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December 2019
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Cover Image
Cover Image
On the cover: Patients with type 2 diabetes mellitus (T2DM) have a considerably high risk of developing dementia, especially for those with mild cognitive impairment (MCI). Investigation of the microstructural change of white matter between T2DM patients with amnesic MCI and T2DM patients with normal cognition can help to understand the brain variations in T2DM-related amnesic cognitive impairment. This image is of the right inferior fronto-occipital fasciculus and the right inferior longitudinal fasciculus correlations with episodic memory and attention function impairment in T2DM patients with amnesic MCI. Image courtesy of Shudan Gao, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, People’s Republic of China. This image is a version of Fig. 2A in the article by Gao et al., “White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes,” which appeared in the November 2019 issue of Diabetes.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes November 2019, Vol.68, 2193-2194. doi:https://doi.org/10.2337/db19-ti12
Commentary
New Antidiabetes Agent Targeting Both Mitochondrial Uncoupling and Pyruvate Catabolism: Two Birds With One Stone
Diabetes November 2019, Vol.68, 2195-2196. doi:https://doi.org/10.2337/dbi19-0024
Metabolism
Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
Haowen Jiang; Jia Jin; Yanan Duan; Zhifu Xie; Yufeng Li; Anhui Gao; Min Gu; Xinwen Zhang; Chang Peng; Chunmei Xia; Tiancheng Dong; Hui Li; Lifang Yu; Jie Tang; Fan Yang; Jingya Li; Jia Li
Diabetes August 2019, Vol.68, 2197-2209. doi:https://doi.org/10.2337/db19-0589
MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance
Omar Al-Massadi; Mar Quiñones; Jerome Clasadonte; René Hernandez-Bautista; Amparo Romero-Picó; Cintia Folgueira; Donald A. Morgan; Imre Kalló; Violeta Heras; Ana Senra; Samuel C. Funderburk; Michael J. Krashes; Yara Souto; Miguel Fidalgo; Serge Luquet; Melissa J. Chee; Monica Imbernon; Daniel Beiroa; Lucía García-Caballero; Rosalia Gallego; Brian Y.H. Lam; Giles Yeo; Miguel Lopez; Zsolt Liposits; Kamal Rahmouni; Vincent Prevot; Carlos Dieguez; Ruben Nogueiras
Diabetes September 2019, Vol.68, 2210-2222. doi:https://doi.org/10.2337/db19-0029
The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1
Daniela Herrera Moro Chao; Yanan Wang; Ewout Foppen; Roelof Ottenhoff; Cindy van Roomen; Edwin T. Parlevliet; Marco van Eijk; Marri Verhoek; Rolf Boot; Andre R. Marques; Saskia Scheij; Mina Mirzaian; Sander Kooijman; Kirstin Jansen; Dawei Wang; Clarita Mergen; Randy J. Seeley; Matthias H. Tschöp; Herman Overkleeft; Patrick C.N. Rensen; Andries Kalsbeek; Johannes M.F.G. Aerts; Chun-Xia Yi
Diabetes October 2019, Vol.68, 2223-2234. doi:https://doi.org/10.2337/db19-0049
Obesity Studies
Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease
Priska Stahel; Avital Nahmias; Shawn K. Sud; So Jeong Lee; Andrea Pucci; Ahmed Yousseif; Alaa Youseff; Timothy Jackson; David R. Urbach; Allan Okrainec; Johane P. Allard; Sanjeev Sockalingam; Tony Yao; Moumita Barua; Hong Jiao; Reedik Magi; Anne S. Bassett; Andrew D. Paterson; Ingrid Dahlman; Rachel L. Batterham; Satya Dash
Diabetes September 2019, Vol.68, 2235-2246. doi:https://doi.org/10.2337/db18-1254
Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans
Birgitta W. van der Kolk; Marianthi Kalafati; Michiel Adriaens; Marleen M.J. van Greevenbroek; Nicole Vogelzangs; Wim H.M. Saris; Arne Astrup; Armand Valsesia; Dominique Langin; Carla J.H. van der Kallen; Simone J.P.M. Eussen; Casper G. Schalkwijk; Coen D.A. Stehouwer; Gijs H. Goossens; Ilja C.W. Arts; Johan W.E. Jocken; Chris T. Evelo; Ellen E. Blaak
Diabetes September 2019, Vol.68, 2247-2258. doi:https://doi.org/10.2337/db19-0560
Islet Studies
Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1
Diabetes September 2019, Vol.68, 2259-2271. doi:https://doi.org/10.2337/db19-0117
Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset
Lingzi Li; Petra Krznar; Alexander Erban; Andrea Agazzi; Juliette Martin-Levilain; Sachin Supale; Joachim Kopka; Nicola Zamboni; Pierre Maechler
Diabetes September 2019, Vol.68, 2272-2286. doi:https://doi.org/10.2337/db19-0131
Complications
Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2
Barend W. Florijn; Jacques M.G.J. Duijs; Johannes H. Levels; Geesje M. Dallinga-Thie; Yanan Wang; Anita N. Boing; Yuana Yuana; Wendy Stam; Ronald W.A.L. Limpens; Yu Wah Au; Rienk Nieuwland; Ton J. Rabelink; Marlies E.J. Reinders; Anton Jan van Zonneveld; Roel Bijkerk
Diabetes September 2019, Vol.68, 2287-2300. doi:https://doi.org/10.2337/db18-1360
Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression
Ying Fan; Zhengzi Yi; Vivette D. D’Agati; Zeguo Sun; Fang Zhong; Weijia Zhang; Jiejun Wen; Ting Zhou; Ze Li; Li He; Qunzi Zhang; Kyung Lee; John Cijiang He; Niansong Wang
Diabetes October 2019, Vol.68, 2301-2314. doi:https://doi.org/10.2337/db19-0204
Genetics / Genomes / Proteomics / Metabolomics
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study
Alexia Cardona; Felix R. Day; John R.B. Perry; Marie Loh; Audrey Y. Chu; Benjamin Lehne; Dirk S. Paul; Luca A. Lotta; Isobel D. Stewart; Nicola D. Kerrison; Robert A. Scott; Kay-Tee Khaw; Nita G. Forouhi; Claudia Langenberg; Chunyu Liu; Michael M. Mendelson; Daniel Levy; Stephan Beck; R. David Leslie; Josée Dupuis; James B. Meigs; Jaspal S. Kooner; Jussi Pihlajamäki; Allan Vaag; Alexander Perfilyev; Charlotte Ling; Marie-France Hivert; John C. Chambers; Nicholas J. Wareham; Ken K. Ong
Diabetes September 2019, Vol.68, 2315-2326. doi:https://doi.org/10.2337/db18-0290
Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study
Ruifang Li-Gao; Françoise Carlotti; Renée de Mutsert; Astrid van Hylckama Vlieg; Eelco J.P. de Koning; J. Wouter Jukema; Frits R. Rosendaal; Ko Willems van Dijk; Dennis O. Mook-Kanamori
Diabetes September 2019, Vol.68, 2327-2336. doi:https://doi.org/10.2337/db19-0378
Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program
Zsu-Zsu Chen; Jinxi Liu; Jordan Morningstar; Brandy M. Heckman-Stoddard; Christine G. Lee; Samuel Dagogo-Jack; Jane F. Ferguson; Richard F. Hamman; William C. Knowler; Kieren J. Mather; Leigh Perreault; Jose C. Florez; Thomas J. Wang; Clary Clish; Marinella Temprosa; Robert E. Gerszten; Diabetes Prevention Program Research Group
Diabetes October 2019, Vol.68, 2337-2349. doi:https://doi.org/10.2337/db19-0236
