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A.M. James Shapiro
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Meeting Abstracts

336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline

ALICE L.J. CARR, BRAULIO A. MARFIL-GARZA, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2024;73(Supplement_1):336-OR
https://doi.org/10.2337/db24-336-OR
Published: 14 June 2024
View article titled, 336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline
Meeting Abstracts

225-OR: Sequential Islet Transplants for Type 1 Diabetes Do Not Cumulatively Increase Hepatic Portal Venous Pressure

ALICE L.J. CARR, RAHI SHAH, BRAULIO A. MARFIL-GARZA, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2024;73(Supplement_1):225-OR
https://doi.org/10.2337/db24-225-OR
Published: 14 June 2024
View article titled, 225-OR: Sequential Islet Transplants for Type 1 Diabetes Do Not Cumulatively Increase Hepatic Portal Venous Pressure
Meeting Abstracts

238-OR: Changes In Renal Function after Islet Transplantation in a Single-Centre Cohort in Canada over 20 Years

ALICE L.J. CARR, BRAULIO A. MARFIL-GARZA, YING LING, RICHARD A. ORAM, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2023;72(Supplement_1):238-OR
https://doi.org/10.2337/db23-238-OR
Published: 20 June 2023
View article titled, 238-OR: Changes In Renal Function after Islet Transplantation in a Single-Centre Cohort in Canada over 20 Years
Journal Articles

Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Jinghe Li, Ryota Inoue, Yu Togashi, Tomoko Okuyama, Aoi Satoh, Mayu Kyohara, Kuniyuki Nishiyama, Takahiro Tsuno, Daisuke Miyashita, Tatsuya Kin, A.M. James Shapiro, Resilind Su Ern Chew, Adrian Kee Keong Teo, Seiichi Oyadomari, Yasuo Terauchi, Jun Shirakawa
Journal: Diabetes
Diabetes 2022;71(3):424–439
https://doi.org/10.2337/db21-0123
Published: 29 September 2021
View article titled, Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway
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Meeting Abstracts

362-OR: The Biological Variability of the BETA-2 Score in Islet Transplant Recipients

ROBYN MILLOTT, RICHARD A. ORAM, SHAREEN FORBES, A.M. JAMES SHAPIRO, PETER A. SENIOR, ANNA LAM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):362-OR
https://doi.org/10.2337/db20-362-OR
Published: 01 June 2020
View article titled, 362-OR: The Biological Variability of the BETA-2 Score in Islet Transplant Recipients
Meeting Abstracts

116-OR: Comparison of Pancreas vs. Islet Transplantation Outcomes from a Large Single Center

BRAULIO A. MARFIL-GARZA, ANNA LAM, DAVID BIGAM, PETER SENIOR, A.M. JAMES SHAPIRO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):116-OR
https://doi.org/10.2337/db20-116-OR
Published: 01 June 2020
View article titled, 116-OR: Comparison of Pancreas vs. Islet Transplantation Outcomes from a Large Single Center
Journal Articles

Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts

Andrew R. Pepper, Antonio Bruni, Rena Pawlick, Doug O’Gorman, Tatsuya Kin, Aducio Thiesen, A.M. James Shapiro
Journal: Diabetes
Diabetes 2019;68(5):953–962
https://doi.org/10.2337/db18-0788
Published: 19 November 2018
View article titled, Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
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Meeting Abstracts

Flash Glucose Monitoring Reflects Graft Function after Clinical Islet Transplantation—An Initial Report

ANNA LAM, SHAREEN FORBES, CECILIA HAMMING, ANDREW J. MALCOLM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1740-P
https://doi.org/10.2337/db18-1740-P
Published: 01 July 2018
View article titled, Flash Glucose Monitoring Reflects Graft Function after Clinical Islet Transplantation—An Initial Report
Meeting Abstracts

Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)

ROBERT R. HENRY, JEREMY PETTUS, JON WILENSKY, A.M. JAMES SHAPIRO, PETER A. SENIOR, BART ROEP, RICHARD WANG, EVERT J. KROON, MICHAEL SCOTT, KEVIN D'AMOUR, HOWARD L. FOYT
Journal: Diabetes
Diabetes 2018;67(Supplement_1):138-OR
https://doi.org/10.2337/db18-138-OR
Published: 01 July 2018
View article titled, Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)
Meeting Abstracts

Clinical Islet Transplantation Outcomes Are Comparable in Obese Type 1 Diabetes Recipients

ANNA LAM, KATHRYN J. POTTER, SHAREEN FORBES, SHARLEEN IMES, ANDREW J. MALCOLM, ANDREA HAQQ, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):139-OR
https://doi.org/10.2337/db18-139-OR
Published: 01 July 2018
View article titled, Clinical Islet Transplantation Outcomes Are Comparable in Obese Type 1 Diabetes Recipients
Meeting Abstracts

CGM Shows Islet Transplantation Prevents Hypoglycemia, Correcting Time in Range and Reducing Glycemic Variability, Despite Subnormal Beta-Cell Function

SHAREEN FORBES, TOLU OLUTOYIN OLATEJU, ANNA LAM, JOHN CASEY, JOHN CAMPBELL, LAURA REID, RICHARD A. ORAM, ANDREW J. MALCOLM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):143-OR
https://doi.org/10.2337/db18-143-OR
Published: 01 July 2018
View article titled, CGM Shows Islet Transplantation Prevents Hypoglycemia, Correcting Time in Range and Reducing Glycemic Variability, Despite Subnormal Beta-Cell Function
Journal Articles

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Teresa Buenaventura, Nisha Kanda, Phoebe C. Douzenis, Ben Jones, Stephen R. Bloom, Pauline Chabosseau, Ivan R. Corrêa, Jr., Domenico Bosco, Lorenzo Piemonti, Piero Marchetti, Paul R. Johnson, A.M. James Shapiro, Guy A. Rutter, Alejandra Tomas
Journal: Diabetes
Diabetes 2018;67(3):385–399
https://doi.org/10.2337/db17-0639
Published: 28 December 2017
View article titled, A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428

Camillo Ricordi, Julia S. Goldstein, A.N. Balamurugan, Gregory L. Szot, Tatsuya Kin, Chengyang Liu, Christine W. Czarniecki, Barbara Barbaro, Nancy D. Bridges, Jose Cano, William R. Clarke, Thomas L. Eggerman, Lawrence G. Hunsicker, Dixon B. Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F. Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A. Turgeon, Daniel Brandhorst, Andrew S. Friberg, Ji Lei, Ling-jia Wang, Joshua J. Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J. Hering, Andrew M. Posselt, Peter G. Stock, A.M. James Shapiro
Journal: Diabetes
Diabetes 2017;66(9):2531
https://doi.org/10.2337/db17-er09a
Published: 29 June 2017
View article titled, Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428
Open the PDF for Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428 in another window
Journal Articles

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Camillo Ricordi, Julia S. Goldstein, A.N. Balamurugan, Gregory L. Szot, Tatsuya Kin, Chengyang Liu, Christine W. Czarniecki, Barbara Barbaro, Nancy D. Bridges, Jose Cano, William R. Clarke, Thomas L. Eggerman, Lawrence G. Hunsicker, Dixon B. Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F. Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A. Turgeon, Daniel Brandhorst, Xiaojuan Chen, Andrew S. Friberg, Ji Lei, Ling-jia Wang, Joshua J. Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J. Hering, Andrew M. Posselt, Peter G. Stock, A.M. James Shapiro
Journal: Diabetes
Diabetes 2016;65(11):3418–3428
https://doi.org/10.2337/db16-0234
Published: 27 July 2016
View article titled, National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
Open the PDF for National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities in another window
Includes: Supplementary data
Journal Articles

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

Boris L. Gala-Lopez, Andrew R. Pepper, Rena L. Pawlick, Doug O’Gorman, Tatsuya Kin, Antonio Bruni, Nasser Abualhassan, Mariusz Bral, Austin Bautista, Jocelyn E. Manning Fox, Lachlan G. Young, Patrick E. MacDonald, A.M. James Shapiro
Journal: Diabetes
Diabetes 2016;65(2):451–462
https://doi.org/10.2337/db15-0764
Published: 18 November 2015
View article titled, Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice
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Journal Articles

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

David J. Hodson, Ryan K. Mitchell, Lorella Marselli, Timothy J. Pullen, Silvia Gimeno Brias, Francesca Semplici, Katy L. Everett, Dermot M.F. Cooper, Marco Bugliani, Piero Marchetti, Vanessa Lavallard, Domenico Bosco, Lorenzo Piemonti, Paul R. Johnson, Stephen J. Hughes, Daliang Li, Wen-Hong Li, A.M. James Shapiro, Guy A. Rutter
Journal: Diabetes
Diabetes 2014;63(9):3009–3021
https://doi.org/10.2337/db13-1607
Published: 16 August 2014
View article titled, ADCY5 Couples Glucose to Insulin Secretion in Human Islets
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Includes: Supplementary data
Journal Articles

Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells

Paul V. Sabatini, Nicole A.J. Krentz, Bader Zarrouki, Clara Y. Westwell-Roper, Cuilan Nian, Ryan A. Uy, A.M. James Shapiro, Vincent Poitout, Francis C. Lynn
Journal: Diabetes
Diabetes 2013;62(8):2808–2820
https://doi.org/10.2337/db12-1527
Published: 17 July 2013
View article titled, Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Immune Antibody Monitoring Predicts Outcome in Islet Transplantation

A.M. James Shapiro
Journal: Diabetes
Diabetes 2013;62(5):1377–1378
https://doi.org/10.2337/db13-0019
Published: 16 April 2013
View article titled, Immune Antibody Monitoring Predicts Outcome in Islet Transplantation
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Journal Articles

Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival

Juliet A. Emamaullee, Joy Davis, Rena Pawlick, Christian Toso, Shaheed Merani, Sui-Xiong Cai, Ben Tseng, A.M. James Shapiro
Journal: Diabetes
Diabetes 2010;59(6):1469–1477
https://doi.org/10.2337/db09-0502
Published: 23 March 2010
View article titled, Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival
Open the PDF for Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival in another window
Journal Articles

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

Juliet A. Emamaullee, Joy Davis, Shaheed Merani, Christian Toso, John F. Elliott, Aducio Thiesen, A.M. James Shapiro
Journal: Diabetes
Diabetes 2009;58(6):1302–1311
https://doi.org/10.2337/db08-1113
Published: 16 March 2009
View article titled, Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
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Includes: Supplementary data