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On the cover: Section of a transplanted human pancreas obtained from a protocol biopsy of a recipient on tacrolimus, stained for phospho-SMAD1/5 (green) and with cell nuclei counterstained with DAPI (blue). The structure presented on the image is presumed by pathologists to be a large peripheral nerve. Image courtesy of Javier Triñanes, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. His article, “Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress–Activated FOXO1 to Trigger β-Cell Failure,” appears in this issue of Diabetes (p. 193).

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