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January 2023
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Cover Image
Cover Image
On the cover: The diphenylbutylpiperidine class of drugs has a natural attraction to succinyl CoA:3-ketoacid CoA transferase (SCOT), an essential enzyme in ketone oxidation that is upregulated in type 2 diabetes; the interaction between the two restrains SCOT’s enzymatic activity. The illustration shows a concise synopsis of the article by Tabatabaei Dakhili et al., “The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase,” featured in this issue of Diabetes, p. 126. Image courtesy of Seyed Amirhossein Tabatabaei Dakhili, University of Alberta, Edmonton, Alberta, Canada.
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes December 2022, Vol.72, 1-2. doi:https://doi.org/10.2337/db23-ti01
Perspectives in Diabetes
Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug–Induced Dysglycemia
Diabetes December 2022, Vol.72, 3-15. doi:https://doi.org/10.2337/db22-0522
Commentary
Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy
Diabetes December 2022, Vol.72, 16-18. doi:https://doi.org/10.2337/dbi22-0022
Metabolism
Endothelial-Specific Expression of CIDEC Improves High-Fat Diet–Induced Vascular and Metabolic Dysfunction
Bijinu Balakrishnan; Abhishek Gupta; Rabia Basri; Vishva M. Sharma; Mark Slayton; Kailey Gentner; Chloe C. Becker; Shakun Karki; Harrison Muturi; Sonia M. Najjar; Analia S. Loria; Noyan Gokce; Vishwajeet Puri
Diabetes October 2022, Vol.72, 19-32. doi:https://doi.org/10.2337/db22-0294
Obesity Studies
Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage
Diabetes October 2022, Vol.72, 33-44. doi:https://doi.org/10.2337/db21-1087
Islet Studies
Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation
Alexis Vivoli; Julien Ghislain; Ali Filali-Mouhim; Zuraya Elisa Angeles; Anne-Laure Castell; Robert Sladek; Vincent Poitout
Diabetes October 2022, Vol.72, 45-58. doi:https://doi.org/10.2337/db22-0121
Immunology and Transplantation
Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy
Caleigh Mandel-Brehm; Sara E. Vazquez; Christopher Liverman; Mickie Cheng; Zoe Quandt; Andrew F. Kung; Audrey Parent; Brenda Miao; Emmanuel Disse; Christine Cugnet-Anceau; Stéphane Dalle; Elizaveta Orlova; Elena Frolova; Diana Alba; Aaron Michels; Bergithe E. Oftedal; Michail S. Lionakis; Eystein S. Husebye; Anil K. Agarwal; Xilong Li; Chengsong Zhu; Quan Li; Elif Oral; Rebecca Brown; Mark S. Anderson; Abhimanyu Garg; Joseph L. DeRisi
Diabetes June 2022, Vol.72, 59-70. doi:https://doi.org/10.2337/db21-1172
Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy
Fernando Corvillo; Brent S. Abel; Alberto López-Lera; Giovanni Ceccarini; Silvia Magno; Ferruccio Santini; David Araújo-Vilar; Rebecca J. Brown; Pilar Nozal; Margarita López-Trascasa
Diabetes June 2022, Vol.72, 71-84. doi:https://doi.org/10.2337/db21-1086
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes
Perrin Guyer; David Arribas-Layton; Anthony Manganaro; Cate Speake; Sandra Lord; Decio L. Eizirik; Sally C. Kent; Roberto Mallone; Eddie A. James
Diabetes October 2022, Vol.72, 85-96. doi:https://doi.org/10.2337/db22-0191
Complications
FGF13-Sensitive Alteration of Parkin Safeguards Mitochondrial Homeostasis in Endothelium of Diabetic Nephropathy
Jia Sun; Xueqiang Guan; Chao Niu; Peng Chen; Yuankuan Li; Xuejiao Wang; Lan Luo; Mengxue Liu; Yanni Shou; Xiaozhong Huang; Yan Cai; Junjie Zhu; Junfu Fan; Xiaokun Li; Litai Jin; Weitao Cong
Diabetes October 2022, Vol.72, 97-111. doi:https://doi.org/10.2337/db22-0231
Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes
Diabetes November 2022, Vol.72, 112-125. doi:https://doi.org/10.2337/db22-0194
Pharmacology and Therapeutics
The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase
Seyed Amirhossein Tabatabaei Dakhili; Amanda A. Greenwell; Kunyan Yang; Rabih Abou Farraj; Christina T. Saed; Keshav Gopal; Jordan S.F. Chan; Jadin J. Chahade; Farah Eaton; Crystal Lee; Carlos A. Velázquez-Martínez; Peter A. Crawford; J.N. Mark Glover; Rami Al Batran; John R. Ussher
Diabetes October 2022, Vol.72, 126-134. doi:https://doi.org/10.2337/db22-0221
Genetics / Genomes / Proteomics / Metabolomics
Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats
Thu Hong-Le; Wesley L. Crouse; Gregory R. Keele; Katie Holl; Osborne Seshie; Michael Tschannen; Ann Craddock; Swapan K. Das; Alexandria M. Szalanczy; Bailey McDonald; Michael Grzybowski; Jason Klotz; Neeraj K. Sharma; Aron M. Geurts; Chia-Chi Chuang Key; Gregory Hawkins; William Valdar; Richard Mott; Leah C. Solberg Woods
Diabetes October 2022, Vol.72, 135-148. doi:https://doi.org/10.2337/db22-0252
Causal Associations Between Basal Metabolic Rate and COVID-19
Diabetes October 2022, Vol.72, 149-154. doi:https://doi.org/10.2337/db22-0610
