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1 May 2020
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Cover Image
Cover Image
On the cover: The image shows hybridoma cells secreting anti-Gitr monoclonal antibody encapsulated in alginate microbeads and is derived from the overlap of two microphotographs. Image courtesy of the teams of Giuseppe Nocentini and Riccardo Calafiore, Section of Pharmacology and Section of Internal Medicine and Endocrine and Metabolic Sciences, Department of Medicine, University of Perugia, Perugia, Italy. Their article, “Microencapsulated G3C Hybridoma Cell Graft Delays the Onset of Spontaneous Diabetes in NOD Mice by an Expansion of Gitr+ Treg Cells,” appears in this issue of Diabetes (p. 965).
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes April 2020, Vol.69, 801-802. doi:https://doi.org/10.2337/db20-ti05
Editor’s Note
Small Noncoding RNAs in Diabetes
MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes
Diabetes April 2020, Vol.69, 804-812. doi:https://doi.org/10.2337/dbi19-0016
Pervasive Small RNAs in Cardiometabolic Research: Great Potential Accompanied by Biological and Technical Barriers
Diabetes April 2020, Vol.69, 813-822. doi:https://doi.org/10.2337/dbi19-0015
Perspectives in Diabetes
“Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets
Diabetes April 2020, Vol.69, 830-836. doi:https://doi.org/10.2337/dbi19-0012
The Peripheral Peril: Injected Insulin Induces Insulin Insensitivity in Type 1 Diabetes
Diabetes April 2020, Vol.69, 837-847. doi:https://doi.org/10.2337/dbi19-0026
Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity
Diabetes April 2020, Vol.69, 848-858. doi:https://doi.org/10.2337/dbi18-0042
Commentaries
Apolipoprotein M and Sphingosine-1-Phosphate: A Potentially Antidiabetic Tandem Carried by HDL
Diabetes April 2020, Vol.69, 859-861. doi:https://doi.org/10.2337/dbi20-0005
The Use of Mendelian Randomization to Determine the Role of Metabolic Traits on Urinary Albumin-to-Creatinine Ratio
Diabetes April 2020, Vol.69, 862-863. doi:https://doi.org/10.2337/dbi19-0034
A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets
Diabetes April 2020, Vol.69, 864-866. doi:https://doi.org/10.2337/dbi19-0035
Metabolism
Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate
Makoto Kurano; Kazuhisa Tsukamoto; Tomo Shimizu; Hidetoshi Kassai; Kazuki Nakao; Atsu Aiba; Masumi Hara; Yutaka Yatomi
Diabetes January 2020, Vol.69, 867-881. doi:https://doi.org/10.2337/db19-0811
The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition
Megan E. Capozzi; Reilly W. Coch; Jepchumba Koech; Inna I. Astapova; Jacob B. Wait; Sara E. Encisco; Jonathan D. Douros; Kimberly El; Brian Finan; Kyle W. Sloop; Mark A. Herman; David A. D’Alessio; Jonathan E. Campbell
Diabetes January 2020, Vol.69, 882-892. doi:https://doi.org/10.2337/db19-1216
Inorganic Nitrate Promotes Glucose Uptake and Oxidative Catabolism in White Adipose Tissue Through the XOR-Catalyzed Nitric Oxide Pathway
Ben D. McNally; Amy Moran; Nicole T. Watt; Tom Ashmore; Anna Whitehead; Steven A. Murfitt; Mark T. Kearney; Richard M. Cubbon; Andrew J. Murray; Julian L. Griffin; Lee D. Roberts
Diabetes February 2020, Vol.69, 893-901. doi:https://doi.org/10.2337/db19-0892
Islet Studies
Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets
Chiara Saponaro; Markus Mühlemann; Ana Acosta-Montalvo; Anthony Piron; Valery Gmyr; Nathalie Delalleau; Ericka Moerman; Julien Thévenet; Gianni Pasquetti; Anais Coddeville; Miriam Cnop; Julie Kerr-Conte; Bart Staels; François Pattou; Caroline Bonner
Diabetes January 2020, Vol.69, 902-914. doi:https://doi.org/10.2337/db19-0888
DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet Homeostasis
Marina Rubey; Nirav Florian Chhabra; Daniel Gradinger; Adrián Sanz-Moreno; Heiko Lickert; Gerhard K.H. Przemeck; Martin Hrabě de Angelis
Diabetes February 2020, Vol.69, 915-926. doi:https://doi.org/10.2337/db19-0795
Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice
Meritxell Morró; Laia Vilà; Sylvie Franckhauser; Cristina Mallol; Gemma Elias; Tura Ferré; Maria Molas; Estefanía Casana; Jordi Rodó; Anna Pujol; Noèlia Téllez; Fàtima Bosch; Alba Casellas
Diabetes February 2020, Vol.69, 927-939. doi:https://doi.org/10.2337/db19-0757
HRD1, an Important Player in Pancreatic β-Cell Failure and Therapeutic Target for Type 2 Diabetic Mice
Tijun Wu; Shuang Zhang; Jialiang Xu; Yaqin Zhang; Tong Sun; Yixue Shao; Jiahui Wang; Wei Tang; Fang Chen; Xiao Han
Diabetes February 2020, Vol.69, 940-953. doi:https://doi.org/10.2337/db19-1060
Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth
Jinhong Sun; Yi Xiong; Xin Li; Leena Haataja; Wei Chen; Saiful A. Mir; Li Lv; Rachel Madley; Dennis Larkin; Arfah Anjum; Balamurugan Dhayalan; Nischay Rege; Nalinda P. Wickramasinghe; Michael A. Weiss; Pamela Itkin-Ansari; Randal J. Kaufman; David A. Ostrov; Peter Arvan; Ming Liu
Diabetes March 2020, Vol.69, 954-964. doi:https://doi.org/10.2337/db19-1106
Immunology and Transplantation
Microencapsulated G3C Hybridoma Cell Graft Delays the Onset of Spontaneous Diabetes in NOD Mice by an Expansion of Gitr+ Treg Cells
Luigi Cari; Pia Montanucci; Giuseppe Basta; Maria G. Petrillo; Erika Ricci; Teresa Pescara; Alessia Greco; Sabrina Cipriani; Jun Shimizu; Graziella Migliorati; Giuseppe Nocentini; Riccardo Calafiore; Carlo Riccardi
Diabetes March 2020, Vol.69, 965-980. doi:https://doi.org/10.2337/db19-0087
Pathophysiology
Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF–Resistant Diabetic Macular Edema
Mitsuru Arima; Shintaro Nakao; Muneo Yamaguchi; Hao Feng; Yuya Fujii; Kensuke Shibata; Iori Wada; Yoshihiro Kaizu; Hamid Ahmadieh; Tatsuro Ishibashi; Alan W. Stitt; Koh-Hei Sonoda
Diabetes March 2020, Vol.69, 981-999. doi:https://doi.org/10.2337/db19-1121
Complications
Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Barbara H. Braffett; Rose A. Gubitosi-Klug; James W. Albers; Eva L. Feldman; Catherine L. Martin; Neil H. White; Trevor J. Orchard; Maria Lopes-Virella; John M. Lachin; Rodica Pop-Busui; the DCCT/EDIC Research Group
Diabetes February 2020, Vol.69, 1000-1010. doi:https://doi.org/10.2337/db19-1046
Impairment in Baroreflex Sensitivity in Recent-Onset Type 2 Diabetes Without Progression Over 5 Years
Jana-Luise Kück; Gidon J. Bönhof; Alexander Strom; Oana-Patricia Zaharia; Karsten Müssig; Julia Szendroedi; Michael Roden; Dan Ziegler; for the GDS group
Diabetes February 2020, Vol.69, 1011-1019. doi:https://doi.org/10.2337/db19-0990
Activation of Retinal Angiogenesis in Hyperglycemic pdx1−/− Zebrafish Mutants
Lucas M. Wiggenhauser; Haozhe Qi; Sandra J. Stoll; Lena Metzger; Katrin Bennewitz; Gernot Poschet; Guido Krenning; Jan-Luuk Hillebrands; Hans-Peter Hammes; Jens Kroll
Diabetes March 2020, Vol.69, 1020-1031. doi:https://doi.org/10.2337/db19-0873
Pharmacology and Therapeutics
A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity
Jennifer Vogel; Jianning Yin; Liansheng Su; Sharon X. Wang; Richard Zessis; Sena Fowler; Chun-Hao Chiu; Aaron C. Wilson; Amy Chen; Frederic Zecri; Gordon Turner; Thomas M. Smith; Brian DeChristopher; Heming Xing; Deborah M. Rothman; Xinming Cai; Alina Berdichevsky
Diabetes February 2020, Vol.69, 1032-1041. doi:https://doi.org/10.2337/db19-0813
Effects of Vitamin D Receptor Knockout and Vitamin D Deficiency on Corneal Epithelial Wound Healing and Nerve Density in Diabetic Mice
Diabetes March 2020, Vol.69, 1042-1051. doi:https://doi.org/10.2337/db19-1051
MG53 Does Not Manifest the Development of Diabetes in db/db Mice
Qiang Wang; Zehua Bian; Qiwei Jiang; Xiaoliang Wang; Xinyu Zhou; Ki Ho Park; Willa Hsueh; Bryan A. Whitson; Erin Haggard; Haichang Li; Ken Chen; Chuanxi Cai; Tao Tan; Hua Zhu; Jianjie Ma
Diabetes March 2020, Vol.69, 1052-1064. doi:https://doi.org/10.2337/db19-0807
Genetics / Genomes / Proteomics / Metabolomics
Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy
Ingrida Stankute; Rasa Verkauskiene; Jean-Louis Blouin; Philippe Klee; Rimante Dobrovolskiene; Evalda Danyte; Mirjam Dirlewanger; Federico Santoni; Dovile Razanskaite-Virbickiene; Dale Marciulionyte; Edita Jasinskiene; Giedre Mockeviciene; Valerie M. Schwitzgebel
Diabetes February 2020, Vol.69, 1065-1071. doi:https://doi.org/10.2337/db19-0974
A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function
Francesco Casanova; Andrew R. Wood; Hanieh Yaghootkar; Robert N. Beaumont; Samuel E. Jones; Kim M. Gooding; Kunihiko Aizawa; W. David Strain; Andrew T. Hattersley; Faisel Khan; Angela C. Shore; Timothy M. Frayling; Jessica Tyrrell
Diabetes January 2020, Vol.69, 1072-1082. doi:https://doi.org/10.2337/db19-0862
