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1 July 2020
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Cover Image
Cover Image
On the cover: Three-dimensional confocal microscopic image of pancreatic tissue from a human donor. Islets are stained with a pan-endocrine antibody marker (HPi1, cyan). Capillaries are stained with an endothelial cell marker (CD31, red). Arterioles are indicated by α-smooth muscle actin staining (α-SMA, blue). Image courtesy of Bryce K. Hendren-Santiago, Michael P. Dybala, and Manami Hara, Department of Medicine, The University of Chicago, Chicago, IL. Their article, “Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas,” appears in this issue of Diabetes (p. 1439).
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes June 2020, Vol.69, 1309-1310. doi:https://doi.org/10.2337/db20-ti07
Perspectives in Diabetes
T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
Diabetes June 2020, Vol.69, 1311-1335. doi:https://doi.org/10.2337/dbi19-0022
Commentaries
Dopamine and Early Retinal Dysfunction in Diabetes: Insights From a Phase 1 Study
Diabetes April 2020, Vol.69, 1339-1340. doi:https://doi.org/10.2337/dbi20-0009
Metabolism
Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4
Lydie Plecitá-Hlavatá; Martin Jabůrek; Blanka Holendová; Jan Tauber; Vojtěch Pavluch; Zuzana Berková; Monika Cahová; Katrin Schröder; Ralf P. Brandes; Detlef Siemen; Petr Ježek
Diabetes April 2020, Vol.69, 1341-1354. doi:https://doi.org/10.2337/db19-1130
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis
Na Tian; Qi Liu; Yakui Li; Lingfeng Tong; Ying Lu; Yemin Zhu; Ping Zhang; Hanbei Chen; Lei Hu; Jian Meng; Ming Feng; Minle Li; Liang Zheng; Bin Li; Tianle Xu; Lifang Wu; Xuemei Tong
Diabetes April 2020, Vol.69, 1355-1367. doi:https://doi.org/10.2337/db19-1087
Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice
Taylor Landry; Brenton Thomas Laing; Peixin Li; Wyatt Bunner; Zhijian Rao; Amber Prete; Julia Sylvestri; Hu Huang
Diabetes April 2020, Vol.69, 1368-1381. doi:https://doi.org/10.2337/db19-0941
Metabolic Responses to 24-Hour Fasting and Mild Cold Exposure in Overweight Individuals Are Correlated and Accompanied by Changes in FGF21 Concentration
Tim Hollstein; Sascha Heinitz; Takafumi Ando; Theresa L. Rodzevik; Alessio Basolo; Mary Walter; Douglas C. Chang; Jonathan Krakoff; Paolo Piaggi
Diabetes April 2020, Vol.69, 1382-1388. doi:https://doi.org/10.2337/db20-0153
Signal Transduction
Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates
William Campodonico-Burnett; Byron Hetrick; Stephanie R. Wesolowski; Simon Schenk; Diana L. Takahashi; Tyler A. Dean; Elinor L. Sullivan; Paul Kievit; Maureen Gannon; Kjersti Aagaard; Jacob E. Friedman; Carrie E. McCurdy
Diabetes April 2020, Vol.69, 1389-1400. doi:https://doi.org/10.2337/db19-1218
Obesity Studies
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
Tiange Sun; Fanhua Meng; Hongmei Zhao; Min Yang; Rui Zhang; Zhiyan Yu; Xinmei Huang; Heyuan Ding; Jun Liu; Shufei Zang
Diabetes April 2020, Vol.69, 1401-1410. doi:https://doi.org/10.2337/db19-0976
Necrostatin-1 Mitigates Cognitive Dysfunction in Prediabetic Rats With No Alteration in Insulin Sensitivity
Kewarin Jinawong; Nattayaporn Apaijai; Supawit Wongsuchai; Wasana Pratchayasakul; Nipon Chattipakorn; Siriporn C. Chattipakorn
Diabetes April 2020, Vol.69, 1411-1423. doi:https://doi.org/10.2337/db19-1128
Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence in an Inbred Population of Pakistan
Sadia Saeed; Muhammad Arslan; Jaida Manzoor; Sadia M. Din; Qasim M. Janjua; Hina Ayesha; Qura-tul Ain; Laraib Inam; Stephane Lobbens; Emmanuel Vaillant; Emmanuelle Durand; Mehdi Derhourhi; Souhila Amanzougarene; Alaa Badreddine; Lionel Berberian; Stefan Gaget; Waqas I. Khan; Taeed A. Butt; Amélie Bonnefond; Philippe Froguel
Diabetes April 2020, Vol.69, 1424-1438. doi:https://doi.org/10.2337/db19-1238
Islet Studies
Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas
Michael P. Dybala; Andrey Kuznetsov; Maki Motobu; Bryce K. Hendren-Santiago; Louis H. Philipson; Alexander V. Chervonsky; Manami Hara
Diabetes March 2020, Vol.69, 1439-1450. doi:https://doi.org/10.2337/db19-1034
Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2
Diabetes April 2020, Vol.69, 1451-1462. doi:https://doi.org/10.2337/db19-0276
Lactogens Reduce Endoplasmic Reticulum Stress–Induced Rodent and Human β-Cell Death and Diabetes Incidence in Akita Mice
Rosemary Li; Nagesha Guthalu Kondegowda; Joanna Filipowska; Rollie F. Hampton; Silvia Leblanc; Adolfo Garcia-Ocana; Rupangi C. Vasavada
Diabetes April 2020, Vol.69, 1463-1475. doi:https://doi.org/10.2337/db19-0909
Immunology and Transplantation
Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01
David Arribas-Layton; Perrin Guyer; Thomas Delong; Mylinh Dang; I-Ting Chow; Cate Speake; Carla J. Greenbaum; William W. Kwok; Rocky L. Baker; Kathryn Haskins; Eddie A. James
Diabetes April 2020, Vol.69, 1492-1502. doi:https://doi.org/10.2337/db19-0620
Pathophysiology
Pericyte Bridges in Homeostasis and Hyperglycemia
Bruce A. Corliss; H. Clifton Ray; Richard W. Doty; Corbin Mathews; Natasha Sheybani; Kathleen Fitzgerald; Remi Prince; Molly R. Kelly-Goss; Walter L. Murfee; John Chappell; Gary K. Owens; Paul A. Yates; Shayn M. Peirce
Diabetes April 2020, Vol.69, 1503-1517. doi:https://doi.org/10.2337/db19-0471
Complications
Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy
Cara T. Motz; Kyle C. Chesler; Rachael S. Allen; Katie L. Bales; Lukas M. Mees; Andrew J. Feola; April Y. Maa; Darin E. Olson; Peter M. Thule; P. Michael Iuvone; Andrew M. Hendrick; Machelle T. Pardue
Diabetes February 2020, Vol.69, 1518-1527. doi:https://doi.org/10.2337/db19-0869
Acute Hyperglycemia Increases Brain Pregenual Anterior Cingulate Cortex Glutamate Concentrations in Type 1 Diabetes
Diabetes April 2020, Vol.69, 1528-1539. doi:https://doi.org/10.2337/db19-0936
Cardiac Magnetic Resonance Myocardial Feature Tracking for Optimized Risk Assessment After Acute Myocardial Infarction in Patients With Type 2 Diabetes
Sören J. Backhaus; Johannes T. Kowallick; Thomas Stiermaier; Torben Lange; Jenny-Lou Navarra; Alexander Koschalka; Ruben Evertz; Joachim Lotz; Shelby Kutty; Gerd Hasenfuß; Matthias Gutberlet; Holger Thiele; Ingo Eitel; Andreas Schuster
Diabetes April 2020, Vol.69, 1540-1548. doi:https://doi.org/10.2337/db20-0001
Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes
Serena Tedesco; Stefano Ciciliot; Lisa Menegazzo; Marianna D’Anna; Valentina Scattolini; Roberta Cappellari; Andrea Cignarella; Angelo Avogaro; Mattia Albiero; Gian Paolo Fadini
Diabetes April 2020, Vol.69, 1562-1572. doi:https://doi.org/10.2337/db19-0640
Genetics / Genomes / Proteomics / Metabolomics
Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children
Lue Ping Zhao; George K. Papadopoulos; William W. Kwok; Antonis K. Moustakas; George P. Bondinas; Helena Elding Larsson; Johnny Ludvigsson; Claude Marcus; Ulf Samuelsson; Ruihan Wang; Chul-Woo Pyo; Wyatt C. Nelson; Daniel E. Geraghty; Åke Lernmark
Diabetes April 2020, Vol.69, 1573-1587. doi:https://doi.org/10.2337/db20-0075
Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study
Shuai Yuan; Siddhartha Kar; Paul Carter; Mathew Vithayathil; Amy M. Mason; Stephen Burgess; Susanna C. Larsson
Diabetes April 2020, Vol.69, 1588-1596. doi:https://doi.org/10.2337/db20-0084
Issues and Events
e-Letters: Comments and Responses
Comment on Miller and Orchard: Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 2020;69:291–299
Diabetes June 2020, Vol.69, e7-e8. doi:https://doi.org/10.2337/db20-0311
