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Metabolism September 26 2024
Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice
Michael W. Schleh; Magdalene Ameka; Alec Rodriguez; Hasty Alyssa H.
View articletitled, Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice
Islet Studies September 26 2024
Role of Sec61α2 translocon in insulin biosynthesis
Xiaoxi Xu, M.D.; Thomas W. Bell, Ph.D.; Truc Le, Ph.D.; Ivy Zhao, B.S.; Emily Walker, Ph.D.; Yiqing Wang, M.D.; Ning Xu, M.D.; Scott A. Soleimanpour, M.D.; Holger A. Russ, Ph.D.; Ling Qi, Ph.D.; Billy Tsai, Ph.D.; Ming Liu, M.D.; Peter Arvan, M.D.
View articletitled, Role of Sec61α2 translocon in insulin biosynthesis
Complications September 25 2024
Podocyte-Specific Expression of the Stress Response Protein REDD1 is Necessary for Diabetes-induced Podocytopenia
Siddharth Sunilkumar; Esma I. Yerlikaya; Allyson L. Toro; Han Chen; Yandong Zhou; Donald L. Gill; Scot R. Kimball; Michael D. Dennis
View articletitled, Podocyte-Specific Expression of the Stress Response Protein REDD1 is Necessary for Diabetes-induced Podocytopenia
Pathophysiology September 25 2024
Microglia Mediate Metabolic Dysfunction from Common Air Pollutants through NF-κB Signaling
Lucas K. Debarba, Ph.D.; Hashan S.M. Jayarathne; Lukas Stilgenbauer; Ana L.Terra dos Santos; Lisa Koshko, M.S.; Sydney Scofield; Ryan Sullivan; Abhijit Mandal, Ph.D.; Ulrike Klueh, Ph.D.; Marianna Sadagurski, Ph.D.
View articletitled, Microglia Mediate Metabolic Dysfunction from Common Air Pollutants through NF-κB Signaling
Islet Studies September 25 2024
Optimised proteomic analysis of insulin granules from MIN6 cells identifies Scamp3, a novel regulator of insulin secretion and content.
Nicholas Norris; Belinda Yau; Carlo Famularo; Hayley Webster; Thomas Loudovaris; Helen E. Thomas; Mark Larance; Alistair M. Senior; Melkam A. Kebede
View articletitled, Optimised proteomic analysis of insulin granules from MIN6 cells identifies Scamp3, a novel regulator of insulin secretion and content.
Obesity Studies September 20 2024
Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity
Chae Beom Park; Chan Hee Lee; Kae Won Cho; Sunghun Shin; Won Hee Jang; Junyeong Byeon; Yu Rim Oh; Sung Jun Kim; Jae Woo Park; Gil Myoung Kang; Se Hee Min; Seyun Kim; Rina Yu; Min-Seon Kim
View articletitled, Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity
Islet Studies September 16 2024
Selective Reduction of Ca2+-Independent Phospholipase A2β (iPLA2β)-Derived Lipid Signaling from Macrophages Mitigates Type 1 Diabetes Development
Abdulaziz Almutairi; Tayleur D. White; Daniel J. Stephenson; Benjamin D. Stephenson; Ying Gai-Tusing; Paran Goel; Daniel W. Phillips; Robert S. Welner; Xiaoyong Lei; Bruce D. Hammock; Charles E. Chalfant; Sasanka Ramanadham
View articletitled, Selective Reduction of Ca<sup>2+</sup>-Independent Phospholipase A<sub>2</sub>β (iPLA<sub>2</sub>β)-Derived Lipid Signaling from Macrophages Mitigates Type 1 Diabetes Development
Genetics/Genomes/Proteomics/Metabolomics September 16 2024
Bidirectional Mendelian randomization highlights causal relationships between circulating INHBC and multiple cardiometabolic diseases and traits
Nellie Y. Loh, DPhil; Daniel B. Rosoff, AB/ScB; Rebecca Richmond, PhD; Raymond Noordam, PhD; George Davey Smith, MD; David Ray, MD; Fredrik Karpe, MD; Falk W. Lohoff, MD; Constantinos Christodoulides, MD
View articletitled, Bidirectional Mendelian randomization highlights causal relationships between circulating INHBC and multiple cardiometabolic diseases and traits
Metabolism September 12 2024
A Single Dose of Phosphoinositide-3-kinase Inhibitor Alpelisib Induces Insulin Resistance in Healthy Adults: A Randomized Feasibility Study
Joshua R. Cook; Nur Bedeir; Zachary D. Sone; Julia Wattacheril; Henry N. Ginsberg; Blandine Laferrère
View articletitled, A Single Dose of Phosphoinositide-3-kinase Inhibitor Alpelisib Induces Insulin Resistance in Healthy Adults: A Randomized Feasibility Study
Pathophysiology September 12 2024
Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People with Obesity and Type 2 Diabetes
Max C. Petersen, M.D., Ph.D.; Mihoko Yoshino, M.D., Ph.D.; Gordon I. Smith, Ph.D.; Rafael C. Gaspar, Ph.D.; Mario Kahn, M.S.; Dmitri Samovski, Ph.D.; Gerald I. Shulman, M.D., Ph.D.; Samuel Klein, M.D.
View articletitled, Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People with Obesity and Type 2 Diabetes
Metabolism September 12 2024
CRTC1 in Mc4r-expressing cells is required for peripheral metabolism and systemic energy homeostasis
Haruka Miyamori, M.S.; Takumi Yokokawa, Ph.D.; Motoki Miyakita, M.S.; Kazuki Ozaki, B.S.; Tsuyoshi Goto, Ph.D.; Kazuo Inoue, Ph.D.; Shigenobu Matsumura, Ph.D.
View articletitled, CRTC1 in Mc4r-expressing cells is required for peripheral metabolism and systemic energy homeostasis
Erratum August 29 2024
Erratum. 189-OR: Food Insecurity and Inability to Obtain Recommended Medications, Diabetes Technology, and Multidisciplinary Services in Youth and Young Adults with Diabetes. Diabetes 2024;73 (Suppl. 1):189-OR
Angela D. Liese; Emmanuel F. Julceus; Caroline Rudisill; Faisal Malik; Kate Flory; Edward A. Frongillo; Katherine A. Sauder; Jason A. Mendoza
View articletitled, Erratum. 189-OR: Food Insecurity and Inability to Obtain Recommended Medications, Diabetes Technology, and Multidisciplinary Services in Youth and Young Adults with Diabetes. Diabetes 2024;73 (Suppl. 1):189-OR
Pathophysiology August 28 2024
Glucagon Stimulation Test and Insulin Secretory Capacity in Clinical Assessment of Incretin-Based Therapy for Diabetes
Takuya Haraguchi; Yuji Yamazaki; Hitoshi Kuwata; Ryota Usui; Yoshiyuki Hamamoto; Yutaka Seino; Daisuke Yabe; Yuichiro Yamada
View articletitled, Glucagon Stimulation Test and Insulin Secretory Capacity in Clinical Assessment of Incretin-Based Therapy for Diabetes
Genetics/Genomes/Proteomics/Metabolomics August 23 2024
Müller cells harboring exosomal lncRNA OGRU modulates microglia polarization in diabetic retinopathy via serving as miRNA sponges
ShuHua Fu, MD; WenJing Sun, MM; Lu Liu, MM; JiPing Xiao, MM; Jian Xiong, MD; YaoYun Hu, MM; QianQian Zhou, MM; XiaoLong Yin, MM
View articletitled, Müller cells harboring exosomal lncRNA OGRU modulates microglia polarization in diabetic retinopathy via serving as miRNA sponges
Islet Studies August 21 2024
Pancreatic β cell TRAPδ deficiency reduces insulin production but improves insulin sensitivity
Jiyun Guo, M.M.; Yanshu Yang, M.M.; Ning Xu, M.M.; Xin Li, M.D.; Ying Yang, M.D.; Wenli Feng, Ph.D.; Yuanyuan Ye, M.M.; Xiaoxi Xu, M.D.; Jingqiu Cui, M.D.; Ming Liu, M.D., Ph.D.; Yumeng Huang, M.D.
View articletitled, Pancreatic β cell TRAPδ deficiency reduces insulin production but improves insulin sensitivity
Islet Studies August 21 2024
Visceral adipocyte-derived extracellular vesicle miR-27a-5p elicits glucose intolerance by inhibiting pancreatic β-cell insulin secretion
Yaqin Zhang, Ph.D.; Bin Qian, MS; Yang Yang, MS; Fandi Niu, MS; Changsong Lin, Ph.D.; Honglei Yuan, B.S.; Jianan Wang, MS; Tijun Wu, Ph.D.; Yixue Shao, Ph.D.; Shulin Shao, MS; Aiming Liu, MS; Jingwen Wu, MS; Peng Sun, Ph.D.; Xiaoai Chang, MS; Yan Bi, M.D.; Wei Tang, M.D.; Yunxia Zhu, Ph.D.; Fang Chen, Ph.D.; Dongming Su, M.D.; Xiao Han, Ph.D.
View articletitled, Visceral adipocyte-derived extracellular vesicle miR-27a-5p elicits glucose intolerance by inhibiting pancreatic β-cell insulin secretion
Obesity Studies August 21 2024
Leptin activation of dorsal raphe neurons inhibits feeding behavior
Nicholas David Maxwell, PhD; Cora Elizabeth Smiley, PhD; Alia Tereza Sadek, BS; Frances Zoe Loyo-Rosado, BS; Daniel Christian Giles, BS; Victoria Alice Macht, PhD; Jennifer Lynn Woodruff, BS; Donzelle Lee Taylor, BS; Victoria Marie Glass, BS; Steven Peter Wilson, PhD; Lawrence Patrick Reagan, PhD; James Robert Fadel, PhD; Claudia Alejandra Grillo, PhD
View articletitled, Leptin activation of dorsal raphe neurons inhibits feeding behavior
Pathophysiology August 21 2024
The effect of metformin on peripheral nerve morphology in type 2 diabetes: a cross-sectional observational study
Roshan Dhanapalaratnam, MMed; Tushar Issar, PhD; Leiao Leon Wang, MD; Darren Tran, MD; Ann M. Poynten, PhD; Kerry-Lee Milner, PhD; Natalie CG. Kwai, PhD; Arun V. Krishnan, PhD
View articletitled, The effect of metformin on peripheral nerve morphology in type 2 diabetes: a cross-sectional observational study
Perspectives in Diabetes August 21 2024
Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop
Carla J. Greenbaum, MD; Gerald T. Nepom, MD, PhD; Lauren K. Wood-Heickman, MD; Diane K. Wherrett, MD; Linda A. DiMeglio, MD; Kevan C. Herold, MD; Jeffrey P. Krischer, PhD
View articletitled, Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop
Complications August 20 2024
High-intensity interval training, caloric restriction, or their combination have beneficial effects on metabolically acquired peripheral neuropathy
Stéphanie A. Eid; Sarah E. Elzinga; Bhumsoo Kim; Amy E. Rumora; John M. Hayes; Andrew Carter; Crystal Pacut; Adam M. Allouch; Emily J. Koubek; Eva L. Feldman
View articletitled, High-intensity interval training, caloric restriction, or their combination have beneficial effects on metabolically acquired peripheral neuropathy
Immunology and Transplantation August 13 2024
Role of Peptidyl arginine deiminase 4-dependent macrophage extracellular traps formation on Type 1 Diabetes pathogenesis
Yiming Shen, M.Sc.; Ruiya Shi, B.Sc.; ShiPing Lu, Ph.D.; Yan Wang, M.Sc.; Ziqi Zhou, M.Sc.; Chenhua Wu, M.Sc.; Qi You, Ph.D.; Hongye Fan, Ph.D.; Jie Wu, Ph.D.
View articletitled, Role of Peptidyl arginine deiminase 4-dependent macrophage extracellular traps formation on Type 1 Diabetes pathogenesis
Obesity Studies August 13 2024
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy
Xinyi Chen; Andrea Ruiz-Velasco, PhD; Zhiyong Zou, PhD; Susanne S Hille; Claire Ross, PhD; Oveena Fonseka; Sanskruti R Gare; Nasser hawimel o Alatawi; Rida Raja; Jiayan Zhang; Namrita Kaur, PhD; Xiangjun Zhao, PhD; Henrietta Morrell-Davies; Jessica M Miller, PhD; Riham R.E Abouleisa, PhD; Qinghui Ou; Derk Frank, MD PhD; Martin K Rutter, MD; Christian Pinali, PhD; Tao Wang, MD PhD; Tamer M.A Mohamed, PhD; Oliver J Müller, MD PhD; Wei Liu, PhD
View articletitled, PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy
Genetics/Genomes/Proteomics/Metabolomics August 13 2024
PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism
Lucas Maurin; Lorella Marselli; Mathilde Boissel; Lijiao Ning; Raphael Boutry; Justine Fernandes; Mara Suleiman; Carmela De Luca; Audrey Leloire; Vincent Pascat; Bénédicte Toussaint; Souhila Amanzougarene; Mehdi Derhourhi; Anne Jörns; Sigurd Lenzen; François Pattou; Julie Kerr-Conte; Mickaël Canouil; Piero Marchetti; Amélie Bonnefond; Philippe Froguel; Amna Khamis
View articletitled, <em>PNLIPRP1 </em>hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism
Perspectives in Diabetes August 6 2024
Revisiting the pattern of loss of β-cell function in preclinical Type 1 Diabetes.
Mariangela Martino, MD; Alfonso Galderisi, MD, PhD; Carmella Evans-Molina, MD, PhD; Colin Dayan, MA MBBS, FRCP, PhD
View articletitled, Revisiting the pattern of loss of β-cell function in preclinical Type 1 Diabetes.
Obesity Studies August 6 2024
The association between low sex hormone binding globulin and increased risk of type 2 diabetes is mediated by increased visceral and liver fat: results from observational and Mendelian randomization analyses
Theresa A. Stangl, MD; Chantal M. Wiepjes, MD, PhD; Roelof A.J. Smit, MD, PhD; Astrid van Hylckama Vlieg, PhD; Hildo. J. Lamb, MD, PhD; Jeroen H.P.M. van der Velde, PhD; Esther Winters van Eekelen, PhD; Sebastiaan C. Boone, MD; Martijn C.G.J. Brouwers, MD, PhD; Frits R. Rosendaal, MD, PhD; Martin den Heijer, MD, PhD; Annemieke C. Heijboer, MD, PhD; Renée de Mutsert, PhD
View articletitled, The association between low sex hormone binding globulin and increased risk of type 2 diabetes is mediated by increased visceral and liver fat: results from observational and Mendelian randomization analyses
Complications July 5 2024
Deciphering the connection between microvascular damage and neurodegeneration in early diabetic retinopathy
Qian Yang, PhD; Marina Yasvoina, PhD; Abraham Olvera-Barrios, MD; Joel Mendes, MSc; Meidong Zhu, MBBS, PhD; Cathy Egan, FRCOphth1; Adnan Tufail, MD FRCOphth; Marcus Fruttiger, PhD
View articletitled, Deciphering the connection between microvascular damage and neurodegeneration in early diabetic retinopathy
Perspectives in Diabetes April 11 2024
Engineering a Pathway to Glucose-Responsive Therapeutics
Matthew J. Webber, PhD
View articletitled, Engineering a Pathway to Glucose-Responsive Therapeutics
Pathophysiology January 8 2024
OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity.
Gareth S. D. Purvis; Massimo Collino; Andrea D. van Dam; Giacomo Einaudi; Yujung Ng; Mayooran Shanmuganathan; Smita Y. Patel; Christoph Thiemermann; Keith M. Channon; David R. Greaves; Oxford Acute Myocardial Infarction (OxAMI) Study
View articletitled, OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity.
  • Online ISSN 1939-327X
  • Print ISSN 0012-1797

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