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On the cover: Electron micrograph of a representative pancreas section from 5-week-old mice lacking succinate dehydrogenase subunit B (SDHB) in β-cells. SDHB knockout β-cells exhibited membraned vacuoles that contain engulfed organelles including insulin granules and damaged mitochondria. Image courtesy of Justin P. Annes, Division of Endocrinology, Department of Medicine, and Stanford ChEM-H and Diabetes Research Center, Stanford University, Stanford, California. This image is a version of Fig. 3J in the article by Lee et al., “β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes,” which appears in this issue of Diabetes (p. 1439).

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