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June 2020
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Cover Image
Cover Image
On the cover: PPARα knockout mouse corneal nerves immunolabeled with β-III tubulin antibody. Image courtesy of H. Greg Matlock, Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK. His article, “Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes,” appears in this issue of Diabetes (p. 1279).
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes May 2020, Vol.69, 1085-1086. doi:https://doi.org/10.2337/db20-ti06
Commentary
Window of Opportunity: Targeting ANGPTL4 Improves Triglyceride Levels in Maternal Obesity During Pregnancy
Diabetes May 2020, Vol.69, 1087-1089. doi:https://doi.org/10.2337/dbi20-0010
Metabolism
Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic Steatosis
Malte P. Suppli; Jonatan I. Bagger; Asger Lund; Mia Demant; Gerrit van Hall; Charlotte Strandberg; Merete J. Kønig; Kristoffer Rigbolt; Jill L. Langhoff; Nicolai J. Wewer Albrechtsen; Jens J. Holst; Tina Vilsbøll; Filip K. Knop
Diabetes January 2020, Vol.69, 1090-1099. doi:https://doi.org/10.2337/db19-0715
Obesity Reduces Maternal Blood Triglyceride Concentrations by Reducing Angiopoietin-Like Protein 4 Expression in Mice
Liping Qiao; Shwetha K. Shetty; Kathryn M. Spitler; Jean-Sebastien Wattez; Brandon S.J. Davies; Jianhua Shao
Diabetes February 2020, Vol.69, 1100-1109. doi:https://doi.org/10.2337/db19-1181
Amylin/Calcitonin Receptor–Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice
Diabetes March 2020, Vol.69, 1110-1125. doi:https://doi.org/10.2337/db19-0849
Repurposing Doxepin to Ameliorate Steatosis and Hyperglycemia by Activating FAM3A Signaling Pathway
Zhenzhen Chen; Xiangyang Liu; Yanjin Luo; Junpei Wang; Yuhong Meng; Lei Sun; Yongsheng Chang; Qinghua Cui; Jichun Yang
Diabetes April 2020, Vol.69, 1126-1139. doi:https://doi.org/10.2337/db19-1038
Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents
Michelle Carey; Eric Lontchi-Yimagou; William Mitchell; Sarah Reda; Kehao Zhang; Sylvia Kehlenbrink; Sudha Koppaka; Sylvan Roger Maginley; Sandra Aleksic; Shobhit Bhansali; Derek M. Huffman; Meredith Hawkins
Diabetes March 2020, Vol.69, 1140-1148. doi:https://doi.org/10.2337/db19-1256
Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice
Jie Lu; Yuwei He; Lingling Cui; Xiaoming Xing; Zhen Liu; Xinde Li; Hui Zhang; Hailong Li; Wenyan Sun; Aichang Ji; Yao Wang; Huiyong Yin; Changgui Li
Diabetes April 2020, Vol.69, 1149-1163. doi:https://doi.org/10.2337/db19-0704
Obesity Studies
Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling
Huishou Zhao; Fuyang Zhang; Dan Sun; Xiong Wang; Xiaomeng Zhang; Jinglong Zhang; Feng Yan; Chong Huang; Huaning Xie; Chen Lin; Yi Liu; Miaomiao Fan; Wenjun Yan; Youhu Chen; Kun Lian; Yueyang Li; Ling Zhang; Shan Wang; Ling Tao
Diabetes March 2020, Vol.69, 1164-1177. doi:https://doi.org/10.2337/db19-0920
Islet Studies
Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells
Siming Liu; Joseph A. Promes; Mikako Harata; Akansha Mishra; Samuel B. Stephens; Eric B. Taylor; Anthony J. Burand, Jr.; William I. Sivitz; Brian D. Fink; James A. Ankrum; Yumi Imai
Diabetes March 2020, Vol.69, 1178-1192. doi:https://doi.org/10.2337/db19-0951
Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
Mototsugu Nagao; Jonathan L.S. Esguerra; Akira Asai; Jones K. Ofori; Anna Edlund; Anna Wendt; Hitoshi Sugihara; Claes B. Wollheim; Shinichi Oikawa; Lena Eliasson
Diabetes March 2020, Vol.69, 1193-1205. doi:https://doi.org/10.2337/db19-0944
Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling
Jonathan R. Weitz; Carol Jacques-Silva; Mirza Muhammed Fahd Qadir; Oliver Umland; Elizabeth Pereira; Farhan Qureshi; Alejandro Tamayo; Juan Dominguez-Bendala; Rayner Rodriguez-Diaz; Joana Almaça; Alejandro Caicedo
Diabetes April 2020, Vol.69, 1206-1218. doi:https://doi.org/10.2337/db19-0687
Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response
Xiaodun Yang; Sarah M. Graff; Cody N. Heiser; Kung-Hsien Ho; Bob Chen; Alan J. Simmons; Austin N. Southard-Smith; Gregory David; David A. Jacobson; Irina Kaverina; Christopher V.E. Wright; Ken S. Lau; Guoqiang Gu
Diabetes April 2020, Vol.69, 1219-1231. doi:https://doi.org/10.2337/db19-0721
Immunology and Transplantation
TWIST1-Reprogrammed Endothelial Cell Transplantation Potentiates Neovascularization-Mediated Diabetic Wound Tissue Regeneration
Diabetes March 2020, Vol.69, 1232-1247. doi:https://doi.org/10.2337/db20-0138
Pathophysiology
Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes
Diabetes March 2020, Vol.69, 1248-1263. doi:https://doi.org/10.2337/db19-0935
Complications
MANF Promotes Diabetic Corneal Epithelial Wound Healing and Nerve Regeneration by Attenuating Hyperglycemia-Induced Endoplasmic Reticulum Stress
Xiaochuan Wang; Weina Li; Qingjun Zhou; Jing Li; Xiaolei Wang; Jing Zhang; Dewei Li; Xia Qi; Ting Liu; Xiaowen Zhao; Suxia Li; Lingling Yang; Lixin Xie
Diabetes April 2020, Vol.69, 1264-1278. doi:https://doi.org/10.2337/db19-0835
Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes
H. Greg Matlock; Fangfang Qiu; Volha Malechka; Kelu Zhou; Rui Cheng; Siribhinya Benyajati; Amy Whelchel; Dimitrios Karamichos; Jian-xing Ma
Diabetes March 2020, Vol.69, 1279-1291. doi:https://doi.org/10.2337/db19-0898
Pharmacology and Therapeutics
Erratum
Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441—456
Samuela Pollack; Robert P. Igo, Jr.; Richard A. Jensen; Mark Christiansen; Xiaohui Li; Ching-Yu Cheng; Maggie C.Y. Ng; Albert V. Smith; Elizabeth J. Rossin; Ayellet V. Segrè; Samaneh Davoudi; Gavin S. Tan; Yii-Der Ida Chen; Jane Z. Kuo; Latchezar M. Dimitrov; Lynn K. Stanwyck; Weihua Meng; S. Mohsen Hosseini; Minako Imamura; Darryl Nousome; Jihye Kim; Yang Hai; Yucheng Jia; Jeeyun Ahn; Aaron Leong; Kaanan Shah; Kyu Hyung Park; Xiuqing Guo; Eli Ipp; Kent D. Taylor; Sharon G. Adler; John R. Sedor; Barry I. Freedman; Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group; I-Te Lee; Wayne H.-H. Sheu; Michiaki Kubo; Atsushi Takahashi; Samy Hadjadj; Michel Marre; David-Alexandre Tregouet; Roberta Mckean-Cowdin; Rohit Varma; Mark I. McCarthy; Leif Groop; Emma Ahlqvist; Valeriya Lyssenko; Elisabet Agardh; Andrew Morris; Alex S.F. Doney; Helen M. Colhoun; Iiro Toppila; Niina Sandholm; Per-Henrik Groop; Shiro Maeda; Craig L. Hanis; Alan Penman; Ching J. Chen; Heather Hancock; Paul Mitchell; Jamie E. Craig; Emily Y. Chew; Andrew D. Paterson; Michael A. Grassi; Colin Palmer; Donald W. Bowden; Brian L. Yaspan; David Siscovick; Mary Frances Cotch; Jie Jin Wang; Kathryn P. Burdon; Tien Y. Wong; Barbara E.K. Klein; Ronald Klein; Jerome I. Rotter; Sudha K. Iyengar; Alkes L. Price; Lucia Sobrin
Diabetes May 2020, Vol.69, 1306. doi:https://doi.org/10.2337/db20-er06a