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July 2021
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On the cover: Transmission electron micrograph of pancreas. Credit: Scott Camazine / Science Source.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions
Diabetes July 2021, Vol.70, 1419-1430. doi:https://doi.org/10.2337/dbi20-0015
Commentary
A Novel Mechanism of Regulation for Exosome Secretion in the Diabetic Kidney
Diabetes July 2021, Vol.70, 1440-1442. doi:https://doi.org/10.2337/dbi21-0015
Metabolism
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
Alexandre Picard; Salima Metref; David Tarussio; Wanda Dolci; Xavier Berney; Sophie Croizier; Gwenaël Labouebe; Bernard Thorens
Diabetes April 2021, Vol.70, 1443-1457. doi:https://doi.org/10.2337/db20-1121
l-Theanine Activates the Browning of White Adipose Tissue Through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-Induced Obesity in Mice
Diabetes April 2021, Vol.70, 1458-1472. doi:https://doi.org/10.2337/db20-1210
Obesity Studies
Brown Adipose Tissue Volume and Fat Content Are Positively Associated With Whole-Body Adiposity in Young Men—Not in Women
Guillermo Sanchez-Delgado; Borja Martinez-Tellez; Francisco M. Acosta; Samuel Virtue; Antonio Vidal-Puig; Angel Gil; Jose M. Llamas-Elvira; Jonatan R. Ruiz
Diabetes April 2021, Vol.70, 1473-1485. doi:https://doi.org/10.2337/db21-0011
Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State
Enrichetta Mileti; Kelvin H.M. Kwok; Daniel P. Andersson; Anthony Mathelier; Amitha Raman; Jesper Bäckdahl; Jutta Jalkanen; Lucas Massier; Anders Thorell; Hui Gao; Peter Arner; Niklas Mejhert; Carsten O. Daub; Mikael Rydén
Diabetes April 2021, Vol.70, 1486-1497. doi:https://doi.org/10.2337/db21-0001
STAT3 but Not ERK2 Is a Crucial Mediator Against Diet-Induced Obesity via VMH Neurons
Gabriel Henrique Marques Gonçalves; Sabrina Mara Tristão; Rafaella Eduarda Volpi; Gislaine Almeida-Pereira; Beatriz de Carvalho Borges; José Donato, Jr.; Margaret de Castro; José Antunes-Rodrigues; Lucila Leico Kagohara Elias
Diabetes April 2021, Vol.70, 1498-1507. doi:https://doi.org/10.2337/db20-0658
Islet Studies
Conversion of α-Cells to β-Cells in the Postpartum Mouse Pancreas Involves Lgr5 Progeny
Uylissa A. Rodriguez; Mairobys Socorro; Angela Criscimanna; Christina P. Martins; Nada Mohamed; Jing Hu; Krishna Prasadan; George K. Gittes; Farzad Esni
Diabetes April 2021, Vol.70, 1508-1518. doi:https://doi.org/10.2337/db20-1059
MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis
Yoshiko Matsumoto Ikushima; Motoharu Awazawa; Naoki Kobayashi; Sho Osonoi; Seiichi Takemiya; Hiroshi Kobayashi; Hirotsugu Suwanai; Yuichi Morimoto; Kotaro Soeda; Jun Adachi; Masafumi Muratani; Jean Charron; Hiroki Mizukami; Noriko Takahashi; Kohjiro Ueki
Diabetes April 2021, Vol.70, 1519-1535. doi:https://doi.org/10.2337/db20-1295
Complications
FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys
Diabetes February 2021, Vol.70, 1536-1548. doi:https://doi.org/10.2337/db20-1108
Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes
Andreia Goncalves; Alyssa Dreffs; Cheng-mao Lin; Sarah Sheskey; Natalie Hudson; Jason Keil; Matthew Campbell; David A. Antonetti
Diabetes April 2021, Vol.70, 1549-1560. doi:https://doi.org/10.2337/db20-1220
Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair
LaTonya J. Hickson; Alfonso Eirin; Sabena M. Conley; Timucin Taner; Xiaohui Bian; Ahmed Saad; Sandra M. Herrmann; Ramila A. Mehta; Travis J. McKenzie; Todd A. Kellogg; James L. Kirkland; Tamar Tchkonia; Ishran M. Saadiq; Hui Tang; Kyra L. Jordan; Xiangyang Zhu; Mathew D. Griffin; Andrew D. Rule; Andre J. van Wijnen; Stephen C. Textor; Lilach O. Lerman
Diabetes April 2021, Vol.70, 1561-1574. doi:https://doi.org/10.2337/db19-1268
Pharmacology and Therapeutics
Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase
Diabetes April 2021, Vol.70, 1575-1580. doi:https://doi.org/10.2337/db20-1143
Genetics / Genomes / Proteomics / Metabolomics
A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures
Arushi Varshney; Yasuhiro Kyono; Venkateswaran Ramamoorthi Elangovan; Collin Wang; Michael R. Erdos; Narisu Narisu; Ricardo D’Oliveira Albanus; Peter Orchard; Michael L. Stitzel; Francis S. Collins; Jacob O. Kitzman; Stephen C.J. Parker
Diabetes April 2021, Vol.70, 1581-1591. doi:https://doi.org/10.2337/db20-1087
Phospholipid Levels at Seroconversion Are Associated With Resolution of Persistent Islet Autoimmunity: The Diabetes Autoimmunity Study in the Young
Patrick M. Carry; Lauren A. Vanderlinden; Randi K. Johnson; Teresa Buckner; Oliver Fiehn; Andrea K. Steck; Katerina Kechris; Ivana Yang; Tasha E. Fingerlin; Marian Rewers; Jill M. Norris
Diabetes April 2021, Vol.70, 1592-1601. doi:https://doi.org/10.2337/db20-1251
