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April 2019
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Cover Image
Cover Image
On the cover: Color-enhanced transmission electron micrograph of a human pancreatic acinar cell. The cell apex is crowded with spherical zymogen granules (red) of uniform size. Cisternae of the endoplasmic reticulum that follow a meandering course among the secretory granules are more variable in width and less highly ordered than those at the cell base. Credit: Don W. Fawcett/Science Source. For further information, please visit sciencesource.com.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes March 2019, Vol.68, 679-680. doi:https://doi.org/10.2337/db19-ti04
Publications Policy Update
Diabetes Takes New Steps to Increase Transparency and Reproducibility
Martin G. Myers, Jr.; on behalf of the Diabetes Editorial Team
Diabetes February 2019, Vol.68, 681-682. doi:https://doi.org/10.2337/dbi19-0008
Metabolism
Determining the Effects of Combined Liraglutide and Phentermine on Metabolic Parameters, Blood Pressure, and Heart Rate in Lean and Obese Male Mice
Stephanie E. Simonds; Jack T. Pryor; Frank H. Koegler; Alberte S. Buch-Rasmussen; Lauren E. Kelly; Kevin L. Grove; Michael A. Cowley
Diabetes January 2019, Vol.68, 683-695. doi:https://doi.org/10.2337/db18-1149
Insulin Therapy for Gestational Diabetes Mellitus Does Not Fully Protect Offspring From Diet-Induced Metabolic Disorders
Hong Zhu; Bin Chen; Yi Cheng; Yin Zhou; Yi-Shang Yan; Qiong Luo; Ying Jiang; Jian-Zhong Sheng; Guo-Lian Ding; He-Feng Huang
Diabetes January 2019, Vol.68, 696-708. doi:https://doi.org/10.2337/db18-1151
Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate
Yurika Katsu-Jiménez; Carmela Vázquez-Calvo; Camilla Maffezzini; Maria Halldin; Xiaoxiao Peng; Christoph Freyer; Anna Wredenberg; Alfredo Giménez-Cassina; Anna Wedell; Elias S.J. Arnér
Diabetes February 2019, Vol.68, 709-723. doi:https://doi.org/10.2337/db18-0557
Obesity Studies
Islet Studies
Endoplasmic Reticulum–Associated Degradation (ERAD) Has a Critical Role in Supporting Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells
Yabing Hu; Yuanyuan Gao; Manman Zhang; Ke-Yu Deng; Rajni Singh; Qiongge Tian; Yi Gong; Zhixiong Pan; Qingqing Liu; Yves R. Boisclair; Qiaoming Long
Diabetes January 2019, Vol.68, 733-746. doi:https://doi.org/10.2337/db18-0624
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling
Seyed Mojtaba Ghiasi; Tina Dahlby; Caroline Hede Andersen; Leena Haataja; Sólrun Petersen; Muhmmad Omar-Hmeadi; Mingyu Yang; Celina Pihl; Sophie Emilie Bresson; Muhammad Saad Khilji; Kristian Klindt; Oana Cheta; Marcelo J. Perone; Björn Tyrberg; Clara Prats; Sebastian Barg; Anders Tengholm; Peter Arvan; Thomas Mandrup-Poulsen; Michal Tomasz Marzec
Diabetes January 2019, Vol.68, 747-760. doi:https://doi.org/10.2337/db18-0671
Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate
Lukas Huijbregts; Maja Borup Kjær Petersen; Claire Berthault; Mattias Hansson; Virginie Aiello; Latif Rachdi; Anne Grapin-Botton; Christian Honore; Raphael Scharfmann
Diabetes January 2019, Vol.68, 761-773. doi:https://doi.org/10.2337/db18-0224
β-Cell–Derived Angiopoietin-1 Regulates Insulin Secretion and Glucose Homeostasis by Stabilizing the Islet Microenvironment
Ho Seon Park; Hak Zoo Kim; Jong Suk Park; Junyeop Lee; Seung-Pyo Lee; Hail Kim; Chul Woo Ahn; Yoshikazu Nakaoka; Gou Young Koh; Shinae Kang
Diabetes February 2019, Vol.68, 774-786. doi:https://doi.org/10.2337/db18-0864
Immunology and Transplantation
Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes
Menno van Lummel; David T.P. Buis; Cherish Ringeling; Arnoud H. de Ru; Jos Pool; George K. Papadopoulos; Peter A. van Veelen; Helena Reijonen; Jan W. Drijfhout; Bart O. Roep
Diabetes January 2019, Vol.68, 787-795. doi:https://doi.org/10.2337/db18-0501
Complications
Structural and Functional Abnormalities of the Primary Somatosensory Cortex in Diabetic Peripheral Neuropathy: A Multimodal MRI Study
Dinesh Selvarajah; Iain D. Wilkinson; Fang Fang; Adithya Sankar; Jennifer Davies; Elaine Boland; Joseph Harding; Ganesh Rao; Rajiv Gandhi; Irene Tracey; Solomon Tesfaye
Diabetes January 2019, Vol.68, 796-806. doi:https://doi.org/10.2337/db18-0509
Proximal Tubular Cell–Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis
Claudia Kruger; Trang-Tiffany Nguyen; Chelsea Breaux; Alana Guillory; Margaret Mangelli; Kevin T. Fridianto; Jean-Paul Kovalik; David H. Burk; Robert C. Noland; Randall Mynatt; Krisztian Stadler
Diabetes February 2019, Vol.68, 819-831. doi:https://doi.org/10.2337/db18-0090
Neurovascular Response to Pressure in Patients With Diabetic Foot Ulcer
Julien Vouillarmet; Audrey Josset-Lamaugarny; Paul Michon; Jean Louis Saumet; Audrey Koitka-Weber; Samir Henni; Berengere Fromy; Dominique Sigaudo-Roussel
Diabetes January 2019, Vol.68, 832-836. doi:https://doi.org/10.2337/db18-0694
Pharmacology and Therapeutics
Potential of Allogeneic Adipose-Derived Stem Cell–Hydrogel Complex for Treating Diabetic Foot Ulcers
Diabetes January 2019, Vol.68, 837-846. doi:https://doi.org/10.2337/db18-0699
Genetics / Genomes / Proteomics / Metabolomics
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
Markus Hippich; Andreas Beyerlein; William A. Hagopian; Jeffrey P. Krischer; Kendra Vehik; Jan Knoop; Christiane Winker; Jorma Toppari; Åke Lernmark; Marian J. Rewers; Andrea K. Steck; Jin-Xiong She; Beena Akolkar; Catherine C. Robertson; Suna Onengut-Gumuscu; Stephen S. Rich; Ezio Bonifacio; Anette-G. Ziegler; Teddy Study Group
Diabetes January 2019, Vol.68, 847-857. doi:https://doi.org/10.2337/db18-0882
Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes
Anna Syreeni; Niina Sandholm; Jingjing Cao; Iiro Toppila; David M. Maahs; Marian J. Rewers; Janet K. Snell-Bergeon; Tina Costacou; Trevor J. Orchard; M. Luiza Caramori; Michael Mauer; Barbara E.K. Klein; Ronald Klein; Erkka Valo; Maija Parkkonen; Carol Forsblom; Valma Harjutsalo; Andrew D. Paterson; for the DCCT/EDIC Research Group; Per-Henrik Groop; on behalf of the FinnDiane Study Group
Diabetes January 2019, Vol.68, 858-867. doi:https://doi.org/10.2337/db18-0573
