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January 2020
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Cover Image
Cover Image
On the cover: Three-dimensional confocal microscopic image of epididymal adipose tissue from mouse. Lipids in adipocytes are detected by symmetric CH2 bond signal, using coherent anti-stokes Raman scattering microscopy, and a macrophage is stained with CD11b and CD11c (red and green, respectively; merged signal is presented) and nucleus is counterstained with DAPI (blue). Image courtesy of Yong Geun Jeon and Yul Ji, Department of Biological Sciences, Seoul National University, Seoul, Korea. Their article, “RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes,” appears in this issue of Diabetes (p. 20).
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process. Click here for more information. - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes December 2019, Vol.69, 1-2. doi:https://doi.org/10.2337/db20-ti01
Perspectives in Diabetes
Brain and Body: A Review of Central Nervous System Contributions to Movement Impairments in Diabetes
Diabetes December 2019, Vol.69, 3-11. doi:https://doi.org/10.2337/db19-0321
Metabolism
Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies
Maarit K. Koskinen; Mari-Liis Mikk; Antti-Pekka Laine; Johanna Lempainen; Eliisa Löyttyniemi; Paula Vähäsalo; Anne Hekkala; Taina Härkönen; Minna Kiviniemi; Olli Simell; Mikael Knip; Riitta Veijola; Jorma Ilonen; Jorma Toppari
Diabetes October 2019, Vol.69, 12-19. doi:https://doi.org/10.2337/db19-0329
RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes
Yong Geun Jeon; Jae Ho Lee; Yul Ji; Jee Hyung Sohn; Dabin Lee; Dong Wook Kim; Seul Gi Yoon; Kyung Cheul Shin; Jeu Park; Je Kyung Seong; Je-Yoel Cho; Sung Sik Choe; Jae Bum Kim
Diabetes October 2019, Vol.69, 20-34. doi:https://doi.org/10.2337/db19-0508
Obesity Studies
Fat-Specific Knockout of Mecp2 Upregulates Slpi to Reduce Obesity by Enhancing Browning
Chengyu Liu; Jiao Wang; Yujuan Wei; Wenquan Zhang; Mengyuan Geng; Yangmian Yuan; Yuchen Chen; Yu Sun; Hong Chen; Yu Zhang; Mingrui Xiong; Yangkai Li; Ling Zheng; Kun Huang
Diabetes October 2019, Vol.69, 35-47. doi:https://doi.org/10.2337/db19-0502
Islet Studies
Atorvastatin Targets the Islet Mevalonate Pathway to Dysregulate mTOR Signaling and Reduce β-Cell Functional Mass
Linyan Shen; Yanyun Gu; Yixuan Qiu; Tingting Cheng; Aifang Nie; Canqi Cui; Chenyang Fu; Tingting Li; Xuelin Li; Lihong Fu; Yanqiu Wang; Qicheng Ni; Qidi Wang; Weiqing Wang; Bo Feng
Diabetes October 2019, Vol.69, 48-59. doi:https://doi.org/10.2337/db19-0178
Pathophysiology
Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues
Irina Kusmartseva; Maria Beery; Helmut Hiller; Myriam Padilla; Stephen Selman; Amanda Posgai; Harry S. Nick; Martha Campbell-Thompson; Desmond A. Schatz; Michael J. Haller; Clive H. Wasserfall; Mark A. Atkinson
Diabetes October 2019, Vol.69, 60-66. doi:https://doi.org/10.2337/db19-0554
Complications
RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin
Yuxia Zhou; Zhiyu Liu; Shengmei Zhang; Ruijuan Zhuang; Huiying Liu; Xiaoqing Liu; Xi Qiu; Ming Zhang; Yanpan Zheng; Liangcheng Li; Wanjin Hong; Tuanlao Wang
Diabetes October 2019, Vol.69, 67-82. doi:https://doi.org/10.2337/db19-0086
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility
Sih Min Tan; Mark Ziemann; Vicki Thallas-Bonke; Matthew Snelson; Vinod Kumar; Adrienne Laskowski; Tuong-Vi Nguyen; Kevin Huynh; Michele V. Clarke; Renata Libianto; Scott T. Baker; Alison Skene; David A. Power; Richard J. MacIsaac; Darren C. Henstridge; Rick A. Wetsel; Assam El-Osta; Peter J. Meikle; Scott G. Wilson; Josephine M. Forbes; Mark E. Cooper; Elif I. Ekinci; Trent M. Woodruff; Melinda T. Coughlan
Diabetes October 2019, Vol.69, 83-98. doi:https://doi.org/10.2337/db19-0043
CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes
Diabetes November 2019, Vol.69, 99-111. doi:https://doi.org/10.2337/db19-0635
Genetics / Genomes / Proteomics / Metabolomics
Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
Jordi Merino; Kathleen A. Jablonski; Josep M. Mercader; Steven E. Kahn; Ling Chen; Maegan Harden; Linda M. Delahanty; Maria Rosario G. Araneta; Geoffrey A. Walford; Suzanne B.R. Jacobs; Uzoma N. Ibebuogu; Paul W. Franks; William C. Knowler; Jose C. Florez; Diabetes Prevention Program Research Group
Diabetes October 2019, Vol.69, 112-120. doi:https://doi.org/10.2337/db19-0097
High Prevalence of a Monogenic Cause in Han Chinese Diagnosed With Type 1 Diabetes, Partly Driven by Nonsyndromic Recessive WFS1 Mutations
Meihang Li; Sihua Wang; Kuanfeng Xu; Yang Chen; Qi Fu; Yong Gu; Yun Shi; Mei Zhang; Min Sun; Heng Chen; Xiuqun Han; Yangxi Li; Zhoukai Tang; Lejing Cai; Zhiqiang Li; Yongyong Shi; Tao Yang; Constantin Polychronakos
Diabetes October 2019, Vol.69, 121-126. doi:https://doi.org/10.2337/db19-0510
