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October 2023
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Cover Image
Cover Image
On the cover: Isolated mouse islet stained for pyruvate dehydrogenase kinase (PDK) 4 (yellow), glucagon (magenta), insulin (light blue), and nuclear DAPI (dark blue). PDK4 is highly expressed in α-cells and plays a key role in their distinct metabolic phenotype. Image courtesy of Sarah L. Armour and Jakob G. Knudsen, Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. The article “Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells” appears in this issue of Diabetes, p. 1446.
Authors are invited to submit images for use on the cover of Diabetes. Black and white or color photographic or photomicrographic images are acceptable. Cover image submission and selection is completely independent of article submission and the peer-review process.
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes September 2023, Vol.72, 1345-1346. doi:https://doi.org/10.2337/db23-ti10
Commentary
Decoding the Mechanisms Behind Early Weaning–Driven Obesity and the Leucine “Solution”
Diabetes September 2023, Vol.72, 1347-1349. doi:https://doi.org/10.2337/dbi23-0011
Metabolism
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling
Henrik Palmgren; Kasparas Petkevicius; Stefano Bartesaghi; Andrea Ahnmark; Mario Ruiz; Ralf Nilsson; Lars Löfgren; Matthew S. Glover; Anne-Christine Andréasson; Liselotte Andersson; Cécile Becquart; Michael Kurczy; Bengt Kull; Simonetta Wallin; Daniel Karlsson; Sonja Hess; Marcello Maresca; Mohammad Bohlooly-Y; Xiao-Rong Peng; Marc Pilon
Diabetes December 2022, Vol.72, 1350-1363. doi:https://doi.org/10.2337/db22-0293
Diurnal Cycling of Insulin Sensitivity in Type 2 Diabetes: Evidence for Deviation From Physiology at an Early Stage
Paola Lucidi; Gabriele Perriello; Francesca Porcellati; Simone Pampanelli; Michelantonio De Fano; Andrea Tura; Geremia B. Bolli; Carmine G. Fanelli
Diabetes July 2023, Vol.72, 1364-1373. doi:https://doi.org/10.2337/db22-0721
Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons
Kwang Kon Kim; Tae Hwan Lee; Byong Seo Park; Dasol Kang; Dong Hee Kim; Bora Jeong; Jin Woo Kim; Hye Rim Yang; Han Rae Kim; Sungho Jin; Sung Hoon Back; Jeong Woo Park; Jae Geun Kim; Byung Ju Lee
Diabetes July 2023, Vol.72, 1384-1396. doi:https://doi.org/10.2337/db23-0004
AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores
Kohei Kido; Nicolas O. Eskesen; Nicolai S. Henriksen; Johan Onslev; Jonas M. Kristensen; Magnus R. Larsen; Janne R. Hingst; Jonas R. Knudsen; Jesper B. Birk; Nicoline R. Andersen; Thomas E. Jensen; Christian Pehmøller; Jørgen F.P. Wojtaszewski; Rasmus Kjøbsted
Diabetes July 2023, Vol.72, 1397-1408. doi:https://doi.org/10.2337/db23-0358
Obesity Studies
Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats
Diabetes May 2023, Vol.72, 1409-1423. doi:https://doi.org/10.2337/db22-0862
Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss
Diabetes July 2023, Vol.72, 1424-1432. doi:https://doi.org/10.2337/db23-0131
Islet Studies
Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling
Paul Sohn; Madeline R. McLaughlin; Preethi Krishnan; Wenting Wu; Marjan Slak Rupnik; Akira Takasu; Toshiya Senda; Chih-Chun Lee; Tatsuyoshi Kono; Carmella Evans-Molina
Diabetes July 2023, Vol.72, 1433-1445. doi:https://doi.org/10.2337/db22-0988
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells
Sarah L. Armour; Alexander Frueh; Margarita V. Chibalina; Haiqiang Dou; Lidia Argemi-Muntadas; Alexander Hamilton; Georgios Katzilieris-Petras; Peter Carmeliet; Benjamin Davies; Thomas Moritz; Lena Eliasson; Patrik Rorsman; Jakob G. Knudsen
Diabetes July 2023, Vol.72, 1446-1459. doi:https://doi.org/10.2337/db23-0056
Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
Diabetes July 2023, Vol.72, 1460-1469. doi:https://doi.org/10.2337/db23-0256
Immunology and Transplantation
A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes
Gabriele Sassi; Giada Licata; Giuliana Ventriglia; Amber Wouters; Pierre Lemaitre; Ruth Seurinck; Alessia Mori; Giuseppina Emanuela Grieco; Samal Bissenova; Darcy Ellis; Silvia Caluwaerts; Pieter Rottiers; Niels Vandamme; Chantal Mathieu; Francesco Dotta; Conny Gysemans; Guido Sebastiani
Diabetes July 2023, Vol.72, 1470-1482. doi:https://doi.org/10.2337/db22-0852
Pathophysiology
Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes
Martin Schön; Oana P. Zaharia; Klaus Strassburger; Yuliya Kupriyanova; Kálmán Bódis; Geronimo Heilmann; Alexander Strom; Gidon J. Bönhof; Filippo Michelotti; Iryna Yurchenko; Clara Möser; Maximilian Huttasch; Maria Bombrich; Malte Kelm; Volker Burkart; Vera B. Schrauwen-Hinderling; Robert Wagner; Michael Roden; GDS Group
Diabetes July 2023, Vol.72, 1483-1492. doi:https://doi.org/10.2337/db23-0353
Complications
Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes
Asger Wretlind; Viktor R. Curovic; Tommi Suvitaival; Simone Theilade; Nete Tofte; Signe A. Winther; Tina Vilsbøll; Henrik Vestergaard; Peter Rossing; Cristina Legido-Quigley
Diabetes July 2023, Vol.72, 1493-1501. doi:https://doi.org/10.2337/db23-0052
Genetics / Genomes / Proteomics / Metabolomics
Lysine 117 Residue Is Essential for the Function of the Hepatocyte Nuclear Factor 1α
Yuan Chu; Long Zhao; Xian Liu; Hui Chen; Chen Zhao; Sicong Chen; Shensi Xiang; Jun Lu; Xiaofang Wang; Yue Wan; Diandian Dong; Songhui Yao; Changyan Li; Ronghua Yin; Guangming Ren; Xiaoming Yang; Miao Yu
Diabetes July 2023, Vol.72, 1502-1516. doi:https://doi.org/10.2337/db22-0672
