi:https://doi.org/10.2337/db17-1195
SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes
Jihoon Shin; Atsunori Fukuhara; Toshiharu Onodera; Shunbun Kita; Chieko Yokoyama; Michio Otsuki; Iichiro Shimomura
Diabetes March 2018, Vol.67, 1068-1078. doi:https://doi.org/10.2337/db17-0706
Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity
Samir Abu-Gazala; Elad Horwitz; Rachel Ben-Haroush Schyr; Aya Bardugo; Hadar Israeli; Ayat Hija; Jonathan Schug; Soona Shin; Yuval Dor; Klaus H. Kaestner; Danny Ben-Zvi
Diabetes February 2018, Vol.67, 1079-1085. doi:https://doi.org/10.2337/db17-1028
A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations
Maura Agostini; Erik Schoenmakers; Junaid Beig; Louise Fairall; Istvan Szatmari; Odelia Rajanayagam; Frederick W. Muskett; Claire Adams; A. David Marais; Stephen O’Rahilly; Robert K. Semple; Laszlo Nagy; Amit R. Majithia; John W.R. Schwabe; Dirk J. Blom; Rinki Murphy; Krishna Chatterjee; David B. Savage
Diabetes April 2018, Vol.67, 1086-1092. doi:https://doi.org/10.2337/db17-1236
Obesity Studies
Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action
Margaret B. Allison; Warren Pan; Alexander MacKenzie; Christa Patterson; Kimi Shah; Tammy Barnes; Wenwen Cheng; Alan Rupp; David P. Olson; Martin G. Myers, Jr.
Diabetes March 2018, Vol.67, 1093-1104. doi:https://doi.org/10.2337/db17-1395
Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes
Sudha S. Shankar; R. Ravi Shankar; Lori A. Mixson; Deborah L. Miller; Barnali Pramanik; Amy K. O’Dowd; Donna M. Williams; Clay B. Frederick; Chan R. Beals; S. Aubrey Stoch; Helmut O. Steinberg; David E. Kelley
Diabetes March 2018, Vol.67, 1105-1112. doi:https://doi.org/10.2337/db17-1331
Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway
Yosuke Okuno; Atsunori Fukuhara; Erika Hashimoto; Hironori Kobayashi; Sachiko Kobayashi; Michio Otsuki; Iichiro Shimomura
Diabetes April 2018, Vol.67, 1113-1127. doi:https://doi.org/10.2337/db17-1032
Islet Studies
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells
Alexander Hamilton; Quan Zhang; Albert Salehi; Mara Willems; Jakob G. Knudsen; Anna K. Ringgaard; Caroline E. Chapman; Alejandro Gonzalez-Alvarez; Nicoletta C. Surdo; Manuela Zaccolo; Davide Basco; Paul R.V. Johnson; Reshma Ramracheya; Guy A. Rutter; Antony Galione; Patrik Rorsman; Andrei I. Tarasov
Diabetes March 2018, Vol.67, 1128-1139. doi:https://doi.org/10.2337/db17-1102
Complications
Altered Brain Dynamics in Patients With Type 1 Diabetes During Working Memory Processing
Christine M. Embury; Alex I. Wiesman; Amy L. Proskovec; Elizabeth Heinrichs-Graham; Timothy J. McDermott; Grace H. Lord; Kaitlin L. Brau; Andjela T. Drincic; Cyrus V. Desouza; Tony W. Wilson
Diabetes March 2018, Vol.67, 1140-1148. doi:https://doi.org/10.2337/db17-1382
Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway
Guo Nan Yin; Hai-Rong Jin; Min-Ji Choi; Anita Limanjaya; Kalyan Ghatak; Nguyen Nhat Minh; Jiyeon Ock; Mi-Hye Kwon; Kang-Moon Song; Heon Joo Park; Ho Min Kim; Young-Guen Kwon; Ji-Kan Ryu; Jun-Kyu Suh
Diabetes March 2018, Vol.67, 1149-1161. doi:https://doi.org/10.2337/db17-0833
Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas
Diabetes April 2018, Vol.67, 1162-1172. doi:https://doi.org/10.2337/db17-1336
Pharmacology and Therapeutics
Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts
Mary Courtney Moore; David E. Kelley; Raul C. Camacho; Peter Zafian; Tian Ye; Songnian Lin; Niels C. Kaarsholm; Ravi Nargund; Terri M. Kelly; Margaret Van Heek; Stephen F. Previs; Christopher Moyes; Marta S. Smith; Ben Farmer; Phil Williams; Alan D. Cherrington
Diabetes March 2018, Vol.67, 1173-1181. doi:https://doi.org/10.2337/db18-0099
Endogenous Glucose Production and Hormonal Changes in Response to Canagliflozin and Liraglutide Combination Therapy
Robert Martinez; Hussein Al-Jobori; Ali M. Ali; John Adams; Muhammad Abdul-Ghani; Curtis Triplitt; Ralph A. DeFronzo; Eugenio Cersosimo
Diabetes March 2018, Vol.67, 1182-1189. doi:https://doi.org/10.2337/db17-1278
Genetics / Genomes / Proteomics / Metabolomics
Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid
Ondrej Kuda; Marie Brezinova; Jan Silhavy; Vladimir Landa; Vaclav Zidek; Chandra Dodia; Franziska Kreuchwig; Marek Vrbacky; Laurence Balas; Thierry Durand; Norbert Hübner; Aron B. Fisher; Jan Kopecky; Michal Pravenec
Diabetes March 2018, Vol.67, 1190-1199. doi:https://doi.org/10.2337/db17-1087
Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis
Janine Kröger; Karina Meidtner; Norbert Stefan; Marcela Guevara; Nicola D. Kerrison; Eva Ardanaz; Dagfinn Aune; Heiner Boeing; Miren Dorronsoro; Courtney Dow; Guy Fagherazzi; Paul W. Franks; Heinz Freisling; Marc J. Gunter; José María Huerta; Rudolf Kaaks; Timothy J. Key; Kay Tee Khaw; Vittorio Krogh; Tilman Kühn; Francesca Romana Mancini; Amalia Mattiello; Peter M. Nilsson; Anja Olsen; Kim Overvad; Domenico Palli; J. Ramón Quirós; Olov Rolandsson; Carlotta Sacerdote; Núria Sala; Elena Salamanca-Fernández; Ivonne Sluijs; Annemieke M.W. Spijkerman; Anne Tjonneland; Konstantinos K. Tsilidis; Rosario Tumino; Yvonne T. van der Schouw; Nita G. Forouhi; Stephen J. Sharp; Claudia Langenberg; Elio Riboli; Matthias B. Schulze; Nicholas J. Wareham
Diabetes March 2018, Vol.67, 1200-1205. doi:https://doi.org/10.2337/db17-1268
Erratum
Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172–2182
Jason L. Vassy; Marie-France Hivert; Bianca Porneala; Marco Dauriz; Jose C. Florez; Josée Dupuis; David S. Siscovick; Myriam Fornage; Laura J. Rasmussen-Torvik; Claude Bouchard; James B. Meigs
Diabetes April 2018, Vol.67, 1206. doi:https://doi.org/10.2337/db18-er06a
