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On the cover: Immunofluorescence image of the pancreatic islet from Pdx1 βKO mice detected with anti-insulin antibody (blue). The EGFP- and RFP-positive cells show the effective knockout of Pdx1 without insulin staining. Image courtesy of Kyosei Ueki, Yuya Nishida, and Hirotaka Watada, Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan. This image is a version of Fig. 6B in the article by Ueki et al., “Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery,” which appears in this issue of Diabetes (p. 1609).

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