On the cover: Confocal microscopy of a representative pancreas section from 5-week-old mice lacking HMG-CoA reductase in β-cells with immunofluorescent antibodies for insulin (red), glucagon (green), and DAPI (blue). The β-cell mass was reduced, and the normal architecture of the islets was lost. Image courtesy of Shun Ishibashi, Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan. This image is a version of Fig. 6A in the article by Takei et al., “β-Cell–Specific Deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) Reductase Causes Overt Diabetes due to Reduction of β-Cell Mass and Impaired Insulin Secretion,” which appears in this issue of Diabetes (p. 2352).
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