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July 2018
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Cover Image
Cover Image
On the cover: Micrograph showing cross-section of mouse gastrocnemius muscle stained for CD36 protein (red). Image courtesy of Dmitri Samovski, Washington University in St. Louis, St. Louis, MO. His article, “Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling,” appears in this issue of Diabetes (p. 1272)
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes June 2018, Vol.67, 1209-1210. doi:https://doi.org/10.2337/db18-ti07
Perspectives in Diabetes
Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes—The TrialNet Experience
Carla J. Greenbaum; Cate Speake; Jeffrey Krischer; Jane Buckner; Peter A. Gottlieb; Desmond A. Schatz; Kevan C. Herold; Mark A. Atkinson
Diabetes May 2018, Vol.67, 1216-1225. doi:https://doi.org/10.2337/db18-0065
Metabolism
Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue
Minna Lahesmaa; Olof Eriksson; Thorsten Gnad; Vesa Oikonen; Marco Bucci; Jussi Hirvonen; Kalle Koskensalo; Jarmo Teuho; Tarja Niemi; Markku Taittonen; Salla Lahdenpohja; Mueez U Din; Merja Haaparanta-Solin; Alexander Pfeifer; Kirsi A. Virtanen; Pirjo Nuutila
Diabetes April 2018, Vol.67, 1226-1236. doi:https://doi.org/10.2337/db17-1366
Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day
Mary Courtney Moore; Marta S. Smith; Ben Farmer; Katie C. Coate; Guillaume Kraft; Masakazu Shiota; Phillip E. Williams; Alan D. Cherrington
Diabetes April 2018, Vol.67, 1237-1245. doi:https://doi.org/10.2337/db17-0979
TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding
Diabetes April 2018, Vol.67, 1246-1257. doi:https://doi.org/10.2337/db17-1485
Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions
Cécile L. Bandet; Rana Mahfouz; Julien Véret; Athanassia Sotiropoulos; Maxime Poirier; Paola Giussani; Mélanie Campana; Erwann Philippe; Agnieszka Blachnio-Zabielska; Raphaëlle Ballaire; Xavier Le Liepvre; Olivier Bourron; Dušan Berkeš; Jan Górski; Pascal Ferré; Hervé Le Stunff; Fabienne Foufelle; Eric Hajduch
Diabetes May 2018, Vol.67, 1258-1271. doi:https://doi.org/10.2337/db17-0901
Signal Transduction
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling
Dmitri Samovski; Pallavi Dhule; Terri Pietka; Miriam Jacome-Sosa; Eric Penrose; Ni-Huiping Son; Charles Robb Flynn; Kooresh I. Shoghi; Krzysztof L. Hyrc; Ira J. Goldberg; Eric R. Gamazon; Nada A. Abumrad
Diabetes May 2018, Vol.67, 1272-1284. doi:https://doi.org/10.2337/db17-1226
Obesity Studies
Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure
Sophie Carter; Stéphanie Miard; Alexandre Caron; Sandrine Sallé-Lefort; Philippe St-Pierre; Fernando Forato Anhê; Emilie Lavoie-Charland; Pascale Blais-Lecours; Marie-Claude Drolet; Julie S. Lefebvre; Julie Lacombe; Yves Deshaies; Jacques Couet; Mathieu Laplante; Mathieu Ferron; Yohan Bossé; André Marette; Denis Richard; David Marsolais; Frédéric Picard
Diabetes March 2018, Vol.67, 1285-1296. doi:https://doi.org/10.2337/db17-0558
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes
Amar Abderrahmani; Loïc Yengo; Robert Caiazzo; Mickaël Canouil; Stéphane Cauchi; Violeta Raverdy; Valérie Plaisance; Valérie Pawlowski; Stéphane Lobbens; Julie Maillet; Laure Rolland; Raphael Boutry; Gurvan Queniat; Maxime Kwapich; Mathie Tenenbaum; Julien Bricambert; Sophie Saussenthaler; Elodie Anthony; Pooja Jha; Julien Derop; Olivier Sand; Iandry Rabearivelo; Audrey Leloire; Marie Pigeyre; Martine Daujat-Chavanieu; Sabine Gerbal-Chaloin; Tasnim Dayeh; Guillaume Lassailly; Philippe Mathurin; Bart Staels; Johan Auwerx; Annette Schürmann; Catherine Postic; Clemens Schafmayer; Jochen Hampe; Amélie Bonnefond; François Pattou; Philippe Froguel
Diabetes May 2018, Vol.67, 1310-1321. doi:https://doi.org/10.2337/db17-1539
Islet Studies
T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells
Cristina Aguayo-Mazzucato; Terence B. Lee, Jr.; Michelle Matzko; Amanda DiIenno; Habib Rezanejad; Preeti Ramadoss; Thomas Scanlan; Ann Marie Zavacki; P. Reed Larsen; Anthony Hollenberg; Clark Colton; Arun Sharma; Susan Bonner-Weir
Diabetes April 2018, Vol.67, 1322-1331. doi:https://doi.org/10.2337/db18-0030
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function
Arianne Aslamy; Eunjin Oh; Erika M. Olson; Jing Zhang; Miwon Ahn; Abu Saleh Md Moin; Ragadeepthi Tunduguru; Vishal A. Salunkhe; Rajakrishnan Veluthakal; Debbie C. Thurmond
Diabetes April 2018, Vol.67, 1332-1344. doi:https://doi.org/10.2337/db17-1352
Human Proislet Peptide Promotes Pancreatic Progenitor Cells to Ameliorate Diabetes Through FOXO1/Menin-Mediated Epigenetic Regulation
Zongzhe Jiang; Diwen Shi; Yifan Tu; Jingjing Tian; Wenjian Zhang; Bowen Xing; Jihua Wang; Suhuan Liu; Jinning Lou; Jan-Åke Gustafsson; Xianxin Hua; Xiaosong Ma
Diabetes May 2018, Vol.67, 1345-1355. doi:https://doi.org/10.2337/db17-0885
Immunology and Transplantation
Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes
Meghan L. Marre; John W. McGinty; I-Ting Chow; Megan E. DeNicola; Noah W. Beck; Sally C. Kent; Alvin C. Powers; Rita Bottino; David M. Harlan; Carla J. Greenbaum; William W. Kwok; Jon D. Piganelli; Eddie A. James
Diabetes April 2018, Vol.67, 1356-1368. doi:https://doi.org/10.2337/db17-1166
Pathophysiology
Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes
Melanie Cree-Green; Rebecca L. Scalzo; Kylie Harrall; Bradley R. Newcomer; Irene E. Schauer; Amy G. Huebschmann; Shawna McMillin; Mark S. Brown; David Orlicky; Leslie Knaub; Kristen J. Nadeau; P. Mason McClatchey; Timothy A. Bauer; Judith G. Regensteiner; Jane E.B. Reusch
Diabetes April 2018, Vol.67, 1369-1379. doi:https://doi.org/10.2337/db17-1124
MCP-1 Feedback Loop Between Adipocytes and Mesenchymal Stromal Cells Causes Fat Accumulation and Contributes to Hematopoietic Stem Cell Rarefaction in the Bone Marrow of Patients With Diabetes
David Ferland-McCollough; Davide Maselli; Gaia Spinetti; Maria Sambataro; Niall Sullivan; Ashley Blom; Paolo Madeddu
Diabetes April 2018, Vol.67, 1380-1394. doi:https://doi.org/10.2337/db18-0044
Relation of Aortic Stiffness to Left Ventricular Remodeling in Younger Adults With Type 2 Diabetes
Gaurav S. Gulsin; Daniel J. Swarbrick; William H. Hunt; Eylem Levelt; Matthew P.M. Graham-Brown; Kelly S. Parke; Joanne V. Wormleighton; Florence Y. Lai; Thomas Yates; Emma G. Wilmot; David R. Webb; Melanie J. Davies; Gerry P. McCann
Diabetes April 2018, Vol.67, 1395-1400. doi:https://doi.org/10.2337/db18-0112
Pharmacology and Therapeutics
GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia
Nina Xiaoyan Li; Stacey Brown; Tim Kowalski; Margaret Wu; Liming Yang; Ge Dai; Aleksandr Petrov; Yuyan Ding; Tamara Dlugos; Harold B. Wood; Liangsu Wang; Mark Erion; Robert Sherwin; David E. Kelley
Diabetes April 2018, Vol.67, 1401-1413. doi:https://doi.org/10.2337/db18-0031
Genetics / Genomes / Proteomics / Metabolomics
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
Natalie R. van Zuydam; Emma Ahlqvist; Niina Sandholm; Harshal Deshmukh; N. William Rayner; Moustafa Abdalla; Claes Ladenvall; Daniel Ziemek; Eric Fauman; Neil R. Robertson; Paul M. McKeigue; Erkka Valo; Carol Forsblom; Valma Harjutsalo; Annalisa Perna; Erica Rurali; M. Loredana Marcovecchio; Robert P. Igo, Jr.; Rany M. Salem; Norberto Perico; Maria Lajer; Annemari Käräjämäki; Minako Imamura; Michiaki Kubo; Atsushi Takahashi; Xueling Sim; Jianjun Liu; Rob M. van Dam; Guozhi Jiang; Claudia H.T. Tam; Andrea O.Y. Luk; Heung Man Lee; Cadmon K.P. Lim; Cheuk Chun Szeto; Wing Yee So; Juliana C.N. Chan; Su Fen Ang; Rajkumar Dorajoo; Ling Wang; Tan Si Hua Clara; Amy-Jayne McKnight; Seamus Duffy; Marcus G. Pezzolesi; Michel Marre; Beata Gyorgy; Samy Hadjadj; Linda T. Hiraki; Tarunveer S. Ahluwalia; Peter Almgren; Christina-Alexandra Schulz; Marju Orho-Melander; Allan Linneberg; Cramer Christensen; Daniel R. Witte; Niels Grarup; Ivan Brandslund; Olle Melander; Andrew D. Paterson; David Tregouet; Alexander P. Maxwell; Su Chi Lim; Ronald C.W. Ma; E Shyong Tai; Shiro Maeda; Valeriya Lyssenko; Tiinamaija Tuomi; Andrzej S. Krolewski; Stephen S. Rich; Joel N. Hirschhorn; Jose C. Florez; David Dunger; Oluf Pedersen; Torben Hansen; Peter Rossing; Giuseppe Remuzzi; Mary Julia Brosnan; Colin N.A. Palmer; Per-Henrik Groop; Helen M. Colhoun; Leif C. Groop; Mark I. McCarthy; Finnish Diabetic Nephropathy Study (FinnDiane); Hong Kong Diabetes Registry Theme-based Research Scheme Project Group; Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group; GENIE (GEnetics of Nephropathy an International Effort) Consortium; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group; SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium
Diabetes April 2018, Vol.67, 1414-1427. doi:https://doi.org/10.2337/db17-0914
Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes
Daniel M. Rotroff; Sook Wah Yee; Kaixin Zhou; Skylar W. Marvel; Hetal S. Shah; John R. Jack; Tammy M. Havener; Monique M. Hedderson; Michiaki Kubo; Mark A. Herman; He Gao; Josyf C. Mychaleckyi; Howard L. McLeod; Alessandro Doria; Kathleen M. Giacomini; Ewan R. Pearson; Michael J. Wagner; John B. Buse; Alison A. Motsinger-Reif; MetGen Investigators; ACCORD/ACCORDion Investigators
Diabetes April 2018, Vol.67, 1428-1440. doi:https://doi.org/10.2337/db17-1164
mtDNA Haplogroup N9a Increases the Risk of Type 2 Diabetes by Altering Mitochondrial Function and Intracellular Mitochondrial Signals
Hezhi Fang; Nianqi Hu; Qiongya Zhao; Bingqian Wang; Huaibin Zhou; Qingzi Fu; Lijun Shen; Xiong Chen; Feixia Shen; Jianxin Lyu
Diabetes May 2018, Vol.67, 1441-1453. doi:https://doi.org/10.2337/db17-0974
