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1 August 2018
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Cover Image
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Close ModalOn the cover: Light micrograph of a section through the human pancreas. The central purple islets of Langerhans are hormone-secreting and form the endocrine (secreting directly into the blood) part of the pancreas. The surrounding exocrine (secreting into the gut via ducts) tissue produces digestive enzymes. Magnification: ×200 when printed at 10 cm wide. Credit: Steve Gschmeissner/Science Source. For further information, please visit www.sciencesource.com
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Topics:
antigen-presenting cells
,
antigens
,
combined modality therapy
,
diabetes mellitus, type 1
,
diabetic neuropathies
Diabetes July 2018, Vol.67, 1455-1456. doi:https://doi.org/10.2337/db18-ti08
Commentary
Strong Heart, Low Ceramides
Topics:
ceramides
,
heart
,
insulin resistance
Diabetes July 2018, Vol.67, 1457-1460. doi:https://doi.org/10.2337/dbi18-0018
Diabetes Symposium: Emerging Areas of Islet Biology
This section features two articles from the 5th Diabetes Symposium held in conjunction with the ADA's 78th Scientific Sessions in Orlando, FL, 22–26 June 2018.
Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization
Diabetes June 2018, Vol.67, 1461-1470. doi:https://doi.org/10.2337/dbi18-0001
Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors
Angeliki M. Stamatouli; Zoe Quandt; Ana Luisa Perdigoto; Pamela L. Clark; Harriet Kluger; Sarah A. Weiss; Scott Gettinger; Mario Sznol; Arabella Young; Robert Rushakoff; James Lee; Jeffrey A. Bluestone; Mark Anderson; Kevan C. Herold
Topics:
autoantibodies
,
cancer
,
clinical pulmonary infection score
,
diabetes mellitus, type 1
,
immune checkpoint inhibitors
Diabetes June 2018, Vol.67, 1471-1480. doi:https://doi.org/10.2337/dbi18-0002
Methodology Review
Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?
Topics:
antigens
,
atrial premature complexes
,
mice, inbred nod
,
genes
,
t-lymphocytes
Diabetes July 2018, Vol.67, 1481-1494. doi:https://doi.org/10.2337/db17-1564
Metabolism
Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin
Isaac Asare-Bediako; Rebecca L. Paszkiewicz; Stella P. Kim; Orison O. Woolcott; Cathryn M. Kolka; Miguel A. Burch; Morvarid Kabir; Richard N. Bergman
Topics:
insulin
,
infusion procedures
,
plasma
Diabetes May 2018, Vol.67, 1495-1503. doi:https://doi.org/10.2337/db17-1520
Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor
Jonathan D. Douros; Alfor G. Lewis; Eric P. Smith; JingJing Niu; Megan Capozzi; April Wittmann; Jonathan Campbell; Jenny Tong; Constance Wagner; Parinaz Mahbod; Randy Seeley; David A. D’Alessio
Topics:
glucagon-like peptide 1
,
glucose
,
glucose tolerance
,
glycemic control
,
insulin
Diabetes May 2018, Vol.67, 1504-1511. doi:https://doi.org/10.2337/db18-0081
Obesity Studies
The Transplantation of ω3 PUFA–Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders
Célia Bidu; Quentin Escoula; Sandrine Bellenger; Aymé Spor; Maxime Galan; Audrey Geissler; André Bouchot; Dominique Dardevet; Béatrice Morio; Patrice D. Cani; Laurent Lagrost; Michel Narce; Jérôme Bellenger
Topics:
diet
,
mice
,
microbiome
,
obesity
,
polyunsaturated fatty acids
Diabetes May 2018, Vol.67, 1512-1523. doi:https://doi.org/10.2337/db17-1488
Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A
Kazutaka Ueda; Eiki Takimoto; Qing Lu; Pangyen Liu; Nobuaki Fukuma; Yusuke Adachi; Ryo Suzuki; Shengpu Chou; Wendy Baur; Mark J. Aronovitz; Andrew S. Greenberg; Issei Komuro; Richard H. Karas
Topics:
estrogen
,
mice
,
signal transduction
,
tissue membrane
,
protein phosphatase
Diabetes May 2018, Vol.67, 1524-1537. doi:https://doi.org/10.2337/db17-1342
Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor–Expressing Glutamatergic Neurons
Jessica M. Adams; Hongjuan Pei; Darleen A. Sandoval; Randy J. Seeley; Rui B. Chang; Stephen D. Liberles; David P. Olson
Topics:
liraglutide
,
neurons
,
mice
Diabetes May 2018, Vol.67, 1538-1548. doi:https://doi.org/10.2337/db17-1385
Perivascular Adipose Tissue–Derived PDGF-D Contributes to Aortic Aneurysm Formation During Obesity
Ze-Bei Zhang; Cheng-Chao Ruan; Jing-Rong Lin; Lian Xu; Xiao-Hui Chen; Ya-Nan Du; Meng-Xia Fu; Ling-Ran Kong; Ding-Liang Zhu; Ping-Jin Gao
Topics:
mice
,
mice, obese
,
obesity
,
platelet-derived growth factor
,
infusion procedures
Diabetes May 2018, Vol.67, 1549-1560. doi:https://doi.org/10.2337/db18-0098
Islet Studies
Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation
Anil Kumar; Liora S. Katz; Anna M. Schulz; Misung Kim; Lee B. Honig; Lucy Li; Bennett Davenport; Dirk Homann; Adolfo Garcia-Ocaña; Mark A. Herman; Cole M. Haynes; Jerry E. Chipuk; Donald K. Scott
Topics:
glucose
,
mitochondria
,
antioxidants
Diabetes May 2018, Vol.67, 1561-1575. doi:https://doi.org/10.2337/db17-0943
Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response
Michelle R. Marasco; Abass M. Conteh; Christopher A. Reissaus; John E. Cupit, V; Evan M. Appleman; Raghavendra G. Mirmira; Amelia K. Linnemann
Topics:
antioxidants
,
interleukin-6
,
mice
,
autophagy
,
streptozocin
Diabetes May 2018, Vol.67, 1576-1588. doi:https://doi.org/10.2337/db17-1280
Immunology and Transplantation
TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis
Lunhua Liu; Karen Etsuko Inouye; Windy Rose Allman; Adam Steven Coleman; Shafiuddin Siddiqui; Gökhan Siddik Hotamisligil; Mustafa Akkoyunlu
Topics:
mice
,
obesity
,
insulin
,
transfer technique
Diabetes June 2018, Vol.67, 1589-1603. doi:https://doi.org/10.2337/db17-1089
Pathophysiology
Production of Elastin-Derived Peptides Contributes to the Development of Nonalcoholic Steatohepatitis
Béatrice Romier; Corinne Ivaldi; Hervé Sartelet; Andrea Heinz; Christian E.H. Schmelzer; Roselyne Garnotel; Alexandre Guillot; Jessica Jonquet; Eric Bertin; Jean-Louis Guéant; Jean-Marc Alberto; Jean-Pierre Bronowicki; Johanne Amoyel; Thinhinane Hocine; Laurent Duca; Pascal Maurice; Amar Bennasroune; Laurent Martiny; Laurent Debelle; Vincent Durlach; Sébastien Blaise
Topics:
elastin
,
mice
,
non-alcoholic fatty liver disease
,
peptides
,
steatohepatitis, non-alcoholic
Diabetes May 2018, Vol.67, 1604-1615. doi:https://doi.org/10.2337/db17-0490
Complications
Vascular and Neural Complications in Type 2 Diabetic Rats: Improvement by Sacubitril/Valsartan Greater Than Valsartan Alone
Topics:
cornea
,
early intervention (education)
,
rats
,
sacubitril/valsartan
,
valsartan
Diabetes June 2018, Vol.67, 1616-1626. doi:https://doi.org/10.2337/db18-0062
MicroRNA-129 and -335 Promote Diabetic Wound Healing by Inhibiting Sp1-Mediated MMP-9 Expression
Wei Wang; Chuan Yang; Xiao yi Wang; Li yan Zhou; Guo juan Lao; Dan Liu; Chuan Wang; Meng die Hu; Ting ting Zeng; Li Yan; Meng Ren
Topics:
gelatinase b
,
micrornas
,
skin
,
wound healing
Diabetes May 2018, Vol.67, 1627-1638. doi:https://doi.org/10.2337/db17-1238
Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway
Chao Huang; Kiera P. Fisher; Sandra S. Hammer; Svetlana Navitskaya; Gary J. Blanchard; Julia V. Busik
Topics:
exosomes
,
plasma
,
mice
,
complement system proteins
,
western blotting
Diabetes June 2018, Vol.67, 1639-1649. doi:https://doi.org/10.2337/db17-1587
Impaired Nociception in the Diabetic Ins2+/Akita Mouse
Nisha Vastani; Franziska Guenther; Clive Gentry; Amazon L. Austin; Aileen J. King; Stuart Bevan; David A. Andersson
Topics:
mice
,
neurons
,
pain perception
,
common cold
,
islets of langerhans transplantation
Diabetes June 2018, Vol.67, 1650-1662. doi:https://doi.org/10.2337/db17-1306
Genetics / Genomes / Proteomics / Metabolomics
Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study
Rozenn N. Lemaitre; Chaoyu Yu; Andrew Hoofnagle; Nair Hari; Paul N. Jensen; Amanda M. Fretts; Jason G. Umans; Barbara V. Howard; Colleen M. Sitlani; David S. Siscovick; Irena B. King; Nona Sotoodehnia; Barbara McKnight
Topics:
ceramides
,
insulin
,
sphingolipids
,
sphingomyelins
,
fasting
Diabetes March 2018, Vol.67, 1663-1672. doi:https://doi.org/10.2337/db17-1449
Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy
Andres Cardenas; Valerie Gagné-Ouellet; Catherine Allard; Diane Brisson; Patrice Perron; Luigi Bouchard; Marie-France Hivert
Topics:
deuterium
,
dna methylation
,
glucose
,
oral glucose tolerance test
,
placenta
Diabetes May 2018, Vol.67, 1673-1683. doi:https://doi.org/10.2337/db18-0123
Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study
Stephanie J. Loomis; Man Li; Nisa M. Maruthur; Abigail S. Baldridge; Kari E. North; Hao Mei; Alanna Morrison; April P. Carson; James S. Pankow; Eric Boerwinkle; Robert Scharpf; Laura J. Rasmussen-Torvik; Josef Coresh; Priya Duggal; Anna Köttgen; Elizabeth Selvin
Topics:
albumins
,
aric trial
,
fructosamine
,
hemoglobin a, glycosylated
,
single nucleotide polymorphism
Diabetes May 2018, Vol.67, 1684-1696. doi:https://doi.org/10.2337/db17-1362
Issues and Events
Issues and Events
Topics:
podcasts
,
health personnel
Diabetes July 2018, Vol.67, 1697. doi:https://doi.org/10.2337/db18-ie08
