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Volume 68, Issue 8
August 2019
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    On the cover: The image depicts cilia (green) in neurons (red) of a mouse brain. Image courtesy of Kamal Rahmouni, Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA. His article, “The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors,” appears in this issue of Diabetes (p. 1591).

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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Topics: blood glucose , diabetes mellitus, type 1 , diabetic neuropathies , genome-wide association study , high-throughput nucleotide sequencing
Diabetes July 2019, Vol.68, 1539-1540. doi:https://doi.org/10.2337/db19-ti08

Perspectives in Diabetes

Islets for Research: Nothing Is Perfect, but We Can Do Better
Rita Nano; Julie A. Kerr-Conte; Domenico Bosco; Marie Karlsson; Vanessa Lavallard; Raffaella Melzi; Valery Gmyr; Alessia Mercalli; Thierry Berney; François Pattou; Olle Korsgren; Lorenzo Piemonti
View articletitled, Islets for Research: Nothing Is Perfect, but We Can Do Better
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Topics: donors , endocrine pancreas , heterogeneity , islets of langerhans transplantation , hemoglobin a, glycosylated
Diabetes July 2019, Vol.68, 1541-1543. doi:https://doi.org/10.2337/db19-0367
The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity
Emil R. Unanue; Xiaoxiao Wan
View articletitled, The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity
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Topics: epitopes , insulin , peptides , t-lymphocytes , macrophages
Diabetes July 2019, Vol.68, 1544-1551. doi:https://doi.org/10.2337/dbi18-0048

Metabolism

TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle
Jin-Ho Koh; Matthew L. Johnson; Surendra Dasari; Nathan K. LeBrasseur; Ivan Vuckovic; Gregory C. Henderson; Shawna A. Cooper; Shankarappa Manjunatha; Gregory N. Ruegsegger; Gerald I. Shulman; Ian R. Lanza; K. Sreekumaran Nair
View articletitled, TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle
Supplementary data
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Topics: diet , dna, mitochondrial , insulin resistance , mice , mitochondria
Diabetes May 2019, Vol.68, 1552-1564. doi:https://doi.org/10.2337/db19-0088
Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)
Justin M. Gregory; T. Jordan Smith; James C. Slaughter; Holly R. Mason; Curtis C. Hughey; Marta S. Smith; Balamurugan Kandasamy; Siri Atma W. Greeley; Louis H. Philipson; Rochelle N. Naylor; Lisa R. Letourneau; Naji N. Abumrad; Alan D. Cherrington; Daniel J. Moore
View articletitled, Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)
Supplementary data
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Topics: diabetes mellitus, type 1 , glucose , hyperglycemia , hyperinsulinism , insulin
Diabetes May 2019, Vol.68, 1565-1576. doi:https://doi.org/10.2337/db19-0324
Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner
Cheng Dai; Xinyu Wang; Yanjun Wu; Yi Xu; Shu Zhuo; Meiyan Qi; Weiwei Ji; Lixing Zhan
View articletitled, Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner
Supplementary data
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Topics: insulin , insulin resistance , insulin sensitivity , mice , proto-oncogene proteins c-akt
Diabetes May 2019, Vol.68, 1577-1590. doi:https://doi.org/10.2337/db18-0695

Obesity Studies

The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors
Deng-Fu Guo; Zhihong Lin; Yuanming Wu; Charles Searby; Daniel R. Thedens; George B. Richerson; Yuriy M. Usachev; Justin L. Grobe; Val C. Sheffield; Kamal Rahmouni
View articletitled, The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors
Supplementary data
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Topics: agouti-related protein , genes , mice , neurons , obesity
Diabetes May 2019, Vol.68, 1591-1603. doi:https://doi.org/10.2337/db18-1088
Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal β-Cell Development in C57BL/6 Mice
Liping Qiao; Jean-Sebastien Wattez; Lauren Lim; Paul J. Rozance; William W. Hay, Jr.; Jianhua Shao
View articletitled, Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal β-Cell Development in C57BL/6 Mice
Supplementary data
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Topics: blood glucose , fetus , heart failure , insulin , mice
Diabetes May 2019, Vol.68, 1604-1613. doi:https://doi.org/10.2337/db18-1308
Kinin B1 Receptor Acts in Adipose Tissue to Control Fat Distribution in a Cell-Nonautonomous Manner
Vicencia M. Sales; Thais Gonçalves-Zillo; Angela Castoldi; Marina Burgos; Jessica Branquinho; Carolina Batista; Valeria Oliveira; Elton Silva; Charlles H.M. Castro; Niels Câmara; Marcelo A. Mori; João Bosco Pesquero
View articletitled, Kinin B<sub>1</sub> Receptor Acts in Adipose Tissue to Control Fat Distribution in a Cell-Nonautonomous Manner
Supplementary data
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Topics: adipose tissue , insulin , lipids , mice , transplantation
Diabetes June 2019, Vol.68, 1614-1623. doi:https://doi.org/10.2337/db18-1150

Complications

Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger
Yen-Lin Chen; Wenjuan Xu; Robert H. Rosa, Jr.; Lih Kuo; Travis W. Hein
View articletitled, Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger
Supplementary data
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Topics: constriction procedure , endothelin-1 , hyperglycemia , retinal venule , suidae
Diabetes May 2019, Vol.68, 1624-1634. doi:https://doi.org/10.2337/db19-0069
Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice
Yufeng Yao; Yong Li; Qixue Song; Changqin Hu; Wen Xie; Chengqi Xu; Qiuyun Chen; Qing K. Wang
View articletitled, Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice
Supplementary data
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Topics: angiogenesis , diabetes mellitus, type 2 , hyperglycemia , mice , proto-oncogene proteins c-akt
Diabetes May 2019, Vol.68, 1635-1648. doi:https://doi.org/10.2337/db18-1178
A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies
Yaling Tang; Petra A. Lenzini; Rodica Pop-Busui; Pradipta R. Ray; Hannah Campbell; Bruce A. Perkins; Brian Callaghan; Michael J. Wagner; Alison A. Motsinger-Reif; John B. Buse; Theodore J. Price; Josyf C. Mychaleckyj; Sharon Cresci; Hetal Shah; Alessandro Doria
View articletitled, A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies
Supplementary data
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Topics: bari 2d trial , genome-wide association study , diabetes mellitus, type 2 , genetics , chromosomes
Diabetes May 2019, Vol.68, 1649-1662. doi:https://doi.org/10.2337/db19-0109
Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children
Ninon Foussard; Audrey Cougnard-Grégoire; Kalina Rajaobelina; Cécile Delcourt; Catherine Helmer; Thierry Lamireau; Concepcion Gonzalez; Virginie Grouthier; Magalie Haissaguerre; Laurence Blanco; Laure Alexandre; Kamel Mohammedi; Vincent Rigalleau
View articletitled, Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children
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Topics: macrosomia , newborn , pregnancy , diabetes, pregestational , birth weight
Diabetes May 2019, Vol.68, 1663-1669. doi:https://doi.org/10.2337/db18-0906

Pharmacology and Therapeutics

Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults
RISE Consortium Investigators
View articletitled, Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults
Supplementary data
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Topics: adolescent , c-peptide , hyperglycemic agents , insulin glargine , metformin
Diabetes June 2019, Vol.68, 1670-1680. doi:https://doi.org/10.2337/db19-0299

Genetics / Genomes / Proteomics / Metabolomics

Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study
N. Maneka G. De Silva; Maria Carolina Borges; Aroon D. Hingorani; Jorgen Engmann; Tina Shah; Xiaoshuai Zhang; Jian'an Luan; Claudia Langenberg; Andrew Wong; Diana Kuh; John C. Chambers; Weihua Zhang; Marjo-Ritta Jarvelin; Sylvain Sebert; Juha Auvinen; UCLEB consortium; Tom R. Gaunt; Deborah A. Lawlor
View articletitled, Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study
Supplementary data
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Topics: diabetes mellitus, type 2 , liver function , insulin , genetics , fasting
Diabetes May 2019, Vol.68, 1681-1691. doi:https://doi.org/10.2337/db18-1048
Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes
Lue Ping Zhao; George K. Papadopoulos; William W. Kwok; Bryan Xu; Matthew Kong; Antonis K. Moustakas; George P. Bondinas; Annelie Carlsson; Helena Elding-Larsson; Johnny Ludvigsson; Claude Marcus; Martina Persson; Ulf Samuelsson; Ruihan Wang; Chul-Woo Pyo; Wyatt C. Nelson; Daniel E. Geraghty; Åke Lernmark
View articletitled, Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes
Supplementary data
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Topics: alleles , amino acids , autoantibodies , diabetes mellitus, type 1 , disease association
Diabetes May 2019, Vol.68, 1692-1704. doi:https://doi.org/10.2337/db19-0273

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Topics: podcasts , standard of care
Diabetes July 2019, Vol.68, 1705. doi:https://doi.org/10.2337/db19-ie08
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective
Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
  • Online ISSN 1939-327X
  • Print ISSN 0012-1797

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