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June 2022
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Cover Image
Cover Image
On the cover: Illustration showing the progress of diabetic neuropathy. On the left is a normal neuron with an adequate blood supply. Blood vessels serving the middle neuron have become diseased, and the neuron is becoming damaged. The neuron on the right has shriveled as the blood vessels have disappeared. Credit: Carol and Mike Werner/Science Source.
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process.
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ISSN 0012-1797
EISSN 1939-327X
Commentary
T-Cell Autoreactivity in Type 2 Diabetes: Benign or Pathogenic, Smoke or Fire?
Diabetes May 2022, Vol.71, 1167-1169. doi:https://doi.org/10.2337/dbi22-0007
Metabolism
Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation
Joji Kusuyama; Nathan S. Makarewicz; Brent G. Albertson; Ana Barbara Alves-Wagner; Royce H. Conlin; Noah B. Prince; Christiano R.R. Alves; Krithika Ramachandran; Chisayo Kozuka; Yang Xiudong; Yang Xia; Michael F. Hirshman; Toshihisa Hatta; Ryoichi Nagatomi; Eva S. Nozik; Laurie J. Goodyear
Diabetes March 2022, Vol.71, 1170-1181. doi:https://doi.org/10.2337/db21-0706
Obesity Studies
Fat Distribution Within the Pancreas According to Diabetes Status and Insulin Traits
Diabetes March 2022, Vol.71, 1182-1192. doi:https://doi.org/10.2337/db21-0976
Impaired Cold-Stimulated Supraclavicular Brown Adipose Tissue Activity in Young Boys With Obesity
Basma A. Ahmed; Nina Varah; Frank J. Ong; Denis P. Blondin; Elizabeth Gunn; Norman B. Konyer; Nina P. Singh; Michael D. Noseworthy; Francois Haman; Andre C. Carpentier; Zubin Punthakee; Gregory R. Steinberg; Katherine M. Morrison
Diabetes March 2022, Vol.71, 1193-1204. doi:https://doi.org/10.2337/db21-0799
p38α Deficiency in T Cells Ameliorates Diet-Induced Obesity, Insulin Resistance, and Adipose Tissue Senescence
Deyun Meng; Baohua Zhang; Yanyan Wang; Tingting Zheng; Ran Hu; Bin Wang; Kinya Otsu; Ying Wang; Gonghua Huang
Diabetes March 2022, Vol.71, 1205-1217. doi:https://doi.org/10.2337/db21-0653
Islet Studies
Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation
Anne-Laure Castell; Alexis Vivoli; Trevor S. Tippetts; Isabelle Robillard Frayne; Zuraya Elisa Angeles; Valentine S. Moullé; Scott A. Campbell; Matthieu Ruiz; Julien Ghislain; Christine Des Rosiers; William L. Holland; Scott A. Summers; Vincent Poitout
Diabetes March 2022, Vol.71, 1218-1232. doi:https://doi.org/10.2337/db21-0640
Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in KATP-Induced Neonatal Diabetes
Zihan Yan; Manuela Fortunato; Zeenat A. Shyr; Amy L. Clark; Matt Fuess; Colin G. Nichols; Maria S. Remedi
Diabetes March 2022, Vol.71, 1233-1245. doi:https://doi.org/10.2337/db21-0992
DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism
Diti Chatterjee Bhowmick; Arianne Aslamy; Supriyo Bhattacharya; Eunjin Oh; Miwon Ahn; Debbie C. Thurmond
Diabetes April 2022, Vol.71, 1246-1260. doi:https://doi.org/10.2337/db21-0681
Pathophysiology
Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study
Barbara Brooks-Worrell; Christiane S. Hampe; Erica G. Hattery; Brenda Palomino; Sahar Z. Zangeneh; Kristina Utzschneider; Steven E. Kahn; Mary E. Larkin; Mary L. Johnson; Kieren J. Mather; Naji Younes; Neda Rasouli; Cyrus Desouza; Robert M. Cohen; Jean Y. Park; Hermes J. Florez; Willy Marcos Valencia; GRADE β-cell Ancillary Study Network; Ali Shojaie; Jerry P. Palmer; Ashok Balasubramanyam; for the GRADE Research Group
Diabetes January 2022, Vol.71, 1261-1271. doi:https://doi.org/10.2337/db21-0590
Complications
Rate-Dependent Depression: A Predictor of the Therapeutic Efficacy in Treating Painful Diabetic Peripheral Neuropathy
Diabetes March 2022, Vol.71, 1272-1281. doi:https://doi.org/10.2337/db21-0960
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways
Jay C. Jha; Aozhi Dai; Jessica Garzarella; Amelia Charlton; Sofia Urner; Jakob A. Østergaard; Jun Okabe; Chet E. Holterman; Alison Skene; David A. Power; Elif I. Ekinci; Melinda T. Coughlan; Harald H.H.W. Schmidt; Mark E. Cooper; Rhian M. Touyz; Chris R. Kennedy; Karin Jandeleit-Dahm
Diabetes March 2022, Vol.71, 1282-1298. doi:https://doi.org/10.2337/db21-1079
The Role of Long Noncoding RNA MALAT1 in Diabetic Polyneuropathy and the Impact of Its Silencing in the Dorsal Root Ganglion by a DNA/RNA Heteroduplex Oligonucleotide
Akiko Miyashita; Masaki Kobayashi; Satoru Ishibashi; Tetsuya Nagata; Ambika Chandrasekhar; Douglas W. Zochodne; Takanori Yokota
Diabetes March 2022, Vol.71, 1299-1312. doi:https://doi.org/10.2337/db21-0918
Blood Neuroexosomal Mitochondrial Proteins Predict Alzheimer Disease in Diabetes
Haiyan Chi; Ran Yao; Chao Sun; Bing Leng; Tengqun Shen; Tong Wang; Shukun Zhang; Mengfan Li; Yachao Yang; Hairong Sun; Zhenguang Li; Jinbiao Zhang
Diabetes March 2022, Vol.71, 1313-1323. doi:https://doi.org/10.2337/db21-0969
Genetics / Genomes / Proteomics / Metabolomics
Serum Metabolomics of Incident Diabetes and Glycemic Changes in a Population With High Diabetes Burden: The Hispanic Community Health Study/Study of Latinos
Jin Choul Chai; Guo-Chong Chen; Bing Yu; Jiaqian Xing; Jun Li; Tasneem Khambaty; Krista M. Perreira; Marisa J. Perera; Denise C. Vidot; Sheila F. Castaneda; Elizabeth Selvin; Casey M. Rebholz; Martha L. Daviglus; Jianwen Cai; Linda Van Horn; Carmen R. Isasi; Qi Sun; Meredith Hawkins; Xiaonan Xue; Eric Boerwinkle; Robert C. Kaplan; Qibin Qi
Diabetes March 2022, Vol.71, 1338-1349. doi:https://doi.org/10.2337/db21-1056
Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 Diabetes
Diabetes March 2022, Vol.71, 1350-1362. doi:https://doi.org/10.2337/db21-0804
Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes
Maria Giovanna Scarale; Mario Mastroianno; Cornelia Prehn; Massimiliano Copetti; Lucia Salvemini; Jerzy Adamski; Salvatore De Cosmo; Vincenzo Trischitta; Claudia Menzaghi
Diabetes March 2022, Vol.71, 1363-1370. doi:https://doi.org/10.2337/db22-0095
Erratum
Erratum. The Women’s Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes 2021;70:1623–1633
Diabetes March 2022, Vol.71, 1371. doi:https://doi.org/10.2337/db22-er06a
