Skip Nav Destination
Issues
1 January 2021
-
Cover Image
Cover Image
On the cover: Polarized light micrograph of crystals of the hormone insulin. The insulin molecule is made up of two chains of amino acids (A and B chains), which are held together by two sulfur bonds. Insulin is a hormone produced in the pancreas by cells of the islets of Langerhans. Low magnification micrograph with polarized light. Horizontal object size 3 mm. Credit: Pasieka / Science Source.
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process. Click here for more information.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation
Katherine R. Tuttle; Frank C. Brosius, III; Matthew A. Cavender; Paola Fioretto; Kevin J. Fowler; Hiddo J.L. Heerspink; Tom Manley; Darren K. McGuire; Mark E. Molitch; Amy K. Mottl; Leigh Perreault; Sylvia E. Rosas; Peter Rossing; Laura Sola; Volker Vallon; Christoph Wanner; Vlado Perkovic
Topics:
cardiovascular diseases
,
diabetes mellitus, type 2
,
kidney
,
kidney failure, chronic
,
sodium-glucose transporter 2 inhibitors
Diabetes October 2020, Vol.70, 1-16. doi:https://doi.org/10.2337/dbi20-0040
Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function
Topics:
diagnostic imaging
,
endocrine cells
,
endocrine pancreas
,
engineering
,
gamma-aminobutyric acid
Diabetes December 2020, Vol.70, 17-26. doi:https://doi.org/10.2337/dbi19-0033
Commentary
Lifting the Veil on the “Phosphate Flush,” a Cryptic Phenomenon of Experimental Pancreatic Islet Physiology
Topics:
endocrine pancreas
,
lifting
,
phosphates
,
physiology
Diabetes December 2020, Vol.70, 27-28. doi:https://doi.org/10.2337/dbi20-0038
ADA Award Lectures
“Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
Topics:
growth differentiation factor 15
,
insulin
,
insulin resistance
,
lipodystrophy
,
metabolic syndrome x
Diabetes December 2020, Vol.70, 29-38. doi:https://doi.org/10.2337/dbi19-0037
Linking Kidney and Cardiovascular Complications in Diabetes—Impact on Prognostication and Treatment: The 2019 Edwin Bierman Award Lecture
Topics:
albumins
,
albuminuria
,
diabetes mellitus, type 2
,
heart
,
kidney
Diabetes December 2020, Vol.70, 39-50. doi:https://doi.org/10.2337/dbi19-0038
Metabolism
Cardiac Autophagy Deficiency Attenuates ANP Production and Disrupts Myocardial-Adipose Cross Talk, Leading to Increased Fat Accumulation and Metabolic Dysfunction
Erfei Song; Daniel Da Eira; Shailee Jani; Diane Sepa-Kishi; Vivian Vu; Howard Hunter; Mi Lai; Michael B. Wheeler; Rolando B. Ceddia; Gary Sweeney
Topics:
adipocytes
,
autophagy
,
glucose
,
insulin
,
lipids
Diabetes October 2020, Vol.70, 51-61. doi:https://doi.org/10.2337/db19-0762
Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons
Topics:
agouti-related protein
,
amino acids, branched-chain
,
fasting
,
insulin
,
mice
Diabetes October 2020, Vol.70, 62-75. doi:https://doi.org/10.2337/db20-0510
Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy
Camille Gamblin; Christine Rouault; Amélie Lacombe; Francina Langa-Vives; Dominique Farabos; Antonin Lamaziere; Karine Clément; Emmanuel L. Gautier; Laurent Yvan-Charvet; Isabelle Dugail
Topics:
adipocytes
,
cholesterol
,
mice
,
obesity
,
lipase
Diabetes November 2020, Vol.70, 76-90. doi:https://doi.org/10.2337/db20-0578
Small Amounts of Dietary Medium-Chain Fatty Acids Protect Against Insulin Resistance During Caloric Excess in Humans
Anne-Marie Lundsgaard; Andreas M. Fritzen; Kim A. Sjøberg; Maximilian Kleinert; Erik A. Richter; Bente Kiens
Topics:
diet
,
glucose
,
insulin
,
insulin resistance
,
medium chain fatty acid
Diabetes October 2020, Vol.70, 91-98. doi:https://doi.org/10.2337/db20-0582
Obesity Studies
Glucose Sensing Mediated by Portal Glucagon-Like Peptide 1 Receptor Is Markedly Impaired in Insulin-Resistant Obese Animals
Topics:
glucagon-like peptide 1
,
glucose
,
insulin
,
obesity
,
positron-emission tomography
Diabetes October 2020, Vol.70, 99-110. doi:https://doi.org/10.2337/db20-0361
Islet Studies
XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
Christopher J. Barker; Fernando Henrique Galvão Tessaro; Sabrina de Souza Ferreira; Rafael Simas; Thais S. Ayala; Martin Köhler; Subu Surendran Rajasekaran; Joilson O. Martins; Elisabetta Darè; Per-Olof Berggren
Topics:
glucose
,
pancreas
,
phosphates
,
inositol
,
diphosphates
Diabetes August 2020, Vol.70, 111-118. doi:https://doi.org/10.2337/db19-0633
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity
Xing Ming; Arthur C.K. Chung; Dandan Mao; Huanyi Cao; Baoqi Fan; Willy K.K. Wong; Chin Chung Ho; Heung Man Lee; Kristina Schoonjans; Johan Auwerx; Guy A. Rutter; Juliana C.N. Chan; Xiao Yu Tian; Alice P.S. Kong
Topics:
fatty liver
,
mice
,
serotonin
,
pancreas
,
insulin
Diabetes October 2020, Vol.70, 119-131. doi:https://doi.org/10.2337/db20-0339
Adiponectin Promotes Maternal β-Cell Expansion Through Placental Lactogen Expression
Topics:
adiponectin
,
insulin
,
pregnancy
,
human placental lactogen
,
placenta
Diabetes October 2020, Vol.70, 132-142. doi:https://doi.org/10.2337/db20-0471
Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance
Topics:
circadian clocks
,
diet
,
glucose
,
insulin
,
mice
Diabetes October 2020, Vol.70, 143-154. doi:https://doi.org/10.2337/db20-0192
Translational Factor eIF4G1 Regulates Glucose Homeostasis and Pancreatic β-Cell Function
Seokwon Jo; Amber Lockridge; Ramkumar Mohan; Nicholas Esch; Regina Schlichting; Neha Panigrahy; Ahmad Essawy; Eric Gustafson; Emilyn U. Alejandro
Topics:
insulin
,
mice
,
glucose
,
mitochondria
Diabetes October 2020, Vol.70, 155-170. doi:https://doi.org/10.2337/db20-0057
Immunology and Transplantation
InsB9-23 Gene Transfer to Hepatocyte-Based Combined Therapy Abrogates Recurrence of Type 1 Diabetes After Islet Transplantation
Fabio Russo; Antonio Citro; Giorgia Squeri; Francesca Sanvito; Paolo Monti; Silvia Gregori; Maria Grazia Roncarolo; Andrea Annoni
Topics:
insulin
,
islets of langerhans transplantation
,
mice
,
mice, inbred nod
,
hepatocytes
Diabetes October 2020, Vol.70, 171-181. doi:https://doi.org/10.2337/db19-1249
Pathophysiology
Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation
Young Jin; Yul Ji; Yaechan Song; Sung Sik Choe; Yong Geun Jeon; Heeju Na; Tae Wook Nam; Hye Jeong Kim; Hahn Nahmgoong; Sung Min Kim; Jae-woo Kim; Ki Taek Nam; Je Kyung Seong; Daehee Hwang; Chan Bae Park; In Hye Lee; Jae Bum Kim; Han-Woong Lee
Topics:
adipocytes
,
mice
,
adipose tissue
,
stress
Diabetes October 2020, Vol.70, 182-195. doi:https://doi.org/10.2337/db19-1239
The Mineralocorticoid Receptor Antagonist Eplerenone Suppresses Interstitial Fibrosis in Subcutaneous Adipose Tissue in Patients With Type 2 Diabetes
Marie Louise Johansen; Jaime Ibarrola; Amaya Fernández-Celis; Morten Schou; Mette Pauli Sonne; Maria Refsgaard Holm; Jon Rasmussen; Flemming Dela; Frederic Jaisser; Jens Faber; Patrick Rossignol; Natalia Lopez-Andres; Caroline Kistorp
Topics:
adipose tissue
,
diabetes mellitus, type 2
,
eplerenone
,
fibrosis
,
mineralocorticoid receptor antagonists
Diabetes October 2020, Vol.70, 196-203. doi:https://doi.org/10.2337/db20-0394
Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects
Aurora Merovci; Devjit Tripathy; Xi Chen; Ivan Valdez; Muhammad Abdul-Ghani; Carolina Solis-Herrera; Amalia Gastaldelli; Ralph A. DeFronzo
Topics:
glucose
,
hyperglycemic agents
,
infusion procedures
,
insulin
,
hyperglycemia
Diabetes October 2020, Vol.70, 204-213. doi:https://doi.org/10.2337/db20-0039
ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway
Zhuo Mao; Mingji Feng; Zhuoran Li; Minsi Zhou; Langning Xu; Ke Pan; Shaoxiang Wang; Wen Su; Weizhen Zhang
Topics:
diet
,
fatty acid metabolism
,
fatty acids
,
fatty liver
,
hepatocytes
Diabetes October 2020, Vol.70, 214-226. doi:https://doi.org/10.2337/db20-0619
Complications
Long Noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy
Topics:
antioxidants
,
diabetic retinopathy
,
genes
,
glucose
,
kelch-like ech-associated protein 1
Diabetes October 2020, Vol.70, 227-239. doi:https://doi.org/10.2337/db20-0375
CD31+ Extracellular Vesicles From Patients With Type 2 Diabetes Shuttle a miRNA Signature Associated With Cardiovascular Complications
Francesco Prattichizzo; Valeria De Nigris; Jacopo Sabbatinelli; Angelica Giuliani; Carlos Castaño; Marcelina Párrizas; Isabel Crespo; Annalisa Grimaldi; Nicolò Baranzini; Rosangela Spiga; Elettra Mancuso; Maria Rita Rippo; Antonio Domenico Procopio; Anna Novials; Anna Rita Bonfigli; Silvia Garavelli; Lucia La Sala; Giuseppe Matarese; Paola de Candia; Fabiola Olivieri; Antonio Ceriello
Topics:
cd31 antigens
,
diabetes mellitus, type 2
,
micrornas
,
plasma
Diabetes October 2020, Vol.70, 240-254. doi:https://doi.org/10.2337/db20-0199
Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes
Yow Keat Tham; Kaushala S. Jayawardana; Zahir H. Alshehry; Corey Giles; Kevin Huynh; Adam Alexander T. Smith; Jenny Y.Y. Ooi; Sophia Zoungas; Graham S. Hillis; John Chalmers; Peter J. Meikle; Julie R. McMullen
Topics:
atrial fibrillation
,
lipids
Diabetes October 2020, Vol.70, 255-261. doi:https://doi.org/10.2337/db20-0653
Pharmacology and Therapeutics
Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench
Jhih-Yuan Shih; Yu-Wen Lin; Sudeshna Fisch; Juei-Tang Cheng; Nai-Wen Kang; Chon-Seng Hong; Zhih-Cherng Chen; Wei-Ting Chang
Topics:
apoptosis
,
cardiac myocytes
,
dapagliflozin
,
emergency service, hospital
,
glucose
Diabetes October 2020, Vol.70, 262-267. doi:https://doi.org/10.2337/db20-0840
Genetics / Genomes / Proteomics / Metabolomics
Genetic Loci and Physiologic Pathways Involved in Gestational Diabetes Mellitus Implicated Through Clustering
Camille E. Powe; Miriam S. Udler; Sarah Hsu; Catherine Allard; Alan Kuang; Alisa K. Manning; Patrice Perron; Luigi Bouchard; William L. Lowe, Jr.; Denise Scholtens; Jose C. Florez; Marie-France Hivert
Topics:
diabetes mellitus, type 2
,
hapo trial
,
pregnancy
,
glucose
,
genetics
Diabetes October 2020, Vol.70, 268-281. doi:https://doi.org/10.2337/db20-0772
Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study
Qian Li; Xiang Liu; Jimin Yang; Iris Erlund; Åke Lernmark; William Hagopian; Marian Rewers; Jin-Xiong She; Jorma Toppari; Anette-G. Ziegler; Beena Akolkar; Jeffrey P. Krischer; the TEDDY Study Group
Topics:
ascorbic acid
,
autoantibodies
,
biological markers
,
child
,
diabetes mellitus, type 1
Diabetes October 2020, Vol.70, 282-292. doi:https://doi.org/10.2337/db20-0696
A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas
Josephine H. Li; Lukasz Szczerbinski; Adem Y. Dawed; Varinderpal Kaur; Jennifer N. Todd; Ewan R. Pearson; Jose C. Florez
Topics:
diabetes mellitus, type 2
,
sulfonylurea compounds
,
sugars
,
glipizide
,
metformin
Diabetes October 2020, Vol.70, 293-300. doi:https://doi.org/10.2337/db20-0530
Erratum
Erratum. Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage. Diabetes 2011;60:3023–3033
Topics:
diabetic retinopathy
,
gelatinase b
,
genes
,
mice
,
mitochondrial toxicity
Diabetes November 2020, Vol.70, 301. doi:https://doi.org/10.2337/db21-er01a