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August 2024
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Cover Image
Cover Image
On the cover: Inbal Caspi, of Weill Cornell Medicine and Sloan Kettering Institute, New York, NY, conceived the design. The image was generated using Microsoft Copilot based on the following prompt: “a ball of pancreatic islet cells with imaginary blood vessels (looking like highways) with trucks of glucose going in and trucks of insulin going out, and colorful beta cells.” Further modification was made by Rotem Ben Yehuda. The article “Glucose Transporters Are Key Components of the Human Glucostat” appears in this issue of Diabetes (p.
1336 ). - PDF Icon PDF LinkTable of Contents
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ISSN 0012-1797
EISSN 1939-327X
Metabolism
TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance
Diabetes February 2024, Vol.73, 1199-1214. doi:https://doi.org/10.2337/db23-0195
Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices
Ibrahim Choucair; Deepthi P. Mallela; James R. Hilser; Jaana A. Hartiala; Ina Nemet; Valentin Gogonea; Lin Li; Aldons J. Lusis; Michael A. Fischbach; W.H. Wilson Tang; Hooman Allayee; Stanley L. Hazen
Diabetes May 2024, Vol.73, 1215-1228. doi:https://doi.org/10.2337/db23-0676
Signal Transduction
Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis
Kakali Ghoshal; James M. Luther; Suman B. Pakala; Sergei Chetyrkin; John R. Falck; Roy Zent; David H. Wasserman; Ambra Pozzi
Diabetes May 2024, Vol.73, 1229-1243. doi:https://doi.org/10.2337/db23-0493
Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet–Fed Mouse Model of Diet-Induced Obesity
Cole Fisher; Kayla Johnson; Madelyn Moore; Amir Sadrati; Jody L. Janecek; Melanie L. Graham; Amanda H. Klein
Diabetes May 2024, Vol.73, 1244-1254. doi:https://doi.org/10.2337/db23-1030
Islet Studies
Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model
Manon Jaffredo; Nicole A.J. Krentz; Benoite Champon; Claire E. Duff; Sameena Nawaz; Nicola Beer; Christian Honore; Anne Clark; Patrik Rorsman; Jochen Lang; Anna L. Gloyn; Matthieu Raoux; Benoit Hastoy
Diabetes May 2024, Vol.73, 1255-1265. doi:https://doi.org/10.2337/db23-0776
Pathophysiology
Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People With Metabolically Abnormal Obesity
Karen C. Shen; Kelsey H. Collins; Jeremie L.A. Ferey; Alan Fappi; Jeremy J. McCormick; Bettina Mittendorfer; Farshid Guilak; Gretchen A. Meyer
Diabetes May 2024, Vol.73, 1266-1277. doi:https://doi.org/10.2337/db23-0991
Complications
Quantitative Imaging Reveals Steatosis and Fibroinflammation in Multiple Organs in People With Type 2 Diabetes: A Real-World Study
Charlie Diamond; Michele Pansini; Azlinda Hamid; Nicole Eichert; Prashant Pandya; Sarah N. Ali; Graham J. Kemp; Gaya Thanabalasingham; Helena Thomaides Brears; Daniel J. Cuthbertson
Diabetes May 2024, Vol.73, 1285-1299. doi:https://doi.org/10.2337/db23-0926
Heparanase Stimulation of Physiologic Cardiac Hypertrophy Is Suppressed After Chronic Diabetes, Resulting in Cardiac Remodeling and Dysfunction
Chae Syng Lee; Rui Shang; Fulong Wang; Parisa Khayambashi; Hualin Wang; Gala Araujo; Karanjit Puri; Israel Vlodavsky; Bahira Hussein; Brian Rodrigues
Diabetes May 2024, Vol.73, 1300-1316. doi:https://doi.org/10.2337/db24-0217
Reduced Thalamic γ-Aminobutyric Acid (GABA) in Painless but Not Painful Diabetic Peripheral Neuropathy
Pallai Shillo; Gordon Sloan; Dinesh Selvarajah; Marni Greig; Rajiv Gandhi; Praveen Anand; Richard A. Edden; Iain D. Wilkinson; Solomon Tesfaye
Diabetes May 2024, Vol.73, 1317-1324. doi:https://doi.org/10.2337/db23-0921
Pharmacology and Therapeutics
Bioengineered Artificial Extracellular Vesicles Presenting PD-L1 and Gal-9 Ameliorate New-Onset Type 1 Diabetes
Zhaoxin Yang; Zhirang Zhang; Liyan Li; Zhangyan Jing; Yumeng Ma; Tianyu Lan; Yuan Li; Zhongda Lin; Wenli Fang; Jinxie Zhang; Jinling Zhang; Xin Liang; Benqing Wu; Yi Zheng; Xudong Zhang
Diabetes May 2024, Vol.73, 1325-1335. doi:https://doi.org/10.2337/db23-0987
Genetics / Genomes / Proteomics / Metabolomics
Glucose Transporters Are Key Components of the Human Glucostat
Inbal Caspi; Daniel M. Tremmel; Julian Pulecio; Dapeng Yang; Dingyu Liu; Jielin Yan; Jon S. Odorico; Danwei Huangfu
Diabetes May 2024, Vol.73, 1336-1351. doi:https://doi.org/10.2337/db23-0508
Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes
Liana K. Billings; Kathleen A. Jablonski; Qing Pan; Jose C. Florez; Paul W. Franks; Ronald B. Goldberg; Marie-France Hivert; Steven E. Kahn; William C. Knowler; Christine G. Lee; Jordi Merino; Alicia Huerta-Chagoya; Josep M. Mercader; Sridharan Raghavan; Zhuqing Shi; Shylaja Srinivasan; Jianfeng Xu; Miriam S. Udler
Diabetes May 2024, Vol.73, 1352-1360. doi:https://doi.org/10.2337/db23-0761
An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians
Sascha Heinitz; Michael Traurig; Jonathan Krakoff; Philipp Rabe; Claudia Stäubert; Sayuko Kobes; Robert L. Hanson; Michael Stumvoll; Matthias Blüher; Clifton Bogardus; Leslie Baier; Paolo Piaggi
Diabetes May 2024, Vol.73, 1361-1371. doi:https://doi.org/10.2337/db23-0690
