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1 September 2018
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On the cover: Ball-and-stick molecule of the hormone insulin (carbon, green; oxygen, red; and hydrogen, blue). Credit: Alfred Pasieka/Science Source. For further information, please visit www.sciencesource.com
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes August 2018, Vol.67, 1699-1700. doi:https://doi.org/10.2337/db18-ti09
ADA Award Lecture
Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture
Diabetes August 2018, Vol.67, 1701-1709. doi:https://doi.org/10.2337/dbi18-0025
Perspectives in Diabetes
The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications
Diabetes August 2018, Vol.67, 1710-1719. doi:https://doi.org/10.2337/dbi18-0008
Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery
Diabetes August 2018, Vol.67, 1720-1728. doi:https://doi.org/10.2337/dbi17-0007
Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences
Diabetes August 2018, Vol.67, 1729-1741. doi:https://doi.org/10.2337/dbi17-0044
Commentaries
A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes
Diabetes August 2018, Vol.67, 1742-1744. doi:https://doi.org/10.2337/dbi18-0026
Intermittent Fasting and Prevention of Diabetic Retinopathy: Where Do We Go From Here?
Diabetes August 2018, Vol.67, 1745-1747. doi:https://doi.org/10.2337/dbi18-0022
Metabolism
Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity
Yuanyang Wang; Shuai Yan; Bing Xiao; Shengkai Zuo; Qianqian Zhang; Guilin Chen; Yu Yu; Di Chen; Qian Liu; Yi Liu; Yujun Shen; Ying Yu
Diabetes May 2018, Vol.67, 1748-1760. doi:https://doi.org/10.2337/db17-1521
Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages
Yun Bu; Katsuhide Okunishi; Satomi Yogosawa; Kouichi Mizuno; Maria Johnson Irudayam; Chester W. Brown; Tetsuro Izumi
Diabetes June 2018, Vol.67, 1761-1772. doi:https://doi.org/10.2337/db17-1201
Obesity Studies
Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21
Teayoun Kim; Shelly Nason; Cassie Holleman; Mark Pepin; Landon Wilson; Taylor F. Berryhill; Adam R. Wende; Chad Steele; Martin E. Young; Stephen Barnes; Daniel J. Drucker; Brian Finan; Richard DiMarchi; Diego Perez-Tilve; Matthias Tschöp; Kirk M. Habegger
Diabetes June 2018, Vol.67, 1773-1782. doi:https://doi.org/10.2337/db17-1502
Islet Studies
Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response
Yurong Xin; Giselle Dominguez Gutierrez; Haruka Okamoto; Jinrang Kim; Ann-Hwee Lee; Christina Adler; Min Ni; George D. Yancopoulos; Andrew J. Murphy; Jesper Gromada
Diabetes June 2018, Vol.67, 1783-1794. doi:https://doi.org/10.2337/db18-0365
Inhibition of SNAT5 Induces Incretin-Responsive State From Incretin-Unresponsive State in Pancreatic β-Cells: Study of β-Cell Spheroid Clusters as a Model
Mahira Hashim; Norihide Yokoi; Harumi Takahashi; Ghupurjan Gheni; Oduori S. Okechi; Tomohide Hayami; Naoya Murao; Shihomi Hidaka; Kohtaro Minami; Akira Mizoguchi; Susumu Seino
Diabetes June 2018, Vol.67, 1795-1806. doi:https://doi.org/10.2337/db17-1486
The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs
Vasumathi Kameswaran; Maria L. Golson; Mireia Ramos-Rodríguez; Kristy Ou; Yue J. Wang; Jia Zhang; Lorenzo Pasquali; Klaus H. Kaestner
Diabetes July 2018, Vol.67, 1807-1815. doi:https://doi.org/10.2337/db17-0682
Immunology and Transplantation
Humanized Mouse Model to Study Type 1 Diabetes
Sandrine Luce; Sophie Guinoiseau; Alexis Gadault; Franck Letourneur; Bertrand Blondeau; Patrick Nitschke; Eric Pasmant; Michel Vidaud; François Lemonnier; Christian Boitard
Diabetes July 2018, Vol.67, 1816-1829. doi:https://doi.org/10.2337/db18-0202
Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice
Diabetes July 2018, Vol.67, 1830-1835. doi:https://doi.org/10.2337/db18-0331
CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse
Rocky L. Baker; Braxton L. Jamison; Timothy A. Wiles; Robin S. Lindsay; Gene Barbour; Brenda Bradley; Thomas Delong; Rachel S. Friedman; Maki Nakayama; Kathryn Haskins
Diabetes July 2018, Vol.67, 1836-1846. doi:https://doi.org/10.2337/db18-0200
Pathophysiology
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes
Zhilian Li; Yan Li; Jessica M. Overstreet; Sungjin Chung; Aolei Niu; Xiaofeng Fan; Suwan Wang; Yinqiu Wang; Ming-Zhi Zhang; Raymond C. Harris
Diabetes June 2018, Vol.67, 1847-1857. doi:https://doi.org/10.2337/db17-1513
Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes
Florence Anquetil; Giada Mondanelli; Nathaly Gonzalez; Teresa Rodriguez Calvo; Jose Zapardiel Gonzalo; Lars Krogvold; Knut Dahl-Jørgensen; Benoit Van den Eynde; Ciriana Orabona; Ursula Grohmann; Matthias G. von Herrath
Diabetes June 2018, Vol.67, 1858-1866. doi:https://doi.org/10.2337/db17-1281
Complications
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice
Eleni Beli; Yuanqing Yan; Leni Moldovan; Cristiano P. Vieira; Ruli Gao; Yaqian Duan; Ram Prasad; Ashay Bhatwadekar; Fletcher A. White; Steven D. Townsend; Luisa Chan; Caitlin N. Ryan; Daniel Morton; Emil G. Moldovan; Fang-I Chu; Gavin Y. Oudit; Hartmut Derendorf; Luciano Adorini; Xiaoxin X. Wang; Carmella Evans-Molina; Raghavendra G. Mirmira; Michael E. Boulton; Mervin C. Yoder; Qiuhong Li; Moshe Levi; Julia V. Busik; Maria B. Grant
Diabetes April 2018, Vol.67, 1867-1879. doi:https://doi.org/10.2337/db18-0158
Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice
Chujun Yuan; Jiyuan Hu; Saj Parathath; Lisa Grauer; Courtney Blachford Cassella; Svetlana Bagdasarov; Ira J. Goldberg; Ravichandran Ramasamy; Edward A. Fisher
Diabetes June 2018, Vol.67, 1880-1891. doi:https://doi.org/10.2337/db18-0156
Genetics / Genomes / Proteomics / Metabolomics
Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population
Soo Heon Kwak; Jeesoo Chae; Seungbok Lee; Sungkyoung Choi; Bo Kyung Koo; Ji Won Yoon; Jin-Ho Park; Belong Cho; Min Kyong Moon; Soo Lim; Young Min Cho; Sanghoon Moon; Young Jin Kim; Sohee Han; Mi Yeong Hwang; Yoon Shin Cho; Myung-Shik Lee; Hak C. Jang; Hyun Min Kang; Taesung Park; Nam H. Cho; Kyunga Kim; Jong-Il Kim; Kyong Soo Park
Diabetes June 2018, Vol.67, 1892-1902. doi:https://doi.org/10.2337/db18-0361
The Common HNF1A Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY
Jonathan M. Locke; Cécile Saint-Martin; Thomas W. Laver; Kashyap A. Patel; Andrew R. Wood; Seth A. Sharp; Sian Ellard; Christine Bellanné-Chantelot; Andrew T. Hattersley; Lorna W. Harries; Michael N. Weedon
Diabetes June 2018, Vol.67, 1903-1907. doi:https://doi.org/10.2337/db18-0133
