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Meeting Abstracts

2140-LB: Process Optimization in Autologous Stem Cell–Derived Islet Generation to Address Key Limitations for Scalability, Safety, and Efficacy

Free
NIDHEESH DADHEECH, ZOFIA CZARNECKA, HAIDE RAZAVY, RENA L. PAWLICK, A.M. JAMES SHAPIRO
Journal: Diabetes
Diabetes 2024;74(Supplement_1):2140-LB
https://doi.org/10.2337/db25-2140-LB
Published: 20 June 2025
View articletitled, 2140-LB: Process Optimization in Autologous Stem Cell–Derived Islet Generation to Address Key Limitations for Scalability, Safety, and Efficacy
Journal Articles

Advances in Cell Replacement Therapies for Diabetes

Free
Bernhard J. Hering, Michael R. Rickels, Melena D. Bellin, Jeffrey R. Millman, Alice A. Tomei, Andrés J. García, Haval Shirwan, Cherie L. Stabler, Minglin Ma, Peng Yi, Xunrong Luo, Qizhi Tang, Sabarinathan Ramachandran, Jose Oberholzer, Camillo Ricordi, Timothy J. Kieffer, A.M. James Shapiro
Journal: Diabetes
Diabetes 2025;74(7):1068–1077
https://doi.org/10.2337/db25-0037
Published: 24 April 2025
View articletitled, Advances in Cell Replacement Therapies for Diabetes
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Meeting Abstracts

336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline

Free
ALICE L.J. CARR, BRAULIO A. MARFIL-GARZA, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2024;73(Supplement_1):336-OR
https://doi.org/10.2337/db24-336-OR
Published: 14 June 2024
View articletitled, 336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline
Meeting Abstracts

225-OR: Sequential Islet Transplants for Type 1 Diabetes Do Not Cumulatively Increase Hepatic Portal Venous Pressure

Free
ALICE L.J. CARR, RAHI SHAH, BRAULIO A. MARFIL-GARZA, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2024;73(Supplement_1):225-OR
https://doi.org/10.2337/db24-225-OR
Published: 14 June 2024
View articletitled, 225-OR: Sequential Islet Transplants for Type 1 Diabetes Do Not Cumulatively Increase Hepatic Portal Venous Pressure
Meeting Abstracts

238-OR: Changes In Renal Function after Islet Transplantation in a Single-Centre Cohort in Canada over 20 Years

Free
ALICE L.J. CARR, BRAULIO A. MARFIL-GARZA, YING LING, RICHARD A. ORAM, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2023;72(Supplement_1):238-OR
https://doi.org/10.2337/db23-238-OR
Published: 20 June 2023
View articletitled, 238-OR: Changes In Renal Function after Islet Transplantation in a Single-Centre Cohort in Canada over 20 Years
Journal Articles

Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Free
Jinghe Li, Ryota Inoue, Yu Togashi, Tomoko Okuyama, Aoi Satoh, Mayu Kyohara, Kuniyuki Nishiyama, Takahiro Tsuno, Daisuke Miyashita, Tatsuya Kin, A.M. James Shapiro, Resilind Su Ern Chew, Adrian Kee Keong Teo, Seiichi Oyadomari, Yasuo Terauchi, Jun Shirakawa
Journal: Diabetes
Diabetes 2022;71(3):424–439
https://doi.org/10.2337/db21-0123
Published: 29 September 2021
View articletitled, Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway
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Meeting Abstracts

362-OR: The Biological Variability of the BETA-2 Score in Islet Transplant Recipients

Free
ROBYN MILLOTT, RICHARD A. ORAM, SHAREEN FORBES, A.M. JAMES SHAPIRO, PETER A. SENIOR, ANNA LAM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):362-OR
https://doi.org/10.2337/db20-362-OR
Published: 01 June 2020
View articletitled, 362-OR: The Biological Variability of the BETA-2 Score in Islet Transplant Recipients
Meeting Abstracts

116-OR: Comparison of Pancreas vs. Islet Transplantation Outcomes from a Large Single Center

Free
BRAULIO A. MARFIL-GARZA, ANNA LAM, DAVID BIGAM, PETER SENIOR, A.M. JAMES SHAPIRO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):116-OR
https://doi.org/10.2337/db20-116-OR
Published: 01 June 2020
View articletitled, 116-OR: Comparison of Pancreas vs. Islet Transplantation Outcomes from a Large Single Center
Journal Articles

Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts

Free
Andrew R. Pepper, Antonio Bruni, Rena Pawlick, Doug O’Gorman, Tatsuya Kin, Aducio Thiesen, A.M. James Shapiro
Journal: Diabetes
Diabetes 2019;68(5):953–962
https://doi.org/10.2337/db18-0788
Published: 19 November 2018
View articletitled, Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
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Meeting Abstracts

Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)

Free
ROBERT R. HENRY, JEREMY PETTUS, JON WILENSKY, A.M. JAMES SHAPIRO, PETER A. SENIOR, BART ROEP, RICHARD WANG, EVERT J. KROON, MICHAEL SCOTT, KEVIN D'AMOUR, HOWARD L. FOYT
Journal: Diabetes
Diabetes 2018;67(Supplement_1):138-OR
https://doi.org/10.2337/db18-138-OR
Published: 01 July 2018
View articletitled, Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)
Meeting Abstracts

Clinical Islet Transplantation Outcomes Are Comparable in Obese Type 1 Diabetes Recipients

Free
ANNA LAM, KATHRYN J. POTTER, SHAREEN FORBES, SHARLEEN IMES, ANDREW J. MALCOLM, ANDREA HAQQ, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):139-OR
https://doi.org/10.2337/db18-139-OR
Published: 01 July 2018
View articletitled, Clinical Islet Transplantation Outcomes Are Comparable in Obese Type 1 Diabetes Recipients
Meeting Abstracts

CGM Shows Islet Transplantation Prevents Hypoglycemia, Correcting Time in Range and Reducing Glycemic Variability, Despite Subnormal Beta-Cell Function

Free
SHAREEN FORBES, TOLU OLUTOYIN OLATEJU, ANNA LAM, JOHN CASEY, JOHN CAMPBELL, LAURA REID, RICHARD A. ORAM, ANDREW J. MALCOLM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):143-OR
https://doi.org/10.2337/db18-143-OR
Published: 01 July 2018
View articletitled, CGM Shows Islet Transplantation Prevents Hypoglycemia, Correcting Time in Range and Reducing Glycemic Variability, Despite Subnormal Beta-Cell Function
Meeting Abstracts

Flash Glucose Monitoring Reflects Graft Function after Clinical Islet Transplantation—An Initial Report

Free
ANNA LAM, SHAREEN FORBES, CECILIA HAMMING, ANDREW J. MALCOLM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1740-P
https://doi.org/10.2337/db18-1740-P
Published: 01 July 2018
View articletitled, Flash Glucose Monitoring Reflects Graft Function after Clinical Islet Transplantation—An Initial Report
Journal Articles

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Free
Teresa Buenaventura, Nisha Kanda, Phoebe C. Douzenis, Ben Jones, Stephen R. Bloom, Pauline Chabosseau, Ivan R. Corrêa, Jr., Domenico Bosco, Lorenzo Piemonti, Piero Marchetti, Paul R. Johnson, A.M. James Shapiro, Guy A. Rutter, Alejandra Tomas
Journal: Diabetes
Diabetes 2018;67(3):385–399
https://doi.org/10.2337/db17-0639
Published: 28 December 2017
View articletitled, A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells
Open the PDF for A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells in another window
Includes: Supplementary data
Journal Articles

Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428

Free
Camillo Ricordi, Julia S. Goldstein, A.N. Balamurugan, Gregory L. Szot, Tatsuya Kin, Chengyang Liu, Christine W. Czarniecki, Barbara Barbaro, Nancy D. Bridges, Jose Cano, William R. Clarke, Thomas L. Eggerman, Lawrence G. Hunsicker, Dixon B. Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F. Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A. Turgeon, Daniel Brandhorst, Andrew S. Friberg, Ji Lei, Ling-jia Wang, Joshua J. Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J. Hering, Andrew M. Posselt, Peter G. Stock, A.M. James Shapiro
Journal: Diabetes
Diabetes 2017;66(9):2531
https://doi.org/10.2337/db17-er09a
Published: 29 June 2017
View articletitled, Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428
Open the PDF for Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428 in another window
Journal Articles

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Free
Camillo Ricordi, Julia S. Goldstein, A.N. Balamurugan, Gregory L. Szot, Tatsuya Kin, Chengyang Liu, Christine W. Czarniecki, Barbara Barbaro, Nancy D. Bridges, Jose Cano, William R. Clarke, Thomas L. Eggerman, Lawrence G. Hunsicker, Dixon B. Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F. Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A. Turgeon, Daniel Brandhorst, Xiaojuan Chen, Andrew S. Friberg, Ji Lei, Ling-jia Wang, Joshua J. Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J. Hering, Andrew M. Posselt, Peter G. Stock, A.M. James Shapiro
Journal: Diabetes
Diabetes 2016;65(11):3418–3428
https://doi.org/10.2337/db16-0234
Published: 27 July 2016
View articletitled, National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
Open the PDF for National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities in another window
Includes: Supplementary data
Journal Articles

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

Free
Boris L. Gala-Lopez, Andrew R. Pepper, Rena L. Pawlick, Doug O’Gorman, Tatsuya Kin, Antonio Bruni, Nasser Abualhassan, Mariusz Bral, Austin Bautista, Jocelyn E. Manning Fox, Lachlan G. Young, Patrick E. MacDonald, A.M. James Shapiro
Journal: Diabetes
Diabetes 2016;65(2):451–462
https://doi.org/10.2337/db15-0764
Published: 18 November 2015
View articletitled, Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice
Open the PDF for Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice in another window
Journal Articles

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

Free
David J. Hodson, Ryan K. Mitchell, Lorella Marselli, Timothy J. Pullen, Silvia Gimeno Brias, Francesca Semplici, Katy L. Everett, Dermot M.F. Cooper, Marco Bugliani, Piero Marchetti, Vanessa Lavallard, Domenico Bosco, Lorenzo Piemonti, Paul R. Johnson, Stephen J. Hughes, Daliang Li, Wen-Hong Li, A.M. James Shapiro, Guy A. Rutter
Journal: Diabetes
Diabetes 2014;63(9):3009–3021
https://doi.org/10.2337/db13-1607
Published: 16 August 2014
View articletitled, ADCY5 Couples Glucose to Insulin Secretion in Human Islets
Open the PDF for ADCY5 Couples Glucose to Insulin Secretion in Human Islets in another window
Includes: Supplementary data
Journal Articles

Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells

Open Access
Paul V. Sabatini, Nicole A.J. Krentz, Bader Zarrouki, Clara Y. Westwell-Roper, Cuilan Nian, Ryan A. Uy, A.M. James Shapiro, Vincent Poitout, Francis C. Lynn
Journal: Diabetes
Diabetes 2013;62(8):2808–2820
https://doi.org/10.2337/db12-1527
Published: 17 July 2013
View articletitled, Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells
Open the PDF for Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells in another window
Includes: Supplementary data
Journal Articles

Immune Antibody Monitoring Predicts Outcome in Islet Transplantation

Open Access
A.M. James Shapiro
Journal: Diabetes
Diabetes 2013;62(5):1377–1378
https://doi.org/10.2337/db13-0019
Published: 16 April 2013
View articletitled, Immune Antibody Monitoring Predicts Outcome in Islet Transplantation
Open the PDF for Immune Antibody Monitoring Predicts Outcome in Islet Transplantation in another window