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1 September 2020
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On the cover: Colored transmission electron micrograph of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particles isolated from a U.S. case of coronavirus disease 2019 (COVID-19). SARS-CoV-2, an enveloped RNA virus, was first identified in Wuhan, China, in December 2019. The coronaviruses take their name from their crown (corona) of surface proteins, which are used to attach and penetrate their host cells. Credit: National Institutes of Health-RML/Science Source. Unique identifier: SS22537344. For further information, please visit sciencesource.com.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19
Diabetes July 2020, Vol.69, 1857-1863. doi:https://doi.org/10.2337/dbi19-0023
Pancreatic Islets and Gestalt Principles
Diabetes July 2020, Vol.69, 1864-1874. doi:https://doi.org/10.2337/db20-0304
SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes
Alexander G. Obukhov; Bruce R. Stevens; Ram Prasad; Sergio Li Calzi; Michael E. Boulton; Mohan K. Raizada; Gavin Y. Oudit; Maria B. Grant
Diabetes July 2020, Vol.69, 1875-1886. doi:https://doi.org/10.2337/dbi20-0019
Metabolism
WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2
Luyao Zhang; Xue Li; Nan Zhang; Xin Yang; Tianyun Hou; Wan Fu; Fengjie Yuan; Lina Wang; He Wen; Yuan Tian; Hongquan Zhang; Xifeng Lu; Wei-Guo Zhu
Diabetes July 2020, Vol.69, 1887-1902. doi:https://doi.org/10.2337/db19-0699
3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism
Mona S. Nilsen; Regine Å. Jersin; Arve Ulvik; André Madsen; Adrian McCann; Per-Arne Svensson; Maria K. Svensson; Bjørn G. Nedrebø; Oddrun A. Gudbrandsen; Grethe S. Tell; C.R. Kahn; Per M. Ueland; Gunnar Mellgren; Simon N. Dankel
Diabetes June 2020, Vol.69, 1903-1916. doi:https://doi.org/10.2337/db19-1174
Obesity Studies
Starch Digestion–Related Amylase Genetic Variants, Diet, and Changes in Adiposity: Analyses in Prospective Cohort Studies and a Randomized Dietary Intervention
Yoriko Heianza; Tao Zhou; Chen Yuhang; Tao Huang; Walter C. Willett; Frank B. Hu; George A. Bray; Frank M. Sacks; Lu Qi
Diabetes June 2020, Vol.69, 1917-1926. doi:https://doi.org/10.2337/db19-1257
Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation
Mara A. Dedual; Stephan Wueest; Tenagne D. Challa; Fabrizio C. Lucchini; Tim R.J. Aeppli; Marcela Borsigova; Andrea A. Mauracher; Stefano Vavassori; Jana Pachlopnik Schmid; Matthias Blüher; Daniel Konrad
Diabetes July 2020, Vol.69, 1927-1935. doi:https://doi.org/10.2337/db19-1206
Islet Studies
Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation
Kung-Hsien Ho; Xiaodun Yang; Anna B. Osipovich; Over Cabrera; Mansuo L. Hayashi; Mark A. Magnuson; Guoqiang Gu; Irina Kaverina
Diabetes June 2020, Vol.69, 1936-1947. doi:https://doi.org/10.2337/db19-1186
Immunology and Transplantation
Localized Immunosuppression With Tannic Acid Encapsulation Delays Islet Allograft and Autoimmune-Mediated Rejection
Diabetes June 2020, Vol.69, 1948-1960. doi:https://doi.org/10.2337/db20-0248
Complications
Regulation of Glycemia in the Recovery Phase After Stroke Counteracts the Detrimental Effect of Obesity-Induced Type 2 Diabetes on Neurological Recovery
Ingrid Lovise Augestad; Hiranya Pintana; Martin Larsson; Camilla Krizhanovskii; Thomas Nyström; Thomas Klein; Vladimer Darsalia; Cesare Patrone
Diabetes June 2020, Vol.69, 1961-1973. doi:https://doi.org/10.2337/db20-0095
DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice
Xu Xu; Wei Wang; Zhengyu Wang; Jianlu Lv; Xiaoju Xu; Jiawen Xu; Juanzhen Yang; Xialin Zhu; Yin Lu; Wenhu Duan; Xi Huang; Jiaying Wang; Jinpei Zhou; Xu Shen
Diabetes July 2020, Vol.69, 1974-1988. doi:https://doi.org/10.2337/db19-1084
Pharmacology and Therapeutics
GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers
Alexander S. Christensen; Sofie Hædersdal; Heidi Storgaard; Kathrine Rose; Nina L. Hansen; Jens J. Holst; Torben Hansen; Filip K. Knop; Tina Vilsbøll
Diabetes June 2020, Vol.69, 1989-2002. doi:https://doi.org/10.2337/db20-0074
A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders
Guang Ren; Teayoun Kim; Hae-Suk Kim; Martin E. Young; Donald D. Muccio; Venkatram R. Atigadda; Samuel I. Blum; Hubert M. Tse; Kirk M. Habegger; Sushant Bhatnagar; Tatjana Coric; Mary-Ann Bjornsti; Anath Shalev; Stuart J. Frank; Jeong-a Kim
Diabetes July 2020, Vol.69, 2003-2016. doi:https://doi.org/10.2337/db19-1001
Genetics / Genomes / Proteomics / Metabolomics
SGCG rs679482 Associates With Weight Loss Success in Response to an Intensively Supervised Outpatient Program
Majid Nikpay; Paulina Lau; Sébastien Soubeyrand; Katey L. Whytock; Kaitlyn Beehler; Chantal Pileggi; Sujoy Ghosh; Mary-Ellen Harper; Robert Dent; Ruth McPherson
Diabetes June 2020, Vol.69, 2017-2026. doi:https://doi.org/10.2337/db20-0219
Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories?
Katharina Herzog; Johan Berggren; Mahmoud Al Majdoub; Claudia Balderas Arroyo; Andreas Lindqvist; Jan Hedenbro; Leif Groop; Nils Wierup; Peter Spégel
Diabetes June 2020, Vol.69, 2027-2035. doi:https://doi.org/10.2337/db20-0131
