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1 April 2021
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Cover Image
Cover Image
On the cover: Confocal microscopy of an islet whole-mount from a “naturally protected” 35-week-old NOD mouse, stained with insulin (red) and immune cell marker CD45 (yellow). Image courtesy of Joanne Boldison and F. Susan Wong, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, U.K. Their article, “Natural Protection From Type 1 Diabetes in NOD Mice Is Characterized by a Unique Pancreatic Islet Phenotype,” appears in this issue of Diabetes (p. 955).
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ISSN 0012-1797
EISSN 1939-327X
Editor's Note
Perspectives in Diabetes
Pregnancies in Diabetes and Obesity: The Capacity-Load Model of Placental Adaptation
Diabetes March 2021, Vol.70, 823-830. doi:https://doi.org/10.2337/db20-1111
Uncovering Pathways to Personalized Therapies in Type 1 Diabetes
Diabetes March 2021, Vol.70, 831-841. doi:https://doi.org/10.2337/db20-1185
Technological Advances
Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography
Olof Eriksson; Irina Velikyan; Torsten Haack; Martin Bossart; Andreas Evers; Katrin Lorenz; Iina Laitinen; Philip J. Larsen; Oliver Plettenburg; Lars Johansson; Stefan Pierrou; Michael Wagner
Diabetes February 2021, Vol.70, 842-853. doi:https://doi.org/10.2337/db20-1096
Obesity Studies
Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring
Josefine Jönsson; Kristina M. Renault; Sonia García-Calzón; Alexander Perfilyev; Angela C. Estampador; Kirsten Nørgaard; Mads Vendelbo Lind; Allan Vaag; Line Hjort; Kim F. Michaelsen; Emma Malchau Carlsen; Paul W. Franks; Charlotte Ling
Diabetes January 2021, Vol.70, 854-866. doi:https://doi.org/10.2337/db20-0487
Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure
David M. Presby; Michael C. Rudolph; Vanessa D. Sherk; Matthew R. Jackman; Rebecca M. Foright; Kenneth L. Jones; Julie A. Houck; Ginger C. Johnson; Janine A. Higgins; P. Darrell Neufer; Robert H. Eckel; Paul S. MacLean
Diabetes February 2021, Vol.70, 867-877. doi:https://doi.org/10.2337/db20-0763
Islet Studies
Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets
Manon Jaffredo; Eléonore Bertin; Antoine Pirog; Emilie Puginier; Julien Gaitan; Sandra Oucherif; Fanny Lebreton; Domenico Bosco; Bogdan Catargi; Daniel Cattaert; Sylvie Renaud; Jochen Lang; Matthieu Raoux
Diabetes January 2021, Vol.70, 878-888. doi:https://doi.org/10.2337/db20-0214
Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ
Diabetes February 2021, Vol.70, 889-902. doi:https://doi.org/10.2337/db20-0868
Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice
Kazuno Omori; Akinobu Nakamura; Hideaki Miyoshi; Yuki Yamauchi; Shinichiro Kawata; Kiyohiko Takahashi; Naoyuki Kitao; Hiroshi Nomoto; Hiraku Kameda; Kyu Yong Cho; Yasuo Terauchi; Tatsuya Atsumi
Diabetes February 2021, Vol.70, 917-931. doi:https://doi.org/10.2337/db20-0881
Immunology and Transplantation
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis
MacKenzie D. Williams; Rhonda Bacher; Daniel J. Perry; C. Ramsey Grace; Kieran M. McGrail; Amanda L. Posgai; Andrew Muir; Srikar Chamala; Michael J. Haller; Desmond A. Schatz; Todd M. Brusko; Mark A. Atkinson; Clive H. Wasserfall
Diabetes January 2021, Vol.70, 932-943. doi:https://doi.org/10.2337/db20-0937
Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size
James J. Ross; Clive H. Wasserfall; Rhonda Bacher; Daniel J. Perry; Kieran McGrail; Amanda L. Posgai; Xiaoru Dong; Andrew Muir; Xia Li; Martha Campbell-Thompson; Todd M. Brusko; Desmond A. Schatz; Michael J. Haller; Mark A. Atkinson
Diabetes January 2021, Vol.70, 944-954. doi:https://doi.org/10.2337/db20-0995
Natural Protection From Type 1 Diabetes in NOD Mice Is Characterized by a Unique Pancreatic Islet Phenotype
Diabetes February 2021, Vol.70, 955-965. doi:https://doi.org/10.2337/db20-0945
Pathophysiology
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Daniel Espes; Per-Ola Carlsson; Ram Kumar Selvaraju; Maria Rosestedt; Pierre Cheung; Håkan Ahlström; Olle Korsgren; Olof Eriksson
Diabetes January 2021, Vol.70, 966-975. doi:https://doi.org/10.2337/db20-0776
Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice
Vanessa Mhanna; Gwladys Fourcade; Pierre Barennes; Valentin Quiniou; Hang P. Pham; Paul-Gydeon Ritvo; Faustine Brimaud; Bruno Gouritin; Guillaume Churlaud; Adrien Six; Encarnita Mariotti-Ferrandiz; David Klatzmann
Diabetes January 2021, Vol.70, 976-985. doi:https://doi.org/10.2337/db20-0896
Complications
Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes
Jani Haukka; Niina Sandholm; Erkka Valo; Carol Forsblom; Valma Harjutsalo; Joanne B. Cole; Stuart J. McGurnaghan; Helen M. Colhoun; Per-Henrik Groop; on behalf of the FinnDiane Study Group
Diabetes January 2021, Vol.70, 986-995. doi:https://doi.org/10.2337/db20-0158
Genetics / Genomes / Proteomics / Metabolomics
The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
Shylaja Srinivasan; Ling Chen; Jennifer Todd; Jasmin Divers; Samuel Gidding; Steven Chernausek; Rose A. Gubitosi-Klug; Megan M. Kelsey; Rachana Shah; Mary Helen Black; Lynne E. Wagenknecht; Alisa Manning; Jason Flannick; Giuseppina Imperatore; Josep M. Mercader; Dana Dabelea; Jose C. Florez; on behalf of the ProDiGY Consortium
Diabetes January 2021, Vol.70, 996-1005. doi:https://doi.org/10.2337/db20-0443
Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress
Hossam Montaser; Kashyap A. Patel; Diego Balboa; Hazem Ibrahim; Väinö Lithovius; Anna Näätänen; Vikash Chandra; Korcan Demir; Sezer Acar; Tawfeg Ben-Omran; Kevin Colclough; Jonathan M. Locke; Matthew Wakeling; Maria Lindahl; Andrew T. Hattersley; Jonna Saarimäki-Vire; Timo Otonkoski
Diabetes January 2021, Vol.70, 1006-1018. doi:https://doi.org/10.2337/db20-1174
Erratum
Erratum. Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults. Diabetes 2020;69:181–192
Brittany Begaye; Karyne L. Vinales; Tim Hollstein; Takafumi Ando; Mary Walter; Clifton Bogardus; Jonathan Krakoff; Paolo Piaggi
Diabetes January 2021, Vol.70, 1019. doi:https://doi.org/10.2337/db21-er04a
