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1 April 2020
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Cover Image
Cover Image
On the cover: Glucagon-like peptide 1 (GLP-1, 7-36) molecule. GLP-1 analogues are used in the treatment of diabetes and include exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, and semaglutide. Stylized combination of a semi-transparent surface model with a cartoon representation. Gradient coloring (N-terminus blue, C-terminus pink). Credit: MOLEKUUL/Science Source. For further information, please visit sciencesource.com.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes March 2020, Vol.69, 497-498. doi:https://doi.org/10.2337/db20-ti04
Perspectives in Diabetes
Stress-Induced Translational Regulation Mediated by RNA Binding Proteins: Key Links to β-Cell Failure in Diabetes
Diabetes March 2020, Vol.69, 499-507. doi:https://doi.org/10.2337/dbi18-0068
Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease
Diabetes March 2020, Vol.69, 508-516. doi:https://doi.org/10.2337/dbi19-0007
Exercise Combats Hepatic Steatosis: Potential Mechanisms and Clinical Implications
Diabetes March 2020, Vol.69, 517-524. doi:https://doi.org/10.2337/dbi18-0043
Epigenetic Regulation of Hepatic Lipogenesis: Role in Hepatosteatosis and Diabetes
Diabetes March 2020, Vol.69, 525-531. doi:https://doi.org/10.2337/dbi18-0032
Diabetes Symposium
Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes
Diabetes June 2019, Vol.69, 532-541. doi:https://doi.org/10.2337/dbi19-0004
The Local Paracrine Actions of the Pancreatic α-Cell
Diabetes December 2019, Vol.69, 550-558. doi:https://doi.org/10.2337/dbi19-0002
Methodology Review
Energy Regulation Mechanism and Therapeutic Potential of Asprosin
Diabetes March 2020, Vol.69, 559-566. doi:https://doi.org/10.2337/dbi19-0009
Metabolism
Bariatric Surgery Rapidly Decreases Cardiac Dietary Fatty Acid Partitioning and Hepatic Insulin Resistance Through Increased Intra-abdominal Adipose Tissue Storage and Reduced Spillover in Type 2 Diabetes
Anne-Marie Carreau; Christophe Noll; Denis P. Blondin; Frédérique Frisch; Mélanie Nadeau; Mélissa Pelletier; Serge Phoenix; Stephen C. Cunnane; Brigitte Guérin; Eric E. Turcotte; Stéfane Lebel; Laurent Biertho; André Tchernof; André C. Carpentier
Diabetes January 2020, Vol.69, 567-577. doi:https://doi.org/10.2337/db19-0773
A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action
Dorte E. Steenberg; Janne R. Hingst; Jesper B. Birk; Anette Thorup; Jonas M. Kristensen; Kim A. Sjøberg; Bente Kiens; Erik A. Richter; Jørgen F.P. Wojtaszewski
Diabetes January 2020, Vol.69, 578-590. doi:https://doi.org/10.2337/db19-1010
Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase
Jian-Hui Shi; Jun-Yu Lu; Heng-Yu Chen; Chun-Chun Wei; Xiongfei Xu; Hao Li; Qiufang Bai; Fang-Zhen Xia; Sin Man Lam; Hai Zhang; Ya-Nan Shi; Dongmei Cao; Liming Chen; Guanghou Shui; Xia Yang; Yingli Lu; Yu-Xia Chen; Weiping J. Zhang
Diabetes January 2020, Vol.69, 591-602. doi:https://doi.org/10.2337/db19-0388
Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles
Alexander H. Turaihi; Erik H. Serné; Carla F.M. Molthoff; Jasper J. Koning; Jaco Knol; Hans W. Niessen; Marie Jose T.H. Goumans; Erik M. van Poelgeest; John S. Yudkin; Yvo M. Smulders; Connie R. Jimenez; Victor W.M. van Hinsbergh; Etto C. Eringa
Diabetes January 2020, Vol.69, 603-613. doi:https://doi.org/10.2337/db18-1066
Signal Transduction
L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Mari Lilith Lund; Giovanni Sorrentino; Kristoffer Lihme Egerod; Chantal Kroone; Brynjulf Mortensen; Filip Krag Knop; Frank Reimann; Fiona M. Gribble; Daniel J. Drucker; Eelco J.P. de Koning; Kristina Schoonjans; Fredrik Bäckhed; Thue W. Schwartz; Natalia Petersen
Diabetes February 2020, Vol.69, 614-623. doi:https://doi.org/10.2337/db19-0764
Islet Studies
Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes
Diabetes January 2020, Vol.69, 624-633. doi:https://doi.org/10.2337/db19-0865
Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell–Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice
Taisuke Mochida; Hikaru Ueno; Noriko Tsubooka-Yamazoe; Hideyuki Hiyoshi; Ryo Ito; Hirokazu Matsumoto; Taro Toyoda
Diabetes January 2020, Vol.69, 634-646. doi:https://doi.org/10.2337/db19-0728
Lamin C Counteracts Glucose Intolerance in Aging, Obesity, and Diabetes Through β-Cell Adaptation
Marion de Toledo; Isabel C. Lopez-Mejia; Patricia Cavelier; Marine Pratlong; Célia Barrachina; Xavier Gromada; Jean-Sébastien Annicotte; Jamal Tazi; Carine Chavey
Diabetes January 2020, Vol.69, 647-660. doi:https://doi.org/10.2337/db19-0377
Immunology and Transplantation
Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring
Jan Knoop; Anne Eugster; Anita Gavrisan; Ramona Lickert; Eva-Maria Sedlmeier; Sevina Dietz; Annett Lindner; Katharina Warncke; Nadine Hummel; Anette-Gabriele Ziegler; Ezio Bonifacio
Diabetes January 2020, Vol.69, 661-669. doi:https://doi.org/10.2337/db19-0751
β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1
Sofia Thomaidou; Maria J.L. Kracht; Arno van der Slik; Sandra Laban; Eelco J. de Koning; Francoise Carlotti; Rob C. Hoeben; Bart O. Roep; Arnaud Zaldumbide
Diabetes January 2020, Vol.69, 670-680. doi:https://doi.org/10.2337/db19-0984
Pathophysiology
Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors
Mariam Alatrach; Nitchakarn Laichuthai; Robert Martinez; Christina Agyin; Ali Muhammed Ali; Hussein Al-Jobori; Olga Lavynenko; John Adams; Curtis Triplitt; Ralph DeFronzo; Eugenio Cersosimo; Muhammad Abdul-Ghani
Diabetes January 2020, Vol.69, 681-688. doi:https://doi.org/10.2337/db19-0770
Complications
Retinopathy in a Diet-Induced Type 2 Diabetic Rat Model and Role of Epigenetic Modifications
Diabetes January 2020, Vol.69, 689-698. doi:https://doi.org/10.2337/db19-1009
Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats
Le Qi; Ali Reza Ahmadi; Jinny Huang; Melissa Chen; Baohan Pan; Hiroshi Kuwabara; Kenichi Iwasaki; Wei Wang; Russell Wesson; Andrew M. Cameron; Shusen Cui; James Burdick; Zhaoli Sun
Diabetes January 2020, Vol.69, 699-712. doi:https://doi.org/10.2337/db19-0907
Troponin T Parallels Structural Nerve Damage in Type 2 Diabetes: A Cross-sectional Study Using Magnetic Resonance Neurography
Johann M.E. Jende; Jan B. Groener; Zoltan Kender; Artur Hahn; Jakob Morgenstern; Sabine Heiland; Peter P. Nawroth; Martin Bendszus; Stefan Kopf; Felix T. Kurz
Diabetes January 2020, Vol.69, 713-723. doi:https://doi.org/10.2337/db19-1094
n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy
Ayana Suzumura; Hiroki Kaneko; Yasuhito Funahashi; Kei Takayama; Masatoshi Nagaya; Seina Ito; Toshiaki Okuno; Toshiaki Hirakata; Norie Nonobe; Keiko Kataoka; Hideyuki Shimizu; Rina Namba; Kazuhisa Yamada; Fuxiang Ye; Yoko Ozawa; Takehiko Yokomizo; Hiroko Terasaki
Diabetes February 2020, Vol.69, 724-735. doi:https://doi.org/10.2337/db19-0550
Pharmacology and Therapeutics
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis
Wenyi Wu; Guohong Zhou; Haote Han; Xionggao Huang; Heng Jiang; Shizuo Mukai; Andrius Kazlauskas; Jing Cui; Joanne Aiko Matsubara; Bart Vanhaesebroeck; Xiaobo Xia; Jiantao Wang; Hetian Lei
Diabetes January 2020, Vol.69, 736-748. doi:https://doi.org/10.2337/db19-0713
Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice
Lei Wang; Michael Chopp; Alexandra Szalad; XueRong Lu; Yi Zhang; Xinli Wang; Pasquale Cepparulo; Mei Lu; Chao Li; Zheng Gang Zhang
Diabetes January 2020, Vol.69, 749-759. doi:https://doi.org/10.2337/db19-0432
Genetics / Genomes / Proteomics / Metabolomics
Comprehensive Glycomic Analysis Reveals That Human Serum Albumin Glycation Specifically Affects the Pharmacokinetics and Efficacy of Different Anticoagulant Drugs in Diabetes
Hongyan Qiu; Lan Jin; Jian Chen; Min Shi; Feng Shi; Mansen Wang; Daoyuan Li; Xiaohui Xu; Xinhuan Su; Xianlun Yin; Wenhua Li; Xiaoming Zhou; Robert J. Linhardt; Zhe Wang; Lianli Chi; Qunye Zhang
Diabetes January 2020, Vol.69, 760-770. doi:https://doi.org/10.2337/db19-0738
PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid
Mario Luca Morieri; Hetal S. Shah; Jennifer Sjaarda; Petra A. Lenzini; Hannah Campbell; Alison A. Motsinger-Reif; He Gao; Laura Lovato; Sabrina Prudente; Assunta Pandolfi; Marcus G. Pezzolesi; Ronald J. Sigal; Guillaume Paré; Santica M. Marcovina; Daniel M. Rotroff; Elisabetta Patorno; Luana Mercuri; Vincenzo Trischitta; Emily Y. Chew; Peter Kraft; John B. Buse; Michael J. Wagner; Sharon Cresci; Hertzel C. Gerstein; Henry N. Ginsberg; Josyf C. Mychaleckyj; Alessandro Doria
Diabetes January 2020, Vol.69, 771-783. doi:https://doi.org/10.2337/db19-0973
Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes
Vincenzo Forgetta; Despoina Manousaki; Roman Istomine; Stephanie Ross; Marie-Catherine Tessier; Luc Marchand; Min Li; Hui-Qi Qu; Jonathan P. Bradfield; Struan F.A. Grant; Hakon Hakonarson; the DCCT/EDIC Research Group; Andrew D. Paterson; Ciriaco Piccirillo; Constantin Polychronakos; J. Brent Richards
Diabetes January 2020, Vol.69, 784-795. doi:https://doi.org/10.2337/db19-0831
Errata
Erratum. miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes. Diabetes 2018;67:2554–2568
Daniele Torella; Claudio Iaconetti; Roberta Tarallo; Fabiola Marino; Giorgio Giurato; Claudia Veneziano; Iolanda Aquila; Mariangela Scalise; Teresa Mancuso; Eleonora Cianflone; Chiara Valeriano; Pina Marotta; Laura Tammè; Carla Vicinanza; Ferdinando C. Sasso; Domenico Cozzolino; Michele Torella; Alessandro Weisz; Ciro Indolfi
Diabetes February 2020, Vol.69, 796. doi:https://doi.org/10.2337/db20-er04a
Erratum. Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression. Diabetes 2019;68:2301–2314
Ying Fan; Zhengzi Yi; Vivette D. D’Agati; Zeguo Sun; Fang Zhong; Weijia Zhang; Jiejun Wen; Ting Zhou; Ze Li; Li He; Qunzi Zhang; Kyung Lee; John Cijiang He; Niansong Wang
Diabetes February 2020, Vol.69, 797. doi:https://doi.org/10.2337/db20-er04b
Erratum. Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease. Diabetes 2019;68:2235–2246
Priska Stahel; Avital Nahmias; Shawn K. Sud; So Jeong Lee; Andrea Pucci; Ahmed Yousseif; Alaa Youseff; Timothy Jackson; David R. Urbach; Allan Okrainec; Johane P. Allard; Sanjeev Sockalingam; Tony Yao; Moumita Barua; Hong Jiao; Reedik Magi; Anne S. Bassett; Andrew D. Paterson; Ingrid Dahlman; Rachel L. Batterham; Satya Dash
Diabetes February 2020, Vol.69, 798. doi:https://doi.org/10.2337/db20-er04c
