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May 2021
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Cover Image
On the cover: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Transmission electron microscopic image of an isolate from the first U.S. case of coronavirus 2019 (COVID-19). The spherical extracellular viral particles contain cross-sections through the viral genome, seen as black dots. Credit: CDC / Science Source.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?
Diabetes February 2021, Vol.70, 1021-1028. doi:https://doi.org/10.2337/dbi20-0045
A Key to T1D Prevention: Screening and Monitoring Relatives as Part of Clinical Care
Diabetes May 2021, Vol.70, 1029-1037. doi:https://doi.org/10.2337/db20-1112
Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
Teresa Rodriguez-Calvo; Yi-Chun Chen; C. Bruce Verchere; Leena Haataja; Peter Arvan; Pia Leete; Sarah J. Richardson; Noel G. Morgan; Wei-Jun Qian; Alberto Pugliese; Mark Atkinson; Carmella Evans-Molina; Emily K. Sims
Diabetes May 2021, Vol.70, 1038-1050. doi:https://doi.org/10.2337/dbi20-0034
Methodology Review
Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research
Diabetes May 2021, Vol.70, 1051-1060. doi:https://doi.org/10.2337/db20-1115
Obesity Studies
Obesity and COVID-19 in Adult Patients With Diabetes
Peihua Cao; Ying Song; Zian Zhuang; Jinjun Ran; Lin Xu; Yan Geng; Lefei Han; Shi Zhao; Jing Qin; Daihai He; Fengfu Wu; Lin Yang
Diabetes February 2021, Vol.70, 1061-1069. doi:https://doi.org/10.2337/db20-0671
Islet Studies
Virgin β-Cells at the Neogenic Niche Proliferate Normally and Mature Slowly
Sharon Lee; Jing Zhang; Supraja Saravanakumar; Marcus F. Flisher; David R. Grimm; Talitha van der Meulen; Mark O. Huising
Diabetes February 2021, Vol.70, 1070-1083. doi:https://doi.org/10.2337/db20-0679
The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation
Xuehua Liang; Hualin Duan; Yahui Mao; Ulrich Koestner; Yiqiu Wei; Feng Deng; Jingshen Zhuang; Huimin Li; Cunchuan Wang; Luis R. Hernandez-Miranda; Weihua Tao; Shiqi Jia
Diabetes February 2021, Vol.70, 1084-1097. doi:https://doi.org/10.2337/db20-0883
Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors
Ayush Midha; Hui Pan; Cristian Abarca; Joshua Andle; Priscila Carapeto; Susan Bonner-Weir; Cristina Aguayo-Mazzucato
Diabetes March 2021, Vol.70, 1098-1116. doi:https://doi.org/10.2337/db20-0553
Single Molecule–Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells
Diabetes March 2021, Vol.70, 1117-1122. doi:https://doi.org/10.2337/db20-0802
Immunology and Transplantation
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Andrea Lin; Jasmine A. Mack; Brittany Bruggeman; Laura M. Jacobsen; Amanda L. Posgai; Clive H. Wasserfall; Todd M. Brusko; Mark A. Atkinson; Stephen E. Gitelman; Peter A. Gottlieb; Matthew J. Gurka; Clayton E. Mathews; Desmond A. Schatz; Michael J. Haller
Diabetes February 2021, Vol.70, 1123-1129. doi:https://doi.org/10.2337/db20-1103
Pathophysiology
Deficits in the Skeletal Muscle Transcriptome and Mitochondrial Coupling in Progressive Diabetes-Induced CKD Relate to Functional Decline
Diabetes February 2021, Vol.70, 1130-1144. doi:https://doi.org/10.2337/db20-0688
The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion
Gregor Sachse; Elizabeth Haythorne; Thomas Hill; Peter Proks; Russell Joynson; Raul Terrón-Expósito; Liz Bentley; Stephen J. Tucker; Roger D. Cox; Frances M. Ashcroft
Diabetes February 2021, Vol.70, 1145-1156. doi:https://doi.org/10.2337/db20-0691
Complications
Cell-Subtype-Specific Remodeling of Intrinsically Photosensitive Retinal Ganglion Cells in Streptozotocin-Induced Diabetic Mice
Wei-Yi Chen; Xu Han; Ling-Jie Cui; Chen-Xi Yu; Wen-Long Sheng; Jun Yu; Fei Yuan; Yong-Mei Zhong; Xiong-Li Yang; Shi-Jun Weng
Diabetes February 2021, Vol.70, 1157-1169. doi:https://doi.org/10.2337/db20-0775
Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing
Hua Qu; Tian Miao; Yuren Wang; Liang Tan; Bangliang Huang; Linlin Zhang; Xiufei Liu; Min Long; Rui Zhang; Xiaoyu Liao; Xiaoli Gong; Ju Wang; Xin Xiong; Junli Liu; Xi Li; Jiang Yu; Gangyi Yang; Zhiming Zhu; Hongting Zheng; Yi Zheng
Diabetes February 2021, Vol.70, 1170-1184. doi:https://doi.org/10.2337/db20-1008
Genetics / Genomes / Proteomics / Metabolomics
Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes
Christian Herder; Haifa Maalmi; Klaus Strassburger; Oana-Patricia Zaharia; Jacqueline M. Ratter; Yanislava Karusheva; Mohamed A. Elhadad; Kálmán Bódis; Brenda W.C. Bongaerts; Wolfgang Rathmann; Sandra Trenkamp; Melanie Waldenberger; Volker Burkart; Julia Szendroedi; Michael Roden; the GDS Group
Diabetes February 2021, Vol.70, 1198-1208. doi:https://doi.org/10.2337/db20-1054
