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October 2024
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Cover Image
Cover Image
On the cover: Striated muscle. Colored scanning electron micrograph (SEM) of a freeze-fractured mammalian striated, or skeletal, muscle fiber. The striations are due to the muscle fibrils, which run left to right. These are made up of the proteins actin and myosin. Skeletal muscle is under voluntary control and moves long skeletal bones. Credit: Steve Gschmeissner/Science Source. For more information, please visit
https://www.sciencesource.com/2421141-skeletal-muscle-sem-stock-image-rights-managed.html . - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Commentary
The Sensory Neuron–Mast Cell Axis Regulation of Skin Microcirculation in Diabetes: Implication for Diabetes-Related Cutaneous Complications
Diabetes September 2024, Vol.73, 1563-1565. doi:https://doi.org/10.2337/dbi24-0035
Methodology Review
Technological Advances
Autoantibodies to Truncated GAD(96-585) Antigen Stratify Risk of Early Insulin Requirement in Adult-Onset Diabetes
Sian L. Grace; Kathleen M. Gillespie; Claire L. Williams; Vito Lampasona; Peter Achenbach; Ewan R. Pearson; Alistair J.K. Williams; Anna E. Long; Timothy J. McDonald; Angus G. Jones
Diabetes July 2024, Vol.73, 1583-1591. doi:https://doi.org/10.2337/db23-0980
Metabolism
Insulin Regulation of Lysine and α-Aminoadipic Acid Dynamics and Amino Metabolites in Women With and Without Insulin Resistance
Alice Y. Chang; Aneesh K. Asokan; Antigoni Z. Lalia; Dhananjay Sakrikar; Ian R. Lanza; Xuan-Mai Petterson; K. Sreekumaran Nair
Diabetes July 2024, Vol.73, 1592-1604. doi:https://doi.org/10.2337/db23-0977
GLP-1 Receptor Agonist Treatment Improves Fasting and Postprandial Lipidomic Profiles Independently of Diabetes and Weight Loss
Giuseppe Della Pepa; Bárbara G. Patrício; Fabrizia Carli; Silvia Sabatini; Brenno Astiarraga; Ele Ferrannini; Stefania Camastra; Amalia Gastaldelli
Diabetes July 2024, Vol.73, 1605-1614. doi:https://doi.org/10.2337/db23-0972
Identification of BAF60b as a Chromatin-Remodeling Checkpoint of Diet-Induced Fatty Liver Disease
Jing Zhong; Xiuyu Ji; Yali Zhao; Yihe Jia; Churui Song; Jinghuan Lv; Yuying Chen; Yanping Zhou; Xue Lv; Zhuoyin Yang; Zheyu Zhang; Qiyao Xu; Weihong Wang; Haiyan Chen; Aoyuan Cui; Yu Li; Zhuo-Xian Meng
Diabetes July 2024, Vol.73, 1615-1630. doi:https://doi.org/10.2337/db24-0002
A 3-Week Ketogenic Diet Increases Skeletal Muscle Insulin Sensitivity in Individuals With Obesity: A Randomized Controlled Crossover Trial
Thien Vinh Luong; Mette Glavind Bülow Pedersen; Caroline Bruun Abild; Katrine Meyer Lauritsen; Mette Louise Gram Kjærulff; Niels Møller; Lars Christian Gormsen; Esben Søndergaard
Diabetes July 2024, Vol.73, 1631-1640. doi:https://doi.org/10.2337/db24-0162
Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis
Magnus F.G. Grøndahl; Andreas H. Lange; Malte P. Suppli; Jonatan I. Bagger; Mira Thing; Lise L. Gluud; Dea H. Kofod; Mads Hornum; Gerrit van Hall; Samuel A.J. Trammell; Trisha J. Grevengoed; Bolette Hartmann; Jens J. Holst; Tina Vilsbøll; Mikkel B. Christensen; Asger B. Lund; Filip K. Knop
Diabetes July 2024, Vol.73, 1641-1647. doi:https://doi.org/10.2337/db24-0305
Signal Transduction
GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes
Céline Schott; Amélie Germain; Julie Lacombe; Monica Pata; Denis Faubert; Jonathan Boulais; Peter Carmeliet; Jean-François Côté; Mathieu Ferron
Diabetes July 2024, Vol.73, 1648-1661. doi:https://doi.org/10.2337/db23-0802
Islet Studies
Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and Survival
Xin Tong; Mahircan Yagan; Ruiying Hu; Simone Nevills; Teri D. Doss; Roland W. Stein; Appakalai N. Balamurugan; Guoqiang Gu
Diabetes July 2024, Vol.73, 1662-1672. doi:https://doi.org/10.2337/db23-0528
The miR-203/ZBTB20/MAFA Axis Orchestrates Pancreatic β-Cell Maturation and Identity During Weaning and Diabetes
Yating Li; Yuqian Yang; Yi Sun; Lu He; Lin Zhao; Haoran Sun; Xiaoai Chang; Rui Liang; Shusen Wang; Xiao Han; Yunxia Zhu
Diabetes July 2024, Vol.73, 1673-1686. doi:https://doi.org/10.2337/db23-0604
Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function
Jessie M. Barra; Austin T. Kratz; Roberto Castro-Gutierrez; James Proia; Gurprit Bhardwaj; Edward A. Phelps; Holger A. Russ
Diabetes July 2024, Vol.73, 1687-1696. doi:https://doi.org/10.2337/db24-0346
No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data
Elisabetta Manduchi; Hélène C. Descamps; Jonathan Schug; Tong Da; Deeksha Lahori; Hilana El-Mekkoussi; Michael R. Betts; Klaus H. Kaestner
Diabetes July 2024, Vol.73, 1697-1704. doi:https://doi.org/10.2337/db24-0076
Immunology and Transplantation
Temporal Alterations in CD8+ T Cells During the Progression From Stage 1 to Stage 3 Type 1 Diabetes
Anna-Mari Schroderus; Viola Pitkänen; Ilse Ekman; Daniella Stevens; Marja Rytkönen-Nissinen; Reeta Rintamäki; Jussi Pihlajamäki; Mikael Knip; Riitta Veijola; Jorma Toppari; Jorma Ilonen; Johanna Lempainen; Tuure Kinnunen
Diabetes July 2024, Vol.73, 1705-1715. doi:https://doi.org/10.2337/db24-0159
Pathophysiology
Glucagon Resistance in Individuals With Obesity and Hepatic Steatosis Can Be Measured Using the GLUSENTIC Test and Index
Sasha A.S. Kjeldsen; Michael M. Richter; Nicole J. Jensen; Malin S.D. Nilsson; Niklas Heinz; Janus D. Nybing; Frederik H. Linden; Erik Høgh-Schmidt; Mikael P. Boesen; Thomas L. Andersen; Helle H. Johannesen; Samuel A.J. Trammell; Trisha J. Grevengoed; Sten Madsbad; Hendrik Vilstrup; Frank Vinholt Schiødt; Andreas Møller; Elias B. Rashu; Kirsten Nørgaard; Signe Schmidt; Lise L. Gluud; Steen B. Haugaard; Jens J. Holst; Jørgen Rungby; Nicolai J. Wewer Albrechtsen
Diabetes July 2024, Vol.73, 1716-1727. doi:https://doi.org/10.2337/db23-0858
Complications
A Neuron–Mast Cell Axis Regulates Skin Microcirculation in Diabetes
Xinran Li; Dan Yuan; Peng Zhang; Chenglei Luo; Xinyang Xie; Yue Zhang; Zhengqi Wei; Mingyang Wang; Yunqiu Cai; Yi Zeng; Luying Lai; Delu Che; Hao Ling; Shengjun Shi; Hong-Fei Zhang; Fang Wang; Fengxian Li
Diabetes June 2024, Vol.73, 1728-1741. doi:https://doi.org/10.2337/db23-0862
Overexpressed Poldip2 Incurs Retinal Fibrosis via the TGF-β1/SMAD3 Signaling Pathway in Diabetic Retinopathy
Zhiyu Ji; Siyu Lin; Siyu Gui; Jie Gao; Fan Cao; Yiming Guan; Qinyu Ni; Keyang Chen; Liming Tao; Jiang Zhengxuan
Diabetes July 2024, Vol.73, 1742-1755. doi:https://doi.org/10.2337/db23-1036
Regulation of AMPK and GAPDH by Transglutaminase 2 Plays a Pivotal Role in Microvascular Leakage in Diabetic Retinas
Diabetes July 2024, Vol.73, 1756-1766. doi:https://doi.org/10.2337/db23-0885
