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January 2019
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Cover Image
Cover Image
On the cover: Image of whole diaphragm obtained from mouse with diet-induced obesity. Adipocyte infiltration (red) was detected with Oil Red O after tissue decellularization. Image courtesy of Eric D. Buras, University of Michigan, Ann Arbor, MI. His article, “Fibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction,” appears in this issue of Diabetes (p. 45).
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process. Click here for more information. - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes December 2018, Vol.68, 1-2. doi:https://doi.org/10.2337/db19-ti01
ADA Award Lecture
Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture
Diabetes December 2018, Vol.68, 3-14. doi:https://doi.org/10.2337/dbi18-0035
Commentaries
Glucagon-Like Peptide 1 in the Brain: Where Is It Coming From, Where Is It Going?
Diabetes December 2018, Vol.68, 15-17. doi:https://doi.org/10.2337/dbi18-0045
Increased Fibro-Adipogenic Progenitors and Intramyocellular Lipid Accumulation in Obesity-Related Skeletal Muscle Dysfunction
Diabetes December 2018, Vol.68, 18-20. doi:https://doi.org/10.2337/dbi18-0047
Metabolism
Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food
Marie K. Holt; James E. Richards; Daniel R. Cook; Daniel I. Brierley; Diana L. Williams; Frank Reimann; Fiona M. Gribble; Stefan Trapp
Diabetes October 2018, Vol.68, 21-33. doi:https://doi.org/10.2337/db18-0729
GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner
Yanqing Zhang; Keshab R. Parajuli; Genevieve E. Fava; Rajesh Gupta; Weiwei Xu; Lauren U. Nguyen; Anadil F. Zakaria; Vivian A. Fonseca; Hongjun Wang; Franck Mauvais-Jarvis; Kyle W. Sloop; Hongju Wu
Diabetes November 2018, Vol.68, 34-44. doi:https://doi.org/10.2337/db18-0317
Obesity Studies
Fibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction
Eric D. Buras; Kimber Converso-Baran; Carol S. Davis; Takeshi Akama; Fumihito Hikage; Daniel E. Michele; Susan V. Brooks; Tae-Hwa Chun
Diabetes October 2018, Vol.68, 45-56. doi:https://doi.org/10.2337/db18-0209
An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance
Knut Mai; Linna Li; Susanna Wiegand; Maria Brachs; Verena Leupelt; Andrea Ernert; Peter Kühnen; Norbert Hübner; Peter Robinson; Wei Chen; Heiko Krude; Joachim Spranger
Diabetes November 2018, Vol.68, 57-65. doi:https://doi.org/10.2337/db18-0440
Islet Studies
MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice
Diabetes October 2018, Vol.68, 66-80. doi:https://doi.org/10.2337/db17-1149
SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress
Gung Lee; Hagoon Jang; Ye Young Kim; Sung Sik Choe; Jinuk Kong; Injae Hwang; Jeu Park; Seung-Soon Im; Jae Bum Kim
Diabetes October 2018, Vol.68, 81-94. doi:https://doi.org/10.2337/db18-0556
Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance
Emilie Courty; Adrien Besseiche; Thi Thu Huong Do; Alexandrine Liboz; Fatima Mohamed Aguid; Evans Quilichini; Melissa Buscato; Pierre Gourdy; Jean-François Gautier; Jean-Pierre Riveline; Cécile Haumaitre; Marion Buyse; Bruno Fève; Ghislaine Guillemain; Bertrand Blondeau
Diabetes October 2018, Vol.68, 95-108. doi:https://doi.org/10.2337/db17-1314
Transient PAX8 Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus
Alejandro Martin-Montalvo; Livia López-Noriega; Carmen Jiménez-Moreno; Amanda Herranz; Petra I. Lorenzo; Nadia Cobo-Vuilleumier; Alejandra Tamayo; Cristian González-Guerrero; Jonathan S.W.R. Hofsteede; Fanny Lebreton; Domenico Bosco; Miguel García Toscano; Lucrecia Herranz; Joao Anselmo; José Carlos Moreno; Benoit R. Gauthier
Diabetes October 2018, Vol.68, 109-118. doi:https://doi.org/10.2337/db18-0285
Immunology and Transplantation
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children
David Endesfelder; Wolfgang zu Castell; Ezio Bonifacio; Marian Rewers; William A. Hagopian; Jin‐Xiong She; Åke Lernmark; Jorma Toppari; Kendra Vehik; Alistair J.K. Williams; Liping Yu; Beena Akolkar; Jeffrey P. Krischer; Anette-G. Ziegler; Peter Achenbach; TEDDY Study Group
Diabetes October 2018, Vol.68, 119-130. doi:https://doi.org/10.2337/db18-0594
Pathophysiology
Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes
Brandon B. Boland; Charles Brown, Jr.; Michelle L. Boland; Jennifer Cann; Michal Sulikowski; Gitte Hansen; Rikke V. Grønlund; Wanda King; Cristina Rondinone; James Trevaskis; Christopher J. Rhodes; Joseph S. Grimsby
Diabetes October 2018, Vol.68, 131-140. doi:https://doi.org/10.2337/db18-0304
Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells
Piul S. Rabbani; Marc A. Soares; Sophia G. Hameedi; Rohini L. Kadle; Adnan Mubasher; Maria Kowzun; Daniel J. Ceradini
Diabetes October 2018, Vol.68, 141-155. doi:https://doi.org/10.2337/db18-0232
Senescent T Cells Predict the Development of Hyperglycemia in Humans
Yong-ho Lee; So Ra Kim; Dai Hoon Han; Hee Tae Yu; Yoon Dae Han; Jin Hee Kim; Soo Hyun Kim; Chan Joo Lee; Byoung-Hoon Min; Dong-Hyun Kim; Kyung Hwan Kim; Jin Won Cho; Won-Woo Lee; Eui-Cheol Shin; Sungha Park
Diabetes November 2018, Vol.68, 156-162. doi:https://doi.org/10.2337/db17-1218
Complications
Glycemic Variability and Brain Glucose Levels in Type 1 Diabetes
Janice J. Hwang; Lihong Jiang; Elizabeth Sanchez Rangel; Xiaoning Fan; Yuyan Ding; Wai Lam; Jessica Leventhal; Feng Dai; Douglas L. Rothman; Graeme F. Mason; Robert S. Sherwin
Diabetes October 2018, Vol.68, 163-171. doi:https://doi.org/10.2337/db18-0722
VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy
Karen L. Onions; Monica Gamez; Nicola R. Buckner; Siân L. Baker; Kai B. Betteridge; Sara Desideri; Benjamin P. Dallyn; Raina D. Ramnath; Chris R. Neal; Louise K. Farmer; Peter W. Mathieson; Luigi Gnudi; Kari Alitalo; David O. Bates; Andrew H.J. Salmon; Gavin I. Welsh; Simon C. Satchell; Rebecca R. Foster
Diabetes November 2018, Vol.68, 172-187. doi:https://doi.org/10.2337/db18-0045
Genetics / Genomes / Proteomics / Metabolomics
Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes
Clemens Wittenbecher; Meriem Ouni; Olga Kuxhaus; Markus Jähnert; Pascal Gottmann; Andrea Teichmann; Karina Meidtner; Jennifer Kriebel; Harald Grallert; Tobias Pischon; Heiner Boeing; Matthias B. Schulze; Annette Schürmann
Diabetes November 2018, Vol.68, 188-197. doi:https://doi.org/10.2337/db18-0620
Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes
Chloe Y.Y. Cheung; Chi-Ho Lee; Clara S. Tang; Aimin Xu; Ka-Wing Au; Carol H.Y. Fong; Kelvin K.K. Ng; Kelvin H.M. Kwok; Wing-Sun Chow; Yu-Cho Woo; Michele M.A. Yuen; JoJo Hai; Kathryn C.B. Tan; Tai-Hing Lam; Hung-Fat Tse; Pak-Chung Sham; Karen S.L. Lam
Diabetes October 2018, Vol.68, 198-206. doi:https://doi.org/10.2337/db18-0500
Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Yingjie Ji; Andrianos M. Yiorkas; Francesca Frau; Dennis Mook-Kanamori; Harald Staiger; E. Louise Thomas; Naeimeh Atabaki-Pasdar; Archie Campbell; Jessica Tyrrell; Samuel E. Jones; Robin N. Beaumont; Andrew R. Wood; Marcus A. Tuke; Katherine S. Ruth; Anubha Mahajan; Anna Murray; Rachel M. Freathy; Michael N. Weedon; Andrew T. Hattersley; Caroline Hayward; Jürgen Machann; Hans-Ulrich Häring; Paul Franks; Renée de Mutsert; Ewan Pearson; Norbert Stefan; Timothy M. Frayling; Karla V. Allebrandt; Jimmy D. Bell; Alexandra I. Blakemore; Hanieh Yaghootkar
Diabetes October 2018, Vol.68, 207-219. doi:https://doi.org/10.2337/db18-0708
Circulating Phylloquinone Concentrations and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Sabine R. Zwakenberg; Sharon Remmelzwaal; Joline W.J. Beulens; Sarah L. Booth; Stephen Burgess; Hassan S. Dashti; Fumiaki Imamura; Edith J.M. Feskens; Yvonne T. van der Schouw; Ivonne Sluijs
Diabetes October 2018, Vol.68, 220-225. doi:https://doi.org/10.2337/db18-0543
DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes
Connor A. Emdin; Amit V. Khera; Krishna Aragam; Mary Haas; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
Diabetes November 2018, Vol.68, 226-234. doi:https://doi.org/10.2337/db18-0857
Errata
Erratum. The Transplantation of ω3 PUFA–Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders. Diabetes 2018;67:1512–1523
Célia Bidu; Quentin Escoula; Sandrine Bellenger; Aymé Spor; Maxime Galan; Audrey Geissler; André Bouchot; Dominique Dardevet; Béatrice Morio-Liondor; Patrice D. Cani; Laurent Lagrost; Michel Narce; Jérôme Bellenger
Diabetes November 2018, Vol.68, 235. doi:https://doi.org/10.2337/db19-er01a
Erratum. SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c. Diabetes 2018;67:2227–2238
Yang Jiao; Jiejie Zhao; Zhijian Zhang; Min Li; Xi Yu; Yanying Yang; Jie Liu; Shengjie Liao; Duanzhuo Li; Yuxing Wang; Die Zhang; Yulu Chen; Guojun Shi; Bin Liu; Yan Lu; Xiaoying Li
Diabetes November 2018, Vol.68, 235. doi:https://doi.org/10.2337/db19-er01b
Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans. Diabetes 2008;57:1246–1253
Xinmei Zhang; Dennis C.Y. Yeung; Michal Karpisek; David Stejskal; Zhi-Guang Zhou; Feng Liu; Rachel L.C. Wong; Wing-Sun Chow; Annette W.K. Tso; Karen S.L. Lam; Aimin Xu
Diabetes November 2018, Vol.68, 235. doi:https://doi.org/10.2337/db19-er01c
