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March 2022
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Cover Image
Cover Image
On the cover: Interactions of insulin (red), anti-insulinic peptide pancreastatin (orange), and a gain-of-function variant of pancreastatin peptide (blue) with the insulin receptor (monomer 1 in gray and monomer 2 in cyan). The pancreastatin peptides share the binding site with insulin in the insulin receptor. Image courtesy of Nitish R. Mahapatra, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India. The article “Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders” appears in this issue of Diabetes, p. 538.
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ISSN 0012-1797
EISSN 1939-327X
Perspectives In Diabetes
ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?
Diabetes February 2022, Vol.71, 367-375. doi:https://doi.org/10.2337/db21-0755
Commentaries
Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival
Diabetes February 2022, Vol.71, 376-378. doi:https://doi.org/10.2337/dbi21-0035
The Need to Increase Clinical Skills and Change the Genetic Testing Strategy for Monogenic Diabetes
Diabetes February 2022, Vol.71, 379-380. doi:https://doi.org/10.2337/dbi21-0037
Obesity Studies
Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans
Ana Elena Espinosa De Ycaza; Esben Søndergaard; Maria Morgan-Bathke; Kelli Lytle; Danae A. Delivanis; Paola Ramos; Barbara Gisella Carranza Leon; Michael D. Jensen
Diabetes December 2021, Vol.71, 381-393. doi:https://doi.org/10.2337/db21-0609
Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway
Qianxing Hu; Jinming Mu; Yuhong Liu; Yue Yang; Yue Liu; Yi Pan; Yanfeng Zhang; Ling Li; Dechen Liu; Jianqiu Chen; Fangfang Zhang; Liang Jin
Diabetes January 2022, Vol.71, 394-411. doi:https://doi.org/10.2337/db21-0134
A Cycle of Inflammatory Adipocyte Death and Regeneration in Murine Adipose Tissue
Akio Monji; Yang Zhang; G.V. Naveen Kumar; Christelle Guillermier; Soomin Kim; Benjamin Olenchock; Matthew L. Steinhauser
Diabetes January 2022, Vol.71, 412-423. doi:https://doi.org/10.2337/db20-1306
Islet Studies
Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway
Jinghe Li; Ryota Inoue; Yu Togashi; Tomoko Okuyama; Aoi Satoh; Mayu Kyohara; Kuniyuki Nishiyama; Takahiro Tsuno; Daisuke Miyashita; Tatsuya Kin; A.M. James Shapiro; Resilind Su Ern Chew; Adrian Kee Keong Teo; Seiichi Oyadomari; Yasuo Terauchi; Jun Shirakawa
Diabetes September 2021, Vol.71, 424-439. doi:https://doi.org/10.2337/db21-0123
The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum
Diabetes December 2021, Vol.71, 440-452. doi:https://doi.org/10.2337/db21-0638
Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy
Tal Israeli; Yael Riahi; Perla Garzon; Ruy Andrade Louzada; Joao Pedro Werneck-de-Castro; Manuel Blandino-Rosano; Roni Yeroslaviz-Stolper; Liat Kadosh; Sharona Tornovsky-Babeay; Gilad Hacker; Nitzan Israeli; Orly Agmon; Boaz Tirosh; Erol Cerasi; Ernesto Bernal-Mizrachi; Gil Leibowitz
Diabetes December 2021, Vol.71, 453-469. doi:https://doi.org/10.2337/db21-0281
Immunology and Transplantation
Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes
Kathryn C.S. Locker; Kritika Kachapati; Yuehong Wu; Kyle J. Bednar; David Adams; Caroline Patel; Hiroki Tsukamoto; Luke S. Heuer; Bruce J. Aronow; Andrew B. Herr; William M. Ridgway
Diabetes January 2022, Vol.71, 470-482. doi:https://doi.org/10.2337/db21-0426
Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse
Braxton L. Jamison; James E. DiLisio; K. Scott Beard; Tobias Neef; Brenda Bradley; Jessica Goodman; Ronald G. Gill; Stephen D. Miller; Rocky L. Baker; Kathryn Haskins
Diabetes January 2022, Vol.71, 483-496. doi:https://doi.org/10.2337/db20-1170
Pathophysiology
Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target
María Garranzo-Asensio; Guillermo Solís-Fernández; Ana Montero-Calle; José Manuel García-Martínez; Maria Carmen Fiuza; Pilar Pallares; Nuria Palacios-Garcia; Custodia García-Jiménez; Ana Guzman-Aranguez; Rodrigo Barderas
Diabetes January 2022, Vol.71, 497-510. doi:https://doi.org/10.2337/db20-1206
Complications
Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes
Guozhi Jiang; Andrea O. Luk; Claudia H.T. Tam; Risa Ozaki; Cadmon K.P. Lim; Elaine Y.K. Chow; Eric S. Lau; Alice P.S. Kong; Baoqi Fan; Hong Kong Diabetes Register TRS Study Group; Ka Fai Lee; Shing Chung Siu; Grace Hui; Chiu Chi Tsang; Kam Piu Lau; Jenny Y. Leung; Man-wo Tsang; Grace Kam; Ip Tim Lau; June K. Li; Vincent T. Yeung; Emmy Lau; Stanley Lo; Samuel Fung; Yuk Lun Cheng; Chun Chung Chow; Hong Kong Diabetes Biobank Study Group; Nelson L.S. Tang; Yu Huang; Hui-yao Lan; Richard A. Oram; Cheuk Chun Szeto; Wing Yee So; Juliana C.N. Chan; Ronald C.W. Ma
Diabetes January 2022, Vol.71, 520-529. doi:https://doi.org/10.2337/db21-0694
Genetics / Genomes / Proteomics / Metabolomics
Syndromic Monogenic Diabetes Genes Should Be Tested in Patients With a Clinical Suspicion of Maturity-Onset Diabetes of the Young
Diabetes November 2021, Vol.71, 530-537. doi:https://doi.org/10.2337/db21-0517
Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders
Prasanna K.R. Allu; Malapaka Kiranmayi; Sromona D. Mukherjee; Venkat R. Chirasani; Richa Garg; Durairajpandian Vishnuprabu; Sudesh Ravi; Lakshmi Subramanian; Bhavani S. Sahu; Dhanya R. Iyer; Sakthisree Maghajothi; Saurabh Sharma; Marimuthu S. Ravi; Madhu Khullar; Arasambattu K. Munirajan; Jiaur R. Gayen; Sanjib Senapati; Ajit S. Mullasari; Viswanathan Mohan; Venkatesan Radha; Sathyamangala V. Naga Prasad; Nitish R. Mahapatra
Diabetes December 2021, Vol.71, 538-553. doi:https://doi.org/10.2337/db21-0289
Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes
Mark J. O’Connor; Philip Schroeder; Alicia Huerta-Chagoya; Paula Cortés-Sánchez; Silvía Bonàs-Guarch; Marta Guindo-Martínez; Joanne B. Cole; Varinderpal Kaur; David Torrents; Kumar Veerapen; Niels Grarup; Mitja Kurki; Carsten F. Rundsten; Oluf Pedersen; Ivan Brandslund; Allan Linneberg; Torben Hansen; Aaron Leong; Jose C. Florez; Josep M. Mercader
Diabetes December 2021, Vol.71, 554-565. doi:https://doi.org/10.2337/db21-0545
Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4+ T Cells That Mark Progression to Type 1 Diabetes
Naiara G. Bediaga; Alexandra L. Garnham; Gaetano Naselli; Esther Bandala-Sanchez; Natalie L. Stone; Joanna Cobb; Jessica E. Harbison; John M. Wentworth; Annette-G. Ziegler; Jennifer J. Couper; Gordon K. Smyth; Leonard C. Harrison
Diabetes January 2022, Vol.71, 566-577. doi:https://doi.org/10.2337/db21-0612
Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations
Cécile Saint-Martin; Delphine Bouvet; Mathilda Bastide; Christine Bellanné-Chantelot; on behalf of the Monogenic Diabetes Study Group of the Société Francophone du Diabète*
Diabetes September 2021, Vol.71, 578-584. doi:https://doi.org/10.2337/db21-0520
