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September 2021
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Cover Image
Cover Image
On the cover: Immunohistochemical staining showing tissue factor expression in the adult mouse heart. Image courtesy of Manvendra K. Singh, Duke-NUS Medical School and National Heart Research Institute, Singapore, and Anamika Singh, Duke–NUS Medical School, Singapore. The article “Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes” appears in this issue of Diabetes (p. 2131).
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
Diabetes September 2021, Vol.70, 1915-1925. doi:https://doi.org/10.2337/dbi20-0046
Commentary
Surplus Ceramides: An Added Twist in the Tale of TREM2 and Insulin Resistance
Diabetes September 2021, Vol.70, 1926-1928. doi:https://doi.org/10.2337/dbi21-0017
Diabetes Symposium
GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders
Diabetes June 2021, Vol.70, 1938-1944. doi:https://doi.org/10.2337/dbi21-0002
Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex
Diabetes June 2021, Vol.70, 1945-1955. doi:https://doi.org/10.2337/dbi21-0003
The Role of GIP in the Regulation of GLP-1 Satiety and Nausea
Diabetes June 2021, Vol.70, 1956-1961. doi:https://doi.org/10.2337/dbi21-0004
Methodology Review
Metabolism
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2
Callie A.S. Corsa; Carolyn M. Walsh; Devika P. Bagchi; Maria C. Foss Freitas; Ziru Li; Julie Hardij; Katrina Granger; Hiroyuki Mori; Rebecca L. Schill; Kenneth T. Lewis; Jessica N. Maung; Ruth D. Azaria; Amy E. Rothberg; Elif A. Oral; Ormond A. MacDougald
Diabetes June 2021, Vol.70, 1970-1984. doi:https://doi.org/10.2337/db20-1001
Insulin Directly Regulates the Circadian Clock in Adipose Tissue
Neta Tuvia; Olga Pivovarova-Ramich; Veronica Murahovschi; Sarah Lück; Astrid Grudziecki; Anne-Catrin Ost; Michael Kruse; Victoria J. Nikiforova; Martin Osterhoff; Pascal Gottmann; Özlem Gögebakan; Carsten Sticht; Norbert Gretz; Michael Schupp; Annette Schürmann; Natalia Rudovich; Andreas F.H. Pfeiffer; Achim Kramer
Diabetes July 2021, Vol.70, 1985-1999. doi:https://doi.org/10.2337/db20-0910
TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue
Cheoljun Choi; Yeonho Son; Jinyoung Kim; Yoon Keun Cho; Abhirup Saha; Minsu Kim; Hyeonyeong Im; Kyungmin Kim; Juhyeong Han; Jung Weon Lee; Je Kyung Seong; Yun-Hee Lee
Diabetes June 2021, Vol.70, 2000-2013. doi:https://doi.org/10.2337/db21-0145
HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis
Neeti Agarwal; Dinakar Iyer; Pradip Saha; Aaron R. Cox; Yan Xia; Netanya S. Utay; Anoma Somasundaram; Ulrich Schubert; Jordan E. Lake; Sean M. Hartig; Ashok Balasubramanyam
Diabetes July 2021, Vol.70, 2014-2025. doi:https://doi.org/10.2337/db20-0888
Signal Transduction
STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity
Anaïs Schaschkow; Lokman Pang; Valerie Vandenbempt; Bernat Elvira; Sara A. Litwak; Beata Vekeriotaite; Elisa Maillard; Marjorie Vermeersch; Flavia M.M. Paula; Michel Pinget; David Perez-Morga; Daniel J. Gough; Esteban N. Gurzov
Diabetes June 2021, Vol.70, 2026-2041. doi:https://doi.org/10.2337/db20-1222
Obesity Studies
Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages
Omar Sharif; Julia Stefanie Brunner; Ana Korosec; Rui Martins; Alexander Jais; Berend Snijder; Andrea Vogel; Michael Caldera; Anastasiya Hladik; Karin Lakovits; Simona Saluzzo; Benedikta Boehm; Anna-Dorothea Gorki; Ildiko Mesteri; Josefine Lindroos-Christensen; Katharina Tillmann; Dagmar Stoiber; Jörg Menche; Gernot Schabbauer; Martin Bilban; Giulio Superti-Furga; Harald Esterbauer; Sylvia Knapp
Diabetes February 2021, Vol.70, 2042-2057. doi:https://doi.org/10.2337/db20-0572
Islet Studies
Immunology and Transplantation
Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota That Protects From Metabolic Diseases
Emelyne Lécuyer; Tiphaine Le Roy; Aurélie Gestin; Amélie Lacombe; Catherine Philippe; Maharajah Ponnaiah; Jean-Baptiste Huré; Magali Fradet; Farid Ichou; Samira Boudebbouze; Thierry Huby; Emmanuel Gautier; Moez Rhimi; Emmanuelle Maguin; Nathalie Kapel; Philippe Gérard; Nicolas Venteclef; Michèle Garlatti; Benoit Chassaing; Philippe Lesnik
Diabetes June 2021, Vol.70, 2067-2080. doi:https://doi.org/10.2337/db20-1177
Pathophysiology
Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome
Diabetes June 2021, Vol.70, 2081-2091. doi:https://doi.org/10.2337/db21-0161
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study
Andrea Tura; Eleonora Grespan; Christian S. Göbl; Robert W. Koivula; Paul W. Franks; Ewan R. Pearson; Mark Walker; Ian M. Forgie; Giuseppe N. Giordano; Imre Pavo; Hartmut Ruetten; Emmanouil T. Dermitzakis; Mark I. McCarthy; Oluf Pedersen; Jochen M. Schwenk; Jerzy Adamski; Federico De Masi; Konstantinos D. Tsirigos; Søren Brunak; Ana Viñuela; Anubha Mahajan; Timothy J. McDonald; Tarja Kokkola; Jagadish Vangipurapu; Henna Cederberg; Markku Laakso; Femke Rutters; Petra J.M. Elders; Anitra D.M. Koopman; Joline W. Beulens; Martin Ridderstråle; Tue H. Hansen; Kristine H. Allin; Torben Hansen; Henrik Vestergaard; Andrea Mari; IMI DIRECT Consortium
Diabetes July 2021, Vol.70, 2092-2106. doi:https://doi.org/10.2337/db21-0227
Complications
Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1
Diabetes June 2021, Vol.70, 2107-2119. doi:https://doi.org/10.2337/db20-0591
LTB4-Driven Inflammation and Increased Expression of ALOX5/ACE2 During Severe COVID-19 in Individuals With Diabetes
Icaro Bonyek-Silva; Antônio Fernando Araújo Machado; Thiago Cerqueira-Silva; Sara Nunes; Márcio Rivison Silva Cruz; Jéssica Silva; Reinan Lima Santos; Aldina Barral; Pablo Rafael Silveira Oliveira; Ricardo Khouri; C. Henrique Serezani; Cláudia Brodskyn; Juliana Ribeiro Caldas; Manoel Barral-Netto; Viviane Boaventura; Natalia Machado Tavares
Diabetes June 2021, Vol.70, 2120-2130. doi:https://doi.org/10.2337/db20-1260
Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes
Dasan Mary Cibi; Reddemma Sandireddy; Hanumakumar Bogireddi; Nicole Tee; Siti Aishah Binte Abdul Ghani; Brijesh K. Singh; Nigel Mackman; Manvendra K. Singh; Anamika Singh
Diabetes June 2021, Vol.70, 2131-2146. doi:https://doi.org/10.2337/db20-0719
Vaccination Against Receptor for Advanced Glycation End Products Attenuates the Progression of Diabetic Kidney Disease
Tatsuhiko Azegami; Takashin Nakayama; Kaori Hayashi; Akihito Hishikawa; Norifumi Yoshimoto; Ran Nakamichi; Hiroshi Itoh
Diabetes June 2021, Vol.70, 2147-2158. doi:https://doi.org/10.2337/db20-1257
Errata
Erratum. NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T-Cell Numbers. Diabetes 2020;69:1749–1762
Andrew P. Trembath; Kelsey L. Krausz; Neekun Sharma; Ivan C. Gerling; Clayton E. Mathews; Mary A. Markiewicz
Diabetes July 2021, Vol.70, 2159. doi:https://doi.org/10.2337/db21-er09a
Issues and Events
e-Letters – Letter to the Editor
A Hundred Years of Insulin Innovation: When Science Meets Technology
Diabetes September 2021, Vol.70, e1-e2. doi:https://doi.org/10.2337/db21-0430
