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February 2022
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On the cover: T cell, scanning electron micrograph. Human immune system cells that play a central role in cell-mediated immunity. Credit: David Scharf/Science Source.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives In Diabetes
Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials
Diabetes January 2022, Vol.71, 173-183. doi:https://doi.org/10.2337/dbi20-0049
Metabolism
Metabolic and Metabo-Clinical Signatures of Type 2 Diabetes, Obesity, Retinopathy, and Dyslipidemia
Noha A. Yousri; Karsten Suhre; Esraa Yassin; Alya Al-Shakaki; Amal Robay; Maha Elshafei; Omar Chidiac; Steven C. Hunt; Ronald G. Crystal; Khalid A. Fakhro
Diabetes November 2021, Vol.71, 184-205. doi:https://doi.org/10.2337/db21-0490
Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression
Hanrui Yin; Feixiang Yuan; Fuxin Jiao; Yuguo Niu; Xiaoxue Jiang; Jiali Deng; Yajie Guo; Shanghai Chen; Qiwei Zhai; Cheng Hu; Yiming Li; Feifan Guo
Diabetes November 2021, Vol.71, 206-218. doi:https://doi.org/10.2337/db21-0336
Exercise-Induced Improvement in Insulin-Stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wild-Type AS160
Amy Zheng; Edward B. Arias; Haiyan Wang; Seong Eun Kwak; Xiufang Pan; Dongsheng Duan; Gregory D. Cartee
Diabetes November 2021, Vol.71, 219-232. doi:https://doi.org/10.2337/db21-0601
GRP75 Regulates Mitochondrial-Supercomplex Turnover to Modulate Insulin Sensitivity
Qiongya Zhao; Ting Luo; Feng Gao; Yinxu Fu; Bin Li; Xiaoli Shao; Haifeng Chen; Zhuohua Zhou; Sihan Guo; Lijun Shen; Liqin Jin; Dong Cen; Huaibin Zhou; Jianxin Lyu; Hezhi Fang
Diabetes November 2021, Vol.71, 233-248. doi:https://doi.org/10.2337/db21-0173
Obesity Studies
Withaferin A Promotes White Adipose Browning and Prevents Obesity Through Sympathetic Nerve–Activated Prdm16-FATP1 Axis
Bingbing Guo; Jiarui Liu; Bingwei Wang; Chenyu Zhang; Zhijie Su; Miao Zhao; Lihua Qin; Weiguang Zhang; Ruimao Zheng
Diabetes November 2021, Vol.71, 249-263. doi:https://doi.org/10.2337/db21-0470
Regulatory T Cells Control Effector T Cell Inflammation in Human Prediabetes
Rui Liu; Gabriella H. Pugh; Erin Tevonian; Katherine Thompson; Douglas A. Lauffenburger; Philip A. Kern; Barbara S. Nikolajczyk
Diabetes November 2021, Vol.71, 264-274. doi:https://doi.org/10.2337/db21-0659
Islet Studies
Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Jones K. Ofori; Alexandros Karagiannopoulos; Mototsugu Nagao; Efraim Westholm; Shaima Ramadan; Anna Wendt; Jonathan L.S. Esguerra; Lena Eliasson
Diabetes November 2021, Vol.71, 275-284. doi:https://doi.org/10.2337/db21-0077
Complications
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Zhichao Zhou; Aida Collado; Changyan Sun; Yahor Tratsiakovich; Ali Mahdi; Hanna Winter; Ekaterina Chernogubova; Till Seime; Sampath Narayanan; Tong Jiao; Hong Jin; Michael Alvarsson; Xiaowei Zheng; Jiangning Yang; Ulf Hedin; Sergiu-Bogdan Catrina; Lars Maegdefessel; John Pernow
Diabetes November 2021, Vol.71, 285-297. doi:https://doi.org/10.2337/db21-0093
MG53 E3 Ligase–Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage
Han Feng; Hao Shen; Matthew J. Robeson; Yue-Han Wu; Hong-Kun Wu; Geng-Jia Chen; Shuo Zhang; Peng Xie; Li Jin; Yanyun He; Yingfan Wang; Fengxiang Lv; Xinli Hu; Yan Zhang; Rui-Ping Xiao
Diabetes November 2021, Vol.71, 298-314. doi:https://doi.org/10.2337/db21-0322
Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study
Carolina López-Cano; Andreea Ciudin; Enric Sánchez; Francisco J. Tinahones; Ferran Barbé; Mireia Dalmases; Marta García-Ramírez; Alfonso Soto; Anna Michela Gaeta; Silvia Pellitero; Raquel Martí; Cristina Hernández; Rafael Simó; Albert Lecube
Diabetes November 2021, Vol.71, 315-320. doi:https://doi.org/10.2337/db21-0688
Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells
Yao Xie; Yongli Ji; Yunrui Lu; Yuankun Ma; Hui Ni; Jian Shen; Hong Ma; Chunna Jin; Yuwen Chen; Yan Lin; Meixiang Xiang
Diabetes November 2021, Vol.71, 321-328. doi:https://doi.org/10.2337/db20-1129
Genetics / Genomes / Proteomics / Metabolomics
Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multicohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
Shafqat Ahmad; Ulf Hammar; Beatrice Kennedy; Samira Salihovic; Andrea Ganna; Lars Lind; Johan Sundström; Johan Ärnlöv; Christian Berne; Ulf Risérus; Patrik K.E. Magnusson; Susanna C. Larsson; Tove Fall
Diabetes November 2021, Vol.71, 329-339. doi:https://doi.org/10.2337/db20-1120
Ancestry-Matched and Cross-Ancestry Genetic Risk Scores of Type 2 Diabetes in Pregnant Women and Fetal Growth: A Study in an Ancestrally Diverse Cohort
Diabetes November 2021, Vol.71, 340-349. doi:https://doi.org/10.2337/db21-0655
Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes
Diabetes November 2021, Vol.71, 350-358. doi:https://doi.org/10.2337/db21-0194
An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript
Fernando Riveros-Mckay; David Roberts; Emanuele Di Angelantonio; Bing Yu; Nicole Soranzo; John Danesh; Elizabeth Selvin; Adam S. Butterworth; Inês Barroso
Diabetes November 2021, Vol.71, 359-364. doi:https://doi.org/10.2337/db21-0320