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August 2022
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Cover Image
On the cover: Light micrograph of mouse kidney tissue section, confocal. Magnification 300x. Credit: Lauren Piedmont/Science Source.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes August 2022, Vol.71, 1599-1600. doi:https://doi.org/10.2337/db22-ti08
Editor's Note
Perspectives in Diabetes
The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
Diabetes August 2022, Vol.71, 1603-1610. doi:https://doi.org/10.2337/dbi21-0036
Commentaries
Going With the Flow: Pericyte-Regulated Islet Blood Flow Influences Glucose Homeostasis
Diabetes August 2022, Vol.71, 1611-1613. doi:https://doi.org/10.2337/dbi22-0016
The Yin and Yang of Modulating β-Cell DNA Damage Response and Functional Mass
Diabetes August 2022, Vol.71, 1614-1616. doi:https://doi.org/10.2337/dbi22-0010
Metabolomic Markers in Early Pregnancy for Gestational Diabetes Mellitus
Diabetes August 2022, Vol.71, 1620-1622. doi:https://doi.org/10.2337/dbi22-0015
Metabolism
Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney
Elina Akalestou; Livia Lopez-Noriega; Iain R. Tough; Ming Hu; Isabelle Leclerc; Helen M. Cox; Guy A. Rutter
Diabetes August 2022, Vol.71, 1623-1635. doi:https://doi.org/10.2337/db21-0768
The Effect of Glucagon on Protein Catabolism During Insulin Deficiency: Exchange of Amino Acids Across Skeletal Muscle and the Splanchnic Bed
Haleigh James; Wilson I. Gonsalves; Shankarappa Manjunatha; Surendra Dasari; Ian R. Lanza; Katherine A. Klaus; Adrian Vella; James C. Andrews; K. Sreekumaran Nair
Diabetes August 2022, Vol.71, 1636-1648. doi:https://doi.org/10.2337/db22-0079
Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study
Alec B. Chaves; Donghai Zheng; Jonathan A. Johnson; Bryan C. Bergman; Zachary W. Patinkin; Vincent Zaegel; Ericka M. Biagioni; Polina Krassovskaia; Nicholas T. Broskey; Linda E. May; Dana Dabelea; Joseph A. Houmard; Kristen E. Boyle
Diabetes August 2022, Vol.71, 1649-1659. doi:https://doi.org/10.2337/db21-0812
Signal Transduction
Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering
Diabetes August 2022, Vol.71, 1660-1678. doi:https://doi.org/10.2337/db21-0898
Islet Studies
Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
Alejandro Tamayo; Luciana Mateus Gonçalves; Rayner Rodriguez-Diaz; Elizabeth Pereira; Melissa Canales; Alejandro Caicedo; Joana Almaça
Diabetes August 2022, Vol.71, 1679-1693. doi:https://doi.org/10.2337/db21-1104
The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse β-Cells
Flavia Letícia Martins Peçanha; Rami Jaafar; Joao Pedro Werneck-de-Castro; Charalampia-Christina Apostolopolou; Anil Bhushan; Ernesto Bernal-Mizrachi
Diabetes August 2022, Vol.71, 1694-1705. doi:https://doi.org/10.2337/db21-0908
Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization
Selina Wrublewsky; Thimoteus Speer; Lisa Nalbach; Anne S. Boewe; Mandy Pack; Dalia Alansary; Leticia P. Roma; Markus D.A. Hoffmann; Beate M. Schmitt; Andrea Weinzierl; Michael D. Menger; Matthias W. Laschke; Emmanuel Ampofo
Diabetes August 2022, Vol.71, 1706-1720. doi:https://doi.org/10.2337/db21-0851
Immunology and Transplantation
Acceptance of Murine Islet Allografts Without Immunosuppression in Inguinal Subcutaneous White Adipose Tissue Pretreated With bFGF
Yuki Nakafusa; Naoyoshi Nitta; Kazunari Ishii; Naoto Shirasu; Takahiro Iwamoto; Takayuki Nemoto; Masafumi Nakamura; Masafumi Goto; Hiroo Iwata; Masaru Taniguchi; Yohichi Yasunami
Diabetes August 2022, Vol.71, 1721-1734. doi:https://doi.org/10.2337/db21-0684
Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes
Yong Lin; Jelena Perovanovic; Yuelin Kong; Botond Z. Igyarto; Sandra Zurawski; Dean Tantin; Gerard Zurawski; Maria Bettini; Matthew L. Bettini
Diabetes August 2022, Vol.71, 1735-1745. doi:https://doi.org/10.2337/db21-1069
Pathophysiology
MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1α-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation
Woobeen Jo; Min Kim; Jiyoung Oh; Chu-Sook Kim; Chanho Park; Sora Yoon; Changhu Lee; Sahee Kim; Dougu Nam; Jiyoung Park
Diabetes August 2022, Vol.71, 1746-1762. doi:https://doi.org/10.2337/db21-0801
The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions
Giuseppina Biondi; Nicola Marrano; Lucia Dipaola; Anna Borrelli; Martina Rella; Rossella D’Oria; Valentina A. Genchi; Cristina Caccioppoli; Immacolata Porreca; Angelo Cignarelli; Sebastio Perrini; Piero Marchetti; Leonardo Vincenti; Luigi Laviola; Francesco Giorgino; Annalisa Natalicchio
Diabetes August 2022, Vol.71, 1763-1771. doi:https://doi.org/10.2337/db21-1066
Complications
New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination
Diabetes August 2022, Vol.71, 1772-1784. doi:https://doi.org/10.2337/db21-0715
Diabetic Neuropathy in Hands: An Endemic Complication Waiting to Unfold?
Diabetes August 2022, Vol.71, 1785-1794. doi:https://doi.org/10.2337/db21-1147
Plasma apoM Levels and Progression to Kidney Dysfunction in Patients With Type 1 Diabetes
Nathaniel L. Baker; Samar M. Hammad; Kelly J. Hunt; Andrea Semler; Richard L. Klein; Maria F. Lopes-Virella
Diabetes August 2022, Vol.71, 1795-1799. doi:https://doi.org/10.2337/db21-0920
Pharmacology and Therapeutics
Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes
Francesca D’Addio; Gianmarco Sabiu; Vera Usuelli; Emma Assi; Ahmed Abdelsalam; Anna Maestroni; Andy Joe Seelam; Moufida Ben Nasr; Cristian Loretelli; Davide Mileto; Giada Rossi; Ida Pastore; Laura Montefusco; Paola S. Morpurgo; Laura Plebani; Antonio Rossi; Enrica Chebat; Andrea M. Bolla; Maria Elena Lunati; Chiara Mameli; Maddalena Macedoni; Spinello Antinori; Stefano Rusconi; Maurizio Gallieni; Cesare Berra; Franco Folli; Massimo Galli; Maria Rita Gismondo; Gianvincenzo Zuccotti; Paolo Fiorina
Diabetes August 2022, Vol.71, 1800-1806. doi:https://doi.org/10.2337/db22-0053
Genetics/Genomes/Proteomics/Metabolomics
Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study
Yeyi Zhu; Dinesh K. Barupal; Amanda L. Ngo; Charles P. Quesenberry; Juanran Feng; Oliver Fiehn; Assiamira Ferrara
Diabetes August 2022, Vol.71, 1807-1817. doi:https://doi.org/10.2337/db21-1093
Causal Graph Among Serum Lipids and Glycemic Traits: A Mendelian Randomization Study
Diabetes August 2022, Vol.71, 1818-1826. doi:https://doi.org/10.2337/db21-0734
Erratum
Erratum. Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice. Diabetes 2022;71:31–42
Wei Sun; Tao Nie; Kuai Li; Wenjie Wu; Qiaoyun Long; Tianshi Feng; Liufeng Mao; Yuan Gao; Qing Liu; Xuefei Gao; Dewei Ye; Kaixuan Yan; Ping Gu; Yong Xu; Xuemei Zhao; Kang Chen; Kerry Martin Loomes; Shaoqiang Lin; Donghai Wu; Xiaoyan Hui
Diabetes August 2022, Vol.71, 1827. doi:https://doi.org/10.2337/db22-er08a
