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March 2020
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Cover Image
Cover Image
On the cover: Confocal immunofluorescence image showing NFATc3 staining (red) in the wall of a mouse skin microvessel. Nuclei are stained with the DNA-binding dye SYTOX Green. Image courtesy of Eliana Garcia-Vaz and Maria F. Gomez, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Lund, Sweden. Their article, “Inhibition of NFAT Signaling Restores Microvascular Endothelial Function in Diabetic Mice,” appears in this issue of Diabetes (p. 424).
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes February 2020, Vol.69, 271-272. doi:https://doi.org/10.2337/db20-ti03
Perspectives in Diabetes
Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell
Diabetes February 2020, Vol.69, 279-290. doi:https://doi.org/10.2337/dbi19-0014
Methodology Review
Understanding Metabolic Memory: A Tale of Two Studies
Diabetes February 2020, Vol.69, 291-299. doi:https://doi.org/10.2337/db19-0514
Metabolism
Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice
Veronika Paluchova; Marina Oseeva; Marie Brezinova; Tomas Cajka; Kristina Bardova; Katerina Adamcova; Petr Zacek; Kristyna Brejchova; Laurence Balas; Hana Chodounska; Eva Kudova; Renate Schreiber; Rudolf Zechner; Thierry Durand; Martin Rossmeisl; Nada A. Abumrad; Jan Kopecky; Ondrej Kuda
Diabetes December 2020, Vol.69, 300-312. doi:https://doi.org/10.2337/db19-0494
A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia
Christine M. Kusminski; Alexandra L. Ghaben; Thomas S. Morley; Ricardo J. Samms; Andrew C. Adams; Yu An; Joshua A. Johnson; Nolwenn Joffin; Toshiharu Onodera; Clair Crewe; William L. Holland; Ruth Gordillo; Philipp E. Scherer
Diabetes December 2020, Vol.69, 313-330. doi:https://doi.org/10.2337/db19-0327
The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and NAFLD/NASH
Shahram Hedjazifar; Roxana Khatib Shahidi; Ann Hammarstedt; Laurianne Bonnet; Christopher Church; Jeremie Boucher; Matthias Blüher; Ulf Smith
Diabetes December 2020, Vol.69, 331-341. doi:https://doi.org/10.2337/db19-0701
Islet Studies
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health
Xin Tong; Chunhua Dai; John T. Walker; Gopika G. Nair; Arion Kennedy; Rotonya M. Carr; Matthias Hebrok; Alvin C. Powers; Roland Stein
Diabetes December 2020, Vol.69, 342-354. doi:https://doi.org/10.2337/db19-0281
PRMT1 Is Required for the Maintenance of Mature β-Cell Identity
Hyunki Kim; Byoung-Ha Yoon; Chang-Myung Oh; Joonyub Lee; Kanghoon Lee; Heein Song; Eunha Kim; Kijong Yi; Mi-Young Kim; Hyeongseok Kim; Yong Kyung Kim; Eun-Hye Seo; Haejeong Heo; Hee-Jin Kim; Junguee Lee; Jae Myoung Suh; Seung-Hoi Koo; Je Kyung Seong; Seyun Kim; Young Seok Ju; Minho Shong; Mirang Kim; Hail Kim
Diabetes December 2020, Vol.69, 355-368. doi:https://doi.org/10.2337/db19-0685
HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats
Hasna Maachi; Grace Fergusson; Melanie Ethier; Gabriel N. Brill; Liora S. Katz; Lee B. Honig; Mallikarjuna R. Metukuri; Donald K. Scott; Julien Ghislain; Vincent Poitout
Diabetes December 2020, Vol.69, 369-380. doi:https://doi.org/10.2337/db19-0643
Immunology and Transplantation
A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery
Baoyu Liu; Jennifer D. Hood; Elizabeth M. Kolawole; Derek M. Woodruff; Dario A. Vignali; Maria Bettini; Brian D. Evavold
Diabetes December 2020, Vol.69, 381-391. doi:https://doi.org/10.2337/db19-0399
A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells
Maria Bettini; Marissa A. Scavuzzo; Baoyu Liu; Elizabeth Kolawole; Lin Guo; Brian D. Evavold; Malgorzata Borowiak; Matthew L. Bettini
Diabetes December 2020, Vol.69, 392-400. doi:https://doi.org/10.2337/db19-0821
Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care
Silke Smeets; Geert Stangé; Gunter Leuckx; Lisbeth Roelants; Wilfried Cools; Diedert Luc De Paep; Zhidong Ling; Nico De Leu; Peter in’t Veld
Diabetes December 2020, Vol.69, 401-412. doi:https://doi.org/10.2337/db19-0529
Pathophysiology
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis
Melanie R. Shapiro; Clive H. Wasserfall; Sean M. McGrail; Amanda L. Posgai; Rhonda Bacher; Andrew Muir; Michael J. Haller; Desmond A. Schatz; Johnna D. Wesley; Matthias von Herrath; William A. Hagopian; Cate Speake; Mark A. Atkinson; Todd M. Brusko
Diabetes December 2020, Vol.69, 413-423. doi:https://doi.org/10.2337/db19-0942
Complications
Inhibition of NFAT Signaling Restores Microvascular Endothelial Function in Diabetic Mice
Eliana Garcia-Vaz; Alison D. McNeilly; Lisa M. Berglund; Abrar Ahmad; Jennifer R. Gallagher; Anna-Maria Dutius Andersson; Rory J. McCrimmon; Anna V. Zetterqvist; Maria F. Gomez; Faisel Khan
Diabetes December 2020, Vol.69, 424-435. doi:https://doi.org/10.2337/db18-0870
Understanding Diabetic Neuropathy—From Subclinical Nerve Lesions to Severe Nerve Fiber Deficits: A Cross-Sectional Study in Patients With Type 2 Diabetes and Healthy Control Subjects
Jan B. Groener; Johann M.E. Jende; Felix T. Kurz; Zoltan Kender; Rolf-Detlef Treede; Sigrid Schuh-Hofer; Peter P. Nawroth; Martin Bendszus; Stefan Kopf
Diabetes December 2020, Vol.69, 436-447. doi:https://doi.org/10.2337/db19-0197
Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice
Stéphanie A. Eid; Mohamed El Massry; Mehdi Hichor; Mary Haddad; Julien Grenier; Batoul Dia; Rasha Barakat; Suzan Boutary; Johan Chanal; Selim Aractingi; Philippe Wiesel; Cédric Szyndralewiez; Sami T. Azar; Christian Boitard; Ghazi Zaatari; Assaad A. Eid; Charbel Massaad
Diabetes December 2020, Vol.69, 448-464. doi:https://doi.org/10.2337/db19-0517
Genetics / Genomes / Proteomics / Metabolomics
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
Qian Li; Hemang Parikh; Martha D. Butterworth; Åke Lernmark; William Hagopian; Marian Rewers; Jin-Xiong She; Jorma Toppari; Anette-G. Ziegler; Beena Akolkar; Oliver Fiehn; Sili Fan; Jeffrey P. Krischer; TEDDY Study Group
Diabetes February 2020, Vol.69, 465-476. doi:https://doi.org/10.2337/db19-0756
De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction
Elisa De Franco; Richard Caswell; Matthew B. Johnson; Matthew N. Wakeling; Amnon Zung; Vũ Chí Dũng; Cấn Thị Bích Ngọc; Rajiv Goonetilleke; Maritza Vivanco Jury; Mohammed El-Khateeb; Sian Ellard; Sarah E. Flanagan; David Ron; Andrew T. Hattersley
Diabetes December 2020, Vol.69, 477-483. doi:https://doi.org/10.2337/db19-1029
Interplay of Placental DNA Methylation and Maternal Insulin Sensitivity in Pregnancy
Marie-France Hivert; Andres Cardenas; Catherine Allard; Myriam Doyon; Camille E. Powe; Patrick M. Catalano; Patrice Perron; Luigi Bouchard
Diabetes December 2020, Vol.69, 484-492. doi:https://doi.org/10.2337/db19-0798
Statements of Retraction
Statement of Retraction. Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, and Marc Y. Donath. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722. DOI: 10.2337/db05-1430. PMID: 17003335
Diabetes January 2020, Vol.69, 493. doi:https://doi.org/10.2337/db20-rt03a
Statement of Retraction. Kathrin Maedler, Desiree M. Schumann, Fabienne Schulthess, José Oberholzer, Domenico Bosco, Thierry Berney, and Marc Y. Donath. Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1. Diabetes 2006;55:2455–2462. DOI: 10.2337/db05-1586. PMID: 16936193
Diabetes January 2020, Vol.69, 494. doi:https://doi.org/10.2337/db20-rt03b
Issues and Events
e-Letters: Comments and Responses
Response to Comment on Foussard et al. Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children. Diabetes 2019;68:1663–1669
Ninon Foussard; Audrey Cougnard-Grégoire; Kalina Rajaobelina; Cécile Delcourt; Catherine Helmer; Thierry Lamireau; Concepcion Gonzalez; Virginie Grouthier; Magalie Haissaguerre; Laurence Blanco; Laure Alexandre; Kamel Mohammedi; Vincent Rigalleau
Diabetes February 2020, Vol.69, e5-e6. doi:https://doi.org/10.2337/dbi19-0029
