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1 March 2021
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Cover Image
Cover Image
On the cover: A confocal micrograph of mouse kidney transplanted with human insulin- (green), glucagon- (red), and somatostatin- (pink) producing islet-derived cells with nuclei stained in blue. Transplantation of in vitro–derived islet-like cell clusters is a standard procedure for functional assessment of insulin-producing cells. Image obtained by Anandwardhan A. Hardikar and Mugdha V. Joglekar, School of Medicine, Western Sydney University, Sydney, Australia.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors
Diabetes February 2021, Vol.70, 653-664. doi:https://doi.org/10.2337/dbi20-0006
Metabolism
Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
Federico Cividini; Brian T. Scott; Jorge Suarez; Darren E. Casteel; Sven Heinz; Anzhi Dai; Tanja Diemer; Jorge A. Suarez; Christopher W. Benner; Majid Ghassemian; Wolfgang H. Dillmann
Diabetes December 2020, Vol.70, 665-679. doi:https://doi.org/10.2337/db20-0779
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance
Regine Å. Jersin; Divya Sri Priyanka Tallapragada; André Madsen; Linn Skartveit; Even Fjære; Adrian McCann; Laurence Lawrence-Archer; Aron Willems; Jan-Inge Bjune; Mona S. Bjune; Villy Våge; Hans Jørgen Nielsen; Håvard Luong Thorsen; Bjørn Gunnar Nedrebø; Christian Busch; Vidar M. Steen; Matthias Blüher; Peter Jacobson; Per-Arne Svensson; Johan Fernø; Mikael Rydén; Peter Arner; Ottar Nygård; Melina Claussnitzer; Ståle Ellingsen; Lise Madsen; Jørn V. Sagen; Gunnar Mellgren; Simon N. Dankel
Diabetes January 2021, Vol.70, 680-695. doi:https://doi.org/10.2337/db20-0096
Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
Diabetes January 2021, Vol.70, 696-709. doi:https://doi.org/10.2337/db20-0954
Signal Transduction
Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance
Diabetes January 2021, Vol.70, 710-719. doi:https://doi.org/10.2337/db20-0181
Obesity Studies
Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet
Antu Antony; Zeqin Lian; Xiaoyuan Dai Perrard; Jerry Perrard; Hua Liu; Aaron R. Cox; Pradip Saha; Lothar Hennighausen; Sean M. Hartig; Christie M. Ballantyne; Huaizhu Wu
Diabetes December 2020, Vol.70, 720-732. doi:https://doi.org/10.2337/db20-0634
Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver
Diabetes December 2020, Vol.70, 733-744. doi:https://doi.org/10.2337/db20-0856
Placental Insulin/IGF-1 Signaling, PGC-1α, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4–6 Years of Age: The ECHO Healthy Start Cohort
Madeline Rose Keleher; Kathryn Erickson; Harry A. Smith; Katerina J. Kechris; Ivana V. Yang; Dana Dabelea; Jacob E. Friedman; Kristen E. Boyle; Thomas Jansson
Diabetes January 2021, Vol.70, 745-751. doi:https://doi.org/10.2337/db20-0902
Immunology and Transplantation
One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24
Diabetes January 2021, Vol.70, 752-758. doi:https://doi.org/10.2337/db20-0908
Complications
Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker–Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19
Sri Nagarjun Batchu; Harmandeep Kaur; Veera Ganesh Yerra; Suzanne L. Advani; M. Golam Kabir; Youan Liu; Thomas Klein; Andrew Advani
Diabetes December 2020, Vol.70, 759-771. doi:https://doi.org/10.2337/db20-0765
Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis
Arpeeta Sharma; Judy S.Y. Choi; Nada Stefanovic; Annas Al-Sharea; Daniel S. Simpson; Nigora Mukhamedova; Karin Jandeleit-Dahm; Andrew J. Murphy; Dmitri Sviridov; James E. Vince; Rebecca H. Ritchie; Judy B. de Haan
Diabetes December 2020, Vol.70, 772-787. doi:https://doi.org/10.2337/db20-0357
Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin
Jianglei Chen; Yan Shao; Temmy Sasore; Gennadiy Moiseyev; Kelu Zhou; Xiang Ma; Yanhong Du; Jian-xing Ma
Diabetes December 2020, Vol.70, 788-799. doi:https://doi.org/10.2337/db20-0609
Pharmacology and Therapeutics
SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial
Katrine M. Lauritsen; Bent R.R. Nielsen; Lars P. Tolbod; Mogens Johannsen; Jakob Hansen; Troels K. Hansen; Henrik Wiggers; Niels Møller; Lars C. Gormsen; Esben Søndergaard
Diabetes December 2020, Vol.70, 800-808. doi:https://doi.org/10.2337/db20-0921
Genetics / Genomes / Proteomics / Metabolomics
Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population
Yumin Ma; Yingying Luo; Siqian Gong; Xianghai Zhou; Yufeng Li; Wei Liu; Simin Zhang; Xiaoling Cai; Qian Ren; Lingli Zhou; Xiuying Zhang; Yanai Wang; Xiuting Huang; Xueying Gao; Mengdie Hu; Xueyao Han; Linong Ji
Diabetes December 2020, Vol.70, 809-816. doi:https://doi.org/10.2337/db20-0564
Errata
Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68:1054–1061
Jenny M. Brown; Jarrad M. Scarlett; Miles E. Matsen; Hong T. Nguyen; Anna Secher; Rasmus Jorgensen; Gregory J. Morton; Michael W. Schwartz
Diabetes December 2020, Vol.70, 817. doi:https://doi.org/10.2337/db21-er03a
Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733–745
Zoi Michailidou; Nicholas M. Morton; José Maria Moreno Navarrete; Christopher C. West; Kenneth J. Stewart; José Manuel Fernández-Real; Christopher J. Schofield; Jonathan R. Seckl; Peter J. Ratcliffe
Diabetes January 2021, Vol.70, 818. doi:https://doi.org/10.2337/db21-er03b
