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March 2025
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Cover Image
Cover Image
On the cover: Modified version of an illustration published in Women in Science: 50 Fearless Pioneers Who Changed the World by Rachel Ignotofsky (Penguin Random House, 2016). For a detailed profile of Rosalyn Yalow, see Pioneers of Progress, p.
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ISSN 0012-1797
EISSN 1939-327X
Diabetes Spotlight
Diabetes Spotlight: Lisa Chow, MD, MS: Quantifiable Lifestyle Changes to Improve Diabetes Outcomes
Diabetes February 2025, Vol.74, 251. doi:https://doi.org/10.2337/dbi24-0056
Classics in Diabetes
Development of the Insulin Radioimmunoassay, the Watershed Moment in Diabetes Research: Revisiting 1960 Diabetes Classics by Berson and Yalow
Diabetes February 2025, Vol.74, 252-254. doi:https://doi.org/10.2337/dbi24-0055
Perspectives in Diabetes
Stopping the Intergenerational Risk of Diabetes—From Mechanisms to Interventions: A Report on Research Supported by Pathway to Stop Diabetes
Diabetes November 2024, Vol.74, 255-264. doi:https://doi.org/10.2337/dbi24-0014
Commentary
Targeting REDD1 in Podocytes: A Promising Strategy for Mitigating Diabetic Kidney Injury
Diabetes February 2025, Vol.74, 265-267. doi:https://doi.org/10.2337/dbi24-0042
Pioneers of Progress
Pioneers of Progress: Rosalyn Yalow (1921–2011): Radioimmunoassay and the Promise of the Nuclear Age
Diabetes February 2025, Vol.74, 268-269. doi:https://doi.org/10.2337/dbi24-0052
Metabolism
Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors
Hannah L. Waterman; Mary Courtney Moore; Marta S. Smith; Ben Farmer; Kalisha Yankey; Melanie Scott; Dale S. Edgerton; Alan D. Cherrington
Diabetes November 2024, Vol.74, 270-281. doi:https://doi.org/10.2337/db24-0786
Ablation of FAM210A in Brown Adipocytes of Mice Exacerbates High-Fat Diet–Induced Metabolic Dysfunction
Jiamin Qiu; Mennatallah A. Khedr; Meijin Pan; Christina R. Ferreira; Jingjuan Chen; Madigan M. Snyder; Kolapo M. Ajuwon; Feng Yue; Shihuan Kuang
Diabetes November 2024, Vol.74, 282-294. doi:https://doi.org/10.2337/db24-0294
Obesity Studies
Blocking Adipocyte YY1 Decouples Thermogenesis From Beneficial Metabolism by Promoting Spermidine Production
Chen Qiu; Yu Lu; Suyang Wu; Wenli Guo; Jiahao Ni; Jiyuan Song; Zichao Liu; Xiaoai Chang; Kai Wang; Peng Sun; Qian Zhang; Shufang Yang; Kai Li
Diabetes December 2024, Vol.74, 295-307. doi:https://doi.org/10.2337/db24-0501
Adipose Tissue Biology and Effect of Weight Loss in Women With Lipedema
Vincenza Cifarelli; Gordon I. Smith; Silvia Gonzalez-Nieves; Dmitri Samovski; Hector H. Palacios; Jun Yoshino; Richard I. Stein; Anja Fuchs; Thomas F. Wright; Samuel Klein
Diabetes December 2024, Vol.74, 308-319. doi:https://doi.org/10.2337/db24-0890
Phenotypic Versus Genetic Mismatch of BMI and Type 2 Diabetes: Evidence From Two Prospective Cohort Studies
Aolin Li; Shuo Gong; Canqing Yu; Pei Pei; Ling Yang; Iona Y. Millwood; Robin G. Walters; Yiping Chen; Huaidong Du; Xiaoming Yang; Wei Hou; Junshi Chen; Zhengming Chen; Jun Lv; Liming Li; Dianjianyi Sun; China Kadoorie Biobank Collaborative Group
Diabetes December 2024, Vol.74, 320-331. doi:https://doi.org/10.2337/db24-0736
Islet Studies
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets
Eric L. Waite; Mark Tigue; Ming Yu; Deeksha Lahori; Kai Kelly; Catherine Lee May; Ali Naji; Jeffrey Roman; Nicolai Doliba; Dana Avrahami; Kim-Vy Nguyen-Ngoc; Maike Sander; Benjamin Glaser; Klaus H. Kaestner
Diabetes November 2024, Vol.74, 332-342. doi:https://doi.org/10.2337/db23-0887
Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays
Anne Gresch; Jana Osthues; Jan D. Hüwel; Jennifer K. Briggs; Tim Berger; Ruben Koch; Thomas Deickert; Christian Beecks; Richard K.P. Benninger; Martina Düfer
Diabetes November 2024, Vol.74, 343-354. doi:https://doi.org/10.2337/db23-0870
SARS-CoV-2 Spike S1 Subunit Triggers Pericyte and Microvascular Dysfunction in Human Pancreatic Islets
Catarina Andrade Barboza; Luciana Mateus Gonçalves; Elizabeth Pereira; Roxana Diaz Cruz; Ruy Andrade Louzada; Maria Boulina; Joana Almaça
Diabetes December 2024, Vol.74, 355-367. doi:https://doi.org/10.2337/db24-0816
Imaging Human Pancreatic Endocrinogenesis During Early Prenatal Life
Adrian Villalba; Yorick Gitton; Virginie Aiello; Maryne Toupin; Séverine Mazaud-Guittot; Alain Chédotal; Raphaël Scharfmann
Diabetes November 2024, Vol.74, 368-375. doi:https://doi.org/10.2337/db24-0641
Loss of β-Cell KATP Reduces Ca2+ Sensitivity of Insulin Secretion and Trpm5 Expression
Nathaniel W. York; Zihan Yan; Anna B. Osipovich; Abbie Tate; Sumit Patel; David W. Piston; Mark A. Magnuson; Maria S. Remedi; Colin G. Nichols
Diabetes December 2024, Vol.74, 376-383. doi:https://doi.org/10.2337/db24-0650
Immunology and Transplantation
Preclinical Development of a Tolerogenic Peptide From Glutamate Decarboxylase as a Candidate for Antigen-Specific Immunotherapy in Type 1 Diabetes
Sky T.H. Ng; Michael J. Price; Naomi Richardson; Maher Nawaf; Alastair Copland; Heather B. Streeter; Parth Narendran; David C. Wraith
Diabetes November 2024, Vol.74, 384-397. doi:https://doi.org/10.2337/db23-0996
Complications
Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia
Siddharth Sunilkumar; Esma I. Yerlikaya; Allyson L. Toro; Han Chen; Yandong Zhou; Donald L. Gill; Scot R. Kimball; Michael D. Dennis
Diabetes September 2024, Vol.74, 398-408. doi:https://doi.org/10.2337/db24-0533
Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy
Keiichi Nishikawa; Tomoaki Murakami; Miyo Yoshida; Noriko Terada; Kenji Ishihara; Yuki Mori; Shinji Ito; Akitaka Tsujikawa
Diabetes December 2024, Vol.74, 409-415. doi:https://doi.org/10.2337/db24-0040
Genetics / Genomes / Proteomics / Metabolomics
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
Charlie G.Y. Lim; Bige Ozkan; Yujian Liang; Jingsha Chen; Jiali Yao; Nang Ei Ei Khaing; Mary R. Rooney; Chiadi E. Ndumele; E Shyong Tai; Josef Coresh; Xueling Sim; Rob M. van Dam
Diabetes December 2024, Vol.74, 416-426. doi:https://doi.org/10.2337/db24-0184
Gain of Function NOTCH3 Variants Cause Familial Partial Lipodystrophy Due to Activation of Senescence Pathways
Abhimanyu Garg; Chao Xing; Anil K. Agarwal; Aundrea K. Westfall; Diana R. Tomchick; Xunzhi Zhang; Michelle Xing; Rebecca J. Brown
Diabetes December 2024, Vol.74, 427-438. doi:https://doi.org/10.2337/db24-0624
Blood-Based Epigenetic Biomarkers Associated With Incident Chronic Kidney Disease in Individuals With Type 2 Diabetes
Marian Marchiori; Alice Maguolo; Alexander Perfilyev; Marlena Maziarz; Mats Martinell; Maria F. Gomez; Emma Ahlqvist; Sonia García-Calzón; Charlotte Ling
Diabetes December 2024, Vol.74, 439-450. doi:https://doi.org/10.2337/db24-0483
Issues and Events
e-Letters – Comments and Responses
Response to Comment on Manduchi et al. No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data. Diabetes 2024;73:1697–1704
Elisabetta Manduchi; Hélène C. Descamps; Jonathan Schug; Tong Da; Deeksha Lahori; Hilana El-Mekkoussi; Michael R. Betts; Klaus H. Kaestner
Diabetes February 2025, Vol.74, e5. doi:https://doi.org/10.2337/dbi24-0043
