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Meeting Abstracts

1331-P: Aggregate Effect of Hemoglobin A1c–Related Genetic Variants on Other Glycated Proteins by Ancestry

NOPPORN THANGTHAENG, RAVI MANDLA, SAADHVI KARTIK, MARIELLA N. FACIBENE, MAUREEN SAMPSON, DAVID B. SACKS, JOSEP M. MERCADER, AARON LEONG

Diabetes 2024;74(Supplement_1):1331-P

https://doi.org/10.2337/db25-1331-P

Published: 20 June 2025

View articletitled, 1331-P: Aggregate Effect of Hemoglobin A1c–Related Genetic Variants on Other Glycated Proteins by Ancestry

Meeting Abstracts

1332-P: The Impact of the African-Ancestry–Specific G6PD Variant on the Relationship between HbA1c and Glucose

AARON LEONG, MARK TRIPPUTI, LUKASZ SZCZERBINSKI, SAMUEL ROSIN, ADAM J. KRETOWSKI, JOSEP M. MERCADER, NAJI YOUNES, JOSEPHINE H. LI, JOSE C. FLOREZ, FOR THE GRADE RESEARCH GROUP

Diabetes 2024;74(Supplement_1):1332-P

https://doi.org/10.2337/db25-1332-P

Published: 20 June 2025

View articletitled, 1332-P: The Impact of the African-Ancestry–Specific G6PD Variant on the Relationship between HbA1c and Glucose

Meeting Abstracts

276-OR: Common Variant Polygenic Risk Score Influences Penetrance of Rare Variants in Monogenic Diabetes Genes

ALICIA HUERTA, RAVI MANDLA, DORKA NAGY, LUKASZ SZCZERBINSKI, JESPER G.S. MADSEN, JOANNE B. COLE, BIANCA PORNEALA, KENNETH E. WESTERMAN, JOSEPHINE H. LI, TONI I. POLLIN, JOSE C. FLOREZ, ANNA L. GLOYN, INES CEBOLA, ALISA MANNING, AARON LEONG, MIRIAM UDLER, JOSEP M. MERCADER

Diabetes 2024;73(Supplement_1):276-OR

https://doi.org/10.2337/db24-276-OR

Published: 14 June 2024

View articletitled, 276-OR: Common Variant Polygenic Risk Score Influences Penetrance of Rare Variants in Monogenic Diabetes Genes

Meeting Abstracts

1333-P: A Mutation Causing Glucose-6-Phosphate Dehydrogenase Deficiency Increases the Risk of Diabetes Complications in Men with African Ancestry

Diabetes 2024;73(Supplement_1):1333-P

https://doi.org/10.2337/db24-1333-P

Published: 14 June 2024

View articletitled, 1333-P: A Mutation Causing Glucose-6-Phosphate Dehydrogenase Deficiency Increases the Risk of Diabetes Complications in Men with African Ancestry

Meeting Abstracts

194-LB: Aggregate Effect of Hemoglobin A1c–Related Genetic Variants on A1c–Glycemia Discordance by Ancestry

NOPPORN THANGTHAENG, MARIELLA N. FACIBENE, SAADHVI KARTIK, RAVI MANDLA, PHILIP H. SCHROEDER, NARA R. NORGIL, JOSEP M. MERCADER, AARON LEONG

Diabetes 2023;72(Supplement_1):194-LB

https://doi.org/10.2337/db23-194-LB

Published: 20 June 2023

View articletitled, 194-LB: Aggregate Effect of Hemoglobin A1c–Related Genetic Variants on A1c–Glycemia Discordance by Ancestry

Meeting Abstracts

186-OR: Genetic Variants That Lower Hemoglobin A1c Independently of Glycemia Are Associated with Higher Diabetic Retinopathy Risk in Diverse Ancestries

PHILIP H. SCHROEDER, RAVI MANDLA, JOSE C. FLOREZ, JOSEP M. MERCADER, AARON LEONG

Diabetes 2023;72(Supplement_1):186-OR

https://doi.org/10.2337/db23-186-OR

Published: 20 June 2023

View articletitled, 186-OR: Genetic Variants That Lower Hemoglobin A1c Independently of Glycemia Are Associated with Higher Diabetic Retinopathy Risk in Diverse Ancestries

Meeting Abstracts

218-LB: Younger Veterans with Adult-Onset Diabetes Who Have High Type 1 Diabetes (T1D) Genetic Risk Are Disproportionately of Minority Ancestry and Have Features Typical of T1D but Are Often Unrecognized—A Health Disparity

PETER K. YANG, YAN SUN, SRIDHARAN RAGHAVAN, ELIZABETH M. LITKOWSKI, BRIAN T. LEGVOLD, MARY K. RHEE, MARIJANA VUJKOVIC, PETER REAVEN, AARON LEONG, LAWRENCE S. PHILLIPS

Diabetes 2023;72(Supplement_1):218-LB

https://doi.org/10.2337/db23-218-LB

Published: 20 June 2023

View articletitled, 218-LB: Younger Veterans with Adult-Onset Diabetes Who Have High Type 1 Diabetes (T1D) Genetic Risk Are Disproportionately of Minority Ancestry and Have Features Typical of T1D but Are Often Unrecognized—A Health Disparity

Meeting Abstracts

139-OR: Large-Scale Sex-Stratified Additive and Recessive GWAS Identifies Novel Large-Effect Variants and Improves Polygenic Prediction for Type 2 Diabetes

PHILIP H. SCHROEDER, JOANNE B. COLE, AARON LEONG, JOSE C. FLOREZ, JOSEP M. MERCADER

Diabetes 2022;71(Supplement_1):139-OR

https://doi.org/10.2337/db22-139-OR

Published: 01 June 2022

View articletitled, 139-OR: Large-Scale Sex-Stratified Additive and Recessive GWAS Identifies Novel Large-Effect Variants and Improves Polygenic Prediction for Type 2 Diabetes

Journal Articles

Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

Diabetes 2022;71(3):554–565

https://doi.org/10.2337/db21-0545

Published: 03 December 2021

View articletitled, Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

Meeting Abstracts

244-OR: Toward Improved Identification of Adult-Onset Type 1 Diabetes (T1D): Clinical Characteristics Associated with T1D Polygenic Risk Scores in the Million Veteran Program (MVP)

PETER K. YANG, SANDRA JACKSON, BRIAN R. CHAREST, MICHAEL N. WEEDON, YILING J. CHENG, YAN V. SUN, SRIDHARAN RAGHAVAN, ELIZABETH M. LITKOWSKI, BRIAN T. LEGVOLD, MARY K. RHEE, CARLA MERCADO, RICHARD A. ORAM, MARIJANA VUJKOVIC, PETER REAVEN, KELLY CHO, LAWRENCE S. PHILLIPS, AARON LEONG

Diabetes 2021;70(Supplement_1):244-OR

https://doi.org/10.2337/db21-244-OR

Published: 01 June 2021

View articletitled, 244-OR: Toward Improved Identification of Adult-Onset Type 1 Diabetes (T1D): Clinical Characteristics Associated with T1D Polygenic Risk Scores in the Million Veteran Program (MVP)

Meeting Abstracts

245-OR: Comprehensive Genome-Wide Association Study (GWAS) Meta-analysis Using TOPMed Imputation in Latinos Identifies Rare Variation Associated with Type 2 Diabetes (T2D)

ALICIA HUERTA, JOANNE B. COLE, PETER DORNBOS, DANIEL A. DICORPO, AARON LEONG, JOSE C. FLOREZ, JOSEP M. MERCADER, CONSORTIUM SIGMA T2D, BIOBANK MX, BIOBANK MGB

Diabetes 2021;70(Supplement_1):245-OR

https://doi.org/10.2337/db21-245-OR

Published: 01 June 2021

View articletitled, 245-OR: Comprehensive Genome-Wide Association Study (GWAS) Meta-analysis Using TOPMed Imputation in Latinos Identifies Rare Variation Associated with Type 2 Diabetes (T2D)

Meeting Abstracts

1643-P: A Recessive Genome-Wide Meta-analysis of Type 2 Diabetes in 300,000 Individuals of European Ancestry Identifies Multiple Novel Variants of Large Effect Size

MARK J. O’CONNOR, PAULA CORTES-SANCHEZ, SÍLVIA BONÀS-GUARCH, JOANNE B. COLE, DAVID TORRENTS, AARON LEONG, JOSE C. FLOREZ, JOSEP M. MERCADER

Diabetes 2020;69(Supplement_1):1643-P

https://doi.org/10.2337/db20-1643-P

Published: 01 June 2020

View articletitled, 1643-P: A Recessive Genome-Wide Meta-analysis of Type 2 Diabetes in 300,000 Individuals of European Ancestry Identifies Multiple Novel Variants of Large Effect Size

Meeting Abstracts

1655-P: Genetic Risk Factors for Incident Cardiovascular Disease in Type 2 Diabetes Patients

SOO HEON KWAK, JOSEP M. MERCADER, AARON LEONG, BIANCA PORNEALA, PEITAO WU, JOANNE B. COLE, JORDI MERINO, KYONG SOO PARK, NAM H. CHO, JOSEE DUPUIS, JOSE C. FLOREZ, JAMES B. MEIGS

Diabetes 2020;69(Supplement_1):1655-P

https://doi.org/10.2337/db20-1655-P

Published: 01 June 2020

View articletitled, 1655-P: Genetic Risk Factors for Incident Cardiovascular Disease in Type 2 Diabetes Patients

Meeting Abstracts

240-OR: Combining Type 2 Diabetes Polygenic Scores Improves Prediction in 36,000 European and Non-European Participants in the Partners Healthcare Biobank

JOSEP M. MERCADER, JOSE C. FLOREZ, AARON LEONG, VARINDERPAL KAUR, MIRIAM UDLER, JAMES B. MEIGS, BIANCA PORNEALA

Diabetes 2020;69(Supplement_1):240-OR

https://doi.org/10.2337/db20-240-OR

Published: 01 June 2020

View articletitled, 240-OR: Combining Type 2 Diabetes Polygenic Scores Improves Prediction in 36,000 European and Non-European Participants in the Partners Healthcare Biobank

Meeting Abstracts

239-OR: Genome-Wide Association Study (GWAS) of Hypoglycemia in the Million Veteran Program (MVP)

SRIDHARAN RAGHAVAN, ZEYUAN WANG, ADRIANA M. HUNG, BRIAN R. CHAREST, LAUREN COSTA, ELIZABETH M. LITKOWSKI, AARON LEONG, JAMES B. MEIGS, PETER W. WILSON, PETER REAVEN, MARY K. RHEE, YAN V. SUN, LAWRENCE S. PHILLIPS, MILLION VETERAN PROGRAM

Diabetes 2020;69(Supplement_1):239-OR

https://doi.org/10.2337/db20-239-OR

Published: 01 June 2020

View articletitled, 239-OR: Genome-Wide Association Study (GWAS) of Hypoglycemia in the Million Veteran Program (MVP)

Meeting Abstracts

2263-PUB: Consideration of Insulin Resistance Improves HbA1c-Based Type 2 Diabetes Risk Assessment

JAMES B. MEIGS, BIANCA C. PORNEALA, AARON LEONG, DOV SHIFFMAN, JAMES DEVLIN, MICHAEL J. MCPHAUL

Diabetes 2020;69(Supplement_1):2263-PUB

https://doi.org/10.2337/db20-2263-PUB

Published: 01 June 2020

View articletitled, 2263-PUB: Consideration of Insulin Resistance Improves HbA1c-Based Type 2 Diabetes Risk Assessment

Journal Articles

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68: 441—456

Samuela Pollack, Robert P. Igo, Jr., Richard A. Jensen, Mark Christiansen, Xiaohui Li, Ching-Yu Cheng, Maggie C.Y. Ng, Albert V. Smith, Elizabeth J. Rossin, Ayellet V. Segrè, Samaneh Davoudi, Gavin S. Tan, Yii-Der Ida Chen, Jane Z. Kuo, Latchezar M. Dimitrov, Lynn K. Stanwyck, Weihua Meng, S. Mohsen Hosseini, Minako Imamura, Darryl Nousome, Jihye Kim, Yang Hai, Yucheng Jia, Jeeyun Ahn, Aaron Leong, Kaanan Shah, Kyu Hyung Park, Xiuqing Guo, Eli Ipp, Kent D. Taylor, Sharon G. Adler, John R. Sedor, Barry I. Freedman, Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group, I-Te Lee, Wayne H.-H. Sheu, Michiaki Kubo, Atsushi Takahashi, Samy Hadjadj, Michel Marre, David-Alexandre Tregouet, Roberta Mckean-Cowdin, Rohit Varma, Mark I. McCarthy, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh, Andrew Morris, Alex S.F. Doney, Helen M. Colhoun, Iiro Toppila, Niina Sandholm, Per-Henrik Groop, Shiro Maeda, Craig L. Hanis, Alan Penman, Ching J. Chen, Heather Hancock, Paul Mitchell, Jamie E. Craig, Emily Y. Chew, Andrew D. Paterson, Michael A. Grassi, Colin Palmer, Donald W. Bowden, Brian L. Yaspan, David Siscovick, Mary Frances Cotch, Jie Jin Wang, Kathryn P. Burdon, Tien Y. Wong, Barbara E.K. Klein, Ronald Klein, Jerome I. Rotter, Sudha K. Iyengar, Alkes L. Price, Lucia Sobrin

Diabetes 2020;69(6):1306

https://doi.org/10.2337/db20-er06a

Published: 14 May 2020

View articletitled, Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68: 441—456

Meeting Abstracts

307-OR: Interaction of Diabetes Genetic Risk and Successful Lifestyle Modification in the Diabetes Prevention Program

SRIDHARAN RAGHAVAN, KATHLEEN A. JABLONSKI, LINDA M. DELAHANTY, NISA MARUTHUR, AARON LEONG, PAUL W. FRANKS, WILLIAM C. KNOWLER, JOSE C. FLOREZ, DANA DABELEA, DPP RESEARCH GROUP

Diabetes 2019;68(Supplement_1):307-OR

https://doi.org/10.2337/db19-307-OR

Published: 01 June 2019

View articletitled, 307-OR: Interaction of Diabetes Genetic Risk and Successful Lifestyle Modification in the Diabetes Prevention Program

Meeting Abstracts

308-OR: Genome-Wide Association Study of Food Frequency Questionnaire Single Nutrients and Dietary Patterns Uncover Hundreds of Genetic Associations

JOANNE B. COLE, AARON LEONG, JOEL HIRSCHHORN, JOSE C. FLOREZ

Diabetes 2019;68(Supplement_1):308-OR

https://doi.org/10.2337/db19-308-OR

Published: 01 June 2019

View articletitled, 308-OR: Genome-Wide Association Study of Food Frequency Questionnaire Single Nutrients and Dietary Patterns Uncover Hundreds of Genetic Associations

Journal Articles

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Diabetes 2019;68(2):441–456

https://doi.org/10.2337/db18-0567

Published: 28 November 2018

View articletitled, Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

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1331-P: Aggregate Effect of Hemoglobin A1c–Related Genetic Variants on Other Glycated Proteins by Ancestry

1332-P: The Impact of the African-Ancestry–Specific G6PD Variant on the Relationship between HbA1c and Glucose

276-OR: Common Variant Polygenic Risk Score Influences Penetrance of Rare Variants in Monogenic Diabetes Genes

1333-P: A Mutation Causing Glucose-6-Phosphate Dehydrogenase Deficiency Increases the Risk of Diabetes Complications in Men with African Ancestry

194-LB: Aggregate Effect of Hemoglobin A1c–Related Genetic Variants on A1c–Glycemia Discordance by Ancestry

186-OR: Genetic Variants That Lower Hemoglobin A1c Independently of Glycemia Are Associated with Higher Diabetic Retinopathy Risk in Diverse Ancestries

218-LB: Younger Veterans with Adult-Onset Diabetes Who Have High Type 1 Diabetes (T1D) Genetic Risk Are Disproportionately of Minority Ancestry and Have Features Typical of T1D but Are Often Unrecognized—A Health Disparity

139-OR: Large-Scale Sex-Stratified Additive and Recessive GWAS Identifies Novel Large-Effect Variants and Improves Polygenic Prediction for Type 2 Diabetes

Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

244-OR: Toward Improved Identification of Adult-Onset Type 1 Diabetes (T1D): Clinical Characteristics Associated with T1D Polygenic Risk Scores in the Million Veteran Program (MVP)

245-OR: Comprehensive Genome-Wide Association Study (GWAS) Meta-analysis Using TOPMed Imputation in Latinos Identifies Rare Variation Associated with Type 2 Diabetes (T2D)

1643-P: A Recessive Genome-Wide Meta-analysis of Type 2 Diabetes in 300,000 Individuals of European Ancestry Identifies Multiple Novel Variants of Large Effect Size

1655-P: Genetic Risk Factors for Incident Cardiovascular Disease in Type 2 Diabetes Patients

240-OR: Combining Type 2 Diabetes Polygenic Scores Improves Prediction in 36,000 European and Non-European Participants in the Partners Healthcare Biobank

239-OR: Genome-Wide Association Study (GWAS) of Hypoglycemia in the Million Veteran Program (MVP)

2263-PUB: Consideration of Insulin Resistance Improves HbA1c-Based Type 2 Diabetes Risk Assessment

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68: 441—456

307-OR: Interaction of Diabetes Genetic Risk and Successful Lifestyle Modification in the Diabetes Prevention Program

308-OR: Genome-Wide Association Study of Food Frequency Questionnaire Single Nutrients and Dietary Patterns Uncover Hundreds of Genetic Associations

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

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