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October 2022
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Cover Image
On the cover: Transverse section of a bladder wall, whose plasma membranes are so thick that they are impermeable to the toxic urine. Credit: Biophoto Associates/Science Source.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes September 2022, Vol.71, 2065-2066. doi:https://doi.org/10.2337/db22-ti10
Perspectives in Diabetes
Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus
Diabetes September 2022, Vol.71, 2067-2074. doi:https://doi.org/10.2337/db22-0240
Commentary
A Reassessment of the Causal Effects of Dysglycemia on Atherosclerotic and Thrombotic Events
Diabetes September 2022, Vol.71, 2075-2077. doi:https://doi.org/10.2337/dbi22-0012
Profiles in Progress
Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor
Diabetes September 2022, Vol.71, 2078-2083. doi:https://doi.org/10.2337/dbi22-0017
Metabolism
AIFM2 Is Required for High-Intensity Aerobic Exercise in Promoting Glucose Utilization
Hai P. Nguyen; Sneha Damal Villivalam; Byung Chul Jung; Dongjoo You; Frances Lin; Danielle Yi; Anna Pi; Katherine Ma; Sunhee Jung; Sang-Hee Park; Cholsoon Jang; Hei Sook Sul; Sona Kang
Diabetes June 2022, Vol.71, 2084-2093. doi:https://doi.org/10.2337/db21-1114
Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues
Diego Hernández-Saavedra; Christina Markunas; Hirokazu Takahashi; Lisa A. Baer; Johan E. Harris; Michael F. Hirshman; Olga Ilkayeva; Christopher B. Newgard; Kristin I. Stanford; Laurie J. Goodyear
Diabetes July 2022, Vol.71, 2094-2105. doi:https://doi.org/10.2337/db22-0341
Forkhead Box i2 Transcription Factor Regulates Systemic Energy Metabolism Via Neuropeptide AgRP
Yatong Fan; Sufang Sheng; Cunle Guo; Wei Qiao; Yue Jin; Lu Tan; Yong Gao; Lei Zhang; Xi Dong; Jun Zhang; Xiaorong Li; Hui Shen; Yunfei Liao; Yongsheng Chang
Diabetes July 2022, Vol.71, 2106-2122. doi:https://doi.org/10.2337/db22-0002
Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice
Teayoun Kim; Shelly Nason; Jessica Antipenko; Brian Finan; Anath Shalev; Richard DiMarchi; Kirk M. Habegger
Diabetes July 2022, Vol.71, 2123-2135. doi:https://doi.org/10.2337/db21-1018
Obesity Studies
BAF60a Deficiency in Macrophage Promotes Diet-Induced Obesity and Metabolic Inflammation
Qin Kong; Jiahuan Zou; Ziyin Zhang; Ran Pan; Zhe Yu Zhang; Shuang Han; Yanyong Xu; Yue Gao; Zhuo-Xian Meng
Diabetes July 2022, Vol.71, 2136-2152. doi:https://doi.org/10.2337/db22-0114
Pathophysiology
Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis
Sarah C. Nyirjesy; Amy J. Peleckis; Jack N. Eiel; Kathryn Gallagher; Andriana Doliba; Abigail Tami; Anneliese J. Flatt; Diva D. De Leon; Denis Hadjiliadis; Saba Sheikh; Darko Stefanovski; Robert Gallop; David A. D’Alessio; Ronald C. Rubenstein; Andrea Kelly; Michael R. Rickels
Diabetes July 2022, Vol.71, 2153-2165. doi:https://doi.org/10.2337/db22-0399
Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes
Zhenlong Chen; Jacob M. Haus; Lin Chen; Ying Jiang; Maria Sverdlov; Luisa A. DiPietro; Na Xiong; Stephanie C. Wu; Timothy J. Koh; Richard D. Minshall
Diabetes July 2022, Vol.71, 2166-2180. doi:https://doi.org/10.2337/db21-1108
Complications
Topical Aspirin Administration Improves Cutaneous Wound Healing in Diabetic Mice Through a Phenotypic Switch of Wound Macrophages Toward an Anti-inflammatory and Proresolutive Profile Characterized by LXA4 Release
Christophe Dardenne; Marie Salon; Hélène Authier; Etienne Meunier; Mohamad AlaEddine; José Bernad; Marielle Bouschbacher; Lise Lefèvre; Bernard Pipy; Agnès Coste
Diabetes July 2022, Vol.71, 2181-2196. doi:https://doi.org/10.2337/db20-1245
Smooth Muscle Insulin Receptor Deletion Causes Voiding Dysfunction: A Mechanism for Diabetic Bladder Dysfunction
Diabetes July 2022, Vol.71, 2197-2208. doi:https://doi.org/10.2337/db22-0233
Pharmacology and Therapeutics
Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes
Signe Stensen; Lærke S. Gasbjerg; Mette M. Rosenkilde; Tina Vilsbøll; Jens J. Holst; Bolette Hartmann; Mikkel B. Christensen; Filip K. Knop
Diabetes July 2022, Vol.71, 2209-2221. doi:https://doi.org/10.2337/db22-0059
Genetics/Genomes/Proteomics/Metabolomics
Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation
Diabetes May 2022, Vol.71, 2222-2232. doi:https://doi.org/10.2337/db21-0905
