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June 2019
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Cover Image
Cover Image
On the cover: Three-dimensional confocal microscopic image of pancreatic tissue from a human donor. Islets are stained with a pan-endocrine antibody marker (HPi1, yellow), and blood vessels are stained with an endothelial cell marker (CD31, red). Image courtesy of Michael P. Dybala and Manami Hara, Department of Medicine, The University of Chicago, Chicago, IL. Their article, “Heterogeneity of the Human Pancreatic Islet,” appears in this issue of Diabetes (p. 1230).
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process. Click here for more information. - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes May 2019, Vol.68, 1097-1098. doi:https://doi.org/10.2337/db19-ti06
Perspectives in Diabetes
The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
Diabetes May 2019, Vol.68, 1099-1108. doi:https://doi.org/10.2337/dbi18-0052
Sodium–Glucose Cotransporter 2 Inhibitors: A Case Study in Translational Research
Diabetes May 2019, Vol.68, 1109-1120. doi:https://doi.org/10.2337/dbi18-0006
Methodology Review
Metabolism
Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization
Xiaofang Chen; Shu Zhuo; Tengfei Zhu; Pengle Yao; Mengmei Yang; Hong Mei; Na Li; Fengguang Ma; Ji Ming Wang; Shiting Chen; Richard D. Ye; Yu Li; Yingying Le
Diabetes March 2019, Vol.68, 1130-1142. doi:https://doi.org/10.2337/db18-0469
Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog
Guillaume Kraft; Anthony Vrba; Melanie Scott; Eric Allen; Dale S. Edgerton; Phil E. Williams; Scott B. Vafai; Bobak R. Azamian; Alan D. Cherrington
Diabetes April 2019, Vol.68, 1143-1155. doi:https://doi.org/10.2337/db18-1209
Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes
Diabetes April 2019, Vol.68, 1156-1167. doi:https://doi.org/10.2337/db18-1236
Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls
Jessica Nouws; Mark Fitch; Mariana Mata; Nicola Santoro; Brittany Galuppo; Romy Kursawe; Deepak Narayan; Alla Vash-Margita; Bridget Pierpont; Gerald I. Shulman; Marc Hellerstein; Sonia Caprio
Diabetes April 2019, Vol.68, 1168-1177. doi:https://doi.org/10.2337/db18-1162
Obesity Studies
A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling–Stimulated Thermogenesis
Diabetes March 2019, Vol.68, 1178-1196. doi:https://doi.org/10.2337/db18-1210
Deficiency of ZnT8 Promotes Adiposity and Metabolic Dysfunction by Increasing Peripheral Serotonin Production
Zhuo Mao; Hui Lin; Wen Su; Jinghui Li; Minsi Zhou; Zhuoran Li; Beibei Zhou; Qing Yang; Mingyan Zhou; Ke Pan; Jinhan He; Weizhen Zhang
Diabetes April 2019, Vol.68, 1197-1209. doi:https://doi.org/10.2337/db18-1321
Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions
Kenji Saito; Kevin C. Davis; Donald A. Morgan; Brandon A. Toth; Jingwei Jiang; Uday Singh; Eric D. Berglund; Justin L. Grobe; Kamal Rahmouni; Huxing Cui
Diabetes March 2019, Vol.68, 1210-1220. doi:https://doi.org/10.2337/db18-1167
Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities
Daniel B. Harmon; W. Kyle Mandler; Ian J. Sipula; Nikolaos Dedousis; Sara E. Lewis; Jeremy T. Eckels; Jianhai Du; Yekai Wang; Brydie R. Huckestein; Patrick J. Pagano; Eugenia Cifuentes-Pagano; Gregg E. Homanics; Thomas J. Van’t Erve; Maja Stefanovic-Racic; Michael J. Jurczak; Robert M. O’Doherty; Eric E. Kelley
Diabetes April 2019, Vol.68, 1221-1229. doi:https://doi.org/10.2337/db18-1198
Islet Studies
Immunology and Transplantation
Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression
Tania Habib; S. Alice Long; Peter L. Samuels; Archana Brahmandam; Megan Tatum; Andrew Funk; Anne M. Hocking; Karen Cerosaletti; Michael T. Mason; Elizabeth Whalen; David J. Rawlings; Carla Greenbaum; Jane H. Buckner; the Type 1 Diabetes TrialNet Study Group
Diabetes March 2019, Vol.68, 1240-1250. doi:https://doi.org/10.2337/db18-1081
T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities
Florian Wiede; Thomas C. Brodnicki; Pei Kee Goh; Yew A. Leong; Gareth W. Jones; Di Yu; Alan G. Baxter; Simon A. Jones; Thomas W.H. Kay; Tony Tiganis
Diabetes April 2019, Vol.68, 1251-1266. doi:https://doi.org/10.2337/db18-1362
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
Michael J. Haller; S. Alice Long; J. Lori Blanchfield; Desmond A. Schatz; Jay S. Skyler; Jeffrey P. Krischer; Brian N. Bundy; Susan M. Geyer; Megan V. Warnock; Jessica L. Miller; Mark A. Atkinson; Dorothy J. Becker; David A. Baidal; Linda A. DiMeglio; Stephen E. Gitelman; Robin Goland; Peter A. Gottlieb; Kevan C. Herold; Jennifer B. Marks; Antoinette Moran; Henry Rodriguez; William E. Russell; Darrell M. Wilson; Carla J. Greenbaum; Type 1 Diabetes TrialNet ATG-GCSF Study Group
Diabetes April 2019, Vol.68, 1267-1276. doi:https://doi.org/10.2337/db19-0057
Complications
Cardiac Autonomic Function Is Associated With Myocardial Flow Reserve in Type 1 Diabetes
Emilie H. Zobel; Philip Hasbak; Signe A. Winther; Christian Stevns Hansen; Jesper Fleischer; Bernt J. von Scholten; Lene Holmvang; Andreas Kjaer; Peter Rossing; Tine W. Hansen
Diabetes March 2019, Vol.68, 1277-1286. doi:https://doi.org/10.2337/db18-1313
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes
Hainan Li; Megan O’Meara; Xiang Zhang; Kezhong Zhang; Berhane Seyoum; Zhengping Yi; Randal J. Kaufman; Terrence J. Monks; Jie-Mei Wang
Diabetes March 2019, Vol.68, 1287-1302. doi:https://doi.org/10.2337/db18-0933
Diabetes-Associated Myelopoiesis Drives Stem Cell Mobilopathy Through an OSM-p66Shc Signaling Pathway
Mattia Albiero; Stefano Ciciliot; Serena Tedesco; Lisa Menegazzo; Marianna D’Anna; Valentina Scattolini; Roberta Cappellari; Gaia Zuccolotto; Antonio Rosato; Andrea Cignarella; Marco Giorgio; Angelo Avogaro; Gian Paolo Fadini
Diabetes April 2019, Vol.68, 1303-1314. doi:https://doi.org/10.2337/db19-0080
Pharmacology and Therapeutics
FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis
Alex M. DePaoli; Mei Zhou; Daniel D. Kaplan; Steven C. Hunt; Ted D. Adams; R. Marc Learned; Hui Tian; Lei Ling
Diabetes March 2019, Vol.68, 1315-1328. doi:https://doi.org/10.2337/db18-1305
Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway
Cecilia Ratner; Zhenyan He; Kaare V. Grunddal; Louise J. Skov; Bolette Hartmann; Fa Zhang; Annette Feuchtinger; Anette Bjerregaard; Christina Christoffersen; Matthias H. Tschöp; Brian Finan; Richard D. DiMarchi; Gina M. Leinninger; Kevin W. Williams; Christoffer Clemmensen; Birgitte Holst
Diabetes April 2019, Vol.68, 1329-1340. doi:https://doi.org/10.2337/db18-1009
Skeletal Muscle–Specific Activation of Gq Signaling Maintains Glucose Homeostasis
Derek B.J. Bone; Jaroslawna Meister; Jonas R. Knudsen; Diptadip Dattaroy; Amanda Cohen; Regina Lee; Huiyan Lu; Daniel Metzger; Thomas E. Jensen; Jürgen Wess
Diabetes April 2019, Vol.68, 1341-1352. doi:https://doi.org/10.2337/db18-0796
Genetics / Genomes / Proteomics / Metabolomics
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men
Diabetes March 2019, Vol.68, 1353-1358. doi:https://doi.org/10.2337/db18-1076
