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May 2022
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Cover Image
Cover Image
On the cover: Expression of the Müller cell marker glutamine synthetase was visualized in longitudinal cross sections of mouse eyes by immunofluorescence in green. Nuclei were stained by Hoechst in blue. Transverse extensions of Müller glia were visible across multiple retinal layers. Image courtesy of William P. Miller and Michael D. Dennis, Penn State College of Medicine, Hershey, PA. The article “Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice” appears in this issue of Diabetes (p. 1051).
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process.
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ISSN 0012-1797
EISSN 1939-327X
Technological Advances
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Guangliang Ding; Lian Li; Li Zhang; Michael Chopp; Esmaeil Davoodi-Bojd; Qingjiang Li; Chao Li; Min Wei; Zhenggang Zhang; Quan Jiang
Diabetes February 2022, Vol.71, 873-880. doi:https://doi.org/10.2337/db21-0754
Metabolism
Canagliflozin Prevents Hyperglycemia-Associated Muscle Extracellular Matrix Accumulation and Improves the Adaptive Response to Aerobic Exercise
Tara L. MacDonald; Pattarawan Pattamaprapanont; Eileen M. Cooney; Roberto C. Nava; Joanna Mitri; Samar Hafida; Sarah J. Lessard
Diabetes February 2022, Vol.71, 881-893. doi:https://doi.org/10.2337/db21-0934
Alteration of the Individual Metabolic Network of the Brain Based on Jensen-Shannon Divergence Similarity Estimation in Elderly Patients With Type 2 Diabetes Mellitus
Yu-Lin Li; Jia-Jia Wu; Jie Ma; Si-Si Li; Xin Xue; Dong Wei; Chun-Lei Shan; Xu-Yun Hua; Mou-Xiong Zheng; Jian-Guang Xu
Diabetes February 2022, Vol.71, 894-905. doi:https://doi.org/10.2337/db21-0600
Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle
Jeppe K. Larsen; Magnus R. Larsen; Jesper B. Birk; Dorte E. Steenberg; Janne R. Hingst; Kurt Højlund; Alexandra Chadt; Hadi Al-Hasani; Atul S. Deshmukh; Jørgen F.P. Wojtaszewski; Rasmus Kjøbsted
Diabetes February 2022, Vol.71, 906-920. doi:https://doi.org/10.2337/db21-0855
Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination
Yuguo Niu; Haizhou Jiang; Hanrui Yin; Fenfen Wang; Ronggui Hu; Xiaoming Hu; Bo Peng; Yousheng Shu; Zhigang Li; Shanghai Chen; Feifan Guo
Diabetes February 2022, Vol.71, 921-933. doi:https://doi.org/10.2337/db21-0857
Obesity Studies
Sleep Disturbance and Changes in Energy Intake and Body Composition During Weight Loss in the POUNDS Lost Trial
Ang Li; Xiang Li; Tao Zhou; Hao Ma; Yoriko Heianza; Donald A. Williamson; Steven R. Smith; George A. Bray; Frank M. Sacks; Lu Qi
Diabetes February 2022, Vol.71, 934-944. doi:https://doi.org/10.2337/db21-0699
Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones
Khyati Girdhar; Marion Soto; Qian Huang; Lucie Orliaguet; Carly Cederquist; Bharathi Sundaresh; Jiang Hu; Maximilian Figura; Amol Raisingani; Emanuel E. Canfora; Ercument Dirice; Shiho Fujisaka; Gijs H. Goossens; Ellen E. Blaak; Rohit N. Kulkarni; C. Ronald Kahn; Emrah Altindis
Diabetes February 2022, Vol.71, 945-960. doi:https://doi.org/10.2337/db21-0382
Islet Studies
YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells
Di Liu; Kevin Y. Yang; Vicken W. Chan; Wenchu Ye; Charing C.N. Chong; Chi Chiu Wang; Huating Wang; Bin Zhou; Kenneth K.Y. Cheng; Kathy O. Lui
Diabetes February 2022, Vol.71, 961-977. doi:https://doi.org/10.2337/db21-0695
The Essential Role of Pancreatic α-Cells in Maternal Metabolic Adaptation to Pregnancy
Diabetes February 2022, Vol.71, 978-988. doi:https://doi.org/10.2337/db21-0923
Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation
Sharon Baumel-Alterzon; Liora S. Katz; Gabriel Brill; Clairete Jean-Pierre; Yansui Li; Isabelle Tse; Shyam Biswal; Adolfo Garcia-Ocaña; Donald K. Scott
Diabetes February 2022, Vol.71, 989-1011. doi:https://doi.org/10.2337/db21-0581
Immunology and Transplantation
T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope
Yi Jing; Yuelin Kong; John McGinty; Gabriele Blahnik-Fagan; Thomas Lee; Stephanie Orozco-Figueroa; Matthew L. Bettini; Eddie A. James; Maria Bettini
Diabetes February 2022, Vol.71, 1012-1022. doi:https://doi.org/10.2337/db21-0993
Pathophysiology
Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control
Chisayo Kozuka; Vissarion Efthymiou; Vicencia M. Sales; Liyuan Zhou; Soravis Osataphan; Yixing Yuchi; Jeremy Chimene-Weiss; Christopher Mulla; Elvira Isganaitis; Jessica Desmond; Suzuka Sanechika; Joji Kusuyama; Laurie Goodyear; Xu Shi; Robert E. Gerszten; Cristina Aguayo-Mazzucato; Priscila Carapeto; Silvania DaSilva Teixeira; Darleen Sandoval; Direna Alonso-Curbelo; Lei Wu; Jun Qi; Mary-Elizabeth Patti
Diabetes January 2022, Vol.71, 1023-1033. doi:https://doi.org/10.2337/db21-0574
Complications
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum–Mitochondria Contact and Mitophagy in Diabetic Nephropathy
Chenrui Li; Li Li; Ming Yang; Jinfei Yang; Chanyue Zhao; Yachun Han; Hao Zhao; Na Jiang; Ling Wei; Ying Xiao; Yan Liu; Xiaofen Xiong; Yiyun Xi; Shilu Luo; Fei Deng; Wei Chen; Shuguang Yuan; Xuejing Zhu; Li Xiao; Lin Sun
Diabetes February 2022, Vol.71, 1034-1050. doi:https://doi.org/10.2337/db21-0983
Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice
William P. Miller; Allyson L. Toro; Siddharth Sunilkumar; Shaunaci A. Stevens; Ashley M. VanCleave; David L. Williamson; Alistair J. Barber; Michael D. Dennis
Diabetes February 2022, Vol.71, 1051-1062. doi:https://doi.org/10.2337/db21-0853
N-Hydroxyethyl-1-Deoxynojirimycin (Miglitol) Restores the Counterregulatory Response to Hypoglycemia Following Antecedent Hypoglycemia
Diabetes February 2022, Vol.71, 1063-1072. doi:https://doi.org/10.2337/db21-0859
pdx1 Knockout Leads to a Diabetic Nephropathy– Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage
Lucas M. Wiggenhauser; Lena Metzger; Katrin Bennewitz; Silas Soleymani; Mike Boger; Christoph T. Tabler; Ingrid Hausser; Carsten Sticht; Paulus Wohlfart; Nadine Volk; Elena Heidenreich; Michael Buettner; Hans-Peter Hammes; Jens Kroll
Diabetes January 2022, Vol.71, 1073-1080. doi:https://doi.org/10.2337/db21-0645
Pharmacology and Therapeutics
Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age
Fabiola Marino; Mariangela Scalise; Nadia Salerno; Luca Salerno; Claudia Molinaro; Donato Cappetta; Michele Torella; Marta Greco; Daniela Foti; Ferdinando C. Sasso; Pasquale Mastroroberto; Antonella De Angelis; Georgina M. Ellison-Hughes; Maurilio Sampaolesi; Marcello Rota; Francesco Rossi; Konrad Urbanek; Bernardo Nadal-Ginard; Daniele Torella; Eleonora Cianflone
Diabetes February 2022, Vol.71, 1081-1098. doi:https://doi.org/10.2337/db21-0536
Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization
Lei Zhao; Cheng-Lin Zhang; Lei He; Qinghua Chen; Limei Liu; Lijing Kang; Jian Liu; Jiang-Yun Luo; Lingshan Gou; Dan Qu; Wencong Song; Chi Wai Lau; Ho Ko; Vincent C.T. Mok; Xiao Yu Tian; Li Wang; Yu Huang
Diabetes February 2022, Vol.71, 1099-1114. doi:https://doi.org/10.2337/db21-0660
GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue
Jonathan E. Campbell; Jacqueline L. Beaudry; Berit Svendsen; Laurie L. Baggio; Andrew N. Gordon; John R. Ussher; Chi Kin Wong; Fiona M. Gribble; David A. D’Alessio; Frank Reimann; Daniel J. Drucker
Diabetes February 2022, Vol.71, 1115-1127. doi:https://doi.org/10.2337/db21-1166
Genetics / Genomes / Proteomics / Metabolomics
Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY
Thomas W. Laver; Matthew N. Wakeling; Olivia Knox; Kevin Colclough; Caroline F. Wright; Sian Ellard; Andrew T. Hattersley; Michael N. Weedon; Kashyap A. Patel
Diabetes February 2022, Vol.71, 1128-1136. doi:https://doi.org/10.2337/db21-0844
Systematic Heritability and Heritability Enrichment Analysis for Diabetes Complications in UK Biobank and ACCORD Studies
Juhyun Kim; Aubrey Jensen; Seyoon Ko; Sridharan Raghavan; Lawrence S. Phillips; Adriana Hung; Yan Sun; Hua Zhou; Peter Reaven; Jin J. Zhou
Diabetes February 2022, Vol.71, 1137-1148. doi:https://doi.org/10.2337/db21-0839
Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy
Yashika Rustagi; Ahmed S. Abouhashem; Priyanka Verma; Sumit S. Verma; Edward Hernandez; Sheng Liu; Manishekhar Kumar; Poornachander R. Guda; Rajneesh Srivastava; Sujit K. Mohanty; Sedat Kacar; Sanskruti Mahajan; Kristen E. Wanczyk; Savita Khanna; Michael P. Murphy; Gayle M. Gordillo; Sashwati Roy; Jun Wan; Chandan K. Sen; Kanhaiya Singh
Diabetes February 2022, Vol.71, 1149-1165. doi:https://doi.org/10.2337/db21-0830
