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December 2024
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Cover Image
Cover Image
On the cover: Striated muscle. Colored transmission electron micrograph (TEM) of a longitudinal section through striated skeletal muscle. The striated banding pattern of the muscle fibrils is seen. The fibrils run in parallel, and between them runs sarcoplasmic reticulum (SR) (yellow) that transmits nerve impulses to the fibrils. Here, the SR contains many mitochondria (blue). Within each fibril are contractile units called sarcomeres. A sarcomere has protein filaments of myosin and actin that slide over each other, thereby causing the whole muscle to contract. Skeletal muscle is responsible for voluntary muscle movement in the body. Credit: Steve Gschmeissner/Science Source. For more infomation, see
https://www.sciencesource.com/2247359-striated-muscle-tem-stock-image-rights-managed.html. - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Diabetes Symposium
NMDA Receptors in POMC Neurons Connect Exercise With Insulin Sensitivity
Bryan Portillo; Eunsang Hwang; Jason Ajwani; Kyle Grose; Linh Lieu; Briana Wallace; Anita Kabahizi; Joel K. Elmquist; Kevin W. Williams
Diabetes October 2024, Vol.73, 1942-1951. doi:https://doi.org/10.2337/dbi24-0002
One Nervous System: Critical Links Between Central and Peripheral Nervous System Health and Implications for Obesity and Diabetes
Diabetes October 2024, Vol.73, 1967-1975. doi:https://doi.org/10.2337/dbi24-0004
Metabolism
CRTC1 in Mc4r-Expressing Cells Is Required for Peripheral Metabolism and Systemic Energy Homeostasis
Haruka Miyamori; Takumi Yokokawa; Motoki Miyakita; Kazuki Ozaki; Tsuyoshi Goto; Kazuo Inoue; Shigenobu Matsumura
Diabetes September 2024, Vol.73, 1976-1989. doi:https://doi.org/10.2337/db24-0014
Deficiency of the Hemoglobin-Haptoglobin Receptor, CD163, Worsens Insulin Sensitivity in Obese Male Mice
Diabetes September 2024, Vol.73, 1990-2002. doi:https://doi.org/10.2337/db24-0405
Single Dose of Phosphatidylinositol 3-Kinase Inhibitor Alpelisib Induces Insulin Resistance in Healthy Adults: A Randomized Feasibility Study
Joshua R. Cook; Nur Bedeir; Zachary D. Sone; Julia Wattacheril; Henry N. Ginsberg; Blandine Laferrère
Diabetes September 2024, Vol.73, 2003-2008. doi:https://doi.org/10.2337/db24-0402
Obesity Studies
Extracellular Cleavage of Microglia-Derived Progranulin Promotes Diet-Induced Obesity
Chae Beom Park; Chan Hee Lee; Kae Won Cho; Sunghun Shin; Won Hee Jang; Junyeong Byeon; Yu Rim Oh; Sung Jun Kim; Jae Woo Park; Gil Myoung Kang; Se Hee Min; Seyun Kim; Rina Yu; Min-Seon Kim
Diabetes September 2024, Vol.73, 2009-2021. doi:https://doi.org/10.2337/db24-0097
Islet Studies
Selective Reduction of Ca2+-Independent Phospholipase A2β (iPLA2β)-Derived Lipid Signaling From Macrophages Mitigates Type 1 Diabetes Development
Abdulaziz Almutairi; Tayleur D. White; Daniel J. Stephenson; Benjamin D. Stephenson; Ying Gai-Tusing; Paran Goel; Daniel W. Phillips; Robert S. Welner; Xiaoyong Lei; Bruce D. Hammock; Charles E. Chalfant; Sasanka Ramanadham
Diabetes September 2024, Vol.73, 2022-2033. doi:https://doi.org/10.2337/db23-0770
Role of Sec61α2 Translocon in Insulin Biosynthesis
Xiaoxi Xu; Thomas W. Bell; Truc Le; Ivy Zhao; Emily Walker; Yiqing Wang; Ning Xu; Scott A. Soleimanpour; Holger A. Russ; Ling Qi; Billy Tsai; Ming Liu; Peter Arvan
Diabetes September 2024, Vol.73, 2034-2044. doi:https://doi.org/10.2337/db24-0115
Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content
Nicholas Norris; Belinda Yau; Carlo Famularo; Hayley Webster; Thomas Loudovaris; Helen E. Thomas; Mark Larance; Alistair M. Senior; Melkam A. Kebede
Diabetes September 2024, Vol.73, 2045-2054. doi:https://doi.org/10.2337/db24-0355
Pathophysiology
Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes
Max C. Petersen; Mihoko Yoshino; Gordon I. Smith; Rafael C. Gaspar; Mario Kahn; Dmitri Samovski; Gerald I. Shulman; Samuel Klein
Diabetes September 2024, Vol.73, 2055-2064. doi:https://doi.org/10.2337/db24-0083
Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling
Lucas K. Debarba; Hashan S.M. Jayarathne; Lukas Stilgenbauer; Ana L. Terra dos Santos; Lisa Koshko; Sydney Scofield; Ryan Sullivan; Abhijit Mandal; Ulrike Klueh; Marianna Sadagurski
Diabetes September 2024, Vol.73, 2065-2077. doi:https://doi.org/10.2337/db24-0110
Glucagon Stimulation Test and Insulin Secretory Capacity in the Clinical Assessment of Incretin-Based Therapy for Diabetes
Takuya Haraguchi; Yuji Yamazaki; Hitoshi Kuwata; Ryota Usui; Yoshiyuki Hamamoto; Yutaka Seino; Daisuke Yabe; Yuichiro Yamada
Diabetes August 2024, Vol.73, 2078-2083. doi:https://doi.org/10.2337/db24-0518
Genetics / Genomes / Proteomics / Metabolomics
Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits
Nellie Y. Loh; Daniel B. Rosoff; Rebecca Richmond; Raymond Noordam; George Davey Smith; David Ray; Fredrik Karpe; Falk W. Lohoff; Constantinos Christodoulides
Diabetes September 2024, Vol.73, 2084-2094. doi:https://doi.org/10.2337/db24-0168
Erratum
Erratum. 189-OR: Food Insecurity and Inability to Obtain Recommended Medications, Diabetes Technology, and Multidisciplinary Services in Youth and Young Adults with Diabetes. Diabetes 2024;73(Suppl. 1):189-OR
Angela D. Liese; Emmanuel F. Julceus; Caroline Rudisill; Faisal Malik; Kate Flory; Edward A. Frongillo; Katherine A. Sauder; Jason A. Mendoza
Diabetes August 2024, Vol.73, 2095. doi:https://doi.org/10.2337/db24-er12b
