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February 2021
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Cover Image
Cover Image
On the cover: Multinucleated giant cells in adipose tissue from obese mice. Image courtesy of Martin Gericke, Institute of Anatomy and Cell Biology, Martin-Luther-University Halle-Wittenberg, Halle, Germany. This image is a version of Fig. 6C in the article “Multinucleated Giant Cells in Adipose Tissue Are Specialized in Adipocyte Degradation,” which appears in this issue of Diabetes (p. 538).
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process. Click here for more information.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders
Diabetes January 2021, Vol.70, 303-312. doi:https://doi.org/10.2337/db20-0884
Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes
Diabetes January 2021, Vol.70, 313-322. doi:https://doi.org/10.2337/dbi20-0026
Commentaries
Adipose Tissue Malfunction Drives Metabolic Dysfunction in Alström Syndrome
Diabetes January 2021, Vol.70, 323-325. doi:https://doi.org/10.2337/dbi20-0041
Staying Connected: Transcriptomics in the Search for Novel Diabetic Kidney Disease Treatments
Diabetes January 2021, Vol.70, 326-327. doi:https://doi.org/10.2337/dbi20-0042
ADA Award Lectures
Epigenetic Mechanisms in Diabetic Vascular Complications and Metabolic Memory: The 2020 Edwin Bierman Award Lecture
Diabetes January 2021, Vol.70, 328-337. doi:https://doi.org/10.2337/dbi20-0030
A Journey in Diabetes: From Clinical Physiology to Novel Therapeutics: The 2020 Banting Medal for Scientific Achievement Lecture
Diabetes January 2021, Vol.70, 338-346. doi:https://doi.org/10.2337/dbi20-0028
Methodology Review
Building Biomimetic Potency Tests for Islet Transplantation
Diabetes January 2021, Vol.70, 347-363. doi:https://doi.org/10.2337/db20-0297
Metabolism
Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance
Tarekegn Geberhiwot; Shanat Baig; Cathy Obringer; Dorothée Girard; Charlotte Dawson; Konstantinos Manolopoulos; Nadia Messaddeq; Pierre Bel Lassen; Karine Clement; Jeremy W. Tomlinson; Richard P. Steeds; Hélène Dollfus; Nikolai Petrovsky; Vincent Marion
Diabetes September 2020, Vol.70, 364-376. doi:https://doi.org/10.2337/db20-0647
Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance
Diabetes October 2020, Vol.70, 377-385. doi:https://doi.org/10.2337/db19-1152
Ablation of AMPK-Related Kinase MPK38/MELK Leads to Male-Specific Obesity in Aged Mature Adult Mice
Diabetes December 2020, Vol.70, 386-399. doi:https://doi.org/10.2337/db20-0436
Obesity Studies
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity
Jessica L. Cote; Lawrence S. Argetsinger; Anabel Flores; Alan C. Rupp; Joel M. Cline; Lauren C. DeSantis; Alexander H. Bedard; Devika P. Bagchi; Paul B. Vander; Abrielle M. Cacciaglia; Erik S. Clutter; Gowri Chandrashekar; Ormond A. MacDougald; Martin G. Myers, Jr.; Christin Carter-Su
Diabetes November 2020, Vol.70, 400-414. doi:https://doi.org/10.2337/db20-0687
CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity
Philippe Zizzari; Rongjun He; Sarah Falk; Luigi Bellocchio; Camille Allard; Samantha Clark; Thierry Lesté-Lasserre; Giovanni Marsicano; Christoffer Clemmensen; Diego Perez-Tilve; Brian Finan; Daniela Cota; Carmelo Quarta
Diabetes November 2020, Vol.70, 415-422. doi:https://doi.org/10.2337/db20-0162
Islet Studies
Acyl-Ghrelin Influences Pancreatic β-Cell Function by Interference with KATP Channels
Diabetes November 2020, Vol.70, 423-435. doi:https://doi.org/10.2337/db20-0231
Pancreatic β-Cell–Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion
Christian H. Burns; Belinda Yau; Anjelica Rodriguez; Jenna Triplett; Drew Maslar; You Sun An; Reini E.N. van der Welle; Ross G. Kossina; Max R. Fisher; Gregory W. Strout; Peter O. Bayguinov; Tineke Veenendaal; David Chitayat; James A.J. Fitzpatrick; Judith Klumperman; Melkam A. Kebede; Cedric S. Asensio
Diabetes November 2020, Vol.70, 436-448. doi:https://doi.org/10.2337/db20-0454
Retinol-Binding Protein 4 Activates STRA6, Provoking Pancreatic β-Cell Dysfunction in Type 2 Diabetes
Diabetes November 2020, Vol.70, 449-463. doi:https://doi.org/10.2337/db19-1241
SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients
Tina Fløyel; Kira Meyerovich; Michala C. Prause; Simranjeet Kaur; Caroline Frørup; Henrik B. Mortensen; Lotte B. Nielsen; Flemming Pociot; Alessandra K. Cardozo; Joachim Størling
Diabetes November 2020, Vol.70, 464-476. doi:https://doi.org/10.2337/db20-0092
Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia
Nadejda Bozadjieva Kramer; Camila Lubaczeuski; Manuel Blandino-Rosano; Grant Barker; George K. Gittes; Alejandro Caicedo; Ernesto Bernal-Mizrachi
Diabetes November 2020, Vol.70, 477-491. doi:https://doi.org/10.2337/db20-0440
Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction
Bas Brouwers; Ilaria Coppola; Katlijn Vints; Bastian Dislich; Nathalie Jouvet; Leentje Van Lommel; Charlotte Segers; Natalia V. Gounko; Lieven Thorrez; Frans Schuit; Stefan F. Lichtenthaler; Jennifer L. Estall; Jeroen Declercq; Bruno Ramos-Molina; John W.M. Creemers
Diabetes December 2020, Vol.70, 492-503. doi:https://doi.org/10.2337/db20-0474
Immunology and Transplantation
TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model
Sha Sha; James A. Pearson; Jian Peng; Youjia Hu; Juan Huang; Yanpeng Xing; Luyao Zhang; Ying Zhu; Hongyu Zhao; F. Susan Wong; Li Chen; Li Wen
Diabetes November 2020, Vol.70, 504-515. doi:https://doi.org/10.2337/db20-0373
Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
Fernanda M.C. Sodré; Samal Bissenova; Ylke Bruggeman; Ronak Tilvawala; Dana P. Cook; Claire Berthault; Santanu Mondal; Aïsha Callebaut; Sylvaine You; Raphael Scharfmann; Roberto Mallone; Paul R. Thompson; Chantal Mathieu; Mijke Buitinga; Lut Overbergh
Diabetes November 2020, Vol.70, 516-528. doi:https://doi.org/10.2337/db20-0421
Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes
Diabetes November 2020, Vol.70, 529-537. doi:https://doi.org/10.2337/db19-1050
Pathophysiology
Multinucleated Giant Cells in Adipose Tissue Are Specialized in Adipocyte Degradation
Julia Braune; Andreas Lindhorst; Janine Fröba; Constance Hobusch; Peter Kovacs; Matthias Blüher; Jens Eilers; Ingo Bechmann; Martin Gericke
Diabetes November 2020, Vol.70, 538-548. doi:https://doi.org/10.2337/db20-0293
CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα
Mohamed A. Zayed; Xiaohua Jin; Chao Yang; Larisa Belaygorod; Connor Engel; Kshitij Desai; Nikolai Harroun; Omar Saffaf; Bruce W. Patterson; Fong-Fu Hsu; Clay F. Semenkovich
Diabetes December 2020, Vol.70, 549-561. doi:https://doi.org/10.2337/db20-0635
Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy
Yan Li; Yu Pan; Shirong Cao; Kensuke Sasaki; Yinqiu Wang; Aolei Niu; Xiaofeng Fan; Suwan Wang; Ming-Zhi Zhang; Raymond C. Harris
Diabetes November 2020, Vol.70, 562-576. doi:https://doi.org/10.2337/db20-0660
A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo
Diabetes December 2020, Vol.70, 577-588. doi:https://doi.org/10.2337/db20-0146
Complications
Connectivity Mapping Identifies BI-2536 as a Potential Drug to Treat Diabetic Kidney Disease
Lu Zhang; Zichen Wang; Ruijie Liu; Zhengzhe Li; Jennifer Lin; Megan L. Wojciechowicz; Jiyi Huang; Kyung Lee; Avi Ma’ayan; John Cijiang He
Diabetes October 2020, Vol.70, 589-602. doi:https://doi.org/10.2337/db20-0580
circRNA_010383 Acts as a Sponge for miR-135a, and Its Downregulated Expression Contributes to Renal Fibrosis in Diabetic Nephropathy
Fenfen Peng; Wangqiu Gong; Shuting Li; Bohui Yin; Chen Zhao; Wenting Liu; Xiaowen Chen; Congwei Luo; Qianying Huang; Ting Chen; Lingzhi Sun; Shun Fang; Weidong Zhou; Zhijian Li; Haibo Long
Diabetes November 2020, Vol.70, 603-615. doi:https://doi.org/10.2337/db20-0203
CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy
Jessy Chen; Thomas Fleming; Sylvia Katz; Matthias Dewenter; Kai Hofmann; Alireza Saadatmand; Mariya Kronlage; Moritz P. Werner; Bianca Pokrandt; Friederike Schreiter; Jihong Lin; Daniel Katz; Jakob Morgenstern; Ahmed Elwakiel; Peter Sinn; Hermann-Josef Gröne; Hans-Peter Hammes; Peter P. Nawroth; Berend Isermann; Carsten Sticht; Britta Brügger; Hugo A. Katus; Marco Hagenmueller; Johannes Backs
Diabetes November 2020, Vol.70, 616-626. doi:https://doi.org/10.2337/db19-0659
Genetics / Genomes / Proteomics / Metabolomics
Polycystic Ovary Syndrome and Risk of Type 2 Diabetes, Coronary Heart Disease, and Stroke
Diabetes November 2020, Vol.70, 627-637. doi:https://doi.org/10.2337/db20-0800
Baseline Assessment of Circulating MicroRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion
Diabetes December 2020, Vol.70, 638-651. doi:https://doi.org/10.2337/db20-0817