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November 2021
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On the cover: Transmission electron micrograph of pancreas. Credit: Scott Camazine/Science Source.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells
Diabetes October 2021, Vol.70, 2431-2443. doi:https://doi.org/10.2337/dbi20-0033
Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
Diabetes October 2021, Vol.70, 2444-2456. doi:https://doi.org/10.2337/dbi21-0012
The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?
Diabetes October 2021, Vol.70, 2457-2467. doi:https://doi.org/10.2337/dbi19-0006
ADA Award Lecture
Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture
Diabetes October 2021, Vol.70, 2468-2475. doi:https://doi.org/10.2337/dbi21-0026
Metabolism
Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH
Rory P. Cunningham; Mary P. Moore; Ryan J. Dashek; Grace M. Meers; Takamune Takahashi; Ryan D. Sheldon; Andrew A. Wheeler; Alberto Diaz-Arias; Jamal A. Ibdah; Elizabeth J. Parks; John P. Thyfault; R. Scott Rector
Diabetes August 2021, Vol.70, 2476-2491. doi:https://doi.org/10.2337/db20-1228
Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice
Huanqing Gao; Yiming Zhong; Zhen Ding; Sixiong Lin; Xiaoting Hou; Wanze Tang; Xiaoqian Zhou; Xuenong Zou; Jie Shao; Fan Yang; Xiaochun Bai; Chuanju Liu; Huiling Cao; Guozhi Xiao
Diabetes August 2021, Vol.70, 2492-2505. doi:https://doi.org/10.2337/db21-0392
Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α
Yanyong Xu; Shuwei Hu; Kavita Jadhav; Yingdong Zhu; Xiaoli Pan; Fathima Cassim Bawa; Liya Yin; Yanqiao Zhang
Diabetes September 2021, Vol.70, 2506-2517. doi:https://doi.org/10.2337/db21-0181
Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart
Maria da Luz Sousa Fialho; Ujang Purnama; Kaitlyn M.J.H. Dennis; Claudia N. Montes Aparicio; Marcos Castro-Guarda; Emmanuelle Massourides; Damian J. Tyler; Carolyn A. Carr; Lisa C. Heather
Diabetes September 2021, Vol.70, 2518-2531. doi:https://doi.org/10.2337/db21-0398
Signal Transduction
Cavβ3 Regulates Ca2+ Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner
Alexander Becker; Barbara Wardas; Houssein Salah; Maryam Amini; Claudia Fecher-Trost; Qiao Sen; Damian Martus; Andreas Beck; Stephan E. Philipp; Veit Flockerzi; Anouar Belkacemi
Diabetes August 2021, Vol.70, 2532-2544. doi:https://doi.org/10.2337/db21-0078
Obesity Studies
GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist–Induced Nausea and Emesis in Preclinical Models
Tito Borner; Caroline E. Geisler; Samantha M. Fortin; Richard Cosgrove; Jorge Alsina-Fernandez; Mridula Dogra; Sarah Doebley; Marcos J. Sanchez-Navarro; Rosa M. Leon; Jane Gaisinsky; Arianna White; Ankur Bamezai; Misgana Y. Ghidewon; Harvey J. Grill; Richard C. Crist; Benjamin C. Reiner; Minrong Ai; Ricardo J. Samms; Bart C. De Jonghe; Matthew R. Hayes
Diabetes August 2021, Vol.70, 2545-2553. doi:https://doi.org/10.2337/db21-0459
Islet Studies
ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
Fiona M. Docherty; Kent A. Riemondy; Roberto Castro-Gutierrez; JaeAnn M. Dwulet; Ali H. Shilleh; Maria S. Hansen; Shane P.M. Williams; Lucas H. Armitage; Katherine E. Santostefano; Mark A. Wallet; Clayton E. Mathews; Taylor M. Triolo; Richard K.P. Benninger; Holger A. Russ
Diabetes August 2021, Vol.70, 2554-2567. doi:https://doi.org/10.2337/db20-0873
H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation
Stephanie A. Campbell; Jocelyn Bégin; Cassandra L. McDonald; Ben Vanderkruk; Tabea L. Stephan; Brad G. Hoffman
Diabetes August 2021, Vol.70, 2568-2579. doi:https://doi.org/10.2337/db20-1214
Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes
Maroof Alam; Anoop Arunagiri; Leena Haataja; Mauricio Torres; Dennis Larkin; John Kappler; Niyun Jin; Peter Arvan
Diabetes August 2021, Vol.70, 2580-2594. doi:https://doi.org/10.2337/db21-0422
Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes
Diabetes August 2021, Vol.70, 2595-2607. doi:https://doi.org/10.2337/db21-0261
OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1
Ramkumar Mohan; Seokwon Jo; Amber Lockridge; Deborah A. Ferrington; Kevin Murray; Arthur Eschenlauer; Ernesto Bernal-Mizrachi; Yoshio Fujitani; Emilyn U. Alejandro
Diabetes August 2021, Vol.70, 2608-2625. doi:https://doi.org/10.2337/db21-0468
β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice
Haopeng Lin; Nancy Smith; Aliya F. Spigelman; Kunimasa Suzuki; Mourad Ferdaoussi; Tamadher A. Alghamdi; Sophie L. Lewandowski; Yaxing Jin; Austin Bautista; Ying Wayne Wang; Jocelyn E. Manning Fox; Matthew J. Merrins; Jean Buteau; Patrick E. MacDonald
Diabetes August 2021, Vol.70, 2626-2638. doi:https://doi.org/10.2337/db20-1235
Pathophysiology
VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy
Bin Wang; Jing-yi Qian; Tao-tao Tang; Li-lu Lin; Nan Yu; Hong-lei Guo; Wei-jie Ni; Ling-Li Lv; Yi Wen; Zuo-Lin Li; Min Wu; Jing-Yuan Cao; Bi-Cheng Liu
Diabetes August 2021, Vol.70, 2639-2651. doi:https://doi.org/10.2337/db21-0205
Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation
Jacqueline M. Ratter-Rieck; Haifa Maalmi; Sandra Trenkamp; Oana-Patricia Zaharia; Wolfgang Rathmann; Nanette C. Schloot; Klaus Straßburger; Julia Szendroedi; Christian Herder; Michael Roden; for the German Diabetes Study (GDS) Group
Diabetes August 2021, Vol.70, 2652-2662. doi:https://doi.org/10.2337/db21-0364
Complications
Effect of Systemic Hypertension on Peripapillary RNFL Thickness in Patients With Diabetes Without Diabetic Retinopathy
Diabetes September 2021, Vol.70, 2663-2667. doi:https://doi.org/10.2337/db21-0491
Pharmacology and Therapeutics
Mineralocorticoid Receptor Pathway and Its Antagonism in a Model of Diabetic Retinopathy
Min Zhao; Emmanuelle Gelize; Rinath Levy; Alexandre Moulin; Frédéric Azan; Marianne Berdugo; Marie-Christine Naud; Justine Guegan; Kimberley Delaunay; Eric Pussard; Patricia Lassiaz; Irene Bravo-Osuna; Rocio Herrero-Vanrell; Francine Behar-Cohen
Diabetes August 2021, Vol.70, 2668-2682. doi:https://doi.org/10.2337/db21-0099
Genetics / Genomes / Proteomics / Metabolomics
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
Roderick C. Slieker; Louise A. Donnelly; Hugo Fitipaldi; Gerard A. Bouland; Giuseppe N. Giordano; Mikael Åkerlund; Mathias J. Gerl; Emma Ahlqvist; Ashfaq Ali; Iulian Dragan; Petra Elders; Andreas Festa; Michael K. Hansen; Amber A. van der Heijden; Dina Mansour Aly; Min Kim; Dmitry Kuznetsov; Florence Mehl; Christian Klose; Kai Simons; Imre Pavo; Timothy J. Pullen; Tommi Suvitaival; Asger Wretlind; Peter Rossing; Valeriya Lyssenko; Cristina Legido Quigley; Leif Groop; Bernard Thorens; Paul W. Franks; Mark Ibberson; Guy A. Rutter; Joline W.J. Beulens; Leen M. ’t Hart; Ewan R. Pearson
Diabetes August 2021, Vol.70, 2683-2693. doi:https://doi.org/10.2337/db20-1281
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
Nicholas Bowker; Robert Hansford; Stephen Burgess; Christopher N. Foley; Victoria P.W. Auyeung; A. Mesut Erzurumluoglu; Isobel D. Stewart; Eleanor Wheeler; Maik Pietzner; Fiona Gribble; Frank Reimann; Pallav Bhatnagar; Matthew P. Coghlan; Nicholas J. Wareham; Claudia Langenberg
Diabetes August 2021, Vol.70, 2706-2719. doi:https://doi.org/10.2337/db21-0103
