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June 2025
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Cover Image
Cover Image
On the cover: A pancreatic islet with α-cell hyperplasia from a mouse treated with a GCGR-blocking antibody for 4 weeks. The islet is stained for glucagon (red), insulin (white), and DAPI (blue). Image courtesy of Kehan Bao, Regeneron Pharmaceuticals, Tarrytown, NY. The article “Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk” appears in this issue of Diabetes, p.
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ISSN 0012-1797
EISSN 1939-327X
Diabetes Spotlight
Diabetes Spotlight: Soo Heon Kwak, MD, PhD—Advancing Precision Medicine in Diabetes Through Genetic Insights
Diabetes May 2025, Vol.74, 861-862. doi:https://doi.org/10.2337/dbi25-0020
Commentaries
Technological Advances
Intermittent Low-Magnitude Pressure Applied Across Macroencapsulation Devices Enables Physiological Insulin Delivery Dynamics
Ella A. Thomson; Sooyeon Lee; Haixia Xu; Hannah Moeller; Joanna Sands; Rayhan A. Lal; Justin P. Annes; Ada S.Y. Poon
Diabetes February 2025, Vol.74, 873-884. doi:https://doi.org/10.2337/db24-0818
Metabolism
Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk
Diabetes March 2025, Vol.74, 885-897. doi:https://doi.org/10.2337/db24-0958
The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans
Clinton R. Bruce; Teddy Ang; Jason D. Toms; Giang M. Dao; Jean Liu; Glenn M. Ward; David N. O’Neal; Dale J. Morrison; Greg M. Kowalski
Diabetes November 2024, Vol.74, 898-906. doi:https://doi.org/10.2337/db24-0388
Islet Studies
Regulation of Type 1 Diabetes via Brown Adipocyte–Secreted Proteins and the Novel Glucagon Regulator Nidogen-2
Jeongmin Lee; Alessandro Ustione; Emily M. Wilkerson; Rekha Balakrishnan; Debbie C. Thurmond; Dennis Goldfarb; David W. Piston
Diabetes February 2025, Vol.74, 907-920. doi:https://doi.org/10.2337/db24-1003
Immunology and Transplantation
Type 1 Diabetes Depends on CD4-Driven Expression of the Transcriptional Repressor Bcl6
Dudley H. McNitt; Jonathan M. Williams; Joseph G. Santitoro; Jacob Kim; James W. Thomas; Rachel H. Bonami
Diabetes November 2024, Vol.74, 921-932. doi:https://doi.org/10.2337/db23-0709
Novel T-Cell Reactivities to Hybrid Insulin Peptides in Islet Autoantibody–Positive At-Risk Individuals
Anita C. Hohenstein; Joylynn B. Gallegos; Mylinh Dang; Jason Groegler; Hali Broncucia; Fatima A. Tensun; Kathleen Waugh; Fran Dong; Eddie A. James; Cate Speake; Andrea K. Steck; Marian J. Rewers; Peter A. Gottlieb; Kathryn Haskins; Thomas Delong; Rocky L. Baker
Diabetes January 2025, Vol.74, 933-942. doi:https://doi.org/10.2337/db24-0611
Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell–Intrinsic Immune Tolerance
Taylor K. Watson; Aaron B.I. Rosen; Travis Drow; Jacob A. Medjo; Matthew A. MacQuivey; Yan Ge; H. Denny Liggitt; Dane A. Grosvenor; Kimberly A. Dill-McFarland; Matthew C. Altman; Patrick J. Concannon; Jane H. Buckner; David J. Rawlings; Eric J. Allenspach
Diabetes March 2025, Vol.74, 943-955. doi:https://doi.org/10.2337/db24-0655
Pathophysiology
Soluble HLA Class I Is Released From Human β-Cells Following Exposure to Interferons
Pouria Akhbari; Javier Perez-Hernandez; Mark A. Russell; Shalinee Dhayal; K. Afi Leslie; Stephanie L. Hunter; Kathryn Murrall; Alexia Carré; Noel G. Morgan; Roberto Mallone; Sarah J. Richardson
Diabetes March 2025, Vol.74, 956-968. doi:https://doi.org/10.2337/db24-0827
Complications
Targeting SETD7 Rescues Diabetes-Induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin-3G
Shafeeq A. Mohammed; Era Gorica; Mattia Albiero; Gergely Karsai; Alessandro Mengozzi; Carlo Maria Caravaggi; Samuele Ambrosini; Stefano Masi; Maria Cristina Vinci; Omer Dzemali; Gaia Spinetti; Sanjay Rajagopalan; Assam El-Osta; Jaroslav Pelisek; Frank Ruschitzka; Gian Paolo Fadini; Sarah Costantino; Francesco Paneni
Diabetes February 2025, Vol.74, 969-982. doi:https://doi.org/10.2337/db24-0997
Antihypertensive Drug Amlodipine Besylate Shows Potential in Alleviating Diabetic Peripheral Neuropathy
Yuxi Wei; Yujie Huang; Runzhi Huang; Yuan Ruan; Tian Feng; Fan Zhou; Wei Zhang; Jianyu Lu; Sujie Xie; Yuntao Yao; Jiaying Wang; Shizhao Ji; Xu Shen
Diabetes February 2025, Vol.74, 983-997. doi:https://doi.org/10.2337/db24-0403
Association of Plasma Angiogenin With Risk of Incident End-Stage Kidney Disease in Individuals With Type 2 Diabetes
Resham L. Gurung; Jian-Jun Liu; Sylvia Liu; Janus Lee; Huili Zheng; Clara Chan; Keven Ang; Su Chi Lim
Diabetes March 2025, Vol.74, 998-1006. doi:https://doi.org/10.2337/db24-0699
Upregulation of Acid-Sensing Ion Channel 1a in the Anterior Cingulate Cortex by TNF-α/NF-κB Pathway Contributes to Diabetes-Related Pain
Ai-Jun Jiang; Hong-Rui Wei; Sijia Chu; Mengyuan Wang; Jinling Yan; Xing-Lei Song; Tian-Le Xu; Zhi Zhang; Yan Jin; Wei Wang
Diabetes March 2025, Vol.74, 1007-1020. doi:https://doi.org/10.2337/db24-0847
Pharmacology and Therapeutics
Cardioprotection During Myocardial Infarction in Diabetic Cardiomyopathy
Sebastià Alcover; Sergi López; Lisaidy Ramos-Regalado; Natàlia Muñoz-García; Alex Gallinat; Rosa Suades; Lina Badimon; Gemma Vilahur
Diabetes March 2025, Vol.74, 1021-1032. doi:https://doi.org/10.2337/db24-0510
